QSAR and docking based semi-synthesis and in vivo evaluation of artemisinin derivatives for antimalarial activity

Current Drug Targets

Volumn 15, Issue 8, 2014, Pages 753-761

  Yadav, Dharmendra Kumar ^a   Dhawan, Sangeeta ^a   Chauhan, Akanksha ^a   Qidwai, Tabish ^a   Sharma, Pooja ^a   Bhakuni, Rajendra Singh ^a   Dhawan, Om Prakash ^a   Khan, Feroz ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

ADMET; Artemisinin; Docking; Malaria; p. yoelii nigeriensis; Plasmepsins; QSAR

Indexed keywords

9 (BETA DIHYDROARTEMISINOXY)METHYL ANTHRACENE; ARTEETHER; ARTEMETHER; ARTEMISININ DERIVATIVE; BETA ARTECYCLOPROPYLMETHER HMCP; BETA ARTEPIPERNOYLETHER; UNCLASSIFIED DRUG; 9-(BETA-DIHYDROARTEMISINOXY)METHYLANTHRACENE; ANTIMALARIAL AGENT; ARTEMISININ; ASPARTIC PROTEINASE; BETA-ARTECYCLOPROPYLMETHER HMCP-1; BETA-ARTEPIPERNOYLETHER; PLASMEPSIN II; PROTOZOAL PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SYNTHESIS; GEOMETRY; INFRARED SPECTROPHOTOMETRY; MALARIA; MOLECULAR DOCKING; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM YOELII INFECTION; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; BIOAVAILABILITY; CHEMISTRY; COMPUTER AIDED DESIGN; DISEASE MODEL; DRUG DESIGN; DRUG EFFECTS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITOLOGY; PLASMODIUM YOELII;

ANIMALS; ANTIMALARIALS; ARTEMISININS; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; BIOLOGICAL AVAILABILITY; COMPUTER-AIDED DESIGN; DISEASE MODELS, ANIMAL; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA; MICE; MOLECULAR DOCKING SIMULATION; PLASMODIUM YOELII; PROTOZOAN PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904747943     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450115666140630102711     Document Type: Article

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