A mass spectrometry-based approach to host cell protein identification and its application in a comparability exercise

Analytical Biochemistry

Volumn 463, Issue , 2014, Pages 1-6

  Reisinger, Veronika ^a   Toll, Hansjoerg ^a   Mayer, Robert Ernst ^a   Visser, Jan ^b   Wolschin, Florian ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Sandoz Biopharmaceuticals   (Germany)

Author keywords

Biopharmaceutical; Comparability; HCP; Mass spectrometry

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS; PURIFICATION;

ACTIVE PHARMACEUTICAL INGREDIENTS; BIOPHARMACEUTICAL; BIOPHARMACEUTICALS; COMPARABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; PROCESS-RELATED IMPURITIES; PRODUCTION PROCESS; TRADITIONAL APPROACHES;

DRUG PRODUCTS;

CELL PROTEIN; HOST CELL PROTEIN; PROTEIN A; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; DRUG; PROTEIN; PROTEIN S 100; TRYPSIN;

ARTICLE; CONTROLLED STUDY; HOST CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DATABASE; PROTEIN PURIFICATION; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; WORKFLOW; ENZYME LINKED IMMUNOSORBENT ASSAY; FILTER; HYDROPHOBICITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; CHEMICAL ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES;

CHEMISTRY TECHNIQUES, ANALYTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PROTEINS; S100 PROTEINS; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 84905174217     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.06.005     Document Type: Article

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