CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα14 and Gα16 signaling cascades

Journal of Leukocyte Biology

Volumn 86, Issue 6, 2009, Pages 1319-1329

  Lee, Maggie M K ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Chemokine; G protein; Inhibitor B kinase; Leukotactin 1; Signal transduction

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN; CHEMOKINE RECEPTOR CCR1; GUANINE NUCLEOTIDE BINDING PROTEIN; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PERTUSSIS TOXIN; PHOSPHOLIPASE C BETA; PROTEIN KINASE C; RAF PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MONOCYTE; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MONOCYTES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTORS, CCR1; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 73149103713     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0209052     Document Type: Article

References (64)

1. Olson, T. S., Ley, K. (2002) Chemokines and chemokine receptors in leukocyte trafficking. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R7-R28.
2. Ono, S. J., Nakamura, T., Miyazaki, D., Ohbayashi, M., Dawson, M., Toda, M. (2003) Chemokines: roles in leukocyte development, trafficking, and effector function. J. Allergy Clin. Immunol. 111, 1185-1199.
3. Lee, W. H., Kim, S. H., Jeong, E. M., Choi, Y. H., Kim, D. I., Lee, B. B., Cho, Y. S., Kwon, B. S., Park, J. E. (2002) A novel chemokine, leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis. Atherosclerosis 161, 255-260.
4. Yu, R., Kim, C. S., Kawada, T., Kwon, T. W., Lim, T. H., Kim, Y. W., Kwon, B. S. (2004) Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis. Atherosclerosis 174, 35-42.
5. Hwang, J., Kim, C. W., Son, K. N., Han, K. Y., Lee, K. H., Kleinman, H. K., Ko, J., Na, D. S., Kwon, B. S., Gho, Y. S., Kim, J. (2004) Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo. FEBS Lett. 570, 47-51.
6. Gao, J. L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., Murphy, P. M. (1997) Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185, 1959-1968.
7. Potteaux, S., Combadière, C., Esposito, B., Casanova, S., Merval, R., Ardouin, P., Gao, J. L., Murphy, P. M., Tedgui, A., Mallat, Z. (2005) Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice. Mol. Med. 11, 16-20.
8. Baeuerle, P. A., Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
9. Ghosh, S., May, M. J., Kopp, E. B. (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260.
10. Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T., Grumont, R. (1999) Genetic approaches in mice to understand Rel/NFκB and IκB function: transgenics and knockouts. Oncogene 18, 6888-6895.
11. Ko, J., Kim, I. S., Jang, S. W., Lee, Y. H., Shin, S. Y., Min, D. S., Na, D. S. (2002) Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells. FEBS Lett. 515, 159-164.
12. Viedt, C., Vogel, J., Athanasiou, T., Shen, W., Orth, S. R., Kübler, W., Kreuzer, J. (2002) Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-κB and activator protein-1. Arterioscler. Thromb. Vasc. Biol. 22, 914-920.
13. Wang, D., Richmond, A. (2001) Nuclear factor-κB activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 276, 3650-3659.
14. Ganju, R. K., Brubaker, S. A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., Groopman, J. E. (1998) The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J. Biol. Chem. 273, 23169-23175.
15. Jang, S. W., Kim, Y. S., Kim, Y. R., Sung, H. J., Ko, J. (2007) Regulation of human LZIP expression by NF-κB and its involvement in monocyte cell migration induced by Lkn-1. J. Biol. Chem. 282, 11092-11100.
16. Ko, J., Jang, S. W., Kim, Y. S., Kim, I. S., Sung, H. J., Kim, H. H., Park, J. Y., Lee, Y. H., Kim, J., Na, D. S. (2004) Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J. 18, 890-892.
17. Ciesielski, C. J., Andreakos, E., Foxwell, B. M., Feldmann, M. (2002) TNFα-induced macrophage chemokine secretion is more dependent on NF-κB expression than lipopolysaccharides-induced macrophage chemokine secretion. Eur. J. Immunol. 32, 2037-2045.
18. Devalaraja, M. N., Wang, D. Z., Ballard, D. W., Richmond, A. (1999) Elevated constitutive IκB kinase activity and IκB-α phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-α transcription. Cancer Res. 59, 1372-1377.
19. Shin, Y. H., Son, K. N., Lee, G. W., Kwon, B. S., Kim, J. (2005) Transcriptional regulation of human CC chemokine CCL15 gene by NF-αB and AP-1 elements in PMA-stimulated U937 monocytoid cells. Biochim. Biophys. Acta 1732, 38-42.
20. Ueda, A., Okuda, K., Ohno, S., Shirai, A., Igarashi, T., Matsunaga, K., Fukushima, J., Kawamoto, S., Ishigatsubo, Y., Okubo, T. (1994) NF-κB and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J. Immunol. 153, 2052-2063.
21. Helbig, G., Christopherson II, K. W., Bhat-Nakshatri, P., Kumar, S., Kishimoto, H., Miller, K. D., Broxmeyer, H. E., Nakshatri, H. (2003) NF-κB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J. Biol. Chem. 278, 21631-21638.
22. 16 couples chemoattractant receptors to NF-κB activation. J. Immunol. 166, 6885-6892.
23. Liu, A. M., Wong, Y. H. (2004) G16-mediated activation of nuclear factor κB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling. J. Biol. Chem. 279, 53196-53204.
24. 14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src. J. Biol. Chem. 280, 34617-34625.
25. 16, a G protein α subunit specifically expressed in hematopoietic cells. Proc. Natl. Acad. Sci. USA 88, 5587-5591.
26. McLaughlin, S. K., McKinnon, P. J., Spickofsky, N., Danho, W., Margolskee, R. F. (1994) Molecular cloning of G proteins and phosphodiesterases from rat taste cells. Physiol. Behav. 56, 1157-1164.
27. Nakamura, F., Ogata, K., Shiozaki, K., Kameyama, K., Ohara, K., Haga, T., Nukada, T. (1991) Identification of two novel GTP-binding protein α-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. J. Biol. Chem. 266, 12676-12681.
28. 16 signaling. Neurosignals 17, 71-81.
29. q class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc. Natl. Acad. Sci. USA 88, 10049-10053.
30. zα, and other G-protein α-subunit messenger ribonucleic acids in pancreatic islets. Endocrinology 135, 31-37.
31. s -coupled receptors to the stimulation of phospholipase C. Br. J. Pharmacol. 132, 1431-1440.
32. 16-mediated stimulation of phospholipase C. J. Neurochem. 70, 2203-2211.
33. 16 couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 270, 15175-15180.
34. Neote, K., DiGregorio, D., Mak, J. Y., Horuk, R., Schall, T. J. (1993) Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72, 415-425.
35. Proudfoot, A. E., Power, C. A., Hoogewerf, A., Montjovent, M. O., Borlat, F., Wells, T. N. (1995) Characterization of the RANTES/MIP-1α receptor (CC CKR-1) stably transfected in HEK 293 cells and the recombinant ligands. FEBS Lett. 376, 19-23.
36. 16 in CC chemokine-induced stimulations of phospholipase Cβ, ERK, and chemotaxis. Cell. Signal. 20, 1179-1189.
37. 14-coupled pathways. Eur. J. Immunol. 34, 785-795.
38. Arai, H., Charo, I. F. (1996) Differential regulation of G-protein-mediated signaling by chemokine receptors. J. Biol. Chem. 271, 21814-21819.
39. Kuang, Y., Wu, Y., Jiang, H., Wu, D. (1996) Selective G protein coupling by C-C chemokine receptors. J. Biol. Chem. 271, 3975-3978.
40. Wu, D., LaRosa, G. J., Simon, M. I. (1993) G protein-coupled signal transduction pathways for interleukin-8. Science 261, 101-103.
41. 16 toward Gi-coupled receptors. Mol. Pharmacol. 57, 13-23.
42. Maniatis, T. (1997) Catalysis by a multiprotein IκB kinase complex. Science 278, 818-819.
43. Menten, P., Wuyts, A., Van Damme, J. (2002) Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 13, 455-481.
44. Zella, D., Barabitskaja, O., Burns, J. M., Romerio, F., Dunn, D. E., Revello, M. G., Gerna, G., Reitz Jr., M. S., Gallo, R. C., Weichold, F. F. (1998) Interferon-γ increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells. Blood 91, 4444-4450.
45. Thelen, M. (2001) Dancing to the tune of chemokines. Nat. Immunol. 2, 129-134.
46. Wymann, M. P., Zvelebil, M., Laffargue, M. (2003) Phosphoinositide 3-kinase signaling-which way to target? Trends Pharmacol. Sci. 24, 366-376.
47. Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., Wu, D. (2000) Roles of PLC-β2 and -β3 and PI3γ in chemoattractant-mediated signal transduction. Science 287, 1046-1049.
48. Thelen, M., Peveri, P., Kernen, P., Von Tscharner, V., Walz, A., Baggiolini, M. (1988) Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. FASEB J. 2, 2702-2706.
49. o protein/PLC/PKCδ/Ras cascades in HOS cells. Life Sci. 73, 447-459.
50. Zhao, Q., Lee, F. S. (1999) Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IδB kinase-α and IκB kinase-β. J. Biol. Chem. 274, 8355-8358.
51. Tuyt, L. M., Dokter, W. H., Birkenkamp, K., Koopmans, S. B., Lummen, C., Kruijer, W., Vellenga, E. (1999) Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-βB-dependent IL-6 expression in human monocytes. J. Immunol. 162, 4893-4902.
52. Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M. L., Fiers, W., Haegeman, G. (1998) p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273, 3285-3290.
53. Liang, H., Venema, V. J., Wang, X., Ju, H., Venema, R. C., Marrero, M. B. (1999) Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. J. Biol. Chem. 274, 19846-19851.
54. o protein. Science 287, 142-144.
55. 14 involves multiple intermediates. Mol. Pharmacol. 65, 1427-1439.
56. Wells, T. N. C., Power, C. A., Proudfoot, A. E. I. (1998) Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol. Sci. 19, 376-380.
57. Wong, L. M., Myers, S. J., Tsou, C. L., Gosling, J., Arai, H., Charo, I. F. (1997) Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J. Biol. Chem. 272, 1038-1045.
58. Ember, J. A., Sanderson, S. D., Hugli, T. E., Morgan, E. L. (1994) Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin. Am. J. Pathol. 144, 393-403.
59. Goodman, M. G., Chenoweth, D. E., Weigle, W. O. (1982) Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors. J. Exp. Med. 156, 912-917.
60. Okusawa, S., Yancey, K. B., Van Der Meer, J. W., Endres, S., Lonnemann, G., Hefter, K., Frank, M. M., Burke, J. F., Dinarello, C. A., Gelfand, J. A. (1988) C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 β and interleukin 1 α. J. Exp. Med. 168, 443-448.
61. Scholz, W., McClurg, M. R., Cardenas, G. J., Smith, M., Noonan, D. J., Hugli, T. E., Morgan, E. L. (1990) C5a-mediated release of interleukin 6 by human monocytes. Clin. Immunol. Immunopathol. 57, 297-307.
62. Arbour, N., Tremblay, P., Oth, D. (1996) N-formyl-methionyl-leucyl- phenylalanine induces and modulates IL-1 and IL-6 in human PBMC. Cytokine 8, 468-475.
63. Cassatella, M. A., Bazzoni, F., Ceska, M., Ferro, I., Baggiolini, M., Berton, G. (1992) IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. J. Immunol. 148, 3216-3220.
64. Nanki, T., Nagasaka, K., Hayashida, K., Saita, Y., Miyasaka, N. (2001) Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J. Immunol. 167, 5381-5385.