Activation kinetics of single P2X receptors

Purinergic Signalling

Volumn 3, Issue 4, 2007, Pages 249-253

  Markwardt, Fritz ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Kinetics; Model; P2X4; P2X7; Purinergic receptor; Single channel; Voltage clamp

Indexed keywords

EID: 36248985066     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-007-9070-2     Document Type: Article

References (45)

1. Hille B (2001) Ion channels of excitable membranes. Sinauer, Sunderland, MA
2. Sakmann B, Neher E (1995) Single channel recording. Plenum, New York
3. Colquhoun D (2006) Agonist-activated ion channels. Br J Pharmacol 147:S17-S26
4. Krishtal OA, Marchenko SM, Pidoplichko VI (1983) Receptor for ATP in the membrane of mammalian sensory neurones. Neurosci Lett 35:41-45
5. Kolb HA, Wakelam MJO (1983) Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes. Nature 303:621-623
6. Bean BP (1992) Pharmacology and electrophysiology of ATP-activated ion channels. Trends Pharmacol Sci 13:87-90
7. Bean BP, Friel D (1990) ATP-activated channels in excitable cells. In: Narahashi T (ed) Ion channels, 2nd edn. Plenum, New York, pp 169-203
8. Surprenant A (1996) Functional properties of native and cloned P2X receptors. In: Chadwick DJ, Goode JA (eds) P2 purinoceptors: localization, function and transduction mechanisms. Ciba Foundation Symposium 198. Wiley, Chichester, pp 208-222
9. Bean BP (1990) ATP-activated channels in rat and bullfrog sensory neurons: Concentration dependence and kinetics. J Neurosci 10:1-10
10. 3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels. EMBO J 17:3016-3028
11. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067
12. 6 receptor subunits do not oligomerize. J Biol Chem 280:10759-10765
13. Krishtal OA, Marchenko SM, Obukhov AG (1988) Cationic channels activated by extracellular ATP in rat sensory neurons. Neurosci Lett 27:995-1000
14. 2+ ions. J Neurophysiol 73:312-319
15. 2+ potentiates steady-state ATP activated currents in rat nodose ganglion neurons by increasing the burst duration of a 35 pS channel. Neurosci Lett 193:177-180
16. Markwardt F, Löhn M, Böhm T, Klapperstück M (1997) Purinoceptor-operated cationic channels in human B lymphocytes. J Physiol (Lond) 498:143-151
17. Ugur M, Drummond RM, Zou H, Sheng PH, Singer JJ, Walsh JV (1997) An ATP-gated cation channel with some P2Z-like characteristics in gastric smooth muscle cells of toad. J Physiol (Lond) 498:427-442
18. Wong AYC, Burnstock G, Gibb AJ (2000) Single channel properties of P2X ATP receptors in outside-out patches from rat hippocampal granule cells. J Physiol (Lond) 527:529-547
19. Valera S, Hussy N, Evans RJ, Adami N, North RA, Surprenant A, Buell G (1994) A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature 371:516-519
20. Evans RJ (1996) Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells. Neurosci Lett 212:212-214
21. 1 receptor at nanomolar ATP concentrations. J Gen Physiol 121:451-461
22. 3 receptors. Mol Pharmacol 70:373-382
23. 4 receptor channels expressed in human embryonic kidney cells. Neurosci Lett 279:165-168
24. 4 receptor channels. J Gen Physiol 123:281-293
25. 2 purinoceptors. J Gen Physiol 113:695-719
26. 2 purinoceptors by divalent cations. J Physiol (Lond) 522:199-214
27. 7 receptor. J Physiol (Lond) 534:25-35
28. Ding SH, Sachs F (2002) Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes. BMC Neurosci 3:17
29. 7 receptor-operated single channels currents. Biophys J 92:2377-2391
30. 7 receptor-operated single channels currents. Biophys J 93:846-858. DOI 10.1529/biophysj.106.103614
31. 7). Science 272:735-738
32. Virginio C, MacKenzie A, North RA, Surprenant A (1999) Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X 7 receptor. J Physiol (Lond) 519:335-346
33. 2 purinoceptors: Single channel recordings. J Membr Biol 172:215-223
34. Evans RJ, Lewis C, Virginio C, Lundstrom K, Buell G, Surprenant A, North RA (1996) Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol (Lond) 497:413-422
35. 7 receptor. EMBO J 25:5071-5082
36. 7 receptor death complex. FEBS Lett 581:483-488
37. Locovei S, Wang JJ, Dahl G (2006) Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 580:239-244
38. Bao L, Locovei S, Dahl G (2004) Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett 572:65-68
39. Egan TM, Samways DSK, Li ZY (2006) Biophysics of P2X receptors. Pflugers Arch 452:501-512
40. Khakh BS, Bao XR, Labarca C, Lester HA (1999) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci 2:322-350
41. Virginio C, MacKenzie A, Rassendren FA, North RA, Surprenant A (1999) Pore dilation of neuronal P2X receptor channels. Nat Neurosci 2:315-321
42. 7 receptors. Am J Physiol 289:C1295-C1302
43. 1. Arch Biochem Biophys 362:197-202
44. Colquhoun D (1998) Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol 125:924-947
45. Khakh BS, North RA (2006) P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527-532