메뉴 건너뛰기




Volumn 40, Issue 8, 2013, Pages 551-559

Emerging markers in cardiovascular disease: Where does angiotensin-converting enzyme 2 fit in?

Author keywords

Angiotensin converting enzyme 2; Cardiovas cular disease; Coronary artery disease; Heart failure; Renin angiotensin system

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN[1-7]; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DX 600; EDETIC ACID; MESSENGER RNA; MLN 4760; UNCLASSIFIED DRUG;

EID: 84880990079     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12069     Document Type: Review
Times cited : (89)

References (61)
  • 2
    • 0028087183 scopus 로고
    • Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling
    • Johnston CI. Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling. Hypertension 1994; 23: 258-68.
    • (1994) Hypertension , vol.23 , pp. 258-268
    • Johnston, C.I.1
  • 3
    • 18544369738 scopus 로고    scopus 로고
    • The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
    • Dzau V. The cardiovascular continuum and renin-angiotensin-aldosterone system blockade. J. Hypertens. Suppl. 2005; 23: S9-17.
    • (2005) J. Hypertens. Suppl. , vol.23
    • Dzau, V.1
  • 4
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    • Donoghue M, Hsieh F, Baronas E et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 2000; 87: E1-9.
    • (2000) Circ. Res. , vol.87
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3
  • 5
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 2000; 275: 33238-43.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 6
    • 18544378161 scopus 로고    scopus 로고
    • Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    • Vickers C, Hales P, Kaushik V et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J. Biol. Chem. 2002; 277: 14838-43.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14838-14843
    • Vickers, C.1    Hales, P.2    Kaushik, V.3
  • 7
    • 0037478671 scopus 로고    scopus 로고
    • Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    • Santos RA, Simoes e Silva AC, Maric C et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl Acad. Sci. USA 2003; 100: 8258-63.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8258-8263
    • Santos, R.A.1    Simoes e Silva, A.C.2    Maric, C.3
  • 8
    • 33644970894 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 and angiotensin-(1-7): An evolving story in cardiovascular regulation
    • Ferrario CM. Angiotensin-converting enzyme 2 and angiotensin-(1-7): An evolving story in cardiovascular regulation. Hypertension 2006; 47: 515-21.
    • (2006) Hypertension , vol.47 , pp. 515-521
    • Ferrario, C.M.1
  • 9
    • 0141893551 scopus 로고    scopus 로고
    • Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7)
    • Tallant EA, Clark MA. Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7). Hypertension 2003; 42: 574-9.
    • (2003) Hypertension , vol.42 , pp. 574-579
    • Tallant, E.A.1    Clark, M.A.2
  • 10
    • 2342418543 scopus 로고    scopus 로고
    • ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
    • Towler P, Staker B, Prasad SG et al. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J. Biol. Chem. 2004; 279: 17996-8007.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17996-18007
    • Towler, P.1    Staker, B.2    Prasad, S.G.3
  • 11
    • 0242569193 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme-2 (ACE2): Comparative modeling of the active site, specificity requirements, and chloride dependence
    • Guy JL, Jackson RM, Acharya KR, Sturrock ED, Hooper NM, Turner AJ. Angiotensin-converting enzyme-2 (ACE2): Comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry 2003; 42: 13185-92.
    • (2003) Biochemistry , vol.42 , pp. 13185-13192
    • Guy, J.L.1    Jackson, R.M.2    Acharya, K.R.3    Sturrock, E.D.4    Hooper, N.M.5    Turner, A.J.6
  • 12
    • 2642539225 scopus 로고    scopus 로고
    • Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
    • Hamming I, Timens W, Bulthuis ML, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J. Pathol. 2004; 203: 631-7.
    • (2004) J. Pathol. , vol.203 , pp. 631-637
    • Hamming, I.1    Timens, W.2    Bulthuis, M.L.3    Lely, A.T.4    Navis, G.J.5    van Goor, H.6
  • 13
    • 84859993289 scopus 로고    scopus 로고
    • Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma
    • Bernardi S, Zennaro C, Palmisano S et al. Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma. J. Renin Angiotensin Aldosterone Syst. 2012; 13: 202-9.
    • (2012) J. Renin Angiotensin Aldosterone Syst. , vol.13 , pp. 202-209
    • Bernardi, S.1    Zennaro, C.2    Palmisano, S.3
  • 14
    • 84856027350 scopus 로고    scopus 로고
    • Review article: The pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract
    • Garg M, Angus PW, Burrell LM, Herath C, Gibson PR, Lubel JS. Review article: The pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract. Aliment. Pharmacol. Ther. 2012; 35: 414-28.
    • (2012) Aliment. Pharmacol. Ther. , vol.35 , pp. 414-428
    • Garg, M.1    Angus, P.W.2    Burrell, L.M.3    Herath, C.4    Gibson, P.R.5    Lubel, J.S.6
  • 15
    • 12344331796 scopus 로고    scopus 로고
    • Identification of angiotensin converting enzyme 2 in the rodent retina
    • Tikellis C, Johnston CI, Forbes JM et al. Identification of angiotensin converting enzyme 2 in the rodent retina. Curr. Eye Res. 2004; 29: 419-27.
    • (2004) Curr. Eye Res. , vol.29 , pp. 419-427
    • Tikellis, C.1    Johnston, C.I.2    Forbes, J.M.3
  • 16
    • 0037341501 scopus 로고    scopus 로고
    • Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
    • Tikellis C, Johnston CI, Forbes JM et al. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension 2003; 41: 392-7.
    • (2003) Hypertension , vol.41 , pp. 392-397
    • Tikellis, C.1    Johnston, C.I.2    Forbes, J.M.3
  • 17
    • 40849127119 scopus 로고    scopus 로고
    • Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls
    • Mizuiri S, Hemmi H, Arita M et al. Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. Am. J. Kidney Dis. 2008; 51: 613-23.
    • (2008) Am. J. Kidney Dis. , vol.51 , pp. 613-623
    • Mizuiri, S.1    Hemmi, H.2    Arita, M.3
  • 18
    • 57049086924 scopus 로고    scopus 로고
    • Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    • Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 2008; 74: 1610-16.
    • (2008) Kidney Int. , vol.74 , pp. 1610-1616
    • Reich, H.N.1    Oudit, G.Y.2    Penninger, J.M.3    Scholey, J.W.4    Herzenberg, A.M.5
  • 20
    • 28144453548 scopus 로고    scopus 로고
    • Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2
    • Paizis G, Tikellis C, Cooper ME et al. Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 2005; 54: 1790-6.
    • (2005) Gut , vol.54 , pp. 1790-1796
    • Paizis, G.1    Tikellis, C.2    Cooper, M.E.3
  • 21
    • 20044377209 scopus 로고    scopus 로고
    • Myocardial infarction increases ACE2 expression in rat and humans
    • Burrell LM, Risvanis J, Kubota E et al. Myocardial infarction increases ACE2 expression in rat and humans. Eur. Heart J. 2005; 26: 369-75.
    • (2005) Eur. Heart J. , vol.26 , pp. 369-375
    • Burrell, L.M.1    Risvanis, J.2    Kubota, E.3
  • 22
    • 77957326124 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure
    • Ohtsuki M, Morimoto S, Izawa H et al. Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. Int. J. Cardiol. 2010; 145: 333-4.
    • (2010) Int. J. Cardiol. , vol.145 , pp. 333-334
    • Ohtsuki, M.1    Morimoto, S.2    Izawa, H.3
  • 25
    • 46849105087 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions
    • Sluimer JC, Gasc JM, Hamming I et al. Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J. Pathol. 2008; 215: 273-9.
    • (2008) J. Pathol. , vol.215 , pp. 273-279
    • Sluimer, J.C.1    Gasc, J.M.2    Hamming, I.3
  • 26
    • 84859871006 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: The first decade
    • Clarke NE, Turner AJ. Angiotensin-converting enzyme 2: The first decade. Int. J. Hypertens. 2012; 2012: 307315.
    • (2012) Int. J. Hypertens. , vol.2012 , pp. 307315
    • Clarke, N.E.1    Turner, A.J.2
  • 27
    • 0035907347 scopus 로고    scopus 로고
    • Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys
    • Zhang H, Wada J, Hida K et al. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J. Biol. Chem. 2001; 276: 17132-9.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17132-17139
    • Zhang, H.1    Wada, J.2    Hida, K.3
  • 28
    • 33645299090 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme II in the heart and the kidney
    • Danilczyk U, Penninger JM. Angiotensin-converting enzyme II in the heart and the kidney. Circ. Res. 2006; 98: 463-71.
    • (2006) Circ. Res. , vol.98 , pp. 463-471
    • Danilczyk, U.1    Penninger, J.M.2
  • 29
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • Hashimoto T, Perlot T, Rehman A et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 2012; 487: 477-81.
    • (2012) Nature , vol.487 , pp. 477-481
    • Hashimoto, T.1    Perlot, T.2    Rehman, A.3
  • 30
    • 24044444558 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    • Lambert DW, Yarski M, Warner FJ et al. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J. Biol. Chem. 2005; 280: 30113-19.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30113-30119
    • Lambert, D.W.1    Yarski, M.2    Warner, F.J.3
  • 31
    • 38049005632 scopus 로고    scopus 로고
    • Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    • Lambert DW, Clarke NE, Hooper NM, Turner AJ. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 2008; 582: 385-90.
    • (2008) FEBS Lett. , vol.582 , pp. 385-390
    • Lambert, D.W.1    Clarke, N.E.2    Hooper, N.M.3    Turner, A.J.4
  • 32
    • 42649095968 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
    • Lew RA, Warner FJ, Hanchapola I et al. Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. Exp. Physiol. 2008; 93: 685-93.
    • (2008) Exp. Physiol. , vol.93 , pp. 685-693
    • Lew, R.A.1    Warner, F.J.2    Hanchapola, I.3
  • 33
    • 67650081069 scopus 로고    scopus 로고
    • Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
    • Jia HP, Look DC, Tan P et al. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 2009; 297: L84-96.
    • (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.297
    • Jia, H.P.1    Look, D.C.2    Tan, P.3
  • 34
    • 79958819480 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: Determinants and constraints
    • Lai ZW, Hanchapola I, Steer DL, Smith AI. Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: Determinants and constraints. Biochemistry 2011; 50: 5182-94.
    • (2011) Biochemistry , vol.50 , pp. 5182-5194
    • Lai, Z.W.1    Hanchapola, I.2    Steer, D.L.3    Smith, A.I.4
  • 35
    • 70449625416 scopus 로고    scopus 로고
    • Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme
    • Iwata M, Silva Enciso JE, Greenberg BH. Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme. Am. J. Physiol. Cell Physiol. 2009; 297: C1318-29.
    • (2009) Am. J. Physiol. Cell Physiol. , vol.297
    • Iwata, M.1    Silva Enciso, J.E.2    Greenberg, B.H.3
  • 36
    • 84867351874 scopus 로고    scopus 로고
    • Combination renin angiotensin system blockade and angiotensin converting enzyme 2 in experimental myocardial infarction: Implications for future therapeutic directions
    • Burchill LJ, Velkoska E, Dean RG, Griggs K, Patel SK, Burrell LM. Combination renin angiotensin system blockade and angiotensin converting enzyme 2 in experimental myocardial infarction: Implications for future therapeutic directions. Clin. Sci. 2012; 123: 649-58.
    • (2012) Clin. Sci. , vol.123 , pp. 649-658
    • Burchill, L.J.1    Velkoska, E.2    Dean, R.G.3    Griggs, K.4    Patel, S.K.5    Burrell, L.M.6
  • 37
    • 42649091118 scopus 로고    scopus 로고
    • Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression
    • Burchill L, Velkoska E, Dean RG et al. Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Exp. Physiol. 2008; 93: 622-30.
    • (2008) Exp. Physiol. , vol.93 , pp. 622-630
    • Burchill, L.1    Velkoska, E.2    Dean, R.G.3
  • 38
    • 33750264733 scopus 로고    scopus 로고
    • Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study
    • Rice GI, Jones AL, Grant PJ, Carter AM, Turner AJ, Hooper NM. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension 2006; 48: 914-20.
    • (2006) Hypertension , vol.48 , pp. 914-920
    • Rice, G.I.1    Jones, A.L.2    Grant, P.J.3    Carter, A.M.4    Turner, A.J.5    Hooper, N.M.6
  • 39
    • 49349093061 scopus 로고    scopus 로고
    • Detection of soluble angiotensin-converting enzyme 2 in heart failure: Insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    • Epelman S, Tang WH, Chen SY, Van Lente F, Francis GS, Sen S. Detection of soluble angiotensin-converting enzyme 2 in heart failure: Insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol. 2008; 52: 750-4.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 750-754
    • Epelman, S.1    Tang, W.H.2    Chen, S.Y.3    Van Lente, F.4    Francis, G.S.5    Sen, S.6
  • 40
    • 68849105984 scopus 로고    scopus 로고
    • Soluble angiotensin-converting enzyme 2 in human heart failure: Relation with myocardial function and clinical outcomes
    • Epelman S, Shrestha K, Troughton RW et al. Soluble angiotensin-converting enzyme 2 in human heart failure: Relation with myocardial function and clinical outcomes. J. Cardiac Fail. 2009; 15: 565-71.
    • (2009) J. Cardiac Fail. , vol.15 , pp. 565-571
    • Epelman, S.1    Shrestha, K.2    Troughton, R.W.3
  • 41
    • 75349101263 scopus 로고    scopus 로고
    • Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP
    • Wang Y, Moreira Mda C, Heringer-Walther S et al. Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP. J. Cardiac Fail. 2010; 16: 157-63.
    • (2010) J. Cardiac Fail. , vol.16 , pp. 157-163
    • Wang, Y.1    Moreira Mda, C.2    Heringer-Walther, S.3
  • 42
    • 84855860581 scopus 로고    scopus 로고
    • Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications
    • Soro-Paavonen A, Gordin D, Forsblom C et al. Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications. J. Hypertens. 2012; 30: 375-83.
    • (2012) J. Hypertens. , vol.30 , pp. 375-383
    • Soro-Paavonen, A.1    Gordin, D.2    Forsblom, C.3
  • 43
    • 84859787726 scopus 로고    scopus 로고
    • N-Terminal pro-brain natriuretic peptide and angiotension converting enzyme 2 levels and their association with post-operative cardiac complications after emergency orthopaedic Surgery
    • Chong CP, Lim WK, Velkoska E et al. N-Terminal pro-brain natriuretic peptide and angiotension converting enzyme 2 levels and their association with post-operative cardiac complications after emergency orthopaedic Surgery. Am. J. Cardiol. 2012; 109: 1365-73.
    • (2012) Am. J. Cardiol. , vol.109 , pp. 1365-1373
    • Chong, C.P.1    Lim, W.K.2    Velkoska, E.3
  • 44
    • 84883799286 scopus 로고    scopus 로고
    • Enzymatic activity of DPIV and renin-angiotensin system (RAS) proteases in patients with left ventricular dysfunction and primary prevention implantable cardioverter/defibrillator (ICD)
    • Epub 10 October 2012; doi:10.1016/j.ijcard.2012.09.083
    • Lehmann HI, Wolke C, Malenke W et al. Enzymatic activity of DPIV and renin-angiotensin system (RAS) proteases in patients with left ventricular dysfunction and primary prevention implantable cardioverter/defibrillator (ICD). Int. J. Cardiol. 2012; Epub 10 October 2012; doi:10.1016/j.ijcard.2012.09.083
    • (2012) Int. J. Cardiol.
    • Lehmann, H.I.1    Wolke, C.2    Malenke, W.3
  • 45
    • 84871204126 scopus 로고    scopus 로고
    • Circulating angiotensin-converting enzyme 2 activity in kidney transplantation: A longitudinal pilot study
    • Soler MJ, Riera M, Crespo M et al. Circulating angiotensin-converting enzyme 2 activity in kidney transplantation: A longitudinal pilot study. Nephron. Clin. Pract. 2012; 121: c144-50.
    • (2012) Nephron. Clin. Pract. , vol.121
    • Soler, M.J.1    Riera, M.2    Crespo, M.3
  • 46
    • 84880968521 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2 in patients with chronic kidney disease
    • Epub 27 March 2013; doi:10.1093/ndt/gft038.
    • Roberts MA, Velkoska E, Ierino FL, Burrell LM. Angiotensin converting enzyme 2 in patients with chronic kidney disease. Nephrol. Dial. Transplant. 2013; Epub 27 March 2013; doi:10.1093/ndt/gft038.
    • (2013) Nephrol. Dial. Transplant.
    • Roberts, M.A.1    Velkoska, E.2    Ierino, F.L.3    Burrell, L.M.4
  • 47
    • 66349096394 scopus 로고    scopus 로고
    • Quenched fluorescent peptide substrates as tools for the discovery of novel cardiovascular disease biomarkers
    • Smith AI, Warner FJ, Lew RA, Yarski M, McGrath B, Burrell LM. Quenched fluorescent peptide substrates as tools for the discovery of novel cardiovascular disease biomarkers. Adv. Exp. Med. Biol. 2009; 611: 419-22.
    • (2009) Adv. Exp. Med. Biol. , vol.611 , pp. 419-422
    • Smith, A.I.1    Warner, F.J.2    Lew, R.A.3    Yarski, M.4    McGrath, B.5    Burrell, L.M.6
  • 48
    • 84859635766 scopus 로고    scopus 로고
    • Chronic kidney disease. Cardiac and renal angiotensin converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition
    • Burrell LM, Burchill L, Dean RG, Griggs K, Patel SK, Velkoska E. Chronic kidney disease. Cardiac and renal angiotensin converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition. Exp. Physiol. 2012; 97: 477-85.
    • (2012) Exp. Physiol. , vol.97 , pp. 477-485
    • Burrell, L.M.1    Burchill, L.2    Dean, R.G.3    Griggs, K.4    Patel, S.K.5    Velkoska, E.6
  • 49
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 fypertensive rats
    • Trask AJ, Groban L, Westwood BM et al. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 fypertensive rats. Am. J. Hypertens. 2010; 23: 687-93.
    • (2010) Am. J. Hypertens. , vol.23 , pp. 687-693
    • Trask, A.J.1    Groban, L.2    Westwood, B.M.3
  • 50
    • 79951779192 scopus 로고    scopus 로고
    • Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy
    • Velkoska E, Dean RG, Griggs K, Burchill L, Burrell LM. Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy. Clin. Sci. 2011; 120: 335-45.
    • (2011) Clin. Sci. , vol.120 , pp. 335-345
    • Velkoska, E.1    Dean, R.G.2    Griggs, K.3    Burchill, L.4    Burrell, L.M.5
  • 51
    • 79954459188 scopus 로고    scopus 로고
    • Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
    • Prieto MC, Gonzalez-Villalobos RA, Botros FT et al. Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am. J. Physiol. Renal Physiol. 2011; 300: F749-55.
    • (2011) Am. J. Physiol. Renal Physiol. , vol.300
    • Prieto, M.C.1    Gonzalez-Villalobos, R.A.2    Botros, F.T.3
  • 52
    • 42449140640 scopus 로고    scopus 로고
    • ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes
    • Tikellis C, Bialkowski K, Pete J et al. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Diabetes 2008; 57: 1018-25.
    • (2008) Diabetes , vol.57 , pp. 1018-1025
    • Tikellis, C.1    Bialkowski, K.2    Pete, J.3
  • 53
    • 84865556205 scopus 로고    scopus 로고
    • Murine recombinant angiotensin-converting enzyme 2: Effect on angiotensin II dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-eonverting enzyme 2
    • Ye M, Wysocki J, Gonzalez-Pacheco FR et al. Murine recombinant angiotensin-converting enzyme 2: Effect on angiotensin II dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-eonverting enzyme 2. Hypertension 2012; 60: 730-40.
    • (2012) Hypertension , vol.60 , pp. 730-740
    • Ye, M.1    Wysocki, J.2    Gonzalez-Pacheco, F.R.3
  • 55
    • 33747052918 scopus 로고    scopus 로고
    • ACE and ACE2 activity in diabetic mice
    • Wysocki J, Ye M, Soler MJ et al. ACE and ACE2 activity in diabetic mice. Diabetes 2006; 55: 2132-9.
    • (2006) Diabetes , vol.55 , pp. 2132-2139
    • Wysocki, J.1    Ye, M.2    Soler, M.J.3
  • 56
    • 84872193018 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2: A novel marker of coronary artery disease
    • Abstract).
    • Freeman M, Patel SK, Lancefield T et al. Angiotensin converting enzyme 2: A novel marker of coronary artery disease. Eur. Heart J. 2011; 31: 515. (Abstract).
    • (2011) Eur. Heart J. , vol.31 , pp. 515
    • Freeman, M.1    Patel, S.K.2    Lancefield, T.3
  • 57
    • 84871878863 scopus 로고    scopus 로고
    • The ACE2 gene: Its potential as a functional candidate for cardiovascular disease
    • Burrell LM, Harrap SB, Velkoska E, Patel SK. The ACE2 gene: Its potential as a functional candidate for cardiovascular disease. Clin. Sci. 2013; 124: 65-76.
    • (2013) Clin. Sci. , vol.124 , pp. 65-76
    • Burrell, L.M.1    Harrap, S.B.2    Velkoska, E.3    Patel, S.K.4
  • 58
    • 4243105120 scopus 로고    scopus 로고
    • ACE2 gene expression is up-regulated in the human failing heart
    • Goulter AB, Goddard MJ, Allen JC, Clark KL. ACE2 gene expression is up-regulated in the human failing heart. BMC Med. 2004; 2: 19.
    • (2004) BMC Med. , vol.2 , pp. 19
    • Goulter, A.B.1    Goddard, M.J.2    Allen, J.C.3    Clark, K.L.4
  • 59
    • 1342333836 scopus 로고    scopus 로고
    • NT-proBNP in heart failure. Therapy decisions and monitoring
    • Richards M, Troughton RW. NT-proBNP in heart failure. Therapy decisions and monitoring. Eur. J. Heart Fail. 2004; 6: 351-4.
    • (2004) Eur. J. Heart Fail. , vol.6 , pp. 351-354
    • Richards, M.1    Troughton, R.W.2
  • 60
    • 4644221457 scopus 로고    scopus 로고
    • Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    • Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 2004; 351: 1296-305.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1296-1305
    • Go, A.S.1    Chertow, G.M.2    Fan, D.3    McCulloch, C.E.4    Hsu, C.Y.5
  • 61
    • 84862334206 scopus 로고    scopus 로고
    • Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options
    • Grace JA, Herath CB, Mak KY, Burrell LM, Angus PW. Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options. Clin. Sci. (Lond) 2012; 123: 225-39.
    • (2012) Clin. Sci. (Lond) , vol.123 , pp. 225-239
    • Grace, J.A.1    Herath, C.B.2    Mak, K.Y.3    Burrell, L.M.4    Angus, P.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.