메뉴 건너뛰기




Volumn 171, Issue 15, 2014, Pages 3595-3603

IL-6 in diabetes and cardiovascular complications

Author keywords

cardiovascular diseases; diabetes; inflammation; interleukin 6

Indexed keywords

INTERLEUKIN 6;

EID: 84904558110     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12713     Document Type: Review
Times cited : (131)

References (79)
  • 1
    • 33947228451 scopus 로고    scopus 로고
    • Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells
    • Andreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, etal. (2007). Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol 27: 2372-2383.
    • (2007) Mol Cell Biol , vol.27 , pp. 2372-2383
    • Andreozzi, F.1    Laratta, E.2    Procopio, C.3    Hribal, M.L.4    Sciacqua, A.5    Perticone, M.6
  • 3
    • 84865325541 scopus 로고    scopus 로고
    • The role of tocilizumab in the management of rheumatoid arthritis
    • Ash Z, Emery P, (2012). The role of tocilizumab in the management of rheumatoid arthritis. Expert Opin Biol Ther 12: 1277-1289.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 1277-1289
    • Ash, Z.1    Emery, P.2
  • 4
    • 0025404324 scopus 로고
    • Induction of in vitro human lymphocyte migration by interleukin 3, interleukin 4, and interleukin 6
    • Bacon K, Gearing A, Camp R, (1990). Induction of in vitro human lymphocyte migration by interleukin 3, interleukin 4, and interleukin 6. Cytokine 2: 100-105.
    • (1990) Cytokine , vol.2 , pp. 100-105
    • Bacon, K.1    Gearing, A.2    Camp, R.3
  • 5
    • 0033678516 scopus 로고    scopus 로고
    • Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    • Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, etal. (2000). Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85: 3338-3342.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3338-3342
    • Bastard, J.P.1    Jardel, C.2    Bruckert, E.3    Blondy, P.4    Capeau, J.5    Laville, M.6
  • 6
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, (2003). Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300: 2101-2104.
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 7
    • 33744797970 scopus 로고    scopus 로고
    • The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: Possible contribution to elevated plasma levels of soluble TNF alpha receptors
    • Canault M, Peiretti F, Kopp F, Bonardo B, Bonzi MF, Coudeyre JC, etal. (2006). The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors. Atherosclerosis 187: 82-91.
    • (2006) Atherosclerosis , vol.187 , pp. 82-91
    • Canault, M.1    Peiretti, F.2    Kopp, F.3    Bonardo, B.4    Bonzi, M.F.5    Coudeyre, J.C.6
  • 8
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    • Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, etal. (2006). Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55: 2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1    Steinberg, G.R.2    Macaulay, S.L.3    Thomas, W.G.4    Holmes, A.G.5    Ramm, G.6
  • 9
    • 66349103988 scopus 로고    scopus 로고
    • CREB-mediated IL-6 expression is required for 15(S)- hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    • Chava KR, Karpurapu M, Wang D, Bhanoori M, Kundumani-Sridharan V, Zhang Q, etal. (2009). CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Arterioscler Thromb Vasc Biol 29: 809-815.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 809-815
    • Chava, K.R.1    Karpurapu, M.2    Wang, D.3    Bhanoori, M.4    Kundumani-Sridharan, V.5    Zhang, Q.6
  • 10
    • 78751652828 scopus 로고    scopus 로고
    • Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives
    • Chiu JJ, Chien S, (2011). Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91: 327-387.
    • (2011) Physiol Rev , vol.91 , pp. 327-387
    • Chiu, J.J.1    Chien, S.2
  • 11
    • 34547118365 scopus 로고    scopus 로고
    • Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress
    • Chiu JJ, Chen LJ, Lee CI, Lee PL, Lee DY, Tsai MC, etal. (2007). Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood 110: 519-528.
    • (2007) Blood , vol.110 , pp. 519-528
    • Chiu, J.J.1    Chen, L.J.2    Lee, C.I.3    Lee, P.L.4    Lee, D.Y.5    Tsai, M.C.6
  • 12
    • 84879377371 scopus 로고    scopus 로고
    • IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: Implication of an anti-apoptotic role during liver regeneration
    • Chou CH, Lai SL, Chen CN, Lee PH, Peng FC, Kuo ML, etal. (2013). IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regeneration. PLoS ONE 8: e66268.
    • (2013) PLoS ONE , vol.8
    • Chou, C.H.1    Lai, S.L.2    Chen, C.N.3    Lee, P.H.4    Peng, F.C.5    Kuo, M.L.6
  • 13
    • 84859210770 scopus 로고    scopus 로고
    • Interleukin-6 receptor pathways in coronary heart disease: A collaborative meta-analysis of 82 studies
    • Collaboration IRGCERF
    • Collaboration IRGCERF, Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, etal. (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 379: 1205-1213.
    • (2012) Lancet , vol.379 , pp. 1205-1213
    • Sarwar, N.1    Butterworth, A.S.2    Freitag, D.F.3    Gregson, J.4    Willeit, P.5
  • 14
    • 20144375594 scopus 로고    scopus 로고
    • The IL-6R alpha chain controls lung CD4 + CD25 + Treg development and function during allergic airway inflammation in vivo
    • Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, etal. (2005). The IL-6R alpha chain controls lung CD4 + CD25 + Treg development and function during allergic airway inflammation in vivo. J Clin Invest 115: 313-325.
    • (2005) J Clin Invest , vol.115 , pp. 313-325
    • Doganci, A.1    Eigenbrod, T.2    Krug, N.3    De Sanctis, G.T.4    Hausding, M.5    Erpenbeck, V.J.6
  • 16
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, etal. (2011). Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 17: 1481-1489.
    • (2011) Nat Med , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3    Habib, A.M.4    Baggio, L.L.5    Meier, D.T.6
  • 17
    • 3042721664 scopus 로고    scopus 로고
    • Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
    • Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK, (2004). Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53: 1643-1648.
    • (2004) Diabetes , vol.53 , pp. 1643-1648
    • Febbraio, M.A.1    Hiscock, N.2    Sacchetti, M.3    Fischer, C.P.4    Pedersen, B.K.5
  • 18
    • 31044437380 scopus 로고    scopus 로고
    • Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    • Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, etal. (2005). Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest 115: 3494-3505.
    • (2005) J Clin Invest , vol.115 , pp. 3494-3505
    • Federici, M.1    Hribal, M.L.2    Menghini, R.3    Kanno, H.4    Marchetti, V.5    Porzio, O.6
  • 20
    • 79955456934 scopus 로고    scopus 로고
    • Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
    • Garbers C, Janner N, Chalaris A, Moss ML, Floss DM, Meyer D, etal. (2011a). Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. J Biol Chem 286: 14804-14811.
    • (2011) J Biol Chem , vol.286 , pp. 14804-14811
    • Garbers, C.1    Janner, N.2    Chalaris, A.3    Moss, M.L.4    Floss, D.M.5    Meyer, D.6
  • 21
    • 83355163340 scopus 로고    scopus 로고
    • Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor
    • Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, etal. (2011b). Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem 286: 42959-42970.
    • (2011) J Biol Chem , vol.286 , pp. 42959-42970
    • Garbers, C.1    Thaiss, W.2    Jones, G.W.3    Waetzig, G.H.4    Lorenzen, I.5    Guilhot, F.6
  • 22
    • 0033533596 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
    • Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, etal. (1999). Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100: 1134-1146.
    • (1999) Circulation , vol.100 , pp. 1134-1146
    • Grundy, S.M.1    Benjamin, I.J.2    Burke, G.L.3    Chait, A.4    Eckel, R.H.5    Howard, B.V.6
  • 24
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M, (1998). Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229-234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 25
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK, (2005). Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352: 1685-1695.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 29
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • Hideshima T, Nakamura N, Chauhan D, Anderson KC, (2001). Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 20: 5991-6000.
    • (2001) Oncogene , vol.20 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 30
    • 51349111709 scopus 로고    scopus 로고
    • Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    • Holmes AG, Mesa JL, Neill BA, Chung J, Carey AL, Steinberg GR, etal. (2008). Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats. J Endocrinol 198: 367-374.
    • (2008) J Endocrinol , vol.198 , pp. 367-374
    • Holmes, A.G.1    Mesa, J.L.2    Neill, B.A.3    Chung, J.4    Carey, A.L.5    Steinberg, G.R.6
  • 31
    • 0026554229 scopus 로고
    • Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection
    • Honda M, Yamamoto S, Cheng M, Yasukawa K, Suzuki H, Saito T, etal. (1992). Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol 148: 2175-2180.
    • (1992) J Immunol , vol.148 , pp. 2175-2180
    • Honda, M.1    Yamamoto, S.2    Cheng, M.3    Yasukawa, K.4    Suzuki, H.5    Saito, T.6
  • 32
    • 0027717582 scopus 로고
    • Expression of intercellular adhesion molecule-1 on rat vascular smooth muscle cells by pro-inflammatory cytokines
    • Ikeda U, Ikeda M, Seino Y, Takahashi M, Kasahara T, Kano S, etal. (1993). Expression of intercellular adhesion molecule-1 on rat vascular smooth muscle cells by pro-inflammatory cytokines. Atherosclerosis 104: 61-68.
    • (1993) Atherosclerosis , vol.104 , pp. 61-68
    • Ikeda, U.1    Ikeda, M.2    Seino, Y.3    Takahashi, M.4    Kasahara, T.5    Kano, S.6
  • 33
    • 84859215358 scopus 로고    scopus 로고
    • The interleukin-6 receptor as a target for prevention of coronary heart disease: A Mendelian randomisation analysis
    • Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium
    • Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Hingorani AD, Casas JP, (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: a Mendelian randomisation analysis. Lancet 379: 1214-1224.
    • (2012) Lancet , vol.379 , pp. 1214-1224
    • Hingorani, A.D.1    Casas, J.P.2
  • 34
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, etal. (2001). Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 268: 160-167.
    • (2001) Eur J Biochem , vol.268 , pp. 160-167
    • Jostock, T.1    Mullberg, J.2    Ozbek, S.3    Atreya, R.4    Blinn, G.5    Voltz, N.6
  • 35
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, etal. (1996). Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11: 88-95.
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6
  • 36
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: The good, the bad, or the indifferent?
    • Kristiansen OP, Mandrup-Poulsen T, (2005). Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54 (Suppl. 2): S114-S124.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Kristiansen, O.P.1    Mandrup-Poulsen, T.2
  • 37
    • 79953331770 scopus 로고    scopus 로고
    • Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis
    • Loppnow H, Buerke M, Werdan K, Rose-John S, (2011). Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis. J Cell Mol Med 15: 484-500.
    • (2011) J Cell Mol Med , vol.15 , pp. 484-500
    • Loppnow, H.1    Buerke, M.2    Werdan, K.3    Rose-John, S.4
  • 38
    • 84894456906 scopus 로고    scopus 로고
    • Circulating Inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes and cardiovascular disease or risk factors: The ADVANCE study
    • Lowe G, Woodward M, Hillis G, Rumley A, Li Q, Harrap S, etal. (2014). Circulating Inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes and cardiovascular disease or risk factors: the ADVANCE study. Diabetes 63: 1115-1123.
    • (2014) Diabetes , vol.63 , pp. 1115-1123
    • Lowe, G.1    Woodward, M.2    Hillis, G.3    Rumley, A.4    Li, Q.5    Harrap, S.6
  • 39
    • 0035884847 scopus 로고    scopus 로고
    • The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: An experimental model involving thrombin
    • Marin V, Montero-Julian FA, Gres S, Boulay V, Bongrand P, Farnarier C, etal. (2001). The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin. J Immunol 167: 3435-3442.
    • (2001) J Immunol , vol.167 , pp. 3435-3442
    • Marin, V.1    Montero-Julian, F.A.2    Gres, S.3    Boulay, V.4    Bongrand, P.5    Farnarier, C.6
  • 40
    • 77957661299 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
    • Matthews VB, Allen TL, Risis S, Chan MH, Henstridge DC, Watson N, etal. (2010). Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 53: 2431-2441.
    • (2010) Diabetologia , vol.53 , pp. 2431-2441
    • Matthews, V.B.1    Allen, T.L.2    Risis, S.3    Chan, M.H.4    Henstridge, D.C.5    Watson, N.6
  • 42
    • 84878843826 scopus 로고    scopus 로고
    • Targeting interleukin-6 in rheumatoid arthritis
    • Md Yusof MY, Emery P, (2013). Targeting interleukin-6 in rheumatoid arthritis. Drugs 73: 341-356.
    • (2013) Drugs , vol.73 , pp. 341-356
    • Md Yusof, M.Y.1    Emery, P.2
  • 43
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, etal. (1993). Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82: 1120-1126.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3    Ohsugi, Y.4    Fukui, H.5    Koishihara, Y.6
  • 44
    • 0842289883 scopus 로고    scopus 로고
    • Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats
    • Orshal JM, Khalil RA, (2004). Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension 43: 434-444.
    • (2004) Hypertension , vol.43 , pp. 434-444
    • Orshal, J.M.1    Khalil, R.A.2
  • 45
    • 0031895668 scopus 로고    scopus 로고
    • Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
    • Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK, (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 508: 949-953.
    • (1998) J Physiol , vol.508 , pp. 949-953
    • Ostrowski, K.1    Rohde, T.2    Zacho, M.3    Asp, S.4    Pedersen, B.K.5
  • 46
    • 0034293075 scopus 로고    scopus 로고
    • Exercise and cytokines
    • Pedersen BK, (2000). Exercise and cytokines. Immunol Cell Biol 78: 532-535.
    • (2000) Immunol Cell Biol , vol.78 , pp. 532-535
    • Pedersen, B.K.1
  • 47
    • 36749027249 scopus 로고    scopus 로고
    • IL-6 signalling in exercise and disease
    • Pedersen BK, (2007). IL-6 signalling in exercise and disease. Biochem Soc Trans 35 (Pt 5): 1295-1297.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 5 , pp. 1295-1297
    • Pedersen, B.K.1
  • 48
    • 0032533949 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis
    • Peters M, Muller AM, Rose-John S, (1998). Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis. Blood 92: 3495-3504.
    • (1998) Blood , vol.92 , pp. 3495-3504
    • Peters, M.1    Muller, A.M.2    Rose-John, S.3
  • 49
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM, (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 50
    • 82955198418 scopus 로고    scopus 로고
    • A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis
    • Protogerou AD, Zampeli E, Fragiadaki K, Stamatelopoulos K, Papamichael C, Sfikakis PP, (2011). A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis. Atherosclerosis 219: 734-736.
    • (2011) Atherosclerosis , vol.219 , pp. 734-736
    • Protogerou, A.D.1    Zampeli, E.2    Fragiadaki, K.3    Stamatelopoulos, K.4    Papamichael, C.5    Sfikakis, P.P.6
  • 51
    • 38949164424 scopus 로고    scopus 로고
    • Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
    • Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, etal. (2008). Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111: 1021-1028.
    • (2008) Blood , vol.111 , pp. 1021-1028
    • Rabe, B.1    Chalaris, A.2    May, U.3    Waetzig, G.H.4    Seegert, D.5    Williams, A.S.6
  • 52
    • 84861833400 scopus 로고    scopus 로고
    • Tocilizumab treatment decreases circulating myeloid dendritic cells and monocytes, 2 components of the myeloid lineage
    • Richez C, Barnetche T, Khoryati L, Duffau P, Kostine M, Contin-Bordes C, etal. (2012). Tocilizumab treatment decreases circulating myeloid dendritic cells and monocytes, 2 components of the myeloid lineage. J Rheumatol 39: 1192-1197.
    • (2012) J Rheumatol , vol.39 , pp. 1192-1197
    • Richez, C.1    Barnetche, T.2    Khoryati, L.3    Duffau, P.4    Kostine, M.5    Contin-Bordes, C.6
  • 53
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6
    • Rose-John S, (2012). IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 8: 1237-1247.
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 54
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: Generation and biological function
    • Rose-John S, Heinrich PC, (1994). Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J 300 (Pt 2): 281-290.
    • (1994) Biochem J , vol.300 , Issue.PART 2 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 56
    • 62649128874 scopus 로고    scopus 로고
    • Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT)
    • Saremi A, Anderson RJ, Luo P, Moritz TE, Schwenke DC, Allison M, etal. (2009). Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT). Atherosclerosis 203: 610-614.
    • (2009) Atherosclerosis , vol.203 , pp. 610-614
    • Saremi, A.1    Anderson, R.J.2    Luo, P.3    Moritz, T.E.4    Schwenke, D.C.5    Allison, M.6
  • 58
    • 0034724305 scopus 로고    scopus 로고
    • Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: Potential implications for inflammation and plaque instability
    • Schieffer B, Schieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, Kaartinen M, etal. (2000). Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation 101: 1372-1378.
    • (2000) Circulation , vol.101 , pp. 1372-1378
    • Schieffer, B.1    Schieffer, E.2    Hilfiker-Kleiner, D.3    Hilfiker, A.4    Kovanen, P.T.5    Kaartinen, M.6
  • 60
    • 34948846112 scopus 로고    scopus 로고
    • Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes
    • Serino M, Menghini R, Fiorentino L, Amoruso R, Mauriello A, Lauro D, etal. (2007). Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes. Diabetes 56: 2541-2546.
    • (2007) Diabetes , vol.56 , pp. 2541-2546
    • Serino, M.1    Menghini, R.2    Fiorentino, L.3    Amoruso, R.4    Mauriello, A.5    Lauro, D.6
  • 61
    • 29144506087 scopus 로고    scopus 로고
    • IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes
    • Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ, (2006). IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res 69: 164-177.
    • (2006) Cardiovasc Res , vol.69 , pp. 164-177
    • Smart, N.1    Mojet, M.H.2    Latchman, D.S.3    Marber, M.S.4    Duchen, M.R.5    Heads, R.J.6
  • 62
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, etal. (2003). Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52: 812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6
  • 63
    • 0034668926 scopus 로고    scopus 로고
    • Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
    • Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B, (2000). Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529 (Pt 1): 237-242.
    • (2000) J Physiol , vol.529 , Issue.PART 1 , pp. 237-242
    • Steensberg, A.1    Van Hall, G.2    Osada, T.3    Sacchetti, M.4    Saltin, B.5    Klarlund Pedersen, B.6
  • 64
    • 84879414277 scopus 로고    scopus 로고
    • Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis
    • Strang AC, Bisoendial RJ, Kootte RS, Schulte DM, Dallinga-Thie GM, Levels JH, etal. (2013). Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis. Atherosclerosis 229: 174-181.
    • (2013) Atherosclerosis , vol.229 , pp. 174-181
    • Strang, A.C.1    Bisoendial, R.J.2    Kootte, R.S.3    Schulte, D.M.4    Dallinga-Thie, G.M.5    Levels, J.H.6
  • 65
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T, Kishimoto T, (1997). Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15: 797-819.
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 67
    • 84888095844 scopus 로고    scopus 로고
    • Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: Cardiovascular Health Study
    • Tehrani DM, Gardin JM, Yanez D, Hirsch CH, Lloyd-Jones DM, Stein PK, etal. (2013). Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: Cardiovascular Health Study. Atherosclerosis 231: 246-251.
    • (2013) Atherosclerosis , vol.231 , pp. 246-251
    • Tehrani, D.M.1    Gardin, J.M.2    Yanez, D.3    Hirsch, C.H.4    Lloyd-Jones, D.M.5    Stein, P.K.6
  • 68
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • Van Snick J, (1990). Interleukin-6: an overview. Annu Rev Immunol 8: 253-278.
    • (1990) Annu Rev Immunol , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 69
    • 0037414930 scopus 로고    scopus 로고
    • Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories
    • Voros G, Maquoi E, Collen D, Lijnen HR, (2003). Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories. Biochim Biophys Acta 1625: 36-42.
    • (2003) Biochim Biophys Acta , vol.1625 , pp. 36-42
    • Voros, G.1    Maquoi, E.2    Collen, D.3    Lijnen, H.R.4
  • 70
    • 0024529891 scopus 로고
    • The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome
    • Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T, (1989). The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med 169: 333-338.
    • (1989) J Exp Med , vol.169 , pp. 333-338
    • Waage, A.1    Brandtzaeg, P.2    Halstensen, A.3    Kierulf, P.4    Espevik, T.5
  • 71
    • 84857411475 scopus 로고    scopus 로고
    • Hitting a complex target: An update on interleukin-6 trans-signalling
    • Waetzig GH, Rose-John S, (2012). Hitting a complex target: an update on interleukin-6 trans-signalling. Expert Opin Ther Targets 16: 225-236.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 225-236
    • Waetzig, G.H.1    Rose-John, S.2
  • 73
    • 34147190251 scopus 로고    scopus 로고
    • An essential role for gp130 in neointima formation following arterial injury
    • Wang D, Liu Z, Li Q, Karpurapu M, Kundumani-Sridharan V, Cao H, etal. (2007). An essential role for gp130 in neointima formation following arterial injury. Circ Res 100: 807-816.
    • (2007) Circ Res , vol.100 , pp. 807-816
    • Wang, D.1    Liu, Z.2    Li, Q.3    Karpurapu, M.4    Kundumani-Sridharan, V.5    Cao, H.6
  • 74
    • 84872023970 scopus 로고    scopus 로고
    • Inflammatory markers and risk of type 2 diabetes: A systematic review and meta-analysis
    • Wang X, Bao W, Liu J, Ouyang YY, Wang D, Rong S, etal. (2013). Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 36: 166-175.
    • (2013) Diabetes Care , vol.36 , pp. 166-175
    • Wang, X.1    Bao, W.2    Liu, J.3    Ouyang, Y.Y.4    Wang, D.5    Rong, S.6
  • 75
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: Current pathogenesis and therapeutic options
    • Weber C, Noels H, (2011). Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 17: 1410-1422.
    • (2011) Nat Med , vol.17 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 76
    • 84879551082 scopus 로고    scopus 로고
    • Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness
    • Weiss TW, Arnesen H, Seljeflot I, (2013). Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness. Metabolism 62: 1008-1013.
    • (2013) Metabolism , vol.62 , pp. 1008-1013
    • Weiss, T.W.1    Arnesen, H.2    Seljeflot, I.3
  • 77
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    • Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, etal. (1998). IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101: 311-320.
    • (1998) J Clin Invest , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3    Baumann, H.4    Jordana, M.5    Lei, X.F.6
  • 78
    • 65549128076 scopus 로고    scopus 로고
    • Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression
    • Yuen DY, Dwyer RM, Matthews VB, Zhang L, Drew BG, Neill B, etal. (2009). Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression. Diabetes 58: 1086-1095.
    • (2009) Diabetes , vol.58 , pp. 1086-1095
    • Yuen, D.Y.1    Dwyer, R.M.2    Matthews, V.B.3    Zhang, L.4    Drew, B.G.5    Neill, B.6
  • 79
    • 0347907720 scopus 로고    scopus 로고
    • PI3-K/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells
    • Zhang J, Li Y, Shen B, (2003). PI3-K/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells. Cancer Cell Int 3: 1.
    • (2003) Cancer Cell Int , vol.3 , pp. 1
    • Zhang, J.1    Li, Y.2    Shen, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.