Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus

FEMS Microbiology Letters

Volumn 272, Issue 1, 2007, Pages 8-14

  Burnham, Carey Ann D ^a   Shokoples, Sandra E ^b   Tyrrell, Gregory J ^a,b,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b PROVINCIAL LABORATORY FOR PUBLIC HEALTH   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Actin; Cdc42; Group B streptococcus; Invasion; Rac; Rho

Indexed keywords

COMPACTIN; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; CELL CULTURE; CELL INVASION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS AGALACTIAE;

ADP RIBOSE TRANSFERASES; BACTERIAL PROTEINS; BACTERIAL TOXINS; BOTULINUM TOXINS; CDC42 GTP-BINDING PROTEIN; COLONY COUNT, MICROBIAL; ENZYME INHIBITORS; EPITHELIAL CELLS; GTP PHOSPHOHYDROLASES; HELA CELLS; HUMANS; LOVASTATIN; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; STREPTOCOCCUS AGALACTIAE; TRANSFECTION;

STREPTOCOCCUS SP. 'GROUP B';

EID: 34250656227     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2007.00768.x     Document Type: Article

References (30)

1. Aktories K (1997) Bacterial toxins that target Rho proteins. J Clin Invest 99 : 827 829.
2. Aktories K, Weller U Chhatwal GS (1987) Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin. FEBS Lett 212 : 109 113.
3. Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM Rosenshine I (1998) Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun 66 : 1755 1758.
4. Borbiev T, Nurmukhambetova S, Liu F, Verin AD Garcia JG (2000) Introduction of C3 exoenzyme into cultured endothelium by lipofectamine. Anal Biochem 285 : 260 264.
5. Burridge K Wennerberg K (2004) Rho and Rac take center stage. Cell 116 : 167 179.
6. Chen LM, Hobbie S Galan JE (1996) Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses. Science 274 : 2115 2118.
7. Criss AK Casanova JE (2003) Coordinate regulation of Salmonella enterica serovar typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases. Infect Immun 71 : 2885 2891.
8. Farley MM, Harvey RC, Stull T, Smith JD, Schuchat A, Wenger JD Stephens DS (1993) A population-based assessment of invasive disease due to group B Streptococcus in nonpregnant adults. N Engl J Med 328 : 1807 1811.
9. Gibson RL, Lee MK, Soderland C, Chi EY Rubens CE (1993) Group B streptococci invade endothelial cells: type III capsular polysaccharide attenuates invasion. Infect Immun 61 : 478 485.
10. Guzman-Verri C, Chaves-Olarte E, von Eichel-Streiber C, Lopez-Goni I, Thelestam M, Arvidson S, Gorvel JP Moreno E (2001) GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42. J Biol Chem 276 : 44435 44443.
11. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279 : 509 514.
12. Lalonde M, Segura M, Lacouture S Gottschalk M (2000) Interactions between Streptococcus suis serotype 2 and different epithelial cell lines. Microbiology 146 : (Part 8) : 1913 1921.
13. Lesser CF, Scherer CA Miller SI (2000) Rac, ruffle and rho: orchestration of Salmonella invasion. Trends Microbiol 8 : 151 152.
14. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K Narumiya S (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 : 895 898.
15. Meerschaert K, De Carte V, De Ville Y, Vandekerckhove J Gettemans J (1998) Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid. EMBO J 17 : 5923 5932.
16. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S Mizuno K (2000) Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275 : 3577 3582.
17. Ozeri V, Rosenshine I, Ben-Ze'Ev A, Bokoch GM, Jou TS Hanski E (2001) De novo formation of focal complex-like structures in host cells by invading streptococci. Mol Microbiol 41 : 561 573.
18. Purushothaman SS, Wang B Cleary PP (2003) M1protein triggers a phosphoinositide cascade for group A Streptococcus invasion of epithelial cells. Infect Immun 71 : 5823 5830.
19. Rubens CE, Smith S, Hulse M, Chi EY van BG (1992) Respiratory epithelial cell invasion by group B streptococci. Infect Immun 60 : 5157 5163.
20. Schuchat A (1998) Epidemiology of group B streptococcal disease in the United States: shifting paradigms. Clin Microbiol Rev 11 : 497 513.
21. Schuchat A, Oxtoby M, Cochi S, Sikes RK, Hightower A, Plikaytis B Broome CV (1990) Population-based risk factors for neonatal group B streptococcal disease: results of a cohort study in metropolitan Atlanta. J Infect Dis 162 : 672 677.
22. Schuchat A, Robinson K, Wenger JD, Harrison LH, Farley M, Reingold AL, Lefkowitz L Perkins BA (1997) Bacterial meningitis in the United States in 1995. Active surveillance team. N Engl J Med 337 : 970 976.
23. Seabra MC (1998) Membrane association and targeting of prenylated Ras-like GTPases. Cell Signal 10 : 167 172.
24. Shin S Kim KS (2006) RhoA and Rac1 contribute to type III group B streptococcal invasion of human brain microvascular endothelial cells. Biochem Biophys Res Commun 345 : 538 542.
25. Subauste MC, Von HM, Benard V, Chamberlain CE, Chuang TH, Chu K, Bokoch GM Hahn KM (2000) Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J Biol Chem 275 : 9725 9733.
26. Tapon N Hall A (1997) Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol 9 : 86 92.
27. Tyrrell GJ, Senzilet LD, Spika JS, Kertesz DA, Alagaratnam M, Lovgren M Talbot JA (2000) Invasive disease due to group B streptococcal infection in adults: results from a Canadian, population-based, active laboratory surveillance study - 1996. Sentinel health unit surveillance system site coordinators. J Infect Dis 182 : 168 173.
28. Tyrrell GJ, Kennedy A, Shokoples SE Sherburne RK (2002) Binding and invasion of HeLa and MRC-5 cells by Streptococcus agalactiae. Microbiology 148 : 3921 3931.
29. Valentin-Weigand P, Jungnitz H, Zock A, Rohde M Chhatwal GS (1997) Characterization of group B streptococcal invasion in HEp-2 epithelial cells. FEMS Microbiol Lett 147 : 69 74.
30. Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ Bokoch GM (1995) Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem 270 : 23934 23936.