BDNF is associated with SFRP1 expression in luminal and basal-like breast cancer cell lines and primary breast cancer tissues: A novel role in tumor suppression?

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Huth, Laura ^a   Rose, Michael ^a   Kloubert, Veronika ^a   Winkens, Wiebke ^a   Schlensog, Martin ^a   Hartmann, Arndt ^b   Knüchel, Ruth ^a   Dahl, Edgar ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DNA; MESSENGER RNA; SECRETED FRIZZLED RELATED PROTEIN 1; SMOOTHENED PROTEIN; WNT PROTEIN; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; HYBRID PROTEIN; MEMBRANE PROTEIN; SFRP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR PROTEIN;

ARTICLE; BASAL LIKE BREAST CANCER; BDNF GENE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRACELLULAR SIGNALING; LUMINAL LIKE BREAST CANCER; PREDICTION; PRIMARY TUMOR; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SFRP1 GENE; WNT SIGNALING PATHWAY; BIOSYNTHESIS; BREAST TUMOR; CELL DIVISION; COMPARATIVE STUDY; FEMALE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

BRAIN-DERIVED NEUROTROPHIC FACTOR; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENES, TUMOR SUPPRESSOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRIMARY CELL CULTURE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; WNT SIGNALING PATHWAY;

EID: 84904498195     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102558     Document Type: Article

References (44)

1. Turashvili G, Bouchal J, Burkadze G, Kolar Z (2006) Wnt signaling pathway in mammary gland development and carcinogenesis. Pathobiology 73: 213-223. (Pubitemid 46332829)
2. Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE (2007) Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 9: R63.
3. Suzuki H, Toyota M, Carraway H, Gabrielson E, Ohmura T, et al. (2008) Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer 98: 1147-1156. (Pubitemid 351399804)
4. Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, et al. (2006) APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 131: 1096-1109. (Pubitemid 44498698)
5. Nusse R (2005) Wnt signaling in disease and in development. Cell Res 15: 28-32.
6. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J (2008) Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121: 737-746. (Pubitemid 351578109)
7. Kawano Y, Kypta R (2003) Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116: 2627-2634. (Pubitemid 36857216)
8. Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, et al. (2004) Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36: 417-422. (Pubitemid 38437267)
9. Caldwell GM, Jones C, Gensberg K, Jan S, Hardy RG, et al. (2004) The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res 64: 883-888. (Pubitemid 38176888)
10. Klopocki E, Kristiansen G, Wild PJ, Klaman I, Castanos-Velez E, et al. (2004) Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25: 641-649.
11. Lee AY, He B, You L, Dadfarmay S, Xu Z, et al. (2004) Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene 23: 6672-6676. (Pubitemid 39265531)
12. Kongkham PN, Northcott PA, Croul SE, Smith CA, Taylor MD, et al. (2010) The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 29: 3017-3024.
13. Veeck J, Niederacher D, An H, Klopocki E, Wiesmann F, et al. (2006) Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 25: 3479-3488. (Pubitemid 43877051)
14. Matsuda Y, Schlange T, Oakeley EJ, Boulay A, Hynes NE (2009) WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res 11: R32.
15. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, et al. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10: 515-527. (Pubitemid 44854747)
16. Dahl E, Kristiansen G, Gottlob K, Klaman I, Ebner E, et al. (2006) Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res 12: 3950-3960. (Pubitemid 44078080)
17. The Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490: 61-70.
18. ten Haaf, Bektas N, von Serenyi S, Losen I, Arweiler EC, et al. (2009) Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival. BMC Cancer 9: 298.
19. Simon R, Lam A, Li MC, Ngan M, Menenzes S, et al. (2007) Analysis of gene expression data using BRB-ArrayTools. Cancer Inform 3: 11-17. (Pubitemid 47075796)
20. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550. (Pubitemid 41528093)
21. Fredlund E, Staaf J, Rantala JK, Kallioniemi O, Borg A, et al. (2012) The gene expression landscape of breast cancer is shaped by tumor protein p53 status and epithelial-mesenchymal transition. Breast Cancer Res 14: R113.
22. Ringner M, Fredlund E, Hakkinen J, Borg A, Staaf J (2011) GOBO: gene expression-based outcome for breast cancer online. PLoS One 6: e17911.
23. Hu Z, Fan C, Oh DS, Marron JS, He X, et al. (2006) The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7: 96.
24. Patani N, Jiang WG, Mokbel K (2011) Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer. Cancer Cell Int 11: 23.
25. Wolfs TG, Dunn-Siegrist I, van't VC, Hodin CM, Germeraad WT, et al. (2008) Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells. Mol Immunol 45: 3268-3277.
26. Chen D, Zhao M, Mundy GR (2004) Bone morphogenetic proteins. Growth Factors 22: 233-241. (Pubitemid 40136452)
27. Massague J, Wotton D (2000) Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754. (Pubitemid 30204386)
28. Huelsken J, Behrens J (2002) The Wnt signalling pathway. J Cell Sci 115: 3977-3978. (Pubitemid 35446796)
29. Gauger KJ, Chenausky KL, Murray ME, Schneider SS (2011) SFRP1 reduction results in an increased sensitivity to TGF-beta signaling. BMC Cancer 11: 59.
30. Labbe E, Lock L, Letamendia A, Gorska AE, Gryfe R, et al. (2007) Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res 67: 75-84. (Pubitemid 46142761)
31. Hussein SM, Duff EK, Sirard C (2003) Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem 278: 48805-48814. (Pubitemid 41079523)
32. Binder DK, Scharfman HE (2004) Brain-derived neurotrophic factor. Growth Factors 22: 123-131. (Pubitemid 39377904)
33. Aid-Pavlidis T, Pavlidis P, Timmusk T (2009) Meta-coexpression conservation analysis of microarray data: a "subset" approach provides insight into brain-derived neurotrophic factor regulation. BMC Genomics 10: 420.
34. Hu Y, Russek SJ (2008) BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J Neurochem 105: 1-17. (Pubitemid 351441645)
35. Li Z, Tan F, Thiele CJ (2007) Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells. Mol Cancer Ther 6: 3113-3121.
36. Yu X, Liu L, Cai B, He Y, Wan X (2008) Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. Cancer Sci 99: 543-552. (Pubitemid 351228572)
37. Au CW, Siu MK, Liao X, Wong ES, Ngan HY, et al. (2009) Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome. Cancer Lett 281: 151-161.
38. Ricci A, Greco S, Mariotta S, Felici L, Bronzetti E, et al. (2001) Neurotrophins and neurotrophin receptors in human lung cancer. Am J Respir Cell Mol Biol 25: 439-446. (Pubitemid 33037676)
39. Bronzetti E, Artico M, Forte F, Pagliarella G, Felici LM, et al. (2008) A possible role of BDNF in prostate cancer detection. Oncol Rep 19: 969-974. (Pubitemid 351802667)
40. Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, et al. (2011) Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin Cancer Res 17: 1741-1752.
41. Blasco-Gutierrez MJ, Jose-Crespo IJ, Zozaya-Alvarez E, Ramos-Sanchez R, Garcia-Atares N (2007) TrkC: a new predictive marker in breast cancer? Cancer Invest 25: 405-410. (Pubitemid 47450671)
42. Yang X, Martin TA, Jiang WG (2012) Biological influence of brain-derived neurotrophic factor on breast cancer cells. Int J Oncol 41: 1541-1546.
43. Yi H, Hu J, Qian J, Hackam AS (2012) Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway. Neuroreport 23: 189-194.
44. Chen BY, Wang X, Wang ZY, Wang YZ, Chen LW, et al. (2013) Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/beta-catenin signaling pathway. J Neurosci Res 91: 30-41.