Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Fatfat, Maamoun ^a   Merhi, Raghida A ^b   Rahal, Omar ^a   Stoyanovsky, Detcho A ^c   Zaki, Angela ^a   Haidar, Hazar ^a   Kagan, Valerian E ^c   Gali Muhtasib, Hala ^a   Machaca, Khaled ^d  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b LEBANESE UNIVERSITY   (Lebanon)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

Colon cancer; Copper; Metal chelation; Reactive oxygen species; Redox cycling; TPEN

Indexed keywords

ANTIOXIDANT; COPPER; HYDROXYL RADICAL; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; REACTIVE OXYGEN METABOLITE; ZINC; CHELATING AGENT; ETHYLENEDIAMINE DERIVATIVE; N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CHELATION; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SELECTIVITY; FEMALE; HCT116 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE CELL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; TUMOR XENOGRAFT; ANIMAL; COLONIC NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; HT 29 CELL LINE; METABOLISM; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CHELATING AGENTS; COLONIC NEOPLASMS; COPPER; ETHYLENEDIAMINES; FEMALE; HCT116 CELLS; HT29 CELLS; HUMANS; MICE; MICE, SCID; NEOPLASMS, EXPERIMENTAL; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904446830     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-527     Document Type: Article

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