메뉴 건너뛰기




Volumn 19, Issue 7, 2014, Pages 10103-10114

Capsaicin: A potent inhibitor of carbonic anhydrase isoenzymes

Author keywords

Affinity chromatography; Capsaicin; Carbonic anhydrase; Enzyme inhibition; Enzyme purification

Indexed keywords

CAPSAICIN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOENZYME; PROTEIN BINDING;

EID: 84904820139     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules190710103     Document Type: Article
Times cited : (140)

References (73)
  • 1
    • 34248659399 scopus 로고    scopus 로고
    • Carbonic anhydrases as targets for medicinal chemistry
    • Supuran, C.T.; Scozzafava, A. Carbonic anhydrases as targets for medicinal chemistry. Bioorg. Med. Chem. 2007, 15, 4336-4350.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 4336-4350
    • Supuran, C.T.1    Scozzafava, A.2
  • 2
    • 84888266626 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors, Synthesis, and molecular structure of novel series N-substituted N'-(2- Arylmethylthio-4-chloro-5- methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor- Associated isozymes IX and XII
    • Zołnowska, B.; Sławinski, J.; Pogorzelska, A.; Chojnacki, J.; Vullo, D.; Supuran, C.T. Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2- Arylmethylthio-4- chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor- Associated isozymes IX and XII. Eur. J. Med. Chem. 2014, 71, 135-147.
    • (2014) Eur. J. Med. Chem. , vol.71 , pp. 135-147
    • Zołnowska, B.1    Sławinski, J.2    Pogorzelska, A.3    Chojnacki, J.4    Vullo, D.5    Supuran, C.T.6
  • 3
    • 84877801455 scopus 로고    scopus 로고
    • The synthesis of sulfamide analogues of dopamine related compounds and their carbonic anhydrase inhibitory properties
    • Aksu, K.; Nar, M.; Tanç, M.; Vullo, D.; Gülçin, I.; Göksu, S.; Tümer, F.; Supuran, C.T. The synthesis of sulfamide analogues of dopamine related compounds and their carbonic anhydrase inhibitory properties. Bioorg. Med. Chem. 2013, 21, 2925-2931.
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 2925-2931
    • Aksu, K.1    Nar, M.2    Tanç, M.3    Vullo, D.4    Gülçin, I.5    Göksu, S.6    Tümer, F.7    Supuran, C.T.8
  • 4
    • 84891825962 scopus 로고    scopus 로고
    • Novel sulfamides and sulfonamides incorporating tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors
    • Akincioglu, A.; Topal, M.; Gülçin, I.; Göksu, S. Novel sulfamides and sulfonamides incorporating tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Arch. Pharm. 2014, 347, 68-76.
    • (2014) Arch. Pharm. , vol.347 , pp. 68-76
    • Akincioglu, A.1    Topal, M.2    Gülçin, I.3    Göksu, S.4
  • 5
    • 84896379999 scopus 로고    scopus 로고
    • Synthesis and carbonic anhydrase isoenzymes inhibitory effects of novel benzylamine derivatives
    • Çetinkaya, Y.; Göçer, H.; Göksu, S.; Gülçin, I. Synthesis and carbonic anhydrase isoenzymes inhibitory effects of novel benzylamine derivatives. J. Enzyme Inhib. Med. Chem. 2014, 29, 168-174.
    • (2014) J. Enzyme Inhib. Med. Chem. , vol.29 , pp. 168-174
    • Çetinkaya, Y.1    Göçer, H.2    Göksu, S.3    Gülçin, I.4
  • 6
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran, C.T. Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Disc. 2008, 7, 168-181.
    • (2008) Nat. Rev. Drug Disc. , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 7
    • 84893455839 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins
    • Akbaba, Y.; Akincioglu, A.; Göçer, H.; Göksu, S.; Gülçin, I.; Supuran, C.T. Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins. J. Enzyme Inhib. Med. Chem. 2014, 29, 35-42.
    • (2014) J. Enzyme Inhib. Med. Chem. , vol.29 , pp. 35-42
    • Akbaba, Y.1    Akincioglu, A.2    Göçer, H.3    Göksu, S.4    Gülçin, I.5    Supuran, C.T.6
  • 8
    • 16644383093 scopus 로고    scopus 로고
    • In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities
    • Gülçin, I.; Beydemir, S.; Büyükokuroglu, M.E. In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biol. Pharm. Bull. 2004, 27, 613-616.
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 613-616
    • Gülçin, I.1    Beydemir, S.2    Büyükokuroglu, M.E.3
  • 9
    • 2942582777 scopus 로고    scopus 로고
    • Effect of melatonin on carbonic anhydrase from human erythrocyte in vitro and from rat erythrocyte in vivo
    • Beydemir, S.; Gülçin, I. Effect of melatonin on carbonic anhydrase from human erythrocyte in vitro and from rat erythrocyte in vivo. J. Enzyme Inhib. Med. Chem. 2004, 19, 193-197.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 193-197
    • Beydemir, S.1    Gülçin, I.2
  • 10
    • 84876861378 scopus 로고    scopus 로고
    • Phenolic compounds as antioxidants: Carbonic anhydrase isoenzymes inhibitors
    • Gülçin, I.; Beydemir, S. Phenolic compounds as antioxidants: Carbonic anhydrase isoenzymes inhibitors. Mini Rev. Med. Chem. 2013, 13, 408-430.
    • (2013) Mini Rev. Med. Chem. , vol.13 , pp. 408-430
    • Gülçin, I.1    Beydemir, S.2
  • 11
    • 84901938556 scopus 로고    scopus 로고
    • Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives
    • Guney, M.; Coskun, A.; Topal, F.; Dastan, A.; Gulcin, I.; Supuran, C.T. Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives. Bioorg. Med. Chem. 2014, 22, 3537-3543.
    • (2014) Bioorg. Med. Chem. , vol.22 , pp. 3537-3543
    • Guney, M.1    Coskun, A.2    Topal, F.3    Dastan, A.4    Gulcin, I.5    Supuran, C.T.6
  • 12
    • 77954218410 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors
    • Supuran, C.T. Carbonic anhydrase inhibitors. Bioorg. Med. Chem. Lett. 2010, 20, 3467-3474.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3467-3474
    • Supuran, C.T.1
  • 13
    • 84891527115 scopus 로고    scopus 로고
    • 3, 4-Dihydroxyphenyl(2, 3, 4- Trihydroxyphenyl)methanone and its derivatives as carbonic anhydrase isoenzymes inhibitors
    • Nar, M.; Çetinkaya, Y.; Gülçin, I.; Menzek, A. (3, 4-Dihydroxyphenyl)(2, 3, 4- Trihydroxyphenyl)methanone and its derivatives as carbonic anhydrase isoenzymes inhibitors. J. Enzyme Inhib. Med. Chem. 2013, 28, 402-406.
    • (2013) J. Enzyme Inhib. Med. Chem. , vol.28 , pp. 402-406
    • Nar, M.1    Çetinkaya, Y.2    Gülçin, I.3    Menzek, A.4
  • 14
    • 0034018870 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and their therapeutic potential
    • Supuran, C.T.; Scozzafava, A. Carbonic anhydrase inhibitors and their therapeutic potential. Exp. Opin. Ther. Patents 2000, 10, 575-600.
    • (2000) Exp. Opin. Ther. Patents , vol.10 , pp. 575-600
    • Supuran, C.T.1    Scozzafava, A.2
  • 16
    • 42149099900 scopus 로고    scopus 로고
    • Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
    • De Simone, G.; di Fiore, A.; Supuran, C.T. Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? Curr. Pharm. Des. 2008, 14, 655-660.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 655-660
    • De Simone, G.1    Di Fiore, A.2    Supuran, C.T.3
  • 17
    • 84896704335 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- And 3-nitrophthalimide moieties
    • Sethi, K.K.; Verma, S.M.; Tanç M.; Purper, G.; Calafato, G.; Carta, F.; Supuran, C.T. Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- And 3-nitrophthalimide moieties. Bioorg. Med. Chem. 2014, 22, 1586-1595.
    • (2014) Bioorg. Med. Chem. , vol.22 , pp. 1586-1595
    • Tanç, M.1    Sethi, K.K.2    Verma, S.M.3    Purper, G.4    Calafato, G.5    Carta, F.6    Supuran, C.T.7
  • 19
    • 84879422490 scopus 로고    scopus 로고
    • Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice
    • Banjia, D.; Banjia, O.J.F.; Reddy, M.; Annamalai, A.R. Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice. J. Trace Elem. Med. Biol. 2013, 27, 230-235.
    • (2013) J. Trace Elem. Med. Biol. , vol.27 , pp. 230-235
    • Banjia, D.1    Banjia, O.J.F.2    Reddy, M.3    Annamalai, A.R.4
  • 20
    • 84888042912 scopus 로고    scopus 로고
    • Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise
    • Schwarz, N.A.; Spillane, M.; la Bounty, P.; Grandjean, P.W.; Leutholtz, B.; Willoughby, D.S. Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise. Nutr. Res. 2013, 33, 1034-1042.
    • (2013) Nutr. Res. , vol.33 , pp. 1034-1042
    • Schwarz, N.A.1    Spillane, M.2    La Bounty, P.3    Grandjean, P.W.4    Leutholtz, B.5    Willoughby, D.S.6
  • 21
    • 84890125300 scopus 로고    scopus 로고
    • Mechanisms and clinical uses of capsaicin
    • Sharma, S.K.; Vij, A.S.; Sharma, M. Mechanisms and clinical uses of capsaicin. Eur. J. Pharmacol. 2013, 720, 55-62.
    • (2013) Eur. J. Pharmacol. , vol.720 , pp. 55-62
    • Sharma, S.K.1    Vij, A.S.2    Sharma, M.3
  • 22
    • 84899969642 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
    • Zhu, Y.; Peng, W.; Zhang, J.; Wang, M.; Firempong, C.K.; Feng, C.; Liu, H.; Xu, X.; Yu, J. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation. J. Funct. Foods 2014, 8, 358-366.
    • (2014) J. Funct. Foods , vol.8 , pp. 358-366
    • Zhu, Y.1    Peng, W.2    Zhang, J.3    Wang, M.4    Firempong, C.K.5    Feng, C.6    Liu, H.7    Xu, X.8    Yu, J.9
  • 23
    • 0001315402 scopus 로고    scopus 로고
    • Changes in capsaicinoids during development, maturation, and senescence of Chile peppers and relation with peroxidase activity
    • Contreras-Padilla, M.; Yahia, E.M. Changes in capsaicinoids during development, maturation, and senescence of chile peppers and relation with peroxidase activity. J. Agric. Food Chem. 1998, 46, 2075-2079.
    • (1998) J. Agric. Food Chem. , vol.46 , pp. 2075-2079
    • Contreras-Padilla, M.1    Yahia, E.M.2
  • 24
    • 0025985683 scopus 로고
    • Capsicum-production, technology, chemistry, and quality, Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences
    • Govindarajan, V.S.; Sathyanarayana, M.N. Capsicum-production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit. Rev. Food Sci. Nutr. 1991, 29, 435-473.
    • (1991) Crit. Rev. Food Sci. Nutr. , vol.29 , pp. 435-473
    • Govindarajan, V.S.1    Sathyanarayana, M.N.2
  • 25
    • 0028913539 scopus 로고
    • Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential
    • Surh, Y.J.; Lee, S.S. Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential. Life Sci. 1995, 56, 1845-1855.
    • (1995) Life Sci , vol.56 , pp. 1845-1855
    • Surh, Y.J.1    Lee, S.S.2
  • 26
    • 0029854738 scopus 로고    scopus 로고
    • Capsaicin, a unique anti-oxidant, anti-inflammatory, analgesic compound with antifungal activity against dermatophytes
    • Chowdhury, B.; Mukhopadhyay, S.; Bhattacharayay, D.; De, A.K. Capsaicin, a unique anti-oxidant, anti-inflammatory, analgesic compound with antifungal activity against dermatophytes. Med. Sci. Res. 1996, 24, 669-670.
    • (1996) Med. Sci. Res. , vol.24 , pp. 669-670
    • Chowdhury, B.1    Mukhopadhyay, S.2    Bhattacharayay, D.3    De, A.K.4
  • 27
    • 84866050899 scopus 로고    scopus 로고
    • Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons
    • Lee, J.G, Yon, J.M, Lin, C.; Jung, A.Y.; Jung, K.Y.; Nam, S.Y. Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem. Toxicol. 2012, 50, 3877-3885.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 3877-3885
    • Lee, J.G.1    Yon, J.M.2    Lin, C.3    Jung, A.Y.4    Jung, K.Y.5    Nam, S.Y.6
  • 29
    • 0028134769 scopus 로고
    • Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages
    • Joe, B.; Lokesh, B.R. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta 1994, 1224, 255-263.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 255-263
    • Joe, B.1    Lokesh, B.R.2
  • 31
    • 0027358332 scopus 로고
    • The effect of chilli and its pungent ingredient capsaicin on gastrointestinal transit in the rat
    • Kang, J.Y.; Alexander, B.; Math, M.V.; Williamson, R.C. The effect of chilli and its pungent ingredient capsaicin on gastrointestinal transit in the rat. J. Gastroenterol. Hepatol. 1993, 8, 513-516.
    • (1993) J. Gastroenterol. Hepatol. , vol.8 , pp. 513-516
    • Kang, J.Y.1    Alexander, B.2    Math, M.V.3    Williamson, R.C.4
  • 32
    • 79954569214 scopus 로고    scopus 로고
    • The two faces of capsaicin
    • Bode, A.M.; Dong, Z. The two faces of capsaicin. Cancer Res. 2011, 71, 2809-2814.
    • (2011) Cancer Res , vol.71 , pp. 2809-2814
    • Bode, A.M.1    Dong, Z.2
  • 33
    • 0032487626 scopus 로고    scopus 로고
    • Neonatal primary neuronal death induced by capsaicin and axotomy involves an apoptotic mechanism
    • Sugimoto, T.; Xiao, C.; Ichikawa, H. Neonatal primary neuronal death induced by capsaicin and axotomy involves an apoptotic mechanism. Brain Res. 1998, 807, 147-154.
    • (1998) Brain Res , vol.807 , pp. 147-154
    • Sugimoto, T.1    Xiao, C.2    Ichikawa, H.3
  • 34
    • 0023123355 scopus 로고
    • Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats
    • Watanabe, T.; Kawada, T.; Yamamoto, M.; Iwai, K. Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem. Biophys. Res. Commun. 1987, 142, 259-264.
    • (1987) Biochem. Biophys. Res. Commun. , vol.142 , pp. 259-264
    • Watanabe, T.1    Kawada, T.2    Yamamoto, M.3    Iwai, K.4
  • 35
    • 84879750170 scopus 로고    scopus 로고
    • Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance
    • Janssens, P.L.H.R.; Hursel, R.; Martens, E.A.P.; Westerterp-Plantenga, M.S. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance. PLoS One 2013, 8, e67786.
    • (2013) PLoS One , vol.8
    • Janssens, P.L.H.R.1    Hursel, R.2    Martens, E.A.P.3    Westerterp-Plantenga, M.S.4
  • 36
    • 0032464789 scopus 로고    scopus 로고
    • Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women
    • Yoshioka, M.; St-Pierre, S.; Suzuki, M.; Tremblay, A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br. J. Nutr. 1998, 80, 503-510.
    • (1998) Br. J. Nutr. , vol.80 , pp. 503-510
    • Yoshioka, M.1    St-Pierre, S.2    Suzuki, M.3    Tremblay, A.4
  • 37
    • 84904792844 scopus 로고    scopus 로고
    • Rosmarinic acid: A potent carbonic anhydrase isoenzymes inhibitor
    • doi:10.3906/kim-1403-5
    • Topal, M.; Gülçin, I. Rosmarinic acid: A potent carbonic anhydrase isoenzymes inhibitor. Turk. J. Chem. 2014, doi:10.3906/kim-1403-5.
    • (2014) Turk. J. Chem.
    • Topal, M.1    Gülçin, I.2
  • 38
    • 80051960180 scopus 로고    scopus 로고
    • Antioxidant activity of eugenol- A structure and activity relationship study
    • Gülçin, I. Antioxidant activity of eugenol- A structure and activity relationship study. J. Med. Food 2011, 14, 975-985.
    • (2011) J. Med. Food , vol.14 , pp. 975-985
    • Gülçin, I.1
  • 39
    • 84858069261 scopus 로고    scopus 로고
    • Antioxidant activity of food constituents-An overview
    • Gülçin, I. Antioxidant activity of food constituents-An overview. Arch. Toxicol. 2012, 86, 345-396.
    • (2012) Arch. Toxicol. , vol.86 , pp. 345-396
    • Gülçin, I.1
  • 40
    • 84874643105 scopus 로고    scopus 로고
    • Techniques for analysis of plant phenolic compounds
    • Khoddami, A.; Wilkes, M.A.; Roberts, T.H. Techniques for analysis of plant phenolic compounds. Molecules 2013, 18, 2328-2375.
    • (2013) Molecules , vol.18 , pp. 2328-2375
    • Khoddami, A.1    Wilkes, M.A.2    Roberts, T.H.3
  • 41
    • 77949954345 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids
    • Öztürk Sarikaya, S.B.; Gülçin, I.; Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids. Chem. Biol. Drug Des. 2010, 75, 515-520.
    • (2010) Chem. Biol. Drug Des. , vol.75 , pp. 515-520
    • Öztürk Sarikaya, S.B.1    Gülçin, I.2    Supuran, C.T.3
  • 42
    • 40049101317 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors, Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV)
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C.T. Carbonic anhydrase inhibitors. Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV). Bioorg. Med. Chem. Lett. 2008, 18, 1583-1587.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1583-1587
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Supuran, C.T.4
  • 43
    • 77649236638 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids
    • Innocenti, A.; Öztürk Sarikaya, S.B.; Gülçin, I.; Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg. Med. Chem. 2010, 18, 2159-2164.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 2159-2164
    • Innocenti, A.1    Öztürk Sarikaya, S.B.2    Gülçin, I.3    Supuran, C.T.4
  • 44
    • 48449106536 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg. Med. Chem. 2008, 16, 7424-7428.
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 7424-7428
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Supuran, C.T.4
  • 45
    • 72049112279 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library
    • Davis, R.A.; Innocenti, A.; Poulsen, S.A.; Supuran, C.T. Carbonic anhydrase inhibitors: Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library. Bioorg. Med. Chem. 2010, 18, 14-18.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 14-18
    • Davis, R.A.1    Innocenti, A.2    Poulsen, S.A.3    Supuran, C.T.4
  • 47
    • 64049090201 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols
    • Senturk, M.; Gulcin, I.; Dastan, A.; Kufrevioglu, O.I.; Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg. Med. Chem. 2009, 17, 3207-3211.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 3207-3211
    • Senturk, M.1    Gulcin, I.2    Dastan, A.3    Kufrevioglu, O.I.4    Supuran, C.T.5
  • 50
    • 84899949708 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester (CAPE): A potent carbonic anhydrase isoenzymes inhibitor
    • Göçer, H.; Gülçin, I. Caffeic acid phenethyl ester (CAPE): A potent carbonic anhydrase isoenzymes inhibitor. Int. J. Acad. Res. 2013, 5, 150-155.
    • (2013) Int. J. Acad. Res. , vol.5 , pp. 150-155
    • Göçer, H.1    Gülçin, I.2
  • 51
    • 36849015851 scopus 로고    scopus 로고
    • Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo
    • Çoban, T.A.; Beydemir, S.; Gülçin, I.; Ekinci, D. Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol. Pharm. Bull. 2007, 30, 2257-2261.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 2257-2261
    • Çoban, T.A.1    Beydemir, S.2    Gülçin, I.3    Ekinci, D.4
  • 52
    • 7044226639 scopus 로고    scopus 로고
    • Effect of vitamin E on carbonic anhydrase enzyme activity in rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo
    • ArasHisar, S.; Hisar, O.; Beydemir, S.; Gülçin, I.; Yanik, T. Effect of vitamin E on carbonic anhydrase enzyme activity in rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo. Acta Vet. Hung. 2004, 52, 413-422.
    • (2004) Acta Vet. Hung. , vol.52 , pp. 413-422
    • ArasHisar, S.1    Hisar, O.2    Beydemir, S.3    Gülçin, I.4    Yanik, T.5
  • 53
    • 77956032271 scopus 로고    scopus 로고
    • Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product
    • Balaydin, H.T.; Gülçin, I.; Menzek, A.; Göksu, S.; Sahin, E. Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product. J. Enzyme Inhib. Med. Chem. 2010, 25, 685-695.
    • (2010) J. Enzyme Inhib. Med. Chem. , vol.25 , pp. 685-695
    • Balaydin, H.T.1    Gülçin, I.2    Menzek, A.3    Göksu, S.4    Sahin, E.5
  • 55
    • 84899901463 scopus 로고    scopus 로고
    • Synthesis and carbonic anhydrase isoenzymes inhibitory effects of brominated diphenylmethanone and its derivatives
    • Çetinkaya, Y.; Göçer, H.; Gülçin, I.; Menzek, A. Synthesis and carbonic anhydrase isoenzymes inhibitory effects of brominated diphenylmethanone and its derivatives. Arch. Pharm. 2014, 347, 354-359.
    • (2014) Arch. Pharm. , vol.347 , pp. 354-359
    • Çetinkaya, Y.1    Göçer, H.2    Gülçin, I.3    Menzek, A.4
  • 56
    • 17144421244 scopus 로고    scopus 로고
    • Effect of low molecular weight plasma inhibitors of rainbow trout (Oncorhyncytes mykiss) on human erythrocytes carbonic anhydrase-II isozyme activity in vitro and rat erythrocytes in vivo
    • Hisar, O.; Beydemir, S.; Gülçin, I.; Küfrevioglu, Ö.I.; Supuran, C.T. Effect of low molecular weight plasma inhibitors of rainbow trout (Oncorhyncytes mykiss) on human erythrocytes carbonic anhydrase-II isozyme activity in vitro and rat erythrocytes in vivo. J. Enzyme Inhib. Med. Chem. 2005, 20, 35-39.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 35-39
    • Hisar, O.1    Beydemir, S.2    Gülçin, I.3    Küfrevioglu, Ö.I.4    Supuran, C.T.5
  • 57
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, D.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227, 680-683.
    • (1970) Nature , vol.227 , pp. 680-683
    • Laemmli, D.K.1
  • 58
    • 22544443666 scopus 로고    scopus 로고
    • Purification and characterization of polyphenol oxidase from nettle (Urtica dioica L.) and inhibition effects of some chemicals on the enzyme activity
    • Gülçin, I.; Küfrevioglu Ö.I.; Oktay, M. Purification and characterization of polyphenol oxidase from nettle (Urtica dioica L.) and inhibition effects of some chemicals on the enzyme activity. J. Enzyme Inhib. Med. Chem. 2005, 20, 297-302.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 297-302
    • Küfrevioglu, Ö.I.1    Gülçin, I.2    Oktay, M.3
  • 59
    • 33644558093 scopus 로고    scopus 로고
    • Effect of melatonin on glucose-6- phospate dehydrogenase from rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo
    • Beydemir, S.; Gülçin, I.; Hisar, O.; Küfrevioglu, Ö.I.; Yanik, T. Effect of melatonin on glucose-6- phospate dehydrogenase from rainbow trout (Oncorhynchus mykiss) erythrocytes in vitro and in vivo. J. Appl. Anim. Res. 2005, 28, 65-68.
    • (2005) J. Appl. Anim. Res. , vol.28 , pp. 65-68
    • Beydemir, S.1    Gülçin, I.2    Hisar, O.3    Küfrevioglu, Ö.I.4    Yanik, T.5
  • 60
    • 40949140542 scopus 로고    scopus 로고
    • The inhibitory effect of ethanol on carbonic anhydrase isoenzymes: In vivo and in vitro studies
    • Çoban, T.A.; Beydemir, S.; Gülçin, I.; Ekinci D. The inhibitory effect of ethanol on carbonic anhydrase isoenzymes: In vivo and in vitro studies. J. Enzyme Inhib. Med. Chem. 2008, 23, 266-270.
    • (2008) J. Enzyme Inhib. Med. Chem. , vol.23 , pp. 266-270
    • Ekinci, D.1    Çoban, T.A.2    Beydemir, S.3    Gülçin, I.4
  • 61
    • 0014217102 scopus 로고
    • Esterase activities of human carbonic anhydrases B and C
    • Verpoorte, J.A.; Mehta, S.; Edsall, J.T. Esterase activities of human carbonic anhydrases B and C. J. Biol. Chem. 1967, 242, 4221-4229.
    • (1967) J. Biol. Chem. , vol.242 , pp. 4221-4229
    • Verpoorte, J.A.1    Mehta, S.2    Edsall, J.T.3
  • 62
    • 64049090201 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols
    • Sentürk, M.; Gülçin, I.; Dastan A.; Küfrevioglu, Ö.I.; Supuran C.T. Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg. Med. Chem. 2009, 17, 3207-3211.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 3207-3211
    • Dastan, A.1    Supuran, C.T.2    Sentürk, M.3    Gülçin, I.4    Küfrevioglu, Ö.I.5
  • 63
    • 84887431224 scopus 로고    scopus 로고
    • Synthesis, antioxidant and antiacetylcholinesterase activities of sulfonamide derivatives of dopamine related compounds
    • Göçer, H.; Akincioglu, A.; Öztaskin, N.; Göksu, S.; Gülçin, I. Synthesis, antioxidant and antiacetylcholinesterase activities of sulfonamide derivatives of dopamine related compounds. Arch. Pharm. 2013, 346, 783-792.
    • (2013) Arch. Pharm. , vol.346 , pp. 783-792
    • Göçer, H.1    Akincioglu, A.2    Öztaskin, N.3    Göksu, S.4    Gülçin, I.5
  • 65
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-251.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-251
    • Bradford, M.M.1
  • 66
    • 43549108545 scopus 로고    scopus 로고
    • Purification and characterization of peroxidase from cauliflower (Brassica oleracea L.) buds
    • Köksal, E.; Gülçin, I. Purification and characterization of peroxidase from cauliflower (Brassica oleracea L.) buds. Protein Peptide Lett. 2008, 15, 320-326.
    • (2008) Protein Peptide Lett , vol.15 , pp. 320-326
    • Köksal, E.1    Gülçin, I.2
  • 68
    • 84878411726 scopus 로고    scopus 로고
    • Synthesis and characterization of new chromogenic substrates for exoglycosidases: A-Glucosidase, a-mannosidase, and β-galactosidase
    • Iga, D.P.; Schmidt, R.; Iga, S.; Hotoleanu, C.L.; Duica, F.; Nicolescu, A.; Gitman, S.S. Synthesis and characterization of new chromogenic substrates for exoglycosidases: A-Glucosidase, a-mannosidase, and β-galactosidase. Turk. J. Chem. 2013, 37, 299-307.
    • (2013) Turk. J. Chem. , vol.37 , pp. 299-307
    • Iga, D.P.1    Schmidt, R.2    Iga, S.3    Hotoleanu, C.L.4    Duica, F.5    Nicolescu, A.6    Gitman, S.S.7
  • 69
    • 33751330608 scopus 로고
    • The determination of enzyme dissociation constants
    • Lineweaver, H.; Burk, D. The determination of enzyme dissociation constants. Am. Chem. Soc. 1934, 56, 658-666.
    • (1934) Am. Chem. Soc. , vol.56 , pp. 658-666
    • Lineweaver, H.1    Burk, D.2
  • 70
    • 84859722779 scopus 로고    scopus 로고
    • Synthesis and antioxidant properties of (3, 4- dihydroxyphenyl)(2, 3, 4- Trihydroxyphenyl)methanone and its derivatives
    • Çetinkaya, Y.; Göçer, H.; Menzek, A.; Gülçin, I. Synthesis and antioxidant properties of (3, 4- dihydroxyphenyl)(2, 3, 4- Trihydroxyphenyl)methanone and its derivatives. Arch. Pharm. 2012, 345, 323-334.
    • (2012) Arch. Pharm. , vol.345 , pp. 323-334
    • Çetinkaya, Y.1    Göçer, H.2    Menzek, A.3    Gülçin, I.4
  • 71
    • 77955660041 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Antioxidant polyphenol natural products effectively inhibit mammalian isoforms I-XV
    • Innocenti, A.; Gülçin, I.; Scozzafava, A.; Supuran, C.T. Carbonic anhydrase inhibitors: Antioxidant polyphenol natural products effectively inhibit mammalian isoforms I-XV. Bioorg. Med. Chem. Lett. 2010, 20, 5050-5053.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5050-5053
    • Innocenti, A.1    Gülçin, I.2    Scozzafava, A.3    Supuran, C.T.4
  • 73
    • 84864403423 scopus 로고    scopus 로고
    • Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products
    • Balaydin, H.T.; Senturk, M.; Goksu, S.; Menzek, A. Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B. Eur. J. Med. Chem. 2012, 54, 423-428.
    • (2012) Vidalol B. Eur. J. Med. Chem. , vol.54 , pp. 423-428
    • Balaydin, H.T.1    Senturk, M.2    Goksu, S.3    Menzek, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.