Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 769, Issue , 2014, Pages 11-16

  Wessendorf, Petra ^a   Vijg, Jan ^b   Nussenzweig, André ^c   Digweed, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

DNA damage; Haploinsufficiency; Mismatch repair

Indexed keywords

BETA GALACTOSIDASE; DNA; NIBRIN; CELL CYCLE PROTEIN; NIJMEGEN BREAKAGE SYNDROME 1 PROTEIN, MOUSE; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE; GENE FUNCTION; GENE IDENTIFICATION; IN VITRO STUDY; IN VIVO STUDY; LACZ GENE; MOLECULAR DYNAMICS; MOUSE; MUTATION RATE; NIBRIN GENE; NONHUMAN; NULL ALLELE; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN FUNCTION; BREEDING; COMET ASSAY; DNA REPLICATION; FIBROBLAST; GENE DELETION; IRRADIATION; LYMPHOID TISSUE; NBN GENE; PLASMID; WILD TYPE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL CULTURE; CHROMOSOME BREAKAGE; DEFICIENCY; GAMMA RADIATION; GENETICS; RADIATION RESPONSE; TRANSGENIC MOUSE;

ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMOSOME BREAKAGE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GAMMA RAYS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION RATE; NUCLEAR PROTEINS;

EID: 84904726192     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.07.001     Document Type: Article

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