Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury

Journal of Clinical Investigation

Volumn 123, Issue 2, 2013, Pages 782-786

  Seo, Ji Hae ^a,b   Miyamoto, Nobukazu ^a   Hayakawa, Kazuhide ^a   Pham, Loc Duyen D ^a   Maki, Takakuni ^a   Ayata, Cenk ^a   Kim, Kyu Won ^b,c   Lo, Eng H ^a   Arai, Ken ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; ILOMASTAT;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL CULTURE; CONTROLLED STUDY; DEMYELINATING DISEASE; IN VITRO STUDY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; WHITE MATTER INJURY;

ADULT STEM CELLS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; DIPEPTIDES; DISEASE MODELS, ANIMAL; MALE; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES, SECRETED; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; NEUTROPHIL INFILTRATION; OLIGODENDROGLIA; PROTEASE INHIBITORS;

EID: 84873395795     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI65863     Document Type: Article

References (25)

1. Nishiyama A, Komitova M, Suzuki R, Zhu X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci. 2009;10(1):9-22.
2. Gensert JM, Goldman JE. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron. 1997;19(1):197-203.
3. Redwine JM, Armstrong RC. In vivo proliferation of oligodendrocyte progenitors expressing PDG-FalphaR during early remyelination. J Neurobiol. 1998;37(3):413-428.
4. Tanaka K, et al. Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain. Neuroreport. 2001;12(10):2169-2174.
5. Miyamoto N, et al. Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab. 2010;30(2):299-310.
6. Fitch MT, Silver J. CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol. 2008;209(2):294-301.
7. Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain. 2006;129(pt 10):2761-2772.
8. Xin H, et al. Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. PLoS One. 2010;5(2):e9027.
9. Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci. 2004;5(2):146-156.
10. Ransohoff RM, Brown MA. Innate immunity in the central nervous system. J Clin Invest. 2012;122(4):1164-1171.
11. Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. The role of microglia in the healthy brain. J Neurosci. 2011;31(45):16064-16069.
12. Yenari MA, Kauppinen TM, Swanson RA. Microglial activation in stroke: therapeutic targets. Neurotherapeutics. 2010;7(4):378-391.
13. Du Y, Dreyfus CF. Oligodendrocytes as providers of growth factors. J Neurosci Res. 2002;68(6):647-654.
14. Yang Y, Rosenberg GA. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke. 2011;42(11):3323-3328.
15. Saunders NR, Ek CJ, Habgood MD, Dziegielewska KM. Barriers in the brain: a renaissance? Trends Neurosci. 2008;31(6):279-286.
16. Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke. 2004;35(11):2598-2603.
17. Asahi M, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001;21(19):7724-7732.
18. Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke. 1998;29(10):2189-2195.
19. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010;67(2):181-198.
20. Hermann DM, Chopp M. Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 2012;11(4):369-380.
21. Rivers LE, et al. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat Neurosci. 2008;11(12):1392-1401.
22. Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 1998;29(5):1020-1030.
23. Zlokovic BV. Neurodegeneration and the neurovascular unit. Nat Med. 2010;16(12):1370-1371.
24. Selnes OA, Vinters HV. Vascular cognitive impairment. Nat Clin Pract Neurol. 2006;2(10):538-547.
25. Arai K, Lo E. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009;29(14):4351-4356.