Regulatory T cell subsets in children with systemic lupus erythematosus

Clinical Rheumatology

Volumn 33, Issue 8, 2014, Pages 1085-1091

  Eltayeb, Azza A ^a   Sayed, Douaa M ^a   Afifi, Noha A ^a   Ibrahim, Maggie A ^a   Sheref, Tahra M ^a  

^a Assiut University Faculty of Medicine   (Egypt)

Author keywords

Foxp3; Pediatric immunology; SLE; Treg

Indexed keywords

AUTOANTIBODY; CORTICOSTEROID; DNA; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; PREDNISONE;

ADOLESCENT; BLOOD; CHILD; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; IMMUNOLOGY; INFANT; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; METABOLISM; PRESCHOOL CHILD; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME;

ADOLESCENT; ADRENAL CORTEX HORMONES; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DNA; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFANT; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PREDNISONE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TREATMENT OUTCOME;

EID: 84904413583     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-014-2636-9     Document Type: Article

References (31)

1. Kotzin BL (1996) Systemic lupus erythematosus. Cell 85:303-306
2. Via CS, Handwerger BS (1993) B-cell and T-cell function in systemic lupus erythematosus. Curr Opin Rheumatol 5:570-574 (Pubitemid 23290055)
3. Dean GS, Tyrrell-Price J, Crawley E, Isenberg DA (2000) Cytokines and systemic lupus erythematosus. Ann Rheum Dis 59:243-251 (Pubitemid 30305564)
4. Rocha B, von Boehmer H (1991) Peripheral selection of the T cell repertoire. Science 251:1225-1228 (Pubitemid 21926217)
5. Van Parijs L, Abbas AK (1998) Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280:243-248 (Pubitemid 28178061)
6. Itoh M, Takahashi T, Sakaguchi N et al (1999) Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162:5317-5326 (Pubitemid 29307138)
7. Sakaguchi S (2004) Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531-562
8. Wu HY, Staines NA (2004) A deficiency of CD4+CD25+T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen. Lupus 13(3):192-200 (Pubitemid 38478647)
9. Monk CR, Spachidou M, Rovis F et al (2005) MRL/Mp CD4+, CD25- T cells show reduced sensitivity to suppression by CD4+, CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum 52:1180-1184 (Pubitemid 40530125)
10. La Cava A (2008) T-regulatory cells in systemic lupus erythematosus. Lupus 17(5):421-425
11. Gerli R, Nocentini G, Alunno A, Bocci EB, Bianchini R, Bistoni O et al (2009) Identification of regulatory T cells in systemic lupus erythematosus. Autoimmun Rev 8:426-430
12. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G (2001) Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 193:1303-1310 (Pubitemid 32524780)
13. Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061 (Pubitemid 36222930)
14. Wildin RS, Smyk-Pearson S, Filipovich AH (2002) Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39:537-545 (Pubitemid 34864555)
15. Gavin M, Rudensky A (2003) Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr Opin Immunol 15:690-696 (Pubitemid 37434077)
16. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter]. Arthritis Rheum 40:1725
17. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35(6):630-640
18. Minami R, Sakai K, Miyamura T, Yamamoto M, Suematsu E (2006) The role of CD4(+)CD25(+) regulatory T cells in patients with rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi 1:37-42
19. Suárez A, López P, Gómez J, Gutiérrez C (2006) Enrichment of CD4+CD25 high T cell population in SLE patients treated with glucocorticoids. Ann Rheum Dis 65:1512-1517
20. Valencia X, Yarboro C, Illei G, Lipsky PE (2007) Deficient CD4+ CD25high regulatory T cell function in patients with active systemic lupus erythematosus. J Immunol 178:2579-2588 (Pubitemid 46233461)
21. Cepika AM, Marinic I, Morovic-Vergles J, Soldo-Juresa D, Gagro A (2007) Effect of steroids on the frequency of regulatory T cells and expression of FOXP3 in a patient with systemic lupus erythematosus: a two-year follow-up. Lupus 16:374-377 (Pubitemid 47074842)
22. Yates J, Whittington A, Mitchell P, Lechler RI, Lightstone L, Lombardi G (2008) Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin Exp Immunol 153:44-55 (Pubitemid 351809334)
23. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330-336 (Pubitemid 36432314)
24. Tran DQ, Ramsey H, Shevach EM (2007) Induction of FOXP3 expression in native human CD4+FOXP3- T cells by T cell receptor stimulation is transforming growth factor beta-dependent but does not confer a regulatory phenotype. Blood 110:2983-2990 (Pubitemid 350006952)
25. + regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology 127(2):196-205
26. Suggs MJL, Majithia V, Lewis RE, Cruse JM (2011) HLA DRB1*1503 allelic haplotype predominance and associated immunodysregulation in systemic lupus erythematosus. Exp Mol Pathol 91:548-562
27. Azab NA, Bassyouni IH, Emad Y, Abd El-Wahab GA, Hamdy G, Mashahit MA (2008) CD4+CD25+ regulatory T cells (TREG) in systemic lupus erythematosus (SLE) patients: the possible influence of treatment with corticosteroids. Clin Immunol 127(2):151-157
28. Atfy M, Amr GE, Elnaggar AM, Labib HA, Esh A, Elokely AM (2009) Impact of CD4+CD25 high regulatory T-cells and FoxP3 expression in the peripheral blood of patients with systemic lupus erythematosus. Egypt J Immunol 16(1):117-126
29. Liu MF, Wang CR, Fung LL, Wu CR (2004) Decreased CD4+25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 59:198-202
30. Edelbauer M, Kshirsagar S, RiedlM, Billing H, Tönshoff B, Haffner D et al (2012) Activity of childhood lupus nephritis is linked to altered T cell and cytokine homeostasis. J Clin Immunol 32(3):477-487
31. Shevach EM (2004) Regulatory/suppressor T cells in health and disease. Arthritis Rheum 50(9):2721-2724