Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast

Current Genetics

Volumn 60, Issue 3, 2014, Pages 193-200

  Veide Vilg, Jenny ^a,b   Dahal, Sita ^a   Ljungdahl, Thomas ^a   Grøtli, Morten ^a   Tamás, Markus J ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Chemical biology; Elm1; Hog1; Inhibitors; Protein kinase; Yeast

Indexed keywords

1 NM PP1; 4 (1 BENZYL 4 PHENYL 1H 1,2,3 TRIAZOL 5 YL) N ISOPROPYLPYRIDIN 2 AMINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINO ACID; PROTEIN KINASE; PROTEIN KINASE ELM 1; PROTEIN KINASE ELM 1 AS; PROTEIN KINASE HOG 1; PROTEIN KINASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG; HOG1 PROTEIN, S CEREVISIAE; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR LIBRARY; PEPTIDE; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DRUG SCREENING; ENZYME INHIBITION; ENZYME KINETICS; IC 50; NONHUMAN; PEPTIDE BASED ASSAY; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; YEAST; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; IC50; METABOLISM; MOLECULAR LIBRARY; SACCHAROMYCES CEREVISIAE;

DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES; YEASTS;

EID: 84905082844     PISSN: 01728083     EISSN: 14320983     Source Type: Journal    
DOI: 10.1007/s00294-014-0424-3     Document Type: Article

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