TrkC: A new predictive marker in breast cancer?

Cancer Investigation

Volumn 25, Issue 6, 2007, Pages 405-410

  Blasco Gutiérrez, María Jesús ^a   José Crespo, Isabel Julia San ^a   Zozaya Alvarez, Enrique ^a   Ramos Sánchez, Rafael ^a   García Atarés, Natividad ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Breast cancer; Immunohistochemistry; Neurotrophins; Predictive factors; TrkC

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; NERVE GROWTH FACTOR; NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 3; NEUROTROPHIN 3; PROGESTERONE RECEPTOR; PROTEIN P53; PROTEIN P75; PROTEIN TYROSINE KINASE A; TUMOR MARKER; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ARTICLE; BREAST CANCER; CANCER GRADING; CLINICAL ARTICLE; DISEASE MARKER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

BREAST NEOPLASMS; FEMALE; HUMANS; NEOPLASM STAGING; NERVE GROWTH FACTORS; PROGNOSIS; RECEPTOR, TRKC; TUMOR MARKERS, BIOLOGICAL;

EID: 34548848314     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900701206349     Document Type: Article

References (12)

1. Eggert, A.; Grotzer, M.A.; Ikegaki, N.; Zhao, H.; Cnaan, A.; et al. Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma. Med. Pediatr. Oncol. 2000, 35 (6), 569-572.
2. Krygier, S.; Djakiew, D. Molecular characterization of the loss of p75 (NTR) expression in human prostate tumor cell. Mol. Carcinog. 2001, 31 (1), 46-55.
3. Dolle, L.; El Yazidi-Belkoura, I.; Adriaenssens, E.; Nurcombe, V.; Hondermarck, H. Nerve growth factor overexpression and autocrine loop in breast cancer cell. Oncogene 2003, 22 (36), 5592-5601.
4. Descamps, S.; Toillon, R.A.; Adriaenssens, E.; Pawlowski, V.; Cool, S.M.; et al. Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J. Biol. Chem. 2001, 276 (21), 17864-17870.
5. Sakamoto, Y.; Kitajima, Y.; Edakuni, G., Sasatomi, E.; Mori, M.; et al. Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. Oncol. Rep. 2001, 8, 477-484.
6. Sakamoto, Y.; Kitajima, Y.; Edakuni, G.; Hamamoto, T.; Miyazaki, K. Combined evaluation of NGF and P75 GFR expression is a biomarker for predicting prognosis in human invasive ductal breast carcinoma. Oncol. Rep. 2001, 8, 973-980.
7. Shibayama, E.; Koizumi, H. Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am. J. Pathol. 1996, 148 (6), 1807-1818.
8. Yamamoto, M.; Sobue, G.; Yamamoto, K.; Terao, S.; Mitsuma, T. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT3 and GDNF) and their receptors (p75NGFR, trk A, trkB, and trkC) in the adult human peripheral nervous system and nonneuronal tissues. Neurochem.Res. 1996, 21 (8), 929-938.
9. Lewin, G.R.; Barde, Y.A. Physiology of the neurotrophins. Ann. Rev. Neurosci. 1996, 19, 298-317.
10. Huang, E.J.; Richardt, L.F. Neurotrophins: roles in neuronal development and function. Ann. Rev. Neurosci. 2001, 24, 677-736.
11. Chao, M.V.; Hempstead, B.L. P75 and Trk: a two- receptor system. Trend Neurosci. 1995, 18 (7), 321-326.
12. Mori, I.; Yang, Q.; Kukudo, K. Predictive and prognostic markers for invasive breast cancer. Pathol. Int. 2002, 52, 186-194.