Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors

Journal of the American Chemical Society

Volumn 124, Issue 40, 2002, Pages 11852-11853

  Dales, Natalie A ^a   Gould, Alexandra E ^a   Brown, James A ^a   Calderwood, Emily F ^a   Guan, Bing ^a   Minor, Charles A ^a   Gavin, James M ^a   Hales, Paul ^a   Kaushik, Virendar K ^a   Stewart, Michael ^a   Tummino, Peter J ^a   Vickers, Chad S ^a   Ocain, Timothy D ^a   Patane, Michael A ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE 2 INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; IMIDAZOLE; LISINOPRIL; METALLOPROTEINASE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CATALYSIS; CONSENSUS SEQUENCE; CRYSTALLIZATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IC 50; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CARBOXYPEPTIDASES; CATALYSIS; DRUG DESIGN; IMIDAZOLES; PEPTIDYL-DIPEPTIDASE A; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES;

EID: 0037048716     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0277226     Document Type: Article

References (19)

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