Biological influence of brain-derived neurotrophic factor on breast cancer cells

International Journal of Oncology

Volumn 41, Issue 4, 2012, Pages 1541-1546

  Yang, Xiaomei ^a,b   Martin, Tracey A ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Brain derived neurotrophic factor; Breast cancer; Proliferation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; SIGNAL TRANSDUCTION; TRANSGENES;

EID: 84866484322     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1581     Document Type: Article

References (19)

1. Foretova L, Petrakova K, Palacova M, Kalabova R, Svoboda M, Navratilova M, Schneiderova M, Bolcak K, Krejci E, Drazan L, et al: Genetic testing and prevention of hereditary cancer at the MMCI - over 10 years of experience. Klin Oncol 23: 388-400, 2010.
2. Gluck S and Mamounas T: Improving outcomes in early-stage breast cancer. Oncology 24: 1-15, 2011.
3. Barde YA, Edgar D and Thoenen H: Purification of a new neurotrophic factor from mammalian brain. EMBO J 1: 549-553, 1982.
4. Patani N, Jiang WG and Mokbel K: Brain-derived neurotrophic factor expression predicts adverse pathological and clinical outcomes in human breast cancer. Cancer Cell Int 11: 23, 2011.
5. Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X and Hondermarck H: Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin Cancer Res 17: 1741-1752, 2011.
6. Yoshii A and Constantine-Paton M: Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol 70: 304-322, 2010.
7. Cowansage KK, LeDoux JE and Monfils MH: Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr Mol Pharmacol 3: 12-29, 2010.
8. Guo D, Hou X, Zhang H, Sun W, Zhu L, Liang J and Jiang X: More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells. J Exp Clin Cancer Res 30: 97, 2011.
9. Harada T, Yatabe Y, Takeshita M, Koga T, Yano T, Wang Y and Giaccone G: Role and relevance of TrkB mutations and expression in non-small cell lung cancer. Clin Cancer Res 17: 2638-2645, 2011.
10. Yu X, Liu L, Cai B, He Y and Wan X: Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. Cancer Sci 99: 543-552, 2008.
11. Festuccia C, Gravina GL, Millimaggi D, Muzi P, Speca S, Ricevuto E, Vicentini C and Bologna M: Uncoupling of the epidermal growth factor receptor from downstream signal transduction molecules guides the acquired resistance to gefitinib in prostate cancer cells. Oncol Rep 18: 503-511, 2007.
12. Brunetto de Farias C, Rosemberg DB, Heinen TE, Koehler-Santos P, Abujamra AL, Kapczinski F, Brunetto AL, Ashton-Prolla P, Meurer L, Reis Bogo M, et al: BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer. Oncology 79: 430-439, 2011.
13. Kawamura N, Kawamura K, Manabe M and Tanaka T: Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth. Endocrinology 151: 3006-3014, 2010.
14. Li Z and Thiele CJ: Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway. Expert Opin Ther Targets 11: 1611-1621, 2007.
15. Sheikh AM, Malik M, Wen G, Chauhan A, Chauhan V, Gong CX, Liu F, Brown WT and Li X: BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. J Neurosci Res 88: 2641-2647, 2010.
16. Sun CY, Hu Y, Huang J, Chu ZB, Zhang L, She XM and Chen L: Brain-derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K/AKT signaling. Tumour Biol 31: 121-128, 2010.
17. D'Intino G, Vaccari F, Sivilia S, Scagliarini A, Gandini G, Giardino L and Calza L: A molecular study of hippocampus in dogs with convulsion during canine distemper virus encephalitis. Brain Res 1098: 186-195, 2006.
18. Kalita K, Makonchuk D, Gomes C, Zheng JJ and Hetman M: Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem 105: 2286-2299, 2008.
19. Moon A, Won KY, Lee JY, Kang I, Lee SK and Lee J: Expression of BDNF, TrkB, and p53 in early-stage squamous cell carcinoma of the uterine cervix. Pathology 43: 453-458, 2011.