메뉴 건너뛰기




Volumn 14, Issue 4, 2012, Pages

The gene expression landscape of breast cancer is shaped by tumor protein p53 status and epithelial-mesenchymal transition

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; SMALL INTERFERING RNA; TRANSCRIPTOME;

EID: 84864268943     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3236     Document Type: Article
Times cited : (55)

References (64)
  • 2
    • 34447132081 scopus 로고    scopus 로고
    • Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen
    • 10.1634/theoncologist.12-6-631, 17602054
    • Paik S. Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen. Oncologist 2007, 12:631-635. 10.1634/theoncologist.12-6-631, 17602054.
    • (2007) Oncologist , vol.12 , pp. 631-635
    • Paik, S.1
  • 8
    • 77950308839 scopus 로고    scopus 로고
    • Breast cancer molecular profiling with single sample predictors: a retrospective analysis
    • 10.1016/S1470-2045(10)70008-5, 20181526
    • Weigelt B, Mackay A, A'Hern R, Natrajan R, Tan DS, Dowsett M, Ashworth A, Reis-Filho JS. Breast cancer molecular profiling with single sample predictors: a retrospective analysis. Lancet Oncol 2010, 11:339-349. 10.1016/S1470-2045(10)70008-5, 20181526.
    • (2010) Lancet Oncol , vol.11 , pp. 339-349
    • Weigelt, B.1    Mackay, A.2    A'Hern, R.3    Natrajan, R.4    Tan, D.S.5    Dowsett, M.6    Ashworth, A.7    Reis-Filho, J.S.8
  • 14
    • 0012333539 scopus 로고    scopus 로고
    • Expression profiling to predict outcome in breast cancer: the influence of sample selection
    • 10.1186/bcr682, 154130, 12559041
    • Gruvberger SK, Ringner M, Eden P, Borg A, Ferno M, Peterson C, Meltzer PS. Expression profiling to predict outcome in breast cancer: the influence of sample selection. Breast Cancer Res 2003, 5:23-26. 10.1186/bcr682, 154130, 12559041.
    • (2003) Breast Cancer Res , vol.5 , pp. 23-26
    • Gruvberger, S.K.1    Ringner, M.2    Eden, P.3    Borg, A.4    Ferno, M.5    Peterson, C.6    Meltzer, P.S.7
  • 15
    • 63349091533 scopus 로고    scopus 로고
    • A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer
    • 10.1186/bcr2138, 2575547, 18755024
    • Teschendorff AE, Caldas C. A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer. Breast Cancer Res 2008, 10:R73. 10.1186/bcr2138, 2575547, 18755024.
    • (2008) Breast Cancer Res , vol.10
    • Teschendorff, A.E.1    Caldas, C.2
  • 20
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: a software environment for integrated models of biomolecular interaction networks
    • 10.1101/gr.1239303, 403769, 14597658
    • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003, 13:2498-2504. 10.1101/gr.1239303, 403769, 14597658.
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1    Markiel, A.2    Ozier, O.3    Baliga, N.S.4    Wang, J.T.5    Ramage, D.6    Amin, N.7    Schwikowski, B.8    Ideker, T.9
  • 21
    • 24044440971 scopus 로고    scopus 로고
    • BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks
    • 10.1093/bioinformatics/bti551, 15972284
    • Maere S, Heymans K, Kuiper M. BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 2005, 21:3448-3449. 10.1093/bioinformatics/bti551, 15972284.
    • (2005) Bioinformatics , vol.21 , pp. 3448-3449
    • Maere, S.1    Heymans, K.2    Kuiper, M.3
  • 23
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: understanding the cell's functional organization
    • 10.1038/nrg1272, 14735121
    • Barabasi AL, Oltvai ZN. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004, 5:101-113. 10.1038/nrg1272, 14735121.
    • (2004) Nat Rev Genet , vol.5 , pp. 101-113
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 24
    • 52949154642 scopus 로고    scopus 로고
    • High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
    • 10.1073/pnas.0804455105, 2544584, 18780787
    • Fredlund E, Ringner M, Maris JM, Pahlman S. High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci USA 2008, 105:14094-14099. 10.1073/pnas.0804455105, 2544584, 18780787.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14094-14099
    • Fredlund, E.1    Ringner, M.2    Maris, J.M.3    Pahlman, S.4
  • 25
    • 79953102030 scopus 로고    scopus 로고
    • A cell spot microarray method for production of high density siRNA transfection microarrays
    • 10.1186/1471-2164-12-162, 3073923, 21443765
    • Rantala JK, Makela R, Aaltola AR, Laasola P, Mpindi JP, Nees M, Saviranta P, Kallioniemi O. A cell spot microarray method for production of high density siRNA transfection microarrays. BMC Genomics 2011, 12:162. 10.1186/1471-2164-12-162, 3073923, 21443765.
    • (2011) BMC Genomics , vol.12 , pp. 162
    • Rantala, J.K.1    Makela, R.2    Aaltola, A.R.3    Laasola, P.4    Mpindi, J.P.5    Nees, M.6    Saviranta, P.7    Kallioniemi, O.8
  • 27
    • 34648829133 scopus 로고    scopus 로고
    • An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    • 10.1186/gb-2007-8-8-r157, 2374988, 17683518
    • Teschendorff AE, Miremadi A, Pinder SE, Ellis IO, Caldas C. An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. Genome Biol 2007, 8:R157. 10.1186/gb-2007-8-8-r157, 2374988, 17683518.
    • (2007) Genome Biol , vol.8
    • Teschendorff, A.E.1    Miremadi, A.2    Pinder, S.E.3    Ellis, I.O.4    Caldas, C.5
  • 30
    • 79952819724 scopus 로고    scopus 로고
    • GOBO: Gene Expression-Based Outcome for Breast Cancer Online
    • 10.1371/journal.pone.0017911, 3061871, 21445301
    • Ringner M, Fredlund E, Hakkinen J, Borg A, Staaf J. GOBO: Gene Expression-Based Outcome for Breast Cancer Online. PLoS One 2011, 6:e17911. 10.1371/journal.pone.0017911, 3061871, 21445301.
    • (2011) PLoS One , vol.6
    • Ringner, M.1    Fredlund, E.2    Hakkinen, J.3    Borg, A.4    Staaf, J.5
  • 32
    • 0025583537 scopus 로고
    • Early transcriptional events in cell growth: the Egr family
    • Sukhatme VP. Early transcriptional events in cell growth: the Egr family. J Am Soc Nephrol 1990, 1:859-866.
    • (1990) J Am Soc Nephrol , vol.1 , pp. 859-866
    • Sukhatme, V.P.1
  • 33
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998, 78:783-809.
    • (1998) Physiol Rev , vol.78 , pp. 783-809
    • Gregoire, F.M.1    Smas, C.M.2    Sul, H.S.3
  • 37
    • 78651250284 scopus 로고    scopus 로고
    • FOXA1 is a key determinant of estrogen receptor function and endocrine response
    • 10.1038/ng.730, 3024537, 21151129
    • Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 2011, 43:27-33. 10.1038/ng.730, 3024537, 21151129.
    • (2011) Nat Genet , vol.43 , pp. 27-33
    • Hurtado, A.1    Holmes, K.A.2    Ross-Innes, C.S.3    Schmidt, D.4    Carroll, J.S.5
  • 39
    • 21044455192 scopus 로고    scopus 로고
    • Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
    • 10.1186/bcr1041, 1175069, 15987465
    • Gusterson BA, Ross DT, Heath VJ, Stein T. Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res 2005, 7:143-148. 10.1186/bcr1041, 1175069, 15987465.
    • (2005) Breast Cancer Res , vol.7 , pp. 143-148
    • Gusterson, B.A.1    Ross, D.T.2    Heath, V.J.3    Stein, T.4
  • 40
    • 31544469559 scopus 로고    scopus 로고
    • Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability
    • 10.1158/1078-0432.CCR-05-0903, 16428479
    • Yuan B, Xu Y, Woo JH, Wang Y, Bae YK, Yoon DS, Wersto RP, Tully E, Wilsbach K, Gabrielson E. Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability. Clin Cancer Res 2006, 12:405-410. 10.1158/1078-0432.CCR-05-0903, 16428479.
    • (2006) Clin Cancer Res , vol.12 , pp. 405-410
    • Yuan, B.1    Xu, Y.2    Woo, J.H.3    Wang, Y.4    Bae, Y.K.5    Yoon, D.S.6    Wersto, R.P.7    Tully, E.8    Wilsbach, K.9    Gabrielson, E.10
  • 41
    • 79958733630 scopus 로고    scopus 로고
    • Mad2 Is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition
    • 10.1016/j.ccr.2011.04.017, 3120099, 21665145
    • Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. Mad2 Is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell 2011, 19:701-714. 10.1016/j.ccr.2011.04.017, 3120099, 21665145.
    • (2011) Cancer Cell , vol.19 , pp. 701-714
    • Schvartzman, J.M.1    Duijf, P.H.2    Sotillo, R.3    Coker, C.4    Benezra, R.5
  • 42
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • 10.1038/ng1861, 16921376
    • Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 2006, 38:1043-1048. 10.1038/ng1861, 16921376.
    • (2006) Nat Genet , vol.38 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 43
    • 79955093350 scopus 로고    scopus 로고
    • High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells
    • 10.1073/pnas.1007645108, 3069188, 21402910
    • Daniel J, Coulter J, Woo JH, Wilsbach K, Gabrielson E. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. Proc Natl Acad Sci USA 2011, 108:5384-5389. 10.1073/pnas.1007645108, 3069188, 21402910.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5384-5389
    • Daniel, J.1    Coulter, J.2    Woo, J.H.3    Wilsbach, K.4    Gabrielson, E.5
  • 45
    • 65649122683 scopus 로고    scopus 로고
    • A signature-based method for indexing cell cycle phase distribution from microarray profiles
    • 10.1186/1471-2164-10-137, 2676301, 19331659
    • Mizuno H, Nakanishi Y, Ishii N, Sarai A, Kitada K. A signature-based method for indexing cell cycle phase distribution from microarray profiles. BMC Genomics 2009, 10:137. 10.1186/1471-2164-10-137, 2676301, 19331659.
    • (2009) BMC Genomics , vol.10 , pp. 137
    • Mizuno, H.1    Nakanishi, Y.2    Ishii, N.3    Sarai, A.4    Kitada, K.5
  • 46
    • 43049110552 scopus 로고    scopus 로고
    • Mitotic checkpoints and the maintenance of the chromosome karyotype
    • 10.1016/j.mrgentox.2007.10.020, 18242118
    • Decordier I, Cundari E, Kirsch-Volders M. Mitotic checkpoints and the maintenance of the chromosome karyotype. Mutat Res 2008, 651:3-13. 10.1016/j.mrgentox.2007.10.020, 18242118.
    • (2008) Mutat Res , vol.651 , pp. 3-13
    • Decordier, I.1    Cundari, E.2    Kirsch-Volders, M.3
  • 47
    • 76349126361 scopus 로고    scopus 로고
    • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
    • 10.1083/jcb.200905057, 2819684, 20123995
    • Thompson SL, Compton DA. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol 2010, 188:369-381. 10.1083/jcb.200905057, 2819684, 20123995.
    • (2010) J Cell Biol , vol.188 , pp. 369-381
    • Thompson, S.L.1    Compton, D.A.2
  • 48
    • 26444546442 scopus 로고    scopus 로고
    • An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    • 10.1073/pnas.0506230102, 1197273, 16141321
    • Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A, Pawitan Y, Hall P, Klaar S, Liu ET, Bergh J. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 2005, 102:13550-13555. 10.1073/pnas.0506230102, 1197273, 16141321.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13550-13555
    • Miller, L.D.1    Smeds, J.2    George, J.3    Vega, V.B.4    Vergara, L.5    Ploner, A.6    Pawitan, Y.7    Hall, P.8    Klaar, S.9    Liu, E.T.10    Bergh, J.11
  • 49
    • 84868214412 scopus 로고    scopus 로고
    • TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine +/- trastuzumab
    • Gluck S, Ross JS, Royce M, McKenna EF, Perou CM, Avisar E, Wu L. TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine +/- trastuzumab. Breast Cancer Res Treat 2011,
    • (2011) Breast Cancer Res Treat
    • Gluck, S.1    Ross, J.S.2    Royce, M.3    McKenna, E.F.4    Perou, C.M.5    Avisar, E.6    Wu, L.7
  • 51
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • 10.1186/bcr2635, 3096954, 20813035
    • Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X, Perou CM. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 2010, 12:R68. 10.1186/bcr2635, 3096954, 20813035.
    • (2010) Breast Cancer Res , vol.12
    • Prat, A.1    Parker, J.S.2    Karginova, O.3    Fan, C.4    Livasy, C.5    Herschkowitz, J.I.6    He, X.7    Perou, C.M.8
  • 52
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • 10.1038/nrc822, 12189386
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454. 10.1038/nrc822, 12189386.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 54
    • 77950284093 scopus 로고    scopus 로고
    • LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer
    • 10.1158/0008-5472.CAN-09-3141, 2869247, 20215510
    • Choi YL, Bocanegra M, Kwon MJ, Shin YK, Nam SJ, Yang JH, Kao J, Godwin AK, Pollack JR. LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer. Cancer Res 2010, 70:2296-2306. 10.1158/0008-5472.CAN-09-3141, 2869247, 20215510.
    • (2010) Cancer Res , vol.70 , pp. 2296-2306
    • Choi, Y.L.1    Bocanegra, M.2    Kwon, M.J.3    Shin, Y.K.4    Nam, S.J.5    Yang, J.H.6    Kao, J.7    Godwin, A.K.8    Pollack, J.R.9
  • 55
    • 4143086158 scopus 로고    scopus 로고
    • Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer
    • 10.1016/j.urology.2004.03.025, 15302512
    • Boorjian S, Ugras S, Mongan NP, Gudas LJ, You X, Tickoo SK, Scherr DS. Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology 2004, 64:383-388. 10.1016/j.urology.2004.03.025, 15302512.
    • (2004) Urology , vol.64 , pp. 383-388
    • Boorjian, S.1    Ugras, S.2    Mongan, N.P.3    Gudas, L.J.4    You, X.5    Tickoo, S.K.6    Scherr, D.S.7
  • 56
    • 77954234849 scopus 로고    scopus 로고
    • Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome
    • 10.1158/1078-0432.CCR-09-2509, 20460471
    • Jonsson G, Busch C, Knappskog S, Geisler J, Miletic H, Ringner M, Lillehaug JR, Borg A, Lonning PE. Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res 2010, 16:3356-3367. 10.1158/1078-0432.CCR-09-2509, 20460471.
    • (2010) Clin Cancer Res , vol.16 , pp. 3356-3367
    • Jonsson, G.1    Busch, C.2    Knappskog, S.3    Geisler, J.4    Miletic, H.5    Ringner, M.6    Lillehaug, J.R.7    Borg, A.8    Lonning, P.E.9
  • 57
    • 0036898190 scopus 로고    scopus 로고
    • Molecular portraits and the family tree of cancer
    • Chung CH, Bernard PS, Perou CM. Molecular portraits and the family tree of cancer. Nat Genet 2002, (32 Suppl):533-540.
    • (2002) Nat Genet , Issue.32 SUPPL , pp. 533-540
    • Chung, C.H.1    Bernard, P.S.2    Perou, C.M.3
  • 59
    • 39449095723 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype
    • 10.1158/0008-5472.CAN-07-2017, 18281472
    • Sarrio D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G, Palacios J. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 2008, 68:989-997. 10.1158/0008-5472.CAN-07-2017, 18281472.
    • (2008) Cancer Res , vol.68 , pp. 989-997
    • Sarrio, D.1    Rodriguez-Pinilla, S.M.2    Hardisson, D.3    Cano, A.4    Moreno-Bueno, G.5    Palacios, J.6
  • 64
    • 68949216248 scopus 로고    scopus 로고
    • Systems genetics analysis of cancer susceptibility: from mouse models to humans
    • Quigley D, Balmain A. Systems genetics analysis of cancer susceptibility: from mouse models to humans. Nat Rev Genet 2009, 10:651-657.
    • (2009) Nat Rev Genet , vol.10 , pp. 651-657
    • Quigley, D.1    Balmain, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.