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Volumn 14, Issue 10, 2012, Pages 1235-1244

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord

Author keywords

astrocytes; axon regeneration; chondroitin sulfate proteoglycans; glial scar; microglia; neurotrophin 3; NG2; spinal cord injury

Indexed keywords

LENTIVIRUS VECTOR; NEUROTROPHIN 3; NG2 PROTEIN; PROTEOCHONDROITIN SULFATE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 84867659030     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2012.714865     Document Type: Article
Times cited : (24)

References (44)
  • 1
    • 33745947283 scopus 로고    scopus 로고
    • Neurological aspects of spinal cord repair: Promises and challenges
    • Dietz V, Curt A. Neurological aspects of spinal cord repair: Promises and challenges. Lancet Neurol. 2006; 5: 688-94.
    • (2006) Lancet Neurol. , vol.5 , pp. 688-694
    • Dietz, V.1    Curt, A.2
  • 2
    • 0041700229 scopus 로고    scopus 로고
    • Repair of chronic spinal cord injury
    • Houle J D, Tessler A. Repair of chronic spinal cord injury. Exp Neurol. 2003; 182: 247-60.
    • (2003) Exp Neurol. , vol.182 , pp. 247-260
    • Houle, J.D.1    Tessler, A.2
  • 3
    • 0036904245 scopus 로고    scopus 로고
    • Recent advances in pathophysiology and treatment of spinal cord injury
    • Hulsebosch CE. Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Edu. 2002; 26: 238-55.
    • (2002) Adv Physiol Edu. , vol.26 , pp. 238-255
    • Hulsebosch, C.E.1
  • 4
    • 23644450196 scopus 로고    scopus 로고
    • Increased growth factor expression and cell proliferation after contusive spinal cord injury
    • Zai L J, Yoo S, Wrathall J R. Increased growth factor expression and cell proliferation after contusive spinal cord injury. Brain Res. 2005; 1052: 147-55.
    • (2005) Brain Res. , vol.1052 , pp. 147-155
    • Zai, L.J.1    Yoo, S.2    Wrathall, J.R.3
  • 5
    • 0025513601 scopus 로고
    • Inhibition of neurite outgrowth on astroglial scars in vitro
    • Rudge JS, Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro. J Neurosci. 1990; 10: 3594-603.
    • (1990) J Neurosci. , vol.10 , pp. 3594-3603
    • Rudge, J.S.1    Silver, J.2
  • 7
    • 0025720059 scopus 로고
    • Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes
    • McKeon RJ, Schreiber RC, Rudge JS, Silver J. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci. 1991; 11: 3398-411.
    • (1991) J Neurosci. , vol.11 , pp. 3398-3411
    • McKeon, R.J.1    Schreiber, R.C.2    Rudge, J.S.3    Silver, J.4
  • 10
    • 0034950456 scopus 로고    scopus 로고
    • Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion
    • Bu J, Akhtar N, Nishiyama A. Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion. Glia. 2001; 34: 296-310.
    • (2001) Glia. , vol.34 , pp. 296-310
    • Bu, J.1    Akhtar, N.2    Nishiyama, A.3
  • 11
    • 0037220579 scopus 로고    scopus 로고
    • Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse
    • Ughrin YM, Chen ZJ, Levine JM. Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. J Neurosci. 2003; 23: 175-86.
    • (2003) J Neurosci. , vol.23 , pp. 175-186
    • Ughrin, Y.M.1    Chen, Z.J.2    Levine, J.M.3
  • 12
    • 33646926966 scopus 로고    scopus 로고
    • Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord
    • Colletti M, Rorai A T, Skene JH, Levine JM. Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. J Neurosci. 2006; 26: 4729-39.
    • (2006) J Neurosci. , vol.26 , pp. 4729-4739
    • Colletti, M.1    Rorai, A.T.2    Skene, J.H.3    Levine, J.M.4
  • 13
    • 0042665641 scopus 로고    scopus 로고
    • The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan and versican are differentially regulated following spinal cord injury
    • Jones LL, Margolis RU, Tuszynski MH. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003; 182: 399-411.
    • (2003) Exp Neurol. , vol.182 , pp. 399-411
    • Jones, L.L.1    Margolis, R.U.2    Tuszynski, M.H.3
  • 14
    • 0142250844 scopus 로고    scopus 로고
    • Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition
    • Jones L L, Sajed D, Tuszynski M H. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition. J Neurosci. 2003; 23: 9276-88.
    • (2003) J Neurosci. , vol.23 , pp. 9276-9288
    • Jones, L.L.1    Sajed, D.2    Tuszynski, M.H.3
  • 16
    • 33744999370 scopus 로고    scopus 로고
    • NG2 colocalizes with axons and is expressed by a mixed cell population in spinal cord lesions
    • McTigue DM, Tripathi R, Wei P. NG2 colocalizes with axons and is expressed by a mixed cell population in spinal cord lesions. JNeuropath Exp Neurol. 2006; 65: 406-20.
    • (2006) JNeuropath Exp Neurol. , vol.65 , pp. 406-420
    • McTigue, D.M.1    Tripathi, R.2    Wei, P.3
  • 17
    • 20244378556 scopus 로고    scopus 로고
    • RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
    • Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, et al. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci USA. 2005; 102: 5820-5.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 5820-5825
    • Harper, S.Q.1    Staber, P.D.2    He, X.3    Eliason, S.L.4    Martins, I.H.5    Mao, Q.6
  • 18
    • 27744588007 scopus 로고    scopus 로고
    • Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
    • Singer O, Marr R A, Rockenstein E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neurosci. 2005; 8: 1343-9.
    • (2005) Nature Neurosci. , vol.8 , pp. 1343-1349
    • Singer, O.1    Marr, R.A.2    Rockenstein, E.3
  • 19
    • 78649495402 scopus 로고    scopus 로고
    • Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar
    • Donnelly EM, Strappe PM, McGinley LM, Madigan NN, Geurts E, Rooney GE, et al. Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. JGene Med. 2010; 12: 863-72.
    • (2010) JGene Med. , vol.12 , pp. 863-872
    • Donnelly, E.M.1    Strappe, P.M.2    McGinley, L.M.3    Madigan, N.N.4    Geurts, E.5    Rooney, G.E.6
  • 21
    • 0028854450 scopus 로고
    • Developmentally regulated expression of mRNA for neurotrophin high-affinity (trk) receptors within chick trigeminal sensory neurons
    • Williams R, Backstrom A, Kullander K, Hallbook F, Ebendal T. Developmentally regulated expression of mRNA for neurotrophin high-affinity (trk) receptors within chick trigeminal sensory neurons. Eur J Neurosci. 1995; 7: 116-28.
    • (1995) Eur J Neurosci. , vol.7 , pp. 116-128
    • Williams, R.1    Backstrom, A.2    Kullander, K.3    Hallbook, F.4    Ebendal, T.5
  • 22
    • 1342265613 scopus 로고    scopus 로고
    • Neurotrophins and extracellular matrix molecules modulate sensory axon outgrowth
    • Hari A, Djohar B, Skutella T, Montazeri S. Neurotrophins and extracellular matrix molecules modulate sensory axon outgrowth. Int J Develop Neurosci. 2004; 22: 113-7.
    • (2004) Int J Develop Neurosci. , vol.22 , pp. 113-117
    • Hari, A.1    Djohar, B.2    Skutella, T.3    Montazeri, S.4
  • 23
    • 69449094846 scopus 로고    scopus 로고
    • Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    • Alto L T, Havton L A, Conner J M, Hollis I ER, Blesch A, Tuszynski MH. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neurosci. 2009; 12: 1106-13.
    • (2009) Nature Neurosci. , vol.12 , pp. 1106-1113
    • Alto, L.T.1    Havton, L.A.2    Conner, J.M.3    Hollis I, E.R.4    Blesch, A.5    Tuszynski, M.H.6
  • 24
    • 16944366150 scopus 로고    scopus 로고
    • Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
    • Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci. 1997; 17: 5560-72.
    • (1997) J Neurosci. , vol.17 , pp. 5560-5572
    • Grill, R.1    Murai, K.2    Blesch, A.3    Gage, F.H.4    Tuszynski, M.H.5
  • 25
    • 0027410119 scopus 로고
    • Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture
    • Hory-Lee F, Russell M, Lindsay RM, Frank E. Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture. Proc Natl Acad Sci USA. 1993; 90: 2613-7.
    • (1993) Proc Natl Acad Sci USA. , vol.90 , pp. 2613-2617
    • Hory-Lee, F.1    Russell, M.2    Lindsay, R.M.3    Frank, E.4
  • 26
    • 38649124935 scopus 로고    scopus 로고
    • Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
    • Massey JM, Amps J, Viapiano MS, Matthews RT, Wagoner MR, Whitaker CM, et al. Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp Neurol. 2008; 209: 426-45.
    • (2008) Exp Neurol. , vol.209 , pp. 426-445
    • Massey, J.M.1    Amps, J.2    Viapiano, M.S.3    Matthews, R.T.4    Wagoner, M.R.5    Whitaker, C.M.6
  • 27
    • 0036198235 scopus 로고    scopus 로고
    • Neurotrophin-3-mediated regeneration and recovery of proprioception following dorsal rhizotomy
    • Ramer MS, Bishop T, Dockery P, Mobarak MS, O'Leary D, Fraher JP, et al. Neurotrophin-3-mediated regeneration and recovery of proprioception following dorsal rhizotomy. Mol Cell Neurosci. 2002; 19: 239-49.
    • (2002) Mol Cell Neurosci. , vol.19 , pp. 239-249
    • Ramer, M.S.1    Bishop, T.2    Dockery, P.3    Mobarak, M.S.4    O'Leary, D.5    Fraher, J.P.6
  • 28
    • 0037442795 scopus 로고    scopus 로고
    • Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord
    • Zhou L, Baumgartner B J, Hill-Felberg S J, McGowen L R, Shine HD. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J Neurosci. 2003; 23: 1424-31.
    • (2003) J Neurosci. , vol.23 , pp. 1424-1431
    • Zhou, L.1    Baumgartner, B.J.2    Hill-Felberg, S.J.3    McGowen, L.R.4    Shine, H.D.5
  • 29
    • 0033942954 scopus 로고    scopus 로고
    • Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function
    • Blits B, Dijkhuizen P A, Boer G J, Verhaagen J. Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function. Exp Neurol. 2000; 164: 25-37.
    • (2000) Exp Neurol. , vol.164 , pp. 25-37
    • Blits, B.1    Dijkhuizen, P.A.2    Boer, G.J.3    Verhaagen, J.4
  • 30
    • 0032722126 scopus 로고    scopus 로고
    • NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
    • Bradbury E J, Khemani S, King V R, Priestley J V, McMahon SB. NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. Eur J Neurosci. 1999; 11: 3873-83.
    • (1999) Eur J Neurosci. , vol.11 , pp. 3873-3883
    • Bradbury, E.J.1    Khemani, S.2    King, V.R.3    Priestley, J.V.4    McMahon, S.B.5
  • 31
    • 34249724886 scopus 로고    scopus 로고
    • Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair
    • Galtrey C M, Asher R A, Nothias F, Fawcett J W. Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair. Brain. 2007; 130: 926-39.
    • (2007) Brain. , vol.130 , pp. 926-939
    • Galtrey, C.M.1    Asher, R.A.2    Nothias, F.3    Fawcett, J.W.4
  • 32
    • 29344451629 scopus 로고    scopus 로고
    • Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43- positive fibers after rat spinal cord injury
    • Ikegami T, Nakamura M, Yamane J, Katoh H, Okada S, Iwanami A, et al. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43- positive fibers after rat spinal cord injury. Eur J Neurosci. 2005; 22: 3036-46.
    • (2005) Eur J Neurosci. , vol.22 , pp. 3036-3046
    • Ikegami, T.1    Nakamura, M.2    Yamane, J.3    Katoh, H.4    Okada, S.5    Iwanami, A.6
  • 33
    • 0028115777 scopus 로고
    • Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
    • Schnell L, Schneider R, Kolbeck R, Barde Y-A, Schwab ME. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature. 1994; 367: 170-3.
    • (1994) Nature. , vol.367 , pp. 170-173
    • Schnell, L.1    Schneider, R.2    Kolbeck, R.3    Barde, Y.-A.4    Schwab, M.E.5
  • 34
    • 14844297139 scopus 로고    scopus 로고
    • Differential responses of spinal axons to transection: Infl uence of the NG2 proteoglycan
    • de Castro R Jr, Tajrishi R, Claros J, Stallcup W B. Differential responses of spinal axons to transection: Infl uence of the NG2 proteoglycan. Exp Neurol. 2005; 192: 299-309.
    • (2005) Exp Neurol. , vol.192 , pp. 299-309
    • De Castro Jr., R.1    Tajrishi, R.2    Claros, J.3    Stallcup, W.B.4
  • 35
    • 0142250844 scopus 로고    scopus 로고
    • Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition
    • Jones L L, Sajed D, Tuszynski M H. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition. J Neurosci. 2003; 23: 9276-88.
    • (2003) J Neurosci. , vol.23 , pp. 9276-9288
    • Jones, L.L.1    Sajed, D.2    Tuszynski, M.H.3
  • 36
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J, Miller J H. Regeneration beyond the glial scar. Nature Rev Neurosci. 2004; 5: 146-56.
    • (2004) Nature Rev Neurosci. , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 37
  • 38
    • 0023772364 scopus 로고
    • Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
    • Giulian D, Woodward J, Young D, Krebs J, Lachman L. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci. 1988; 8: 2485-90.
    • (1988) J Neurosci. , vol.8 , pp. 2485-2490
    • Giulian, D.1    Woodward, J.2    Young, D.3    Krebs, J.4    Lachman, L.5
  • 40
    • 0029058922 scopus 로고
    • Arole for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury
    • Winter CG, Saotome Y, Levison SW, Hirsh D. Arole for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. Proc Natl Acad Sci USA. 1995; 92: 5865-9.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 5865-5869
    • Winter, C.G.1    Saotome, Y.2    Levison, S.W.3    Hirsh, D.4
  • 41
    • 0029972857 scopus 로고    scopus 로고
    • Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
    • Elkabes S, DiCicco-Bloom E, Black I. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci. 1996; 16: 2508-21.
    • (1996) J Neurosci. , vol.16 , pp. 2508-2521
    • Elkabes, S.1    DiCicco-Bloom, E.2    Black, I.3
  • 43
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of infl ammation-induced secondary injury after CNS trauma
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of infl ammation-induced secondary injury after CNS trauma. J Neurosci. 1999; 19: 8182-98.
    • (1999) J Neurosci. , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 44
    • 0031426869 scopus 로고    scopus 로고
    • Activated macrophages and the blood- brain barrier: Infl ammation after CNS injury leads to increases in putative inhibitory molecules
    • Fitch MT, Silver J. Activated macrophages and the blood- brain barrier: Infl ammation after CNS injury leads to increases in putative inhibitory molecules. Exp Neurol. 1997; 148: 587-603.
    • (1997) Exp Neurol. , vol.148 , pp. 587-603
    • Fitch, M.T.1    Silver, J.2


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