Alpha-synuclein aggregates in epicardial fat tissue in living subjects without Parkinsonism

Parkinsonism and Related Disorders

Volumn 19, Issue 1, 2013, Pages 27-31

  Navarro Otano, Judith ^a,b   Gelpi, Ellen ^c   Mestres, Carlos A ^a   Quintana, Eduard ^a   Rauek, Sebastian ^a,b   Ribalta, Teresa ^a   Santiago, Verónica ^c   Tolosa, Eduardo ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Alpha synuclein; Autonomic nervous system; Heart; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; TYROSINE 3 MONOOXYGENASE;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; AUTONOMIC NERVE; AUTONOMIC NERVOUS SYSTEM; CONSTIPATION; CONTROLLED STUDY; DREAMING; ELECTIVE SURGERY; EPICARDIAL FAT TISSUE; FEMALE; GANGLION; HALLUCINATION; HEART MUSCLE CELL; HEART SURGERY; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPOSMIA; IMMUNOHISTOCHEMISTRY; LEG SWELLING; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; ORTHOSTATIC HYPOTENSION; PARKINSONISM; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN AGGREGATION; SLEEP DISORDER; UNIFIED PARKINSON DISEASE RATING SCALE; URINARY URGENCY;

ADIPOSE TISSUE; AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; AUTONOMIC NERVOUS SYSTEM; FEMALE; HEART; HUMANS; LEWY BODY DISEASE; MALE; MIDDLE AGED; PARKINSONIAN DISORDERS; PROSPECTIVE STUDIES; TYROSINE 3-MONOOXYGENASE;

EID: 84871477116     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2012.07.005     Document Type: Article

References (30)

1. Beach T.G., Adler C.H., Sue L.I., Vedders L., Lue L., White Iii C.L., et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 2010, 119:689-702.
2. Wakabayashi K., Takahashi H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur Neurol 1997, 38(Suppl. 2):2-7.
3. Orimo S., Uchihara T., Nakamura A., Mori F., Kakita A., Wakabayashi K., et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008, 131:642-650.
4. Ikemura M., Saito Y., Sengoku R., Sakiyama Y., Hatsuta H., Kanemaru K., et al. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 2008, 67:945-953.
5. Miki Y., Tomiyama M., Ueno T., Haga R., Nishijima H., Suzuki C., et al. Clinical availability of skin biopsy in the diagnosis of Parkinson's disease. Neurosci Lett 2010, 469:357-359.
6. Lebouvier T., Neunlist M., Bruley des Varannes S., Coron E., Drouard A., N'Guyen J.M., et al. Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. PLoS One 2010, 5:e12728.
7. Braak H., Del Tredici K., Rub U., de Vos R.A., Jansen Steur E.N., Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003, 24:197-211.
8. Tolosa E., Gaig C., Santamaria J., Compta Y. Diagnosis and the premotor phase of Parkinson disease. Neurology 2009, 72:S12-S20.
9. Dickson D.W., Fujishiro H., DelleDonne A., Menke J., Ahmed Z., Klos K.J., et al. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol 2008, 115:437-444.
10. Beach T.G., Adler C.H., Sue L.I., Peirce J.B., Bachalakuri J., Dalsing-Hernandez J.E., et al. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta Neuropathol 2008, 115:445-451.
11. Gibb W.R., Lees A.J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988, 51:745-752.
12. Oka H., Toyoda C., Yogo M., Mochio S. Cardiovascular dysautonomia in de novo Parkinson's disease without orthostatic hypotension. Eur J Neurol 2011, 18:286-292.
13. Iwanaga K., Wakabayashi K., Yoshimoto M., Tomita I., Satoh H., Takashima H., et al. Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases. Neurology 1999, 52:1269-1271.
14. Fujishiro H., Frigerio R., Burnett M., Klos K.J., Josephs K.A., Delledonne A., et al. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov Disord 2008, 23:1085-1092.
15. Goldstein D.S., Sharabi Y., Karp B.I., Bentho O., Saleem A., Pacak K., et al. Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Cleve Clin J Med 2009, 76(Suppl. 2):S47-S50.
16. Goldstein D.S., Holmes C., Sewell L., Park M.Y., Sharabi Y. Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. Clin Auton Res 2012, 22:57-61.
17. Kaufmann H., Nahm K., Purohit D., Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 2004, 63:1093-1095.
18. Orimo S., Takahashi A., Uchihara T., Mori F., Kakita A., Wakabayashi K., et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease. Brain Pathol 2007, 17:24-30.
19. Chaudhuri K.R., Martinez-Martin P., Schapira A.H., Stocchi F., Sethi K., Odin P., et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006, 21:916-923.
20. Kawano H., Okada R., Yano K. Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels 2003, 18:32-39.
21. Kuusisto E., Parkkinen L., Alafuzoff I. Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol 2003, 62:1241-1253.
22. Saito Y., Kawashima A., Ruberu N.N., Fujiwara H., Koyama S., Sawabe M., et al. Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 2003, 62:644-654.
23. Markesbery W.R., Jicha G.A., Liu H., Schmitt F.A. Lewy body pathology in normal elderly subjects. J Neuropathol Exp Neurol 2009, 68:816-822.
24. Bloch A., Probst A., Bissig H., Adams H., Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006, 32:284-295.
25. Miki Y., Mori F., Wakabayashi K., Kuroda N., Orimo S. Incidental Lewy body disease restricted to the heart and stellate ganglia. Mov Disord 2009, 24:2299-2301.
26. Minguez-Castellanos A., Chamorro C.E., Escamilla-Sevilla F., Ortega-Moreno A., Rebollo A.C., Gomez-Rio M., et al. Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders? A cohort study. Neurology 2007, 68:2012-2018.
27. Goner E.G., van't Hof M., Berger H.J., van Weel C., Horstink M.W. Symptoms and duration of the prodromal phase in Parkinsons disease. Mov Disord 1997, 12:871-876.
28. Frigerio R., Fujishiro H., Maraganore D.M., Klos K.J., DelleDonne A., Heckman M.G., et al. Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. Arch Neurol 2009, 66:1114-1119.
29. Iranzo A., Molinuevo J.L., Santamaria J., Serradell M., Marti M.J., Valldeoriola F., et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 2006, 5:572-577.
30. Postuma R.B., Gagnon J.F., Vendette M., Fantini M.L., Massicotte-Marquez J., Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009, 72:1296-1300.