Minocycline but not tigecycline is neuroprotective and reduces the neuroinflammatory response induced by the superimposition of sepsis upon traumatic brain injury

Critical Care Medicine

Volumn 42, Issue 8, 2014, Pages

  Adembri, Chiara ^a   Selmi, Valentina ^a   Vitali, Luca ^a   Tani, Alessia ^a   Margheri, Martina ^a   Loriga, Beatrice ^a   Carlucci, Martina ^a   Nosi, Daniele ^a   Formigli, Lucia ^a   De Gaudio, Angelo Raffaele ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

cecal ligation and puncture; controlled cortical impact; experimental model; minocycline; sepsis; tigecycline; traumatic brain injury

Indexed keywords

MINOCYCLINE; SODIUM CHLORIDE; TIGECYCLINE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; IMMUNOLOGIC FACTOR; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BRAIN CORTEX LESION; BRAIN TISSUE; CELL ACTIVATION; CELL DEATH; CELL INFILTRATION; CELL LOSS; CHOROID PLEXUS; COGNITION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; EXPERIMENTAL ANIMAL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTOPATHOLOGY; LIGATION; MALE; MICROBIAL GROWTH; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PUNCTURE; RAT; SEPSIS; TIME; TRAUMATIC BRAIN INJURY; WEIGHT REDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN INJURY; COMPARATIVE STUDY; COMPLICATION; ENCEPHALITIS; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BRAIN INJURIES; ENCEPHALITIS; IMMUNOLOGIC FACTORS; MALE; MINOCYCLINE; NEUROPROTECTIVE AGENTS; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 84904731784     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000414     Document Type: Article

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