Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system

Biochemistry

Volumn 48, Issue 45, 2009, Pages 10693-10704

  Jain, Akash K ^a   Reddy, Vishnu Vardhan ^a   Paul, Ananya ^a   Muniyappa, K ^a   Bhattacharya, Santanu ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; BENZIMIDAZOLES; CD SIGNALS; CIRCULAR DICHROISM; FUNCTION OF TIME; G-QUADRUPLEXES; HIGH AFFINITY; HIGH-RESOLUTION TECHNIQUES; PHENYL RINGS; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIDE CHAINS; SMALL MOLECULES; SPECTROPOLARIMETRY; STRUCTURAL CHANGE; TELOMERIC DNA; TETRAHYMENA;

AROMATIC COMPOUNDS; CIRCULAR DICHROISM SPECTROSCOPY; DATA STORAGE EQUIPMENT; DICHROISM; DNA; ELECTROPHORESIS; EMISSION SPECTROSCOPY; GENES; NUCLEIC ACIDS; POSITIVE IONS; SYNTHESIS (CHEMICAL);

DNA SEQUENCES;

1,3 PHENYLENE BIS(PIPERAZINYL BENZIMIDAZOLE); BENZIMIDAZOLE DERIVATIVE; CATION; GUANINE QUADRUPLEX; LITHIUM; POTASSIUM; SODIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; DNA BINDING; DNA SEQUENCE; DNA STRUCTURE; FLAME PHOTOMETRY; KINETICS; MELTING POINT; MOLECULAR LIBRARY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STABILITY; SKELETON; SUBSTITUTION REACTION; SYNTHESIS; TETRAHYMENA THERMOPHILA;

ANIMALS; BENZIMIDAZOLES; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; G-QUADRUPLEXES; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; TETRAHYMENA THERMOPHILA;

TETRAHYMENA THERMOPHILA;

EID: 70449572093     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9003815     Document Type: Article

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