TNF-/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells

Oncogene

Volumn 33, Issue 29, 2014, Pages 3820-3829

  Oshima, H ^a   Ishikawa, T ^a   Yoshida, G J ^b   Naoi, K ^a   Maeda, Y ^a,b   Naka, K ^a   Ju, X ^a   Yamada, Y ^a   Minamoto, T ^a   Mukaida, N ^a   Saya, H ^b   Oshima, M ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

gastric cancer; inflammation; mouse model; TNF A

Indexed keywords

GNA14 PROTEIN; ONCOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE ORGANIZER 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; GNA14 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HERMES ANTIGEN; NOXO1 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CANCER INHIBITION; CARCINOGENICITY; COLONY FORMATION; CONTROLLED STUDY; ENZYME INDUCTION; EPITHELIUM CELL; GENE EXPRESSION; GENE INDUCTION; KNOCKOUT MOUSE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH CARCINOGENESIS; STOMACH TUMOR; TUMOR CELL; TUMOR DIFFERENTIATION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; ANIMAL; BIOLOGICAL MODEL; CANCER STEM CELL; CELL TRANSFORMATION; DENDRITIC CELL; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; TRANSGENIC MOUSE; TUMOR CELL LINE;

HELICOBACTER PYLORI; MUS;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, CD44; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904628057     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.356     Document Type: Article

References (45)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108
2. Peek Jr RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002; 2: 28-37
3. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007; 117: 60-69
4. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-867
5. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883-899
6. El-Omar EM, Carrington M, Chow W-H, McColl KE, Bream JH, Young HA et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402
7. EL-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-1201
8. Mochado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125: 364-371
9. El-Omar EM. Role of host genes in sporadic gastric cancer. Best Pract Res Clin Gastroenterology 2006; 20: 675-686
10. Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA et al. Overexpression of interleukin-1b induces gastric inflammation and cancer mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 2008; 14: 408-419
11. Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002; 8: 1089-1097
12. Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012; 22: 466-478
13. Balkwill F. TNF-A in promotion and progression of cancer. Cancer Metastasis Rev 2006; 25: 409-416
14. Balkwill F. Tumor necrosis factor and cancer. Nat Rev Cancer 2009; 9: 361-371
15. Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N et al. Mice deficient in tumor necrosis factor-A are resistant to skin carcinogenesis. Nat Med 1999; 5: 828-831
16. Arnott CH, Scott KA, Moore RJ, Robinson SC, Thompson RG, Balkwill FR. Expression of both TNF-A receptor subtypes is essential for optimal skin tumour development. Oncogene 2004; 23: 1902-1910
17. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kanoko S et al. Blocking TNF-A in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 2008; 118: 560-570
18. Oshima H, Matsunaga A, Fujimura T, Tsukamoto T, Taketo MM, Oshima M. Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Gastroenterology 2006; 131: 1086-1095
19. Oshima H, Oguma K, Du YC, Oshima M. Prostaglandin E2, Wnt and BMP in gastric tumor mouse models. Cancer Sci 2009; 100: 1779-1785
20. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C et al. b-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 2002; 62: 3503-3506
21. Wang D, DuBois RN. Eicosanoids and cancer. Nat Rev Cancer 2010; 10: 181-193
22. Itadani H, Oshima H, Oshima M, Kotani H. Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer. BMC Genomics 2009; 10: 615
23. Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, Ishikawa TO et al. Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology 2011; 140: 596-607
24. Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J et al. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol 2012; 14: 106-114
25. Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Watering M et al. In vitro expansion of single Lgr5 liver stem cells induced by Wnt-driven regeneration. Nature 2013; 494: 247-250
26. Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T et al. CD44 slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci 2010; 101: 673-678
27. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011; 19: 387-400
28. Zöller M. CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 2011; 11: 254-267
29. Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH et al. Lgr5ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 2011; 6: 25-36
30. Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res 2012; 71: 66-75
31. Seno H, Oshima M, Ishikawa TO, Oshima H, Takaku K, Chiba T et al. Cyclooxygenase 2-And prostaglandin E2 receptor EP2-dependent angiogenesis in ApcD716 mouse intestinal polyps. Cancer Res 2002; 62: 506-511
32. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-Axin-b-catenin signaling axis. Science 2005; 310: 1504-1510
33. Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S et al. Activated macrophages promote Wnt signalling through tumour necrosis factor-Ain gastric tumour cells. EMBO J 2008; 27: 1671-1681
34. Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cellcycle progression during colitis-Associated tumorigenesis. Cancer Cell 2009; 15: 91-102
35. Grivennikov S, Karin E, Terzic J, Mucida D, Yu G-Y, Vallabhapurapu S et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-Associated cancer. Cancer Cell 2009; 15: 103-113
36. Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG et al. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 2012; 150: 165-178
37. Block D, Gorin Y. Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer 2012; 12: 627-637
38. Mitsushita J, Lambeth JD, Kamata T. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res 2004; 64: 3580-3585
39. Adachi Y, Shibai Y, Mitsushita J, Shang WH, Hirose K, Kamata T. Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. Oncogene 2008; 27: 4921-4932
40. Juhasz A, Ge Y, Markel S, Chiu A, Matsumoto L, van Balgooy J et al. Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues. Free Radic Res 2009; 43: 523-532
41. Kostenis E, Waelbroeck M, Milligan G. Techniques: Promiscous Ga proteins in basic research and drug discovery. TrendsPham Sci 2005; 26: 595-602
42. Liu AMF, Wong YH. Activation of nuclear factor kB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Ga14 and multiple signaling components. J Biol Chem 2005; 280: 34617-34625
43. Lee MMK, Wong YH. CCR1-mediated activation of nuclear factor-kB in THP-1 monocytic cells involves pertussis toxin-insensitive Ga14 and Ga16 signaling cascade. J Leukoc Biol 2009; 86: 1319-1329
44. Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stemcell-like properties. Cell 2013; 152: 25-38
45. Kong D, Piao Y-S, Yamashita S, Oshima H, Oguma K, Fushida S et al. Inflammationinduced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene 2012; 31: 3949-3960.