Future perspective: Immunomodulatory therapy for autoimmune hepatitis

Digestive Diseases

Volumn 32, Issue 5, 2014, Pages 502-506

  Sebode, Marcial ^a   Lohse, Ansgar W ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Autoimmune hepatitis; Cellular therapy; Immune regulation; Regulatory T cells

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; PREDNISOLONE; RAPAMYCIN; RETINOIC ACID; VANCOMYCIN; AUTOANTIBODY; HLA ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; AUTOIMMUNE HEPATITIS; CELL THERAPY; EFFECTOR CELL; HOMEOSTASIS; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASE; NONHUMAN; PATHOGENESIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; ADOPTIVE TRANSFER; CD4+ T LYMPHOCYTE; CONFERENCE PAPER; CORTICOSTEROID THERAPY; IMMUNOTHERAPY; MICROENVIRONMENT; REMISSION; BIOLOGICAL MODEL; HEPATITIS, AUTOIMMUNE; IMMUNOLOGY;

HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOMODULATION; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, REGULATORY;

EID: 84904655987     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000360493     Document Type: Review

References (46)

1. Tiegs G, Lohse AW: Immune tolerance: what is unique about the liver. J Autoimmun 2010; 34: 1-6.
2. Calne RY, Sells RA, Pena JR, Davis DR, Millard PR, Herbertson BM, Binns RM, Davies DA: Induction of immunological tolerance by porcine liver allografts. Nature 1969; 223: 472- 476.
3. Lüth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Brück W, Wraith DC, Herkel J, Lohse AW: Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest 2008; 118: 3403-3410.
4. Lohse AW, Mieli-Vergani G: Autoimmune hepatitis. J Hepatol 2011; 55: 171-182.
5. Heneghan MA, Yeoman AD, Verma S, Smith AD, Longhi MS: Autoimmune hepatitis. Lancet 2013; 382: 1433-1444.
6. Löhr H, Manns M, Kyriatsoulis A, Lohse AW, Trautwein C, Meyer zum Büschenfelde KH, Fleischer B: Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibodypositive autoimmune chronic active hepatitis. Clin Exp Immunol 1991; 84: 297-302.
7. Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B: Identification of CD4 T-cell epitopes in soluble liver antigen/ liver pancreas autoantigen in autoimmune hepatitis. Gastroenterology 2008; 135: 2107- 2118.
8. Strettell MD, Donaldson PT, Thomson LJ, Santrach PJ, Moore SB, Czaja AJ, Williams R: Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis. Gastroenterology 1997; 112: 2028-2035.
9. Czaja AJ, Strettell MD, Thomson LJ, Santrach PJ, Moore SB, Donaldson PT, Williams R: Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis. Hepatology 1997; 25: 317- 323.
10. Lohse AW, Weiler-Normann C, Tiegs G: Immune- mediated liver injury. J Hepatol 2010; 52: 136-144.
11. Carambia A, Frenzel C, Bruns OT, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse AW, Herkel J: Inhibition of inflammatory CD4 T-cell activity by murine liver sinusoidal endothelial cells. J Hepatol 2013; 58: 112-118.
12. Kruse N, Neumann K, Schrage A, Derkow K, Schott E, Erben U, Kühl A, Loddenkemper C, Zeitz M, Hamann A, Klugewitz K: Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3-regulatory T cells suppressing autoimmune hepatitis. Hepatology 2009; 50: 1904-1913.
13. Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle PA: Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med 2000; 6: 1348-1354.
14. Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, Johnson EF, Gonzalez FJ, Pfeilschifter J, Manns MP, Herrath MV, Christen U: Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection. J Exp Med 2008; 205: 1409-1422.
15. Gorham JD, Lin JT, Sung JL, Rudner LA, French MA: Genetic regulation of autoimmune disease: BALB/c background TGF-? 1 - deficient mice develop necroinflammatory IFN-?-dependent hepatitis. J Immunol 2001; 166: 6413-6422.
16. Buxbaum J, Qian P, Allen PM, Peters MG: Hepatitis resulting from liver-specific expression and recognition of self-antigen. J Autoimmun 2008; 31: 208-215.
17. Suzuki Y, Kobayashi M, Hosaka T, Someya T, Akuta N, Kobayashi M, Suzuki F, Tsubota A, Saitoh S, Arase Y, Ikeda K, Matsuda M, Sato J, Miyakawa Y, Kumada H: Peripheral CD8+/ CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acuteonset autoimmune hepatitis. J Gastroenterol 2004; 39: 649-653.
18. Miossec P, Korn T, Kuchroo VK: Interleukin- 17 and type 17 helper T cells. N Engl J Med 2009; 361: 888-898.
19. Tesmer LA, Lundy SK, Sarkar S, Fox DA: Th17 cells in human disease. Immunol Rev 2008; 223: 87-113.
20. Lan RY, Salunga TL, Tsuneyama K, Lian ZX, Yang GX, Hsu W, Moritoki Y, Ansari AA, Kemper C, Price J, Atkinson JP, Coppel RL, Gershwin ME: Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun 2009; 32: 43-51.
21. Katt J, Schwinge D, Schoknecht T, Quaas A, Sobottka I, Burandt E, Becker C, Neurath MF, Lohse AW, Herkel J, Schramm C: Increased T-helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis. Hepatology 2013; 58: 1084-1093.
22. Zhao L, Tang Y, You Z, Wang Q, Liang S, Han X, Qiu D, Wei J, Liu Y, Shen L, Chen X, Peng Y, Li Z, Ma X: Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PLoS One 2011; 6:e18909.
23. Patel DD, Lee DM, Kolbinger F, Antoni C: Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis 2013; 72: 116-123.
24. Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B, Adams DH: CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol 2012; 57: 1044-1051.
25. Sakaguchi S, Yamaguchi T, Nomura T, Ono M: Regulatory T cells and immune tolerance. Cell 2008; 133: 775-787.
26. Kido M, Watanabe N, Okazaki T, Akamatsu T, Tanaka J, Saga K, Nishio A, Honjo T, Chiba T: Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. Gastroenterology 2008; 135: 1333-1343.
27. Longhi MS, Ma Y, Mieli-Vergani G, Vergani D: Aetiopathogenesis of autoimmune hepatitis. J Autoimmun 2010; 34: 7-14.
28. Grant CR, Liberal R, Holder BS, Cardone J, Ma Y, Robson SC, Mieli-Vergani G, Vergani D, Longhi MS: Dysfunctional CD39POS regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis. Hepatology 2013, Epub ahead of print.
29. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA: CD4+CD25 high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245-1253.
30. Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF: Induction of FoxP3 and acquisition of T-regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003; 112: 1437-1443.
31. Peiseler M, Sebode M, Franke B, Wortmann F, Schwinge D, Quaas A, Baron U, Olek S, Wiegard C, Lohse AW, Weiler-Normann C, Schramm C, Herkel J: FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency. J Hepatol 2012; 57: 125-132.
32. Speletas M, Argentou N, Germanidis G, Vasiliadis T, Mantzoukis K, Patsiaoura K, Nikolaidis P, Karanikas V, Ritis K, Germenis AE: Foxp3 expression in liver correlates with the degree but not the cause of inflammation. Mediators Inflamm 2011; 2011: 827565.
33. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-238.
34. Luther C, Adamopoulou E, Stoeckle C, Brucklacher-Waldert V, Rosenkranz D, Stoltze L, Lauer S, Poeschel S, Melms A, Tolosa E: Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients. J Immunol 2009; 183: 841-848.
35. Lu L, Qian XF, Rao JH, Wang XH, Zheng SG, Zhang F: Rapamycin promotes the expansion of CD4+ Foxp3+ regulatory T cells after liver transplantation. Transplant Proc 2010; 42: 1755-1757.
36. Zhou X, Kong N, Wang J, Fan H, Zou H, Horwitz D, Brand D, Liu Z, Zheng SG: Cutting edge: all- trans -retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol 2010; 185: 2675-2679.
37. Saadoun D, Rosenzwajg M, Joly F, Six A, Carrat F, Thibault V, Sene D, Cacoub P, Klatzmann D: Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med 2011; 365: 2067-2077.
38. Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL: Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. J Clin Immunol 2013; 33: 397-406.
39. Weiler-Normann C, Wiegard C, Schramm C, Lohse AW: A case of difficult-to-treat autoimmune hepatitis successfully managed by TNF-? blockade. Am J Gastroenterol 2009; 104: 2877-2878.
40. Veltkamp C, Anstaett M, Wahl K, Möller S, Gangl S, Bachmann O, Hardtke-Wolenski M, Länger F, Stremmel W, Manns MP, Schulze- Osthoff K, Bantel H: Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF-? treatment. Gut 2011; 60: 1345- 1353.
41. Lapierre P, Béland K, Yang R, Alvarez F: Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance. Hepatology 2013; 57: 217-227.
42. Longhi MS, Hussain MJ, Kwok WW, Mieli- Vergani G, Ma Y, Vergani D: Autoantigenspecific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis. Hepatology 2011; 53: 536-547.
43. Roncarolo MG, Battaglia M: Regulatory Tcell immunotherapy for tolerance to self-antigens and alloantigens in humans. Nat Rev Immunol 2007; 7: 585-598.
44. Oo YH, Sakaguchi S: Regulatory T-cell directed therapies in liver diseases. J Hepatol 2013; 59: 1127-1134.
45. Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, Defor T, Levine BL, June CH, Rubinstein P, McGlave PB, Blazar BR, Wagner JE: Infusion of ex vivo expanded T-regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 7: 1061-1070.
46. Longhi MS, Liberal R, Holder B, Robson SC, Ma Y, Mieli-Vergani G, Vergani D: Inhibition of interleukin-17 promotes differentiation of CD25 - cells into stable T-regulatory cells in patients with autoimmune hepatitis. Gastroenterology 2012; 142: 1526-1535.