A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 7, 2014, Pages 1344-1357

  Chang, Yu Ling ^a   Chen, Tzu Hui ^a   Wu, Yi Hsiu ^a   Chen, Guann An ^a   Weng, Tzu Huei ^a   Tseng, Ping Hui ^a   Hsieh, Shie Liang ^a,b,c   Fu, Shu Ling ^a   Lin, Chi Hung ^a   Chen, Chun Jen ^d   Chu, Ching Liang ^e   Chio, Iok In Christine ^f   Mak, Tak Wah ^f   Chen, Nien Jung ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Signalling crosstalk; Toll like receptor; TRADD; TRAF6; Tumour necrosis factor

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TRADD PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN;

ANIMAL; C57BL MOUSE; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOPRECIPITATION; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904987540     PISSN: 15821838     EISSN: 15824934     Source Type: Journal    
DOI: 10.1111/jcmm.12294     Document Type: Article

References (57)

1. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010; 11: 373-84.
2. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008; 454: 428-35.
3. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol. 2007; 7: 179-90.
4. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004; 4: 499-511.
5. Cao Z, Xiong J, Takeuchi M, et al. TRAF6 is a signal transducer for interleukin-1. Nature. 1996; 383: 443-6.
6. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001; 413: 78-83.
7. Gray P, Dunne A, Brikos C, et al. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem. 2006; 281: 10489-95.
8. Yamamoto M, Sato S, Hemmi H, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003; 4: 1144-50.
9. Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006; 125: 943-55.
10. Kagan JC, Su T, Horng T, et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008; 9: 361-8.
11. Marino MW, Dunn A, Grail D, et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA. 1997; 94: 8093-8.
12. Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol. 2003; 3: 745-56.
13. Schneider-Brachert W, Tchikov V, Neumeyer J, et al. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity. 2004; 21: 415-28.
14. Hsu H, Xiong J, Goeddel DV. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell. 1995; 81: 495-504.
15. Hsu H, Shu HB, Pan MG, et al. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996; 84: 299-308.
16. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003; 114: 181-90.
17. De Nardo D, De Nardo CM, Nguyen T, et al. Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages. J Immunol. 2009; 183: 8110-8.
18. Gonzalez-Navajas JM, Law J, Nguyen KP, et al. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010; 207: 2799-807.
19. Mathison JC, Virca GD, Wolfson E, et al. Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J Clin Invest. 1990; 85: 1108-18.
20. Freudenberg MA, Galanos C. Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Inf Immun. 1988; 56: 1352-7.
21. Baeuerle PA, Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science. 1988; 242: 540-6.
22. Boone DL, Turer EE, Lee EG, et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol. 2004; 5: 1052-60.
23. Cohen-Kaminsky S, Delattre RM, Devergne O, et al. Synergistic induction of interleukin-6 production and gene expression in human thymic epithelial cells by LPS and cytokines. Cell Immunol. 1991; 138: 79-93.
24. Jersmann HP, Hii CS, Ferrante JV, et al. Bacterial lipopolysaccharide and tumor necrosis factor alpha synergistically increase expression of human endothelial adhesion molecules through activation of NF-kappaB and p38 mitogen-activated protein kinase signaling pathways. Infect Immun. 2001; 69: 1273-9.
25. Pirotzky E, Delattre RM, Hellegouarch A, et al. Interleukin-6 production by tumor necrosis factor and lipopolysaccharide-stimulated rat renal cells. Clin Immunol Immunopathol. 1990; 56: 271-9.
26. Meylan E, Burns K, Hofmann K, et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol. 2004; 5: 503-7.
27. Sasai M, Tatematsu M, Oshiumi H, et al. Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Mol Immunol. 2010; 47: 1283-91.
28. Zhande R, Dauphinee SM, Thomas JA, et al. FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction. Mol Cell Biol. 2007; 27: 7394-404.
29. Chen NJ, Chio II, Lin WJ, et al. Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci USA. 2008; 105: 12429-34.
30. Ermolaeva MA, Michallet MC, Papadopoulou N, et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008; 9: 1037-46.
31. Pobezinskaya YL, Kim YS, Choksi S, et al. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol. 2008; 9: 1047-54.
32. Park SH, Park-Min KH, Chen J, et al. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol. 2011; 12: 607-15.
33. Pasparakis M, Alexopoulou L, Episkopou V, et al. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med. 1996; 184: 1397-411.
34. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008; 29: 272-82.
35. Pear W, Scott M, Nolan GP. Generation of high titre, helper-free retroviruses by transient transfection. In: Robbins P, editor. Methods in molecular medicine: gene therapy protocols. Totowa, NJ: Humana Press, 1997: pp. 41-57.
36. Tseng PH, Matsuzawa A, Zhang W, et al. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010; 11: 70-5.
37. McNab FW, Rajsbaum R, Stoye JP, et al. Tripartite-motif proteins and innate immune regulation. Curr Opin Immunol. 2011; 23: 46-56.
38. Harhaj EW, Dixit VM. Regulation of NF-kappaB by deubiquitinases. Immunol Rev. 2012; 246: 107-24.
39. Kawai T, Adachi O, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 1999; 11: 115-22.
40. Chio IIC, Sasaki M, Ghazarian D, et al. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol. 2012; 14: 625-33.
41. Gohda J, Matsumura T, Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol. 2004; 173: 2913-7.
42. Funakoshi-Tago M, Kamada N, Shimizu T, et al. TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation. Cytokine. 2009; 45: 72-9.
43. Lomaga MA, Yeh WC, Sarosi I, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999; 13: 1015-24.
44. Verstak B, Nagpal K, Bottomley SP, et al. MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem. 2009; 284: 24192-203.
45. Wertz IE, Dixit VM. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ. 2010; 17: 14-24.
46. Deng L, Wang C, Spencer E, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000; 103: 351-61.
47. Aksoy E, Taboubi S, Torres D, et al. The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. 2012; 13: 1045-54.
48. Park YC, Ye H, Hsia C, et al. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000; 101: 777-87.
49. Michallet MC, Meylan E, Ermolaeva MA, et al. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity. 2008; 28: 651-61.
50. Hacker H, Tseng PH, Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011; 11: 457-68.
51. Ogrendik M. Does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? Discov Med. 2012; 13: 349-55.
52. Zandman-Goddard G, Shoenfeld Y. SLE and infections. Clin Rev Allergy Immunol. 2003; 25: 29-40.
53. Aringer M, Smolen JS. Therapeutic blockade of TNF in patients with SLE-promising or crazy? Autoimmun Rev. 2012; 11: 321-5.
54. Nograles KE, Krueger JG. Anti-cytokine therapies for psoriasis. Exp Cell Res. 2011; 317: 1293-300.
55. Perrier C, Rutgeerts P. Cytokine blockade in inflammatory bowel diseases. Immunotherapy. 2011; 3: 1341-52.
56. Goode S, Tierney G, Deighton C. Life threatening intra-abdominal sepsis in patients on anti-TNF-alpha therapy. Gut. 2006; 55: 590-1.
57. Grau GE, Maennel DN. TNF inhibition and sepsis - sounding a cautionary note. Nat Med. 1997; 3: 1193-5.