Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes

Life Sciences

Volumn 87, Issue 23-26, 2010, Pages 707-714

  Sun, Huichao ^a,b   Yang, Xuefang ^a   Zhu, Jing ^b   Lv, Tiewei ^a   Chen, Yuan ^a   Chen, Guozhen ^a   Zhong, Lilin ^a   Li, Yasha ^b   Huang, Xupei ^c   Huang, Guoying ^d   Tian, Jie ^a  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c FLORIDA ATLANTIC UNIVERSITY   (United States)

^d CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Cardiac myocytes; Curcumin; Epigenetics; Histone acetylation; P300

Indexed keywords

CURCUMIN; HISTONE ACETYLTRANSFERASE; HISTONE H3; PROTEIN P300; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; MALE; MOUSE; NEWBORN; NONHUMAN; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; WESTERN BLOTTING;

ACETYLATION; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIGENESIS, GENETIC; HISTONES; MICE; MYOCYTES, CARDIAC; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78649451690     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.10.009     Document Type: Article

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