Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma

Pediatric Pulmonology

Volumn 49, Issue 8, 2014, Pages 800-806

  Koponen, Petri ^a   Nuolivirta, Kirsi ^b   Virta, Miia ^a   Helminen, Merja ^a   Hurme, Mikko ^a   Korppi, Matti ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b SEINÄJOKI CENTRAL HOSPITAL   (Finland)

Author keywords

asthma; asthma pathogenesis; bronchiolitis; IL 10; polymorphism; RSV

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 18; IFNG PROTEIN, HUMAN; IL10 PROTEIN, HUMAN;

ALLELE; ALLERGIC RHINITIS; ALLERGY; ARTICLE; ASTHMA; ATOPIC DERMATITIS; ATOPY; BRONCHIOLITIS; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HOSPITAL PATIENT; HUMAN; IMMUNOLOGICAL TOLERANCE; INFANT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TH2 CELL; COMPLICATION; GENETICS; PROTECTION; STATISTICAL MODEL; VIRAL BRONCHIOLITIS;

ALLELES; ASTHMA; BRONCHIOLITIS, VIRAL; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; FEMALE; GENOTYPE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-18; LOGISTIC MODELS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTECTIVE FACTORS; RHINITIS, ALLERGIC;

EID: 84904801246     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.22909     Document Type: Article

References (37)

1. Piippo-Savolainen E, Korppi M,. Long-term outcomes of early childhood wheezing. Curr Opin Allergy Clin Immunol 2009; 9: 190-196.
2. Glezen WP, Taber LH, Frank AL, Kasel JA,. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986; 140: 543-546. (Pubitemid 16120909)
3. Copenhaver CC, Gern JE, Li Z, Shult PA, Rosenthal LA, Mikus LD, Kirk CJ, Roberg KA, Anderson EL, Tisler CJ, DaSilva DF, Hiemke HJ, Gentile K, Gangnon RE, Lemanske RF, Jr., Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life. Am J Respir Crit Care Med 2004; 170: 175-180. (Pubitemid 38925164)
4. Hoebee B, Bont L, Rietveld E, van Oosten M, Hodemaekers HM, Nagelkerke NJ, Neijens HJ, Kimpen JL, Kimman TG,. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis 2004; 189: 239-247. (Pubitemid 38147247)
5. Helminen M, Nuolivirta K, Virta M, Halkosalo A, Korppi M, Vesikari T, Hurme M,. IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants. Pediatr Pulmonol 2008; 43: 391-395. (Pubitemid 351544048)
6. Wilson J, Rowlands K, Rockett K, Moore C, Lockhart E, Sharland M, Kwiatkowski D, Hull J,. Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J Infect Dis 2005; 191: 1705-1709. (Pubitemid 40656759)
7. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O'Mahony L, Palomares O, Rhyner C, Ouaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA,. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011; 127: 701-721, e1-e70.
8. Ober C, Yao TC,. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 2011; 242: 10-30.
9. Lim S, Crawley E, Woo P, Barnes PJ,. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998; 352: 113. (Pubitemid 28321327)
10. Hoffmann SC, Stanley EM, Cox ED, DiMercurio BS, Koziol DE, Harlan DM, Kirk AD, Blair PJ,. Ethnicity greatly influences cytokine gene polymorphism distribution. Am J Transplant 2002; 2: 560-567. (Pubitemid 36306876)
11. Hussein YM, Shalaby SM, Mohamed RH, Hassan TH,. Association between genes encoding components of the IL-10/IL-0 receptor pathway and asthma in children. Ann Allergy Asthma Immunol 2011; 106: 474-480.
12. Chatterjee R, Batra J, Kumar A, Mabalirajan U, Nahid S, Niphadkar PV, Ghosh B,. Interleukin-10 promoter polymorphisms and atopic asthma in north indians. Clin Exp Allergy 2005; 35: 914-919. (Pubitemid 41032540)
13. Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV,. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 2000; 61: 863-866.
14. Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL,. Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age. Am J Respir Crit Care Med 2004; 169: 70-76. (Pubitemid 38233891)
15. Stern DA, Guerra S, Halonen M, Wright AL, Martinez FD,. Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood. J Allergy Clin Immunol 2007; 120: 835-841. (Pubitemid 47531844)
16. Cebeci AN, Nuhoglu Y, Arslanoglu I, Erguven M, Agachan N,. The role of IL-18 in Th1/Th2 balance in children. Allergy Asthma Proc 2006; 27: 365-370. (Pubitemid 44306268)
17. Heinzmann A, Gerhold K, Ganter K, Kurz T, Schuchmann L, Keitzer R, Berner R, Deichmann KA,. Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthma. Allergy 2004; 59: 845-849. (Pubitemid 39005825)
18. Birbian N, Singh J, Jindal SK,. Protective role of IL-18-137G/C polymorphism in a North Indian population with asthma: a pilot study. Cytokine 2013; 61: 188-193.
19. Nuolivirta K, Hurme M, Halkosalo A, Koponen P, Korppi M, Vesikari T, Helminen M,. Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. Pediatr Infect Dis J 2009; 28: 1121-1123.
20. Koponen P, Helminen M, Paassilta M, Luukkaala T, Korppi M,. Preschool asthma after bronchiolitis in infancy. Eur Respir J 2012; 39: 76-80.
21. Koponen P, He Q, Helminen M, Nuolivirta K, Korppi M,. Association of MBL2 polymorphism with asthma after bronchiolitis in infancy. Pediatr Int 2012; 54: 619-622.
22. Raedler D, Illi S, Pinto LA, von Mutius E, Illig T, Kabesch M, Schaub B,. IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years. J Allergy Clin Immunol 2013; 131: 789-796.
23. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV,. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24: 1-8. (Pubitemid 27050850)
24. Nie W, Fang Z, Li B, Xiu QY,. Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis. Cytokine 2012; 60: 849-855.
25. Jartti T, Paul-Anttila M, Lehtinen P, Parikka V, Vuorinen T, Simell O, Ruuskanen O,. Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study. Respir Res 2009; 10: 85.
26. Koponen P, Karjalainen MK, Korppi M,. IL10 polymorphisms, rhinovirus-induced bronchiolitis, and childhood asthma. J Allergy Clin Immunol 2013; 131: 249-250.
27. Shao C, Suzuki Y, Kamada F, Kanno K, Tamari M, Hasegawa K, Aoki Y, Kure S, Yang X, Endo H, Takayanagi R, Nakazawa C, Morikawa T, Morikawa M, Miyabayashi S, Chiba Y, Karahashi M, Saito S, Tamura G, Shirakawa T, Matsubara Y,. Linkage and association of childhood asthma with the chromosome 12 genes. J Hum Genet 2004; 49: 115-122. (Pubitemid 38506724)
28. Barnes KC, Freidhoff LR, Nickel R, Chiu YF, Juo SH, Hizawa N, Naidu RP, Ehrlich E, Duffy DL, Schou C, Levett PN, Marsh DG, Beaty TH,. Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. J Allergy Clin Immunol 1999; 104: 485-491. (Pubitemid 29420452)
29. Kumar A, Ghosh B,. A single nucleotide polymorphism (A → G) in intron 3 of IFNgamma gene is associated with asthma. Genes Immun 2008; 9: 294-301. (Pubitemid 351791484)
30. Nakao F, Ihara K, Kusuhara K, Sasaki Y, Kinukawa N, Takabayashi A, Nishima S, Hara T,. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. J Allergy Clin Immunol 2001; 107: 499-504. (Pubitemid 32210031)
31. Tanaka H, Miyazaki N, Oashi K, Teramoto S, Shiratori M, Hashimoto M, Ohmichi M, Abe S,. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol 2001; 107: 331-336. (Pubitemid 32173912)
32. Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, Sly PD,. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007; 119: 1105-1110. (Pubitemid 46654175)
33. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O'Toole S, Myint SH, Tyrrell DA,. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995; 310: 1225-1229.
34. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, Printz MC, Lee WM, Shult PA, Reisdorf E, Carlson-Dakes KT, Salazar LP, DaSilva DF, Tisler CJ, Gern JE, Lemanske RF, Jr., Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-672.
35. Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen K, Korppi M,. Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma ? J Allergy Clin Immunol 2003; 111: 66-71. (Pubitemid 36143293)
36. Pritchard AL, Carroll ML, Burel JG, White OJ, Phipps S, Upham JW,. Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma. J Immunol 2012; 188: 5898-5905.
37. Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito H, Matsumoto K,. Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro. Int Arch Allergy Immunol 2011; 155: 27-33.