E-NTPDases in human airways: Regulation and relevance for chronic lung diseases

Purinergic Signalling

Volumn 2, Issue 2, 2006, Pages 399-408

  Burch, Lauranell H ^a   Picher, Maryse ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Apyrase; Bacterial clearance; CD39; Chronic obstructive lung diseases; Diphosphohydrolase; Endotoxin; Oxidative stress; Purinergic signaling

Indexed keywords

EID: 35549006392     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-006-9001-7     Document Type: Review

References (89)

1. Pelleg A, Schulman E (2002) Adenosine 5′-triphosphate axis in obstructive airway diseases. Am J Ther 9:454-64
2. Burnstock G, Knight GE (2004) Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240:31-304
3. Dubyak GR (2000) Purinergic signaling at immunological synapses. J Auton Nerv Syst 81:64-8
4. Homolya L, Steinberg TH, Boucher RC (2000). Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol 150:1349-60
5. Huang P, Lazarowski ER, Tarran R et al (2001) Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc Natl Acad Sci USA 98:14120-5
6. Lazarowski ER, Boucher RC, Harden TK (2003) Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol 64:785-95
7. Gabriel SE (2002) Calcium-activated Cl-conductance in the airway epithelium. In: Fuller CM (ed) Current topics in membranes. San Diego, Elsevier Science, pp 193-207
8. Boeynaems JM, Communi D, Gonzalez NS et al (2005) Overview of the P2 receptors. Semin Thromb Hemost 31:139-49
9. Picher M, Burch LH, Hirsh AJ et al (2003) Ecto 5′-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. J Biol Chem 278:13468-79
10. Picher M, Burch LH, Boucher RC (2004) Metabolism of P2 receptor agonists in human airways: Implications for mucociliary clearance and cystic fibrosis. J Biol Chem 279:20234-41
11. Fredholm BB (2003) Adenosine receptors as targets for drug development. Drug News Perspect 16:283-9
12. Boucher RC (2004) New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 23:146-58
13. Greenberg S, Zhao X, Wang J et al (1997) cAMP and purinergic P2Y receptors up-regulate and enhance inducible NO synthase mRNA and protein in vivo. Am J Physiol 273:L967-79
14. La Sala A, Ferrari D, Di Virgilio F et al (2003) Alerting and tuning the immune response by extracellular nucleotides. J Leukoc Biol 73:339-43
15. Zimmermann H (2001) Ectonucleotidases: Some recent developments and a note on nomenclature. Drug Dev Res 52:44-56
16. Boucher RC (2004) New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 23:146-58
17. Tarran R, Boucher RC (2002) Thin-film measurements of airway surface liquid volume/composition and mucus transport rates in vitro. Methods Mol Med 70:479-92
18. Roomans GM, Kozlova I, Nilsson H et al (2004) Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis. J Cyst Fibros 3(Suppl 2):135-9
19. Tarran R (2004) Regulation of airway surface liquid volume and mucus transport by active ion transport. Proc Am Thorac Soc 1:42-6
20. Gabriel SE, Boucher RC (1997) Ion channels. In: Crystal RG, West JB (eds) The lung. Philadelphia, Lippincott-Raven, pp 205-318
21. + absorption by extracellular nucleotides in human normal and cystic fibrosis airways. Am J Respir Cell Mol Biol 23:755-61
22. Taylor AL, Schwiebert LM, Smith JJ et al (1999) Epithelial P2X purinergic receptor channel expression and function. J Clin Invest 104:875-84
23. Adinolfi E, Pizzirani C, Idzko M et al (2005) P2X 7 receptor: Death or life? Purin Signal 1:219-27
24. Wong LB, Yeates DB (1992) Luminal purinergic regulatory mechanisms of tracheal ciliary beat frequency. Am J Respir Cell Mol Biol 7:447-54
25. Evans JH, Sanderson MJ (1999) Intracellular calcium oscillations regulate ciliary beat frequency of airway epithelial cells. Cell Calcium 26:103-10
26. Morse DM, Smullen JL, Davis CW (2001) Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells. Am J Physiol 280:C1485-97
27. Davis C (2002) Regulation of mucin secretion in in vitro cellular models. Novartis Found Symp 248:113-25
28. Conway JD, Bartolotta T, Abdullah LH, Davis CW (2003) Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts. Am J Physiol 284:L945-54
29. Tarran R, Grubb BR, Parsons D et al (2001) The CF salt controversy: In vivo observations and therapeutic approaches. Mol Cell 8:149-58
30. Polosa R, Rorke S, Holgate ST (2002) Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Thorax 57:649-54
31. Van den Berge M, Polosa R, Kerstjens HAM et al (2004) The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 114:737-46
32. Basoglu OK, Pelleg A, Essilfie-Quaye S et al (2005) Effects of aerosolized adenosine 5′-triphosphate vs adenosine 5′-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest 128:1905-9
33. Pellegrino R, Wilson O, Jenouri G et al (1996) Lung mechanics during induced bronchoconstriction. J Appl Physiol 81:964-75
34. Sabater JR, Mao YM, Shaffer C et al (1999) Aerosolization of P2Y 2 -receptor agonists enhances mucociliary clearance in sheep. J Appl Physiol 87:2191-6
35. Bennett WD, Zeman KL, Foy C et al (2001) Effect of aerosolized uridine 5′-triphosphate on mucociliary clearance in mild chronic bronchitis. Am J Respir Crit Care Med 164:302-6
36. Bennett WD, Olivier KN, Zeman KL et al (1996) Effect of uridine 5′-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. Am J Respir Crit Care Med 153:1796-801
37. Olivier KN, Bennett WD, Hohneker KW et al (1996) Acute safety and effects on mucociliary clearance of aerosolized uridine 5′-triphosphate +/- amiloride in normal human adults. Am J Respir Crit Care Med 154:217-23
38. Noone PG, Bennett WD, Regnis JA et al (1999) Effect of aerosolized uridine-5′-triphosphate on airway clearance with cough in patients with primary ciliary dyskinesia. Am J Respir Crit Care Med 160:144-9
39. 2 receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther 302:871-80
40. 2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease. Adv Drug Deliv Rev 54:1463-74
41. 2 receptor agonist: Results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis. Pediatr Pulmonol 39:339-48
42. 2 receptor-activated transepithelial anion secretion. Am J Physiol Cell Physiol 276:C777-87
43. Rich PB, Douillet CD, Mahler SA et al (2003) Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema. J Trauma 55:290-7
44. Douillet CD, Robinson WP III, Zarzaur BL et al (2005) Mechanical ventilation alters airway nucleotides and purinoceptors in lung and extrapulmonary organs. Am J Respir Cell Mol Biol 32:52-8
45. Geary C, Akinbi HT, Korfhagen T et al Increased susceptibility of purinergic receptor deficient mice to lung infection with Pseudomonas aeruginosa. Am J Physiol 289:L890-5
46. 2+ independent hyperinflammatory response in human cystic fibrosis airway epithelia. J Biol Chem 280:17798-806
47. 7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol 167:1871-6
48. Perregaux DG, McNiff P, Laliberte R et al (2000) ATP Acts as an agonist to promote stimulus-induced secretion of IL-1β and IL-18 in human blood. J Immunol 165:4615-23
49. Brown EA, Hoffmann SP (2002) Update in pulmonary medicine. Clin Pediatr Med Surg 19:1-22
50. Boucher RC (2004) Relationship of airway epithelial ion transport to chronic bronchitis. Proc Am Thorac Soc 1:66-70.
51. Sadikot RT, Blackwell TS, Christman JW, Prince AS (2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med 171:1209-23
52. North RA, Surprenant A (2000) Pharmacology of cloned P2X receptors. Ann Rev Pharmacol Toxicol 40:563-80
53. 2 nucleotide receptor. Mol Cell Biochem 205:115-23
54. Kucher BM, Neary JT (2005) Bi-functional effects of ATP/P2 receptor activation on tumor necrosis factor-alpha release in lipopolysaccharide-stimulated astrocytes. J Neurochem 92:525-35
55. Picher M, Boucher RC (2000) Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways. Am J Respir Cell Mol Biol 23:255-61
56. Donaldson SH, Lazarowski ER, Picher M et al (2000) Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways. Mol Med 6:969-82
57. Lazarowski ER, Boucher RC, Harden TK (2000) Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J Biol Chem 275:31061-8
58. Donaldson SH, Picher M, Boucher RC (2000) Secreted and cell-associated adenylate kinase and nucleoside diphosphokinase contribute to extracellular nucleotide metabolism on human airway surfaces. Am J Respir Cell Mol Biol 26:209-15
59. Fortuna R, Anderson HC, Carty RP, Sajdeja SW (1980) Enzymatic characterization of the matrix vesicle alkaline phosphatase isolated from bovine epiphyseal cartilage. Calcif Tissue Int 30:217-25
60. Zimmermann H (2000) Extracellular metabolism of ATP and other nucleotides. Naunyn-Schmiedeberg's Arch Pharmacol 362:299-309
61. Plesner L (1995) Ecto-ATPases: Identities and functions. Int Rev Cytol 158:141-214
62. Leal DBR, Streher CA, Neu TN et al (2005) Characterization of NTPDase (NTPDase 1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5) activity in human lymphocytes. Biochim Biophys Acta 1721:9-15
63. Smith TM, Kirley TL (1998) Cloning, sequencing and expression of a human brain ecto-apyrase related to both the ecto-ATPase and CD39 ecto-apyrase 1. Biochim Biophys Acta 1386:65-78
64. Shi XJ, Knowles AF (1994) Prevalence of the mercurial-sensitive ectoATPase in human small cell lung carcinoma: Characterization and partial purification. Arch Biochem Biophys 315:177-84
65. Sevigny J, Robson SC, Waelkens E et al (2000) Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase. J Biol Chem 275:5640-7
66. Chadwick BP, Frischauf AM (1998). The CD39-like gene family: Identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Genomics 50:357-67
67. Picher M, Button B, Boucher R (2005) Therapeutic potential of ebselen for nucleotide-mediated mucociliary clearance in the lungs of cystic fibrosis patients. Pediatr Pulmonol 28:274.
68. Kukulski F, Levesque SA, Lavoie EG et al (2005) Comparative hydrolysis of P2 receptor agonists by NTPDase 1, 2, 3 and 8. Purin Signal 1:193-204
69. Button B, Picher M, Lazarowski E, Boucher RC (2004) Sustained release and accumulation of nucleotides during cyclic compressive stress increases mucus clearance in CF human airway epithelial surfaces. Pediatr Pulmonol 27:213
70. App EM, Kieselmann R, Reinhardt D et al (1998) Sputum rheology changes in cystic fibrosis lung disease following two different types of physiotherapy: Flutter vs autogenic drainage. Chest 114:171-7
71. Rosenfeld M, Ramsey B, Gibson R (2003) Pseudomonas acquisition in young patients with cystic fibrosis: Pathophysiology, diagnosis and management. Curr Opin Pulm Med 9:492-7
72. Picher M, Burch LH, Boucher RC (2000) Expression of alkaline phosphatase and ecto 5′-nucleotidase (CD73) in normal and CF airway epithelia. Pediatr Pulmonol 21:227
73. Picher M, Boucher RC (2003) Detoxification of Pseudomonas aeruginosa lipopolysaccharide in human airways: An inflammatory response mediated by non-specific alkaline phosphatase. Pediatr Pulmonol Suppl. 25:271
74. MacNee W (2005) Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2:50-60
75. Rochelle LG, Fischer BM, Adler KB (1998) Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. Free Radic Biol Med 24:863-8
76. Zinchuk VS, Okada T, Seguchi H (2001) Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis. Cell Tissue Res 304:103-9
77. Faas M, Schuiling G, Valkhof N et al (1998) Superoxide-mediated glomerulopathy in the endotoxin-treated pregnant rat. Kidney Blood Press Res 21:432-7
78. Krotz F, Sohn HY, Keller M et al (2002) Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase. Arterioscler Thromb Vasc Biol 22:2003-9
79. Candinas D, Koyamada N, Miyatake T et al (1996) Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions. Thromb Haemost 76:807-12
80. Robson SC, Kaczmarek E, Siegel JB et al (1997) Loss of ATP diphosphohydrolase activity with endothelial cell activation. J Exp Med 185:153-64
81. Kalmar B, Kittel A, Lemmens R et al (2001) Cultured astrocytes react to LPS with increased cyclooxygenase activity and phagocytosis. Neurochem Int 38:453-61
82. Kapojos JJ, Poelstra K, Borghuis T et al (2003) Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide. Int J Exp Pathol 84:135-44
83. Okada T, Zinchuk VS, Seguchi H (2002) Lipopolysaccharide administration increases acid and alkaline phosphatase reactivity in the cardiac muscle. Microsc Res Tech 58:421-6
84. Braun N, Zhu Y, Krieglstein J et al (1998) Up-regulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat. J Neurosci 18:4891-900
85. Pier GB, Grout M, Zaidi TS (1997) Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc Natl Acad Sci 94:12088-93
86. Schroeder TH, Lee MM, Yacono PW et al (2002) CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci 99:6907-12
87. Kikuchi T, Hagiwara K, Honda Y et al (2002) Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-{kappa}B transcription factors. J Antimicrob Chemother 49:745-55
88. Pier GB (2002) CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection. Curr Opin Microbiol 5:81-6
89. Voynow JA, Fischer BM, Malarkey DE et al (2004) Neutrophil elastase induces mucus cell metaplasia in mouse lung. Am J Physiol 287:L1293-302