Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Molecular Microbiology

Volumn 77, Issue 5, 2010, Pages 1172-1185

  Manina, Giulia ^a,b,c   Bellinzoni, Marco ^b   Pasca, Maria Rosalia ^a   Neres, João ^c   Milano, Anna ^a   De Jesus Lopes Ribeiro, Ana Luisa ^a,d   Buroni, Silvia ^a   Škovierová, Henrieta ^e   Dianišková, Petronela ^e   Mikušová, Katarína ^e   Marák, Jozef ^e   Makarov, Vadim ^f   Giganti, David ^b   Haouz, Ahmed ^b   Lucarelli, Anna Paola ^a   Degiacomi, Giulia ^a   Piazza, Aurora ^a   Chiarelli, Laurent R ^a   De Rossi, Edda ^a   Salina, Elena ^f   Cole, Stewart T ^c   Alzari, Pedro M ^b   Riccardi, Giovanna ^a   more..

^a UNIVERSITY OF PAVIA   (Italy)

^b INSTITUT PASTEUR   (France)

^c EPFL   (Switzerland)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e Physics and Informatics   (Slovakia)

^f BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; BENZOTHIAZINONE; BTZ 043; BTZ 045; NITROREDUCTASE; NITROREDUCTASE NFNB; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG INACTIVATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MOLECULAR DOCKING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; GENE KNOCKOUT TECHNIQUES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; NITROREDUCTASES; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; THIAZINES;

MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 77956163145     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2010.07277.x     Document Type: Article

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