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Volumn 34, Issue 31, 2014, Pages 10285-10297

Abrogation of β-Catenin signaling in oligodendrocyte precursor cells reduces glial scarring and promotes axon regeneration after CNS injury

Author keywords

Glia; Inflammation; Repair; Wnt

Indexed keywords

GLIA; INFLAMMATION; REPAIR; WNT;

EID: 84904968661     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4915-13.2014     Document Type: Article
Times cited : (94)

References (78)
  • 2
    • 77955450730 scopus 로고    scopus 로고
    • Optic nerve regeneration
    • CrossRef Medline
    • Benowitz LI, Yin Y (2010) Optic nerve regeneration. Arch Ophthalmol 128: 1059-1064. CrossRef Medline.
    • (2010) Arch Ophthalmol , vol.128 , pp. 1059-1064
    • Benowitz, L.I.1    Yin, Y.2
  • 3
    • 0035034603 scopus 로고    scopus 로고
    • Inactivation of the betacatenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    • Medline
    • Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R (2001) Inactivation of the betacatenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128: 1253-1264. Medline.
    • (2001) Development , vol.128 , pp. 1253-1264
    • Brault, V.1    Moore, R.2    Kutsch, S.3    Ishibashi, M.4    Rowitch, D.H.5    McMahon, A.P.6    Sommer, L.7    Boussadia, O.8    Kemler, R.9
  • 4
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltra-tion, neuronal degeneration, and neurite outgrowth after ablation of scarforming, reactive astrocytes in adult transgenic mice
    • CrossRef Medline
    • Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV (1999) Leukocyte infiltra-tion, neuronal degeneration, and neurite outgrowth after ablation of scarforming, reactive astrocytes in adult transgenic mice. Neuron 23: 297-308. CrossRef Medline.
    • (1999) Neuron , vol.23 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3    Polito, A.4    Ostenfeld, T.5    Svendsen, C.N.6    Mucke, L.7    Johnson, M.H.8    Sofroniew, M.V.9
  • 5
    • 33644967242 scopus 로고    scopus 로고
    • Wnt signaling: Complexity at the surface
    • CrossRef Medline
    • Cadigan KM, Liu YI (2006) Wnt signaling: complexity at the surface. J Cell Sci 119: 395-402. CrossRef Medline.
    • (2006) J Cell Sci , vol.119 , pp. 395-402
    • Cadigan, K.M.1    Liu, Y.I.2
  • 6
    • 0016299239 scopus 로고
    • Heterogeneity of the glial fibrillary acidic protein in gliosed human brains
    • CrossRef Medline
    • Dahl D, Bignami A (1974) Heterogeneity of the glial fibrillary acidic protein in gliosed human brains. J Neurol Sci 23: 551-563. CrossRef Medline.
    • (1974) J Neurol Sci , vol.23 , pp. 551-563
    • Dahl, D.1    Bignami, A.2
  • 7
    • 0019856865 scopus 로고
    • Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
    • CrossRef Medline
    • David S, Aguayo AJ (1981) Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 214: 931-933. CrossRef Medline.
    • (1981) Science , vol.214 , pp. 931-933
    • David, S.1    Aguayo, A.J.2
  • 8
    • 34347254641 scopus 로고    scopus 로고
    • The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo
    • CrossRef Medline
    • DeAlmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B (2007) The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res 67: 5371-5379. CrossRef Medline.
    • (2007) Cancer Res , vol.67 , pp. 5371-5379
    • DeAlmeida, V.I.1    Miao, L.2    Ernst, J.A.3    Koeppen, H.4    Polakis, P.5    Rubinfeld, B.6
  • 11
    • 84861835782 scopus 로고    scopus 로고
    • Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury
    • CrossRef Medline
    • Emmetsberger J, Tsirka SE (2012) Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury. Neurobiol Dis 47: 295-309. CrossRef Medline.
    • (2012) Neurobiol Dis , vol.47 , pp. 295-309
    • Emmetsberger, J.1    Tsirka, S.E.2
  • 14
    • 1542317072 scopus 로고    scopus 로고
    • Reactive astrocytes protect tissue and preserve function after spinal cord injury
    • CrossRef Medline
    • Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV (2004) Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 24: 2143-2155. CrossRef Medline.
    • (2004) J Neurosci , vol.24 , pp. 2143-2155
    • Faulkner, J.R.1    Herrmann, J.E.2    Woo, M.J.3    Tansey, K.E.4    Doan, N.B.5    Sofroniew, M.V.6
  • 15
    • 84867760894 scopus 로고    scopus 로고
    • Defeating inhibition of regeneration by scar and myelin components
    • CrossRef Medline
    • Fawcett JW, Schwab ME, Montani L, Brazda N, Müller HW (2012) Defeating inhibition of regeneration by scar and myelin components. Handb Clin Neurol 109: 503-522. CrossRef Medline.
    • (2012) Handb Clin Neurol , vol.109 , pp. 503-522
    • Fawcett, J.W.1    Schwab, M.E.2    Montani, L.3    Brazda, N.4    Müller, H.W.5
  • 16
    • 69249203776 scopus 로고    scopus 로고
    • Wnt signaling is sufficient to perturb oligodendrocyte maturation
    • CrossRef Medline
    • Feigenson K, Reid M, See J, Crenshaw EB 3rd, Grinspan JB (2009) Wnt signaling is sufficient to perturb oligodendrocyte maturation. Mol Cell Neurosci 42: 255-265. CrossRef Medline.
    • (2009) Mol Cell Neurosci , vol.42 , pp. 255-265
    • Feigenson, K.1    Reid, M.2    See, J.3    Crenshaw III, E.B.4    Grinspan, J.B.5
  • 18
    • 38649112309 scopus 로고    scopus 로고
    • CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
    • CrossRef Medline
    • Fitch MT, Silver J (2008) CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 209: 294-301. CrossRef Medline.
    • (2008) Exp Neurol , vol.209 , pp. 294-301
    • Fitch, M.T.1    Silver, J.2
  • 19
    • 0024852196 scopus 로고
    • The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain
    • Medline
    • Giulian D, Chen J, Ingeman JE, George JK, Noponen M (1989) The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J Neurosci 9: 4416-4429. Medline.
    • (1989) J Neurosci , vol.9 , pp. 4416-4429
    • Giulian, D.1    Chen, J.2    Ingeman, J.E.3    George, J.K.4    Noponen, M.5
  • 20
    • 84870940130 scopus 로고    scopus 로고
    • Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats
    • CrossRef Medline
    • Gonzalez P, Fernandez-Martos CM, Gonzalez-Fernandez C, Arenas E, Rodriguez FJ (2012) Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. PLoS One 7: e50793. CrossRef Medline.
    • (2012) PLoS One , vol.7
    • Gonzalez, P.1    Fernandez-Martos, C.M.2    Gonzalez-Fernandez, C.3    Arenas, E.4    Rodriguez, F.J.5
  • 21
    • 84985187820 scopus 로고
    • Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson
    • CrossRef Medline
    • Gundersen HJ (1986) Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143: 3-45. CrossRef Medline.
    • (1986) J Microsc , vol.143 , pp. 3-45
    • Gundersen, H.J.1
  • 22
    • 0033045425 scopus 로고    scopus 로고
    • The efficiency of systematic sampling in stereology-reconsidered
    • CrossRef Medline
    • Gundersen HJ, Jensen EB, Kiêu K, Nielsen J (1999) The efficiency of systematic sampling in stereology-reconsidered. J Microsc 193: 199-211. CrossRef Medline.
    • (1999) J Microsc , vol.193 , pp. 199-211
    • Gundersen, H.J.1    Jensen, E.B.2    Kiêu, K.3    Nielsen, J.4
  • 24
    • 41149100652 scopus 로고    scopus 로고
    • RGDdependent mechanisms in the endoneurial phagocyte response and axonal regeneration in the nervous system of the snail Lymnaea stagnalis
    • CrossRef Medline
    • Hermann PM, Nicol JJ, Bulloch AG, Wildering WC (2008) RGDdependent mechanisms in the endoneurial phagocyte response and axonal regeneration in the nervous system of the snail Lymnaea stagnalis. J Exp Biol 211: 491-501. CrossRef Medline.
    • (2008) J Exp Biol , vol.211 , pp. 491-501
    • Hermann, P.M.1    Nicol, J.J.2    Bulloch, A.G.3    Wildering, W.C.4
  • 25
    • 84883345906 scopus 로고    scopus 로고
    • NG2 cells in white matter but not gray matter proliferate in response to PDGF
    • CrossRef Medline
    • Hill RA, Patel KD, Medved J, Reiss AM, Nishiyama A (2013) NG2 cells in white matter but not gray matter proliferate in response to PDGF. J Neurosci 33: 14558-14566. CrossRef Medline.
    • (2013) J Neurosci , vol.33 , pp. 14558-14566
    • Hill, R.A.1    Patel, K.D.2    Medved, J.3    Reiss, A.M.4    Nishiyama, A.5
  • 26
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: Activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • CrossRef Medline
    • Horn KP, Busch SA, Hawthorne AL, van Rooijen N, Silver J (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28: 9330-9341. CrossRef Medline.
    • (2008) J Neurosci , vol.28 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    van Rooijen, N.4    Silver, J.5
  • 27
    • 75549087261 scopus 로고    scopus 로고
    • Emerging roles of Wnts in the adult nervous system
    • CrossRef Medline
    • Inestrosa NC, Arenas E (2010) Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci 11: 77-86. CrossRef Medline.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 77-86
    • Inestrosa, N.C.1    Arenas, E.2
  • 29
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • CrossRef Medline
    • Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22: 1172-1183. CrossRef Medline.
    • (2002) Mol Cell Biol , vol.22 , pp. 1172-1183
    • Jho, E.H.1    Zhang, T.2    Domon, C.3    Joo, C.K.4    Freund, J.N.5    Costantini, F.6
  • 30
    • 80054003106 scopus 로고    scopus 로고
    • Recombinant WNTs differentially activate beta-catenin-dependent and-independent signalling in mouse microglia-like cells
    • CrossRef Medline
    • Kilander MB, Halleskog C, Schulte G (2011) Recombinant WNTs differentially activate beta-catenin-dependent and-independent signalling in mouse microglia-like cells. Acta Physiol 203: 363-372. CrossRef Medline.
    • (2011) Acta Physiol , vol.203 , pp. 363-372
    • Kilander, M.B.1    Halleskog, C.2    Schulte, G.3
  • 31
    • 33845351956 scopus 로고    scopus 로고
    • Beta-catenin destruction complex: Insights and questions from a structural perspective
    • CrossRef Medline
    • Kimelman D, XuW (2006) Beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene 25: 7482-7491. CrossRef Medline.
    • (2006) Oncogene , vol.25 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 32
    • 81055149915 scopus 로고    scopus 로고
    • Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
    • CrossRef Medline
    • Kucharova K, Chang Y, Boor A, Yong VW, Stallcup WB (2011) Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord. J Neuroinflammation 8: 158. CrossRef Medline.
    • (2011) J Neuroinflammation , vol.8 , pp. 158
    • Kucharova, K.1    Chang, Y.2    Boor, A.3    Yong, V.W.4    Stallcup, W.B.5
  • 33
    • 78449235139 scopus 로고    scopus 로고
    • Long-distance axon regeneration in the mature optic nerve: Contributions of oncomodulin, cAMP, and pten gene deletion
    • CrossRef Medline
    • Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kügler S, Benowitz LI (2010) Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J Neurosci 30: 15654-15663. CrossRef Medline.
    • (2010) J Neurosci , vol.30 , pp. 15654-15663
    • Kurimoto, T.1    Yin, Y.2    Omura, K.3    Gilbert, H.Y.4    Kim, D.5    Cen, L.P.6    Moko, L.7    Kügler, S.8    Benowitz, L.I.9
  • 34
    • 84859912753 scopus 로고    scopus 로고
    • Role of myelin-associated inhibitors in axonal repair after spinal cord injury
    • CrossRef Medline
    • Lee JK, Zheng B (2012) Role of myelin-associated inhibitors in axonal repair after spinal cord injury. Exp Neurol 235: 33-42. CrossRef Medline.
    • (2012) Exp Neurol , vol.235 , pp. 33-42
    • Lee, J.K.1    Zheng, B.2
  • 35
    • 0034659957 scopus 로고    scopus 로고
    • Lens injury stimulates axon regeneration in the mature rat optic nerve
    • Medline
    • Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI (2000) Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20: 4615-4626. Medline.
    • (2000) J Neurosci , vol.20 , pp. 4615-4626
    • Leon, S.1    Yin, Y.2    Nguyen, J.3    Irwin, N.4    Benowitz, L.I.5
  • 36
    • 0028095147 scopus 로고
    • Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
    • Medline
    • Levine JM (1994) Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury. J Neurosci 14: 4716-4730. Medline.
    • (1994) J Neurosci , vol.14 , pp. 4716-4730
    • Levine, J.M.1
  • 37
    • 0027586119 scopus 로고
    • Development and differentiation of glial precursor cells in the rat cerebellum
    • CrossRef Medline
    • Levine JM, Stincone F, Lee YS (1993) Development and differentiation of glial precursor cells in the rat cerebellum. Glia 7: 307-321. CrossRef Medline.
    • (1993) Glia , vol.7 , pp. 307-321
    • Levine, J.M.1    Stincone, F.2    Lee, Y.S.3
  • 38
    • 0035060665 scopus 로고    scopus 로고
    • The oligodendrocyte precursor cell in health and disease
    • CrossRef Medline
    • Levine JM, Reynolds R, Fawcett JW (2001) The oligodendrocyte precursor cell in health and disease. Trends Neurosci 24: 39-47. CrossRef Medline.
    • (2001) Trends Neurosci , vol.24 , pp. 39-47
    • Levine, J.M.1    Reynolds, R.2    Fawcett, J.W.3
  • 40
    • 45949098158 scopus 로고    scopus 로고
    • An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus
    • CrossRef Medline
    • Liu C, Wang Y, Smallwood PM, Nathans J (2008a) An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28: 5641-5653. CrossRef Medline.
    • (2008) J Neurosci , vol.28 , pp. 5641-5653
    • Liu, C.1    Wang, Y.2    Smallwood, P.M.3    Nathans, J.4
  • 41
    • 51149120003 scopus 로고    scopus 로고
    • Repulsive Wnt signaling inhibits axon regeneration after CNS injury
    • CrossRef Medline
    • Liu Y, Wang X, Lu CC, Kerman R, Steward O, Xu XM, Zou Y (2008b) Repulsive Wnt signaling inhibits axon regeneration after CNS injury. J Neurosci 28: 8376-8382. CrossRef Medline.
    • (2008) J Neurosci , vol.28 , pp. 8376-8382
    • Liu, Y.1    Wang, X.2    Lu, C.C.3    Kerman, R.4    Steward, O.5    Xu, X.M.6    Zou, Y.7
  • 42
    • 84865634647 scopus 로고    scopus 로고
    • Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells
    • CrossRef Medline
    • Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y (2012) Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal 24: 2291-2296. CrossRef Medline.
    • (2012) Cell Signal , vol.24 , pp. 2291-2296
    • Lu, W.1    Lin, C.2    King, T.D.3    Chen, H.4    Reynolds, R.C.5    Li, Y.6
  • 44
    • 34047245282 scopus 로고    scopus 로고
    • Glial cell loss, proliferation and replacement in the contused murine spinal cord
    • CrossRef Medline
    • Lytle JM, Wrathall JR (2007) Glial cell loss, proliferation and replacement in the contused murine spinal cord. Eur J Neurosci 25: 1711-1724. CrossRef Medline.
    • (2007) Eur J Neurosci , vol.25 , pp. 1711-1724
    • Lytle, J.M.1    Wrathall, J.R.2
  • 45
    • 65149090344 scopus 로고    scopus 로고
    • NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury
    • CrossRef Medline
    • Lytle JM, Chittajallu R, Wrathall JR, GalloV (2009) NG2 cell response in the CNP-EGFP mouse after contusive spinal cord injury. Glia 57: 270-285. CrossRef Medline.
    • (2009) Glia , vol.57 , pp. 270-285
    • Lytle, J.M.1    Chittajallu, R.2    Wrathall, J.R.3    Gallo, V.4
  • 46
    • 0019313317 scopus 로고
    • Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
    • CrossRef Medline
    • McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902. CrossRef Medline.
    • (1980) J Cell Biol , vol.85 , pp. 890-902
    • McCarthy, K.D.1    de Vellis, J.2
  • 47
    • 0035873062 scopus 로고    scopus 로고
    • Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
    • Medline
    • McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci 21: 3392-3400. Medline.
    • (2001) J Neurosci , vol.21 , pp. 3392-3400
    • McTigue, D.M.1    Wei, P.2    Stokes, B.T.3
  • 48
    • 0025218632 scopus 로고
    • Rapid initiation of neurite outgrowth onto laminin from explants of adult mouse retina induced by optic nerve crush
    • CrossRef Medline
    • Meyer RL, Miotke J (1990) Rapid initiation of neurite outgrowth onto laminin from explants of adult mouse retina induced by optic nerve crush. Exp Neurol 107: 214-221. CrossRef Medline.
    • (1990) Exp Neurol , vol.107 , pp. 214-221
    • Meyer, R.L.1    Miotke, J.2
  • 49
    • 0027986869 scopus 로고
    • Injury induced expression of growth-associated protein-43 in adult mouse retinal ganglion cells in vitro
    • CrossRef Medline
    • Meyer RL, Miotke JA, Benowitz LI (1994) Injury induced expression of growth-associated protein-43 in adult mouse retinal ganglion cells in vitro. Neuroscience 63: 591-602. CrossRef Medline.
    • (1994) Neuroscience , vol.63 , pp. 591-602
    • Meyer, R.L.1    Miotke, J.A.2    Benowitz, L.I.3
  • 50
    • 69249117748 scopus 로고    scopus 로고
    • Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury
    • CrossRef Medline
    • Miyashita T, Koda M, Kitajo K, Yamazaki M, Takahashi K, Kikuchi A, Yamashita T (2009) Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. J Neurotrauma 26: 955-964. CrossRef Medline.
    • (2009) J Neurotrauma , vol.26 , pp. 955-964
    • Miyashita, T.1    Koda, M.2    Kitajo, K.3    Yamazaki, M.4    Takahashi, K.5    Kikuchi, A.6    Yamashita, T.7
  • 51
    • 0031128225 scopus 로고    scopus 로고
    • WNTs modulate cell fate and behavior during vertebrate development
    • CrossRef Medline
    • Moon RT, Brown JD, TorresM (1997) WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 13: 157-162. CrossRef Medline.
    • (1997) Trends Genet , vol.13 , pp. 157-162
    • Moon, R.T.1    Brown, J.D.2    Torres, M.3
  • 52
    • 0028702505 scopus 로고
    • Possible role of tissuebound calcium ions in citrate-mediated high-temperature antigen retrieval
    • CrossRef Medline
    • Morgan JM, Navabi H, Schmid KW, Jasani B (1994) Possible role of tissuebound calcium ions in citrate-mediated high-temperature antigen retrieval. J Pathol 174: 301-307. CrossRef Medline.
    • (1994) J Pathol , vol.174 , pp. 301-307
    • Morgan, J.M.1    Navabi, H.2    Schmid, K.W.3    Jasani, B.4
  • 53
    • 0030811045 scopus 로고    scopus 로고
    • Role of calcium chelation in hightemperature antigen retrieval at different pH values
    • CrossRef Medline
    • Morgan JM, Navabi H, Jasani B (1997) Role of calcium chelation in hightemperature antigen retrieval at different pH values. J Pathol 182: 233-237. CrossRef Medline.
    • (1997) J Pathol , vol.182 , pp. 233-237
    • Morgan, J.M.1    Navabi, H.2    Jasani, B.3
  • 54
    • 57749172539 scopus 로고    scopus 로고
    • Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity
    • CrossRef Medline
    • Nishiyama A, Komitova M, Suzuki R, Zhu X (2009) Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci 10: 9-22. CrossRef Medline.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 9-22
    • Nishiyama, A.1    Komitova, M.2    Suzuki, R.3    Zhu, X.4
  • 55
    • 84878586832 scopus 로고    scopus 로고
    • Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
    • CrossRef Medline
    • Ortega F, Gascón S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Chichung Lie D, Schroeder T, Berninger B (2013) Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling. Nat Cell Biol 15: 602-613. CrossRef Medline.
    • (2013) Nat Cell Biol , vol.15 , pp. 602-613
    • Ortega, F.1    Gascón, S.2    Masserdotti, G.3    Deshpande, A.4    Simon, C.5    Fischer, J.6    Dimou, L.7    Chichung Lie, D.8    Schroeder, T.9    Berninger, B.10
  • 56
    • 33749053641 scopus 로고    scopus 로고
    • Synaptic communication between neurons and NG2+ cells
    • CrossRef Medline
    • Paukert M, Bergles DE (2006) Synaptic communication between neurons and NG2+ cells. Curr Opin Neurobiol 16: 515-521. CrossRef Medline.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 515-521
    • Paukert, M.1    Bergles, D.E.2
  • 57
    • 84874631221 scopus 로고    scopus 로고
    • Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats
    • CrossRef Medline
    • Petrosyan HA, Hunanyan AS, Alessi V, Schnell L, Levine J, Arvanian VL (2013) Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats. J Neurosci 33: 4032-4043. CrossRef Medline.
    • (2013) J Neurosci , vol.33 , pp. 4032-4043
    • Petrosyan, H.A.1    Hunanyan, A.S.2    Alessi, V.3    Schnell, L.4    Levine, J.5    Arvanian, V.L.6
  • 58
    • 33646348133 scopus 로고    scopus 로고
    • The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines
    • CrossRef Medline
    • Rhodes KE, Raivich G, Fawcett JW (2006) The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience 140: 87-100. CrossRef Medline.
    • (2006) Neuroscience , vol.140 , pp. 87-100
    • Rhodes, K.E.1    Raivich, G.2    Fawcett, J.W.3
  • 59
  • 60
    • 50949084200 scopus 로고    scopus 로고
    • Two faces of chondroitin sulfate proteoglycan in spinal cord repair: A role in microglia/macrophage activation
    • CrossRef Medline
    • Rolls A, Shechter R, London A, Segev Y, Jacob-Hirsch J, Amariglio N, Rechavi G, SchwartzM (2008) Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med 5: e171. CrossRef Medline.
    • (2008) PLoS Med , vol.5
    • Rolls, A.1    Shechter, R.2    London, A.3    Segev, Y.4    Jacob-Hirsch, J.5    Amariglio, N.6    Rechavi, G.7    Schwartz, M.8
  • 61
    • 60549083987 scopus 로고    scopus 로고
    • The bright side of the glial scar in CNS repair
    • CrossRef Medline
    • Rolls A, Shechter R, Schwartz M (2009) The bright side of the glial scar in CNS repair. Nat Rev Neurosci 10: 235-241. CrossRef Medline.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 235-241
    • Rolls, A.1    Shechter, R.2    Schwartz, M.3
  • 62
  • 63
    • 20444363086 scopus 로고    scopus 로고
    • Wnt signaling controls the timing of oligodendrocyte development in the spinal cord
    • CrossRef Medline
    • Shimizu T, Kagawa T, Wada T, Muroyama Y, Takada S, Ikenaka K (2005) Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol 282: 397-410. CrossRef Medline.
    • (2005) Dev Biol , vol.282 , pp. 397-410
    • Shimizu, T.1    Kagawa, T.2    Wada, T.3    Muroyama, Y.4    Takada, S.5    Ikenaka, K.6
  • 64
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • CrossRef Medline
    • Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156. CrossRef Medline.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 65
    • 79954605805 scopus 로고    scopus 로고
    • Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury
    • CrossRef Medline
    • Simon C, GötzM, Dimou L (2011) Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury. Glia 59: 869-881. CrossRef Medline.
    • (2011) Glia , vol.59 , pp. 869-881
    • Simon, C.1    Götz, M.2    Dimou, L.3
  • 67
    • 33646926966 scopus 로고    scopus 로고
    • Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord
    • CrossRef Medline
    • Tan AM, Colletti M, Rorai AT, Skene JH, Levine JM (2006) Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. J Neurosci 26: 4729-4739. CrossRef Medline.
    • (2006) J Neurosci , vol.26 , pp. 4729-4739
    • Tan, A.M.1    Colletti, M.2    Rorai, A.T.3    Skene, J.H.4    Levine, J.M.5
  • 68
    • 34249796963 scopus 로고    scopus 로고
    • Antigen-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by HCl pretreatment
    • CrossRef Medline
    • Tang X, Falls DL, Li X, Lane T, Luskin MB (2007) Antigen-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by HCl pretreatment. J Neurosci 27: 5837-5844. CrossRef Medline.
    • (2007) J Neurosci , vol.27 , pp. 5837-5844
    • Tang, X.1    Falls, D.L.2    Li, X.3    Lane, T.4    Luskin, M.B.5
  • 70
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of beta-catenin
    • CrossRef Medline
    • Valenta T, Hausmann G, Basler K (2012) The many faces and functions of beta-catenin. EMBO J 31: 2714-2736. CrossRef Medline.
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 71
    • 0035029433 scopus 로고    scopus 로고
    • A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
    • CrossRef Medline
    • Vooijs M, Jonkers J, Berns A (2001) A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2: 292-297. CrossRef Medline.
    • (2001) EMBO Rep , vol.2 , pp. 292-297
    • Vooijs, M.1    Jonkers, J.2    Berns, A.3
  • 72
    • 77949355760 scopus 로고    scopus 로고
    • Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice
    • CrossRef Medline
    • White RE, McTigue DM, Jakeman LB (2010) Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice. J Comp Neurol 518: 1370-1390. CrossRef Medline.
    • (2010) J Comp Neurol , vol.518 , pp. 1370-1390
    • White, R.E.1    McTigue, D.M.2    Jakeman, L.B.3
  • 73
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease
    • Medline
    • Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22: 1763-1771. Medline.
    • (2002) J Neurosci , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 74
    • 33746482870 scopus 로고    scopus 로고
    • Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of betacatenin
    • CrossRef Medline
    • Yamamoto H, Komekado H, Kikuchi A (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of betacatenin. Dev Cell 11: 213-223. CrossRef Medline.
    • (2006) Dev Cell , vol.11 , pp. 213-223
    • Yamamoto, H.1    Komekado, H.2    Kikuchi, A.3
  • 76
    • 27744569894 scopus 로고    scopus 로고
    • Optimization of oligodendrocyte progenitor cell culture method for enhanced survival
    • CrossRef Medline
    • Yang Z, Watanabe M, Nishiyama A (2005) Optimization of oligodendrocyte progenitor cell culture method for enhanced survival. J Neurosci Methods 149: 50-56. CrossRef Medline.
    • (2005) J Neurosci Methods , vol.149 , pp. 50-56
    • Yang, Z.1    Watanabe, M.2    Nishiyama, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.