cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics

Cellular Signalling

Volumn 20, Issue 6, 2008, Pages 1104-1116

  Lyle, Karen S ^a   Raaijmakers, Judith H ^a   Bruinsma, Wytse ^a   Bos, Johannes L ^a   de Rooij, Johan ^b  

^a Cancer Genomics Centre   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

cAMP; Cytoskeleton; Epac; Integrin; Migration; Rap

Indexed keywords

ANTIBODY; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; PROTEIN EPAC; RAP PROTEIN; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DYNAMICS; ENZYME ACTIVATION; EPITHELIUM CELL; FOCAL ADHESION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL LINE; CELL MOVEMENT; CYCLIC AMP; DOGS; EPITHELIAL CELLS; FOCAL ADHESIONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEPATOCYTE GROWTH FACTOR; HUMANS; INTEGRINS; INTERCELLULAR JUNCTIONS; PSEUDOPODIA; RAP GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 42249085404     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.01.018     Document Type: Article

References (58)

1. Thiery J.P. Nat. Rev., Cancer 2 6 (2002) 442
2. Danen E.H. Curr. Pharm. Des. 11 7 (2005) 881
3. Horwitz R., and Webb D. Curr. Biol. 13 19 (2003) R756
4. Sheetz M.P., Felsenfeld D.P., and Galbraith C.G. Trends Cell Biol. 8 2 (1998) 51
5. Zamir E., and Geiger B. J. Cell Sci. 114 Pt 20 (2001) 3583
6. Webb D.J., Parsons J.T., and Horwitz A.F. Nat. Cell Biol. 4 4 (2002) E97
7. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., and Horwitz A.R. Science 302 5651 (2003) 1704
8. Huttenlocher A., Ginsberg M.H., and Horwitz A.F. J. Cell Biol. 134 6 (1996) 1551
9. Thiery J.P., and Sleeman J.P. Nat. Rev., Mol. Cell Biol. 7 2 (2006) 131
10. Deckers M., van Dinther M., Buijs J., Que I., Lowik C., van der Pluijm G., and ten Dijke P. Cancer Res. 66 4 (2006) 2202
11. Stoker M., Gherardi E., Perryman M., and Gray J. Nature 327 6119 (1987) 239
12. de Rooij J., Kerstens A., Danuser G., Schwartz M.A., and Waterman-Storer C.M. J. Cell Biol. 171 1 (2005) 153
13. Howe A.K. Biochim. Biophys. Acta 1692 2-3 (2004) 159
14. Edin M.L., Howe A.K., and Juliano R.L. Exp. Cell Res. 270 2 (2001) 214
15. Kim S., Harris M., and Varner J.A. J. Biol. Chem. 275 43 (2000) 33920
16. Dormond O., and Ruegg C. Thromb. Haemost. 90 4 (2003) 577
17. de Rooij J., Zwartkruis F.J., Verheijen M.H., Cool R.H., Nijman S.M., Wittinghofer A., and Bos J.L. Nature 396 6710 (1998) 474
18. Bos J.L. Curr. Opin. Cell Biol. 17 2 (2005) 123
19. Caron E. J. Cell Sci. 116 Pt 3 (2003) 435
20. Kooistra M.R., Dube N., and Bos J.L. J. Cell Sci. 120 Pt 1 (2007) 17
21. Katagiri K., Hattori M., Minato N., Irie S., Takatsu K., and Kinashi T. Mol. Cell. Biol. 20 6 (2000) 1956
22. Caron E., Self A.J., and Hall A. Curr. Biol. 10 16 (2000) 974
23. Reedquist K.A., Ross E., Koop E.A., Wolthuis R.M., Zwartkruis F.J., van Kooyk Y., Salmon M., Buckley C.D., and Bos J.L. J. Cell Biol. 148 6 (2000) 1151
24. de Bruyn K.M., Rangarajan S., Reedquist K.A., Figdor C.G., and Bos J.L. J. Biol. Chem. 277 33 (2002) 29468
25. Lafuente E.M., van Puijenbroek A.A., Krause M., Carman C.V., Freeman G.J., Berezovskaya A., Constantine E., Springer T.A., Gertler F.B., and Boussiotis V.A. Dev. Cell 7 4 (2004) 585
26. Katagiri K., Maeda A., Shimonaka M., and Kinashi T. Nat. Immunol. 4 8 (2003) 741
27. Katagiri K., Imamura M., and Kinashi T. Nat. Immunol. 7 9 (2006) 919
28. Han J., Lim C.J., Watanabe N., Soriani A., Ratnikov B., Calderwood D.A., Puzon-McLaughlin W., Lafuente E.M., Boussiotis V.A., Shattil S.J., and Ginsberg M.H. Curr. Biol. 16 18 (2006) 1796
29. Hoshino T., Sakisaka T., Baba T., Yamada T., Kimura T., and Takai Y. J. Biol. Chem. 280 25 (2005) 24095
30. Glading A., Han J., Stockton R.A., and Ginsberg M.H. J. Cell Biol. 179 2 (2007) 247
31. Wittchen E.S., van Buul J.D., Burridge K., and Worthylake R.A. Curr. Opin. Hematol. 12 1 (2005) 14
32. Lorenowicz M.J., Fernandez-Borja M., and Hordijk P.L. Arterioscler. Thromb. Vasc. Biol. 27 5 (2007) 1014
33. Price L.S., Hajdo-Milasinovic A., Zhao J., Zwartkruis F.J., Collard J.G., and Bos J.L. J. Biol. Chem. 279 34 (2004) 35127
34. Ohba Y., Ikuta K., Ogura A., Matsuda J., Mochizuki N., Nagashima K., Kurokawa K., Mayer B.J., Maki K., Miyazaki J., and Matsuda M. Embo J. 20 13 (2001) 3333
35. Zhang A., Dong Z., and Yang T. Am. J. Physiol. Renal. Physiol. 291 6 (2006) F1332
36. Enserink J.M., Christensen A.E., de Rooij J., van Triest M., Schwede F., Genieser H.G., Doskeland S.O., Blank J.L., and Bos J.L. Nat. Cell Biol. 4 11 (2002) 901
37. Christensen A.E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K.K., Martinez A., Maenhaut C., Bos J.L., Genieser H.G., and Doskeland S.O. J. Biol. Chem. 278 37 (2003) 35394
38. Hogan C., Serpente N., Cogram P., Hosking C.R., Bialucha C.U., Feller S.M., Braga V.M., Birchmeier W., and Fujita Y. Mol. Cell. Biol. 24 15 (2004) 6690
39. Knox A.L., and Brown N.H. Science 295 5558 (2002) 1285
40. Kasai H., Allen J.T., Mason R.M., Kamimura T., and Zhang Z. Respir. Res. 6 (2005) 56
41. Esteban M.A., Tran M.G., Harten S.K., Hill P., Castellanos M.C., Chandra A., Raval R., O'Brien T.S., and Maxwell P.H. Cancer Res. 66 7 (2006) 3567
42. Conrotto P., Yakymovych I., Yakymovych M., and Souchelnytskyi S. J. Proteome Res. 6 1 (2007) 287
43. van de Wiel-van Kemenade E., van Kooyk Y., de Boer A.J., Huijbens R.J., Weder P., van de Kasteele W., Melief C.J., and Figdor C.G. J. Cell Biol. 117 2 (1992) 461
44. Frelinger III A.L., Cohen I., Plow E.F., Smith M.A., Roberts J., Lam S.C., and Ginsberg M.H. J. Biol. Chem. 265 11 (1990) 6346
45. Burridge K., and Chrzanowska-Wodnicka M. Annu. Rev. Cell Dev. Biol. 12 (1996) 463
46. von der Hardt S., Bakkers J., Inbal A., Carvalho L., Solnica-Krezel L., Heisenberg C.P., and Hammerschmidt M. Curr. Biol. 17 6 (2007) 475
47. Zaidel-Bar R., Ballestrem C., Kam Z., and Geiger B. J. Cell Sci. 116 Pt 22 (2003) 4605
48. Webb D.J., Brown C.M., and Horwitz A.F. Curr. Opin. Cell Biol. 15 5 (2003) 614
49. Hu K., Ji L., Applegate K.T., Danuser G., and Waterman-Storer C.M. Science 315 5808 (2007) 111
50. Brown C.M., Hebert B., Kolin D.L., Zareno J., Whitmore L., Horwitz A.R., and Wiseman P.W. J. Cell Sci. 119 Pt 24 (2006) 5204
51. Cullere X., Shaw S.K., Andersson L., Hirahashi J., Luscinskas F.W., and Mayadas T.N. Blood 105 5 (2005) 1950
52. Kooistra M.R., Corada M., Dejana E., and Bos J.L. FEBS Lett. 579 22 (2005) 4966
53. Arthur W.T., Quilliam L.A., and Cooper J.A. J. Cell Biol. 167 1 (2004) 111
54. Valles A.M., Beuvin M., and Boyer B. J. Biol. Chem. 279 43 (2004) 44490
55. Gupton S.L., and Waterman-Storer C.M. Cell 125 7 (2006) 1361
56. Jeon T.J., Lee D.J., Merlot S., Weeks G., and Firtel R.A. J. Cell Biol. 176 7 (2007) 1021
57. Franke B., Akkerman J.W., and Bos J.L. Embo J. 16 2 (1997) 252
58. Schwartz M.A., and Denninghoff K. J. Biol. Chem. 269 15 (1994) 11133