HeLa human cervical cancer cell migration is inhibited by treatment with dibutyryl-cAMP

Anticancer Research

Volumn 34, Issue 7, 2014, Pages 3447-3455

  Lee, Jae Wook ^a   Lee, Jiyoung ^a   Moon, Eun Yi ^a  

^a Sejong University   (South Korea)

Author keywords

cAMP; Cell migration; EPAC1 RAP1; PKA; RAC1

Indexed keywords

BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; RAP1 PROTEIN; GUANOSINE TRIPHOSPHATASE; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN; RAPGEF3 PROTEIN, HUMAN; TELOMERE BINDING PROTEIN; TERF2IP PROTEIN, HUMAN;

ARTICLE; CANCER INHIBITION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MIGRATION INHIBITION; CELL MOTION; EPAC1/RAP1; METABOLISM; PATHOLOGY; PKA; RAC1; UTERINE CERVIX TUMOR;

CAMP; CELL MIGRATION; EPAC1/RAP1; PKA; RAC1;

BUCLADESINE; CELL MOVEMENT; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; RAC1 GTP-BINDING PROTEIN; TELOMERE-BINDING PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 84904478800     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Im YS, Ryu YK and Moon EY: Mouse Melanoma Cell Migration is Dependent on Production of Reactive Oxygen Species under Normoxia Condition. Biomol Ther (Seoul) 20: 165-170, 2012.
2. O'Connor KL and Mercurio AM: Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem 276: 47895-47900, 2001.
3. Pantel K and Brakenhoff RH: Dissecting the metastatic cascade. Nat Rev Cancer 4: 448-456, 2004.
4. Postovit LM, Abbott DE, Payne SL, Wheaton WW, Margaryan NV, Sullivan R, Jansen MK, Csiszar K, Hendrix MJ and Kirschmann DA: Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration. J Cell Biochem 103: 1369-1378, 2008.
5. Chen L, Zhang JJ and Huang XY: cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation. J Biol Chem 283: 13799-13805, 2008.
6. Yamazaki D, Kurisu S and Takenawa T: Regulation of cancer cell motility through actin reorganization. Cancer Sci 96: 379-386, 2005.
7. Bailey CL, Kelly P and Casey PJ: Activation of RAP1 promotes prostate cancer metastasis. Cancer Res 69: 4962-4968, 2009.
8. Burnham CA, Shokoples SE, and Tyrrell GJ: RAC1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus. FEMS Microbiol Lett 272: 8-14, 2007.
9. Takai Y, Sasaki T, Tanaka K and Nakanishi H: Rho as a regulator of the cytoskeleton. Trends Biochem Sci 20: 227-231, 1995.
10. Katoh H, Hiramoto K and Negishi M: Activation of RAC1 by RhoG regulates cell migration. J Cell Sci 119: 56-65, 2006.
11. Parri M and Chiarugi P: Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal 8: 23-36, 2010.
12. Xu B, Chelikani P and Bhullar RP: Characterization and functional analysis of the calmodulin-binding domain of RAC1 GTPase. PLoS One 7: e42975, 2012.
13. Fukumoto Y, Kaibuchi K, Hori Y, Fujioka H, Araki S, Ueda T, Kikuchi A and Takai Y: Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene 5: 1321-1328, 1990.
14. Gao Y, Dickerson JB, Guo F, Zheng J and Zheng Y: Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101: 7618-7623, 2004.
15. Altan ZM and Fenteany G: c-Jun N-terminal kinase regulates lamellipodial protrusion and cell sheet migration during epithelial wound closure by a gene expression-independent mechanism. Biochem Biophys Res Commun 322: 56-67, 2004.
16. Condeelis JS, Wyckoff JB, Bailly M, Pestell R, Lawrence D, Backer J, and Segall JE: Lamellipodia in invasion. Semin Cancer Biol 11: 119-128, 2001.
17. Chen PW, Jian X, Yoon HY and Randazzo PA: ARAP2 signals through Arf6 and RAC1 to control focal adhesion morphology. J Biol Chem 288: 5849-5860, 2013.
18. Sutherland EW and Rall TW: The Properties of an Adenine Ribonucleotide Produced with Cellular Particles, Atp, Mg++, and Epinephrine or Glucagon. Journal of the American Chemical Society 79: 3608-3608, 1957.
19. Beavo JA and Brunton LL: Cyclic nucleotide research - still expanding after half a century. Nat Rev Mol Cell Biol 3: 710-718, 2002.
20. Bos JL, de Rooij J and Reedquist KA: RAP1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2: 369-377, 2001.
21. Moon EY, Lee JH, Lee JW, Song JH and Pyo S: ROS/EPAC1-mediated RAP1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophages. Cell Signal 23: 1479-1488, 2011.
22. Kim S, Harris M and Varner JA: Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A. J Biol Chem 275: 33920-33928, 2000.
23. Dormond O and Ruegg C: Regulation of endothelial cell integrin function and angiogenesis by COX-2, cAMP and Protein Kinase A. Thromb Haemost 90: 577-585, 2003.
24. Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL and de Rooij J: cAMP-induced EPAC-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. Cell Signal 20: 1104-1116, 2008.
25. Dong X, Tang W, Stopenski S, Brose MS, Korch C and Meinkoth JL: RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. Endocr Relat Cancer 19: 575-588, 2012.
26. Baljinnyam E, Iwatsubo K, Kurotani R, Wang X, Ulucan C, Iwatsubo M, Lagunoff D and Ishikawa Y: EPAC increases melanoma cell migration by a heparan sulfate-related mechanism. Am J Physiol Cell Physiol 297: C802-813, 2009.
27. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR and Goodman RH: Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855-859, 1993.
28. Gonzalez GA and Montminy MR: Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675-680, 1989.
29. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR and Goodman RH: Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370: 223-226, 1994.
30. Howe AK: Regulation of actin-based cell migration by cAMP/PKA. Biochim Biophys Acta 1692: 159-174, 2004.
31. Lauffenburger DA and Horwitz AF: Cell migration: a physically integrated molecular process. Cell 84: 359-369, 1996.
32. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT and Horwitz AR: Cell migration: integrating signals from front to back. Science 302: 1704-1709, 2003.
33. Singer SJ and Kupfer A: The directed migration of eukaryotic cells. Annu Rev Cell Biol 2: 337-365, 1986.
34. Glenn HL and Jacobson BS: Cyclooxygenase and cAMP-dependent protein kinase reorganize the actin cytoskeleton for motility in HeLa cells. Cell Motil Cytoskeleton 55: 265-277, 2003.
35. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA and Chien S: Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res 39: 465-476, 2002.
36. Kiosses WB, Shattil SJ, Pampori N and Schwartz MA: Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration. Nat Cell Biol 3: 316-320, 2001.
37. Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28: 15-33, 2009.
38. Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori SE, Danuser G, Fowler VM, Wirtz D, Hanein D and Waterman-Storer CM: Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol 168: 619-631, 2005.
39. Anderson KI, Wang YL and Small JV: Coordination of protrusion and translocation of the keratocyte involves rolling of the cell body. J Cell Biol 134: 1209-1218, 1996.
40. Svitkina TM, Verkhovsky AB, McQuade KM and Borisy GG: Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J Cell Biol 139: 397-415, 1997.