Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells

Bioscience, Biotechnology and Biochemistry

Volumn 74, Issue 3, 2010, Pages 548-552

  Kimura, Ken Ichi ^a   Aburai, Nobuhiro ^a   Yoshida, Mami ^b   Ohnishi, Motoko ^b  

^a IWATE UNIVERSITY   (Japan)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Mitogen activated protein kinase (MAPK); P38; Protein phosphatase (PP) 2C inhibitor; Sanguinarine

Indexed keywords

A PLANTS; APOPTOSIS; APOPTOSIS ACTIVITY; CASPASES; HL-60 CELLS; IN-VITRO; IN-VIVO; INDUCED APOPTOSIS; MITOGEN ACTIVATED PROTEIN KINASE; PROMYELOCYTIC LEUKEMIA; PROTEIN PHOSPHATASE; SANGUINARINE; SPECIFIC INHIBITORS;

CELL CULTURE; CELL DEATH; PHOSPHATASES; PHOSPHORYLATION;

PROTEINS;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZOPHENANTHRIDINE DERIVATIVE; CASPASE 3; CASPASE 7; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PYRIDINE DERIVATIVE; SANGUINARINE;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; DRUG ANTAGONISM; HUMAN; METABOLISM; PHOSPHORYLATION;

APOPTOSIS; BENZOPHENANTHRIDINES; CASPASE 3; CASPASE 7; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; IMIDAZOLES; ISOQUINOLINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PYRIDINES;

EID: 77950159448     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.90735     Document Type: Article

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