CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells

Cell Communication and Signaling

Volumn 12, Issue 1, 2014, Pages

  Kuhny, Marcel ^a   Hochdörfer, Thomas ^a   Ayata, Cemil Korcan ^b   Idzko, Marco ^b   Huber, Michael ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

ATP; BMMC; CD39; Cell death; IL 1 ; P2X7

Indexed keywords

ADENOSINE TRIPHOSPHATE; APYRASE; CD39 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR;

ANIMAL; BONE MARROW CELL; CELL CULTURE; CELL DEATH; INFLAMMATION; MALE; MAST CELL; METABOLISM; MOUSE; PATHOLOGY; SECRETION (PROCESS);

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, CD; APYRASE; BONE MARROW CELLS; CASPASE 1; CELL DEATH; CELLS, CULTURED; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MAST CELLS; MICE; RECEPTORS, PURINERGIC P2X7;

EID: 84905012379     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/s12964-014-0040-3     Document Type: Article

References (56)

1. Mast-cell responses to pathogens. JS Marshall, Nat Rev Immunol 2004 4 787 799 10.1038/nri1460 15459670 (Pubitemid 39336295)
2. Sterile inflammation: sensing and reacting to damage. GY Chen, G Nunez, Nat Rev Immunol 2010 10 826 837 10.1038/nri2873 21088683
3. Mast cells as sensors of cell injury through IL-33 recognition. M Enoksson, K Lyberg, C Möller-Westerberg, PG Fallon, G Nilsson, C Lunderius-Andersson, J Immunol 2011 186 2523 2528 10.4049/jimmunol.1003383 21239713
4. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. T Kawai, S Akira, Nat Immunol 2010 11 373 384 10.1038/ni.1863 20404851
5. Understanding the mechanism of IL-1β secretion. G Lopez-Castejon, D Brough, Cytokine Growth Factor Rev 2011 22 189 195 10.1016/j.cytogfr.2011.10.001 22019906
6. The inflammasome: an integrated view. O Gross, CJ Thomas, G Guarda, J Tschopp, Immunol Rev 2011 243 136 151 10.1111/j.1600-065X.2011.01046.x 21884173
7. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. FJ Sheedy, A Grebe, KJ Rayner, P Kalantari, B Ramkhelawon, SB Carpenter, CE Becker, HN Ediriweera, AE Mullick, DT Golenbock, LM Stuart, E Latz, KA Fitzgerald, KJ Moore, Nat Immunol 2013 14 812 820 10.1038/ni.2639 23812099
8. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. T Misawa, M Takahama, T Kozaki, H Lee, J Zou, T Saitoh, S Akira, Nat Immunol 2013 14 454 460 10.1038/ni.2550 23502856
9. P2X(7) receptor: death or life? E Adinolfi, C Pizzirani, M Idzko, E Panther, J Norgauer, F Di Virgilio, D Ferrari, Purinergic Signal 2005 1 219 227 10.1007/s11302-005-6322-x 18404507 (Pubitemid 41136027)
10. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. P Pelegrin, A Surprenant, EMBO J 2006 25 5071 5082 10.1038/sj.emboj.7601378 17036048 (Pubitemid 44658525)
11. The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release. P Pelegrin, A Surprenant, Purinergic Signal 2009 5 129 137 10.1007/s11302-009-9141-7 19212823
12. Responses of mouse lymphocytes to extracellular adenosine 5'-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP. F Di Virgilio, V Bronte, D Collavo, P Zanovello, J Immunol 1989 143 1955 1960 2789252 (Pubitemid 19241213)
13. CD39 modulates endothelial cell activation and apoptosis. C Goepfert, M Imai, S Brouard, E Csizmadia, E Kaczmarek, SC Robson, Mol Med 2000 6 591 603 10997340
14. NTPDase1 governs P2X7-dependent functions in murine macrophages. SA Lévesque, F Kukulski, K Enjyoji, SC Robson, J Sévigny, Eur J Immunol 2010 40 1473 1485 10.1002/eji.200939741 20201036
15. Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. J Reutershan, I Vollmer, S Stark, R Wagner, K-C Ngamsri, HK Eltzschig, FASEB J 2009 23 473 482 10.1096/fj.08-119701 18838482
16. The IL-1 family: regulators of immunity. JE Sims, DE Smith, Nat Rev Immunol 2010 10 89 102 10.1038/nri2691 20081871
17. Immunological and inflammatory functions of the interleukin-1 family. CA Dinarello, Annu Rev Immunol 2009 27 519 550 10.1146/annurev.immunol.021908. 132612 19302047
18. Critical protective role of mast cells in a model of acute septic peritonitis. B Echtenacher, DN Männel, L Hültner, Nature 1996 381 75 77 10.1038/381075a0 8609992 (Pubitemid 26130005)
19. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. R Malaviya, T Ikeda, E Ross, SN Abraham, Nature 1996 381 77 80 10.1038/381077a0 8609993 (Pubitemid 26130006)
20. Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. T Hochdörfer, M Kuhny, CN Zorn, RW Hendriks, B Vanhaesebroeck, T Bohnacker, G Krystal, M Huber, Cell Signal 2011 23 866 875 10.1016/j.cellsig.2011.01.012 21262348
21. Nucleotide metabolism of platelets. H Holmsen, Annu Rev Physiol 1985 47 677 690 10.1146/annurev.ph.47.030185.003333 3888083 (Pubitemid 15142405)
22. Ecto-ATPase activity in cytolytic T-lymphocytes: protection from the cytolytic effects of extracellular ATP. A Filippini, RE TAFFS, T Agui, MV Sitkovsky, J Biol Chem 1990 265 334 340 2136737
23. Extracellular ATP in T-lymphocyte activation: possible role in effector functions. A Filippini, RE TAFFS, MV Sitkovsky, Proc Natl Acad Sci U S A 1990 87 8267 8271 10.1073/pnas.87.21.8267 2146684
24. Salmonella induces macrophage death by caspase-1-dependent necrosis. MA Brennan, BT Cookson, Mol Microbiol 2000 38 31 40 10.1046/j.1365-2958.2000.02103. x 11029688
25. Pro-inflammatory programmed cell death. BT Cookson, MA Brennan, Trends Microbiol 2001 9 113 114 10.1016/S0966-842X(00)01936-3 11303500
26. P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. P Pelegrin, C Barroso-Gutierrez, A Surprenant, J Immunol 2008 180 7147 7157 10.4049/jimmunol.180.11.7147 18490713
27. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). A Surprenant, F Rassendren, E Kawashima, RA North, G Buell, Science 1996 272 735 738 10.1126/science.272.5262.735 8614837
28. Activation kinetics of single P2X receptors. F Markwardt, Purinergic Signal 2007 3 249 253 10.1007/s11302-007-9070-2 18404439
29. Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis. M Picher, LH Burch, RC Boucher, J Biol Chem 2004 279 20234 20241 10.1074/jbc.M400305200 14993227 (Pubitemid 38623468)
30. E-NTPDases in human airways: Regulation and relevance for chronic lung diseases. LH Burch, M Picher, Purinergic Signal 2006 2 399 408 10.1007/s11302-006-9001-7 18404479
31. Overexpression of CD39 in mouse airways promotes bacteria-induced inflammation. E Théâtre, K Frederix, W Guilmain, C Delierneux, C Lecut, L Bettendorff, V Bours, C Oury, J Immunol 2012 189 1966 1974 10.4049/jimmunol.1102600 22802412
32. Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. AD Michel, E Fonfria, Br J Pharmacol 2007 152 523 537 10.1038/sj.bjp.0707417 17700717 (Pubitemid 47585044)
33. G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. HS Kuehn, AM Gilfillan, Immunol Lett 2007 113 59 69 10.1016/j.imlet.2007.08.007 17919738 (Pubitemid 47562126)
34. Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. D Brough, RA Le Feuvre, RD Wheeler, N Solovyova, S Hilfiker, NJ Rothwell, A Verkhratsky, J Immunol 2003 170 3029 3036 10.4049/jimmunol.170.6.3029 12626557 (Pubitemid 36302177)
35. Inflammatory caspases and inflammasomes: master switches of inflammation. F Martinon, J Tschopp, Cell Death Differ 2007 14 10 22 10.1038/sj.cdd.4402038 16977329 (Pubitemid 44911890)
36. Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. H Mizutani, N Schechter, G Lazarus, RA Black, TS Kupper, J Exp Med 1991 174 821 825 10.1084/jem.174.4.821 1919436
37. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. M Guma, L Ronacher, R Liu-Bryan, S Takai, M Karin, M Corr, Arthritis Rheum 2009 60 3642 3650 10.1002/art.24959 19950258
38. IL-1beta processing in host defense: beyond the inflammasomes. MG Netea, A Simon, F van de Veerdonk, B-J Kullberg, JWM van der Meer, LAB Joosten, PLoS Pathog 2010 6 1000661 10.1371/journal.ppat.1000661 20195505
39. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. LAB Joosten, MG Netea, G Fantuzzi, MI Koenders, MMA Helsen, H Sparrer, CT Pham, JWM van der Meer, CA Dinarello, WB van den Berg, Arthritis Rheum 2009 60 3651 3662 10.1002/art.25006 19950280
40. Granzyme A is an interleukin 1 beta-converting enzyme. M Irmler, S Hertig, HR MacDonald, R Sadoul, JD Becherer, A Proudfoot, R Solari, J Tschopp, J Exp Med 1995 181 1917 1922 10.1084/jem.181.5.1917 7722467
41. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. C Andrei, C Dazzi, L Lotti, MR Torrisi, G Chimini, A Rubartelli, Mol Biol Cell 1999 10 1463 1475 10.1091/mbc.10.5.1463 10233156 (Pubitemid 29230902)
42. P2X7 receptor regulation of non-classical secretion from immune effector cells. GR Dubyak, Cell Microbiol 2012 14 1697 1706 10.1111/cmi.12001 22882764
43. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B. L Shi, G Chen, G MacDonald, L Bergeron, H Li, M Miura, RJ Rotello, DK Miller, P Li, T Seshadri, J Yuan, AH Greenberg, Proc Natl Acad Sci U S A 1996 93 11002 11007 10.1073/pnas.93.20.11002 8855298 (Pubitemid 26333107)
44. Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin. SL Lage, GP Amarante-Mendes, KR Bortoluci, Methods 2013 61 110 116 10.1016/j.ymeth.2013.02.010 23454287
45. ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. A Sarkar, M Duncan, J Hart, E Hertlein, DC Guttridge, MD Wewers, J Immunol 2006 176 4979 4986 10.4049/jimmunol.176.8. 4979 16585594
46. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. SM Miggin, E Pålsson-McDermott, A Dunne, C Jefferies, E Pinteaux, K Banahan, C Murphy, P Moynagh, M Yamamoto, S Akira, N Rothwell, D Golenbock, KA Fitzgerald, LAJ O'Neill, Proc Natl Acad Sci U S A 2007 104 3372 3377 10.1073/pnas.0608100104 17360653 (Pubitemid 46364166)
47. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. JA Hagar, DA Powell, Y Aachoui, RK Ernst, EA Miao, Science 2013 341 1250 1253 10.1126/science.1240988 24031018
48. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. SJ Galli, J Kalesnikoff, MA Grimbaldeston, AM Piliponsky, CMM Williams, M Tsai, Annu Rev Immunol 2005 23 749 786 10.1146/annurev.immunol.21. 120601.141025 15771585 (Pubitemid 40563184)
49. Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Y Nakamura, L Franchi, N Kambe, G Meng, W Strober, G Nunez, Immunity 2012 37 85 95 10.1016/j.immuni.2012.04.013 22819042
50. Interleukin 3: a differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan. E Razin, JN Ihle, D Seldin, JM Mencia-Huerta, HR Katz, PA LeBlanc, A Hein, JP Caulfield, KF Austen, RL Stevens, J Immunol 1984 132 1479 1486 6198393 (Pubitemid 14156069)
51. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. H Karasuyama, F Melchers, Eur J Immunol 1988 18 97 104 10.1002/eji.1830180115 2831066 (Pubitemid 18072702)
52. Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms. C Galanos, C Galanos, O Lüderitz, O Lüderitz, Eur J Biochem 1975 54 603 610 10.1111/j.1432-1033.1975.tb04172.x 1100380
53. Chemical, physicochemical and biological properties of bacterial lipopolysaccharides. C Galanos, MA Freudenberg, O Lüderitz, ET Rietschel, O Westphal, Prog Clin Biol Res 1979 29 321 332 504265
54. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc. L Liu, JE Damen, RL Cutler, G Krystal, Mol Cell Biol 1994 14 6926 6935 7523859 (Pubitemid 24299762)
55. SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. K Gimborn, E Lessmann, S Kuppig, G Krystal, M Huber, J Immunol 2005 174 507 516 10.4049/jimmunol.174.1.507 15611277 (Pubitemid 40007441)
56. 2 receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. CK Ayata, SC Ganal, B Hockenjos, K Willim, RP Vieira, M Grimm, B Robaye, J-M Boeynaems, F Di Virgilio, P Pellegatti, A Diefenbach, M Idzko, P Hasselblatt, Gastroenterology 2012 143 1620 1629 e4 10.1053/j.gastro.2012.08.049 22974709