메뉴 건너뛰기




Volumn 153, Issue 1, 2008, Pages 44-55

Natural regulatory T cells: Number and function are normal in the majority of patients with lupus nephritis

Author keywords

CD4+ CD25+ regulatory T cell; Nucleosomes; SLE

Indexed keywords

GAMMA INTERFERON;

EID: 44949174181     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03665.x     Document Type: Article
Times cited : (58)

References (51)
  • 1
    • 27344457455 scopus 로고    scopus 로고
    • Genetics of susceptibility and severity in systemic lupus erythematosus
    • Croker JA, Kimberly RP. Genetics of susceptibility and severity in systemic lupus erythematosus. Curr Opin Rheumatol 2005 17 : 529 37.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 529-37
    • Croker, J.A.1    Kimberly, R.P.2
  • 2
    • 0037668545 scopus 로고    scopus 로고
    • Pathogenesis of systemic lupus erythematosus
    • Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol 2003 56 : 481 90.
    • (2003) J Clin Pathol , vol.56 , pp. 481-90
    • Mok, C.C.1    Lau, C.S.2
  • 3
    • 0038011861 scopus 로고    scopus 로고
    • The role of antibodies and B cells in the pathogenesis of lupus nephritis
    • Shlomchik MJ, Madaio MP. The role of antibodies and B cells in the pathogenesis of lupus nephritis. Springer Semin Immunopathol 2003 24 : 363 75.
    • (2003) Springer Semin Immunopathol , vol.24 , pp. 363-75
    • Shlomchik, M.J.1    Madaio, M.P.2
  • 4
    • 13444291211 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in lupus nephritis
    • Waldman M, Madaio MP. Pathogenic autoantibodies in lupus nephritis. Lupus 2005 14 : 19 24.
    • (2005) Lupus , vol.14 , pp. 19-24
    • Waldman, M.1    Madaio, M.P.2
  • 5
    • 6044259760 scopus 로고    scopus 로고
    • T cells in the pathogenesis of systemic lupus erythematosus
    • Hoffman RW. T cells in the pathogenesis of systemic lupus erythematosus. Clin Immunol 2004 113 : 4 13.
    • (2004) Clin Immunol , vol.113 , pp. 4-13
    • Hoffman, R.W.1
  • 6
    • 0036096086 scopus 로고    scopus 로고
    • T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system
    • Andreassen K, Bendiksen S, Kjeldsen E et al. T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system. Arthritis Rheum 2002 46 : 1270 81.
    • (2002) Arthritis Rheum , vol.46 , pp. 1270-81
    • Andreassen, K.1    Bendiksen, S.2    Kjeldsen, E.3
  • 8
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 155 : 1151 64.
    • (1995) J Immunol , vol.155 , pp. 1151-64
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 9
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299 : 1057 61.
    • (2003) Science , vol.299 , pp. 1057-61
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 10
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007 8 : 457 62.
    • (2007) Nat Immunol , vol.8 , pp. 457-62
    • Zheng, Y.1    Rudensky, A.Y.2
  • 11
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 2005 202 : 1375 86.
    • (2005) J Exp Med , vol.202 , pp. 1375-86
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 12
    • 25444497719 scopus 로고    scopus 로고
    • Cutting edge: Direct suppression of B cells by CD4+ CD25+ regulatory T cells
    • Lim HW, Hillsamer P, Banham AH, Kim CH. Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J Immunol 2005 175 : 4180 3.
    • (2005) J Immunol , vol.175 , pp. 4180-3
    • Lim, H.W.1    Hillsamer, P.2    Banham, A.H.3    Kim, C.H.4
  • 13
    • 15244363080 scopus 로고    scopus 로고
    • Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    • Lim HW, Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest 2004 114 : 1640 9.
    • (2004) J Clin Invest , vol.114 , pp. 1640-9
    • Lim, H.W.1    Hillsamer, P.2    Kim, C.H.3
  • 14
    • 18344369175 scopus 로고    scopus 로고
    • The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells
    • Seo SJ, Fields ML, Buckler JL et al. The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity 2002 16 : 535 46.
    • (2002) Immunity , vol.16 , pp. 535-46
    • Seo, S.J.1    Fields, M.L.2    Buckler, J.L.3
  • 16
    • 0038297338 scopus 로고    scopus 로고
    • Idiotype-specific CD4+CD25+ T suppressor cells prevent, by limiting antibody diversity, the occurrence of anti-dextran antibodies crossreacting with histone H3
    • Specht C, Schluter B, Rolfing M, Bruning K, Pauels HG, Kolsch E. Idiotype-specific CD4+CD25+ T suppressor cells prevent, by limiting antibody diversity, the occurrence of anti-dextran antibodies crossreacting with histone H3. Eur J Immunol 2003 33 : 1242 9.
    • (2003) Eur J Immunol , vol.33 , pp. 1242-9
    • Specht, C.1    Schluter, B.2    Rolfing, M.3    Bruning, K.4    Pauels, H.G.5    Kolsch, E.6
  • 17
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: Mechanisms of suppression
    • Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 2007 13 : 108 16.
    • (2007) Trends Mol Med , vol.13 , pp. 108-16
    • Miyara, M.1    Sakaguchi, S.2
  • 18
    • 20444364910 scopus 로고    scopus 로고
    • Genetic determination of T cell help in loss of tolerance to nuclear antigens
    • Chen Y, Cuda C, Morel L. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 2005 174 : 7692 702.
    • (2005) J Immunol , vol.174 , pp. 7692-702
    • Chen, Y.1    Cuda, C.2    Morel, L.3
  • 19
    • 33747435166 scopus 로고    scopus 로고
    • The role of CD4CD25 T cells in autoantibody production in murine lupus
    • Hsu WT, Suen JL, Chiang BL. The role of CD4CD25 T cells in autoantibody production in murine lupus. Clin Exp Immunol 2006 145 : 513 19.
    • (2006) Clin Exp Immunol , vol.145 , pp. 513-19
    • Hsu, W.T.1    Suen, J.L.2    Chiang, B.L.3
  • 20
    • 1842681797 scopus 로고    scopus 로고
    • A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen
    • Wu HY, Staines NA. A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen. Lupus 2004 13 : 192 200.
    • (2004) Lupus , vol.13 , pp. 192-200
    • Wu, H.Y.1    Staines, N.A.2
  • 21
    • 23244463009 scopus 로고    scopus 로고
    • Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis
    • Bagavant H, Tung KS. Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis. J Immunol 2005 175 : 944 50.
    • (2005) J Immunol , vol.175 , pp. 944-50
    • Bagavant, H.1    Tung, K.S.2
  • 22
    • 17244378876 scopus 로고    scopus 로고
    • MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: A novel defect of T cell regulation in systemic lupus erythematosus
    • Monk CR, Spachidou M, Rovis F et al. MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum 2005 52 : 1180 4.
    • (2005) Arthritis Rheum , vol.52 , pp. 1180-4
    • Monk, C.R.1    Spachidou, M.2    Rovis, F.3
  • 24
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    • Gavin MA, Torgerson TR, Houston E et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 2006 103 : 6659 64.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6659-64
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 25
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador G, Brown PJ, Maestre L et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005 35 : 1681 91.
    • (2005) Eur J Immunol , vol.35 , pp. 1681-91
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3
  • 26
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003 21 : 273 6.
    • (2003) J Autoimmun , vol.21 , pp. 273-6
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 27
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Miyara M, Amoura Z, Parizot C et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005 175 : 8392 400.
    • (2005) J Immunol , vol.175 , pp. 8392-400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3
  • 29
    • 1342267617 scopus 로고    scopus 로고
    • Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus
    • Liu MF, Wang CR, Fung LL, Wu CR. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004 59 : 198 202.
    • (2004) Scand J Immunol , vol.59 , pp. 198-202
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3    Wu, C.R.4
  • 30
    • 33750358659 scopus 로고    scopus 로고
    • Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids
    • Suarez A, Lopez P, Gomez J, Gutierrez C. Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheum Dis 2006 65 : 1512 17.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1512-17
    • Suarez, A.1    Lopez, P.2    Gomez, J.3    Gutierrez, C.4
  • 31
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007 178 : 2579 88.
    • (2007) J Immunol , vol.178 , pp. 2579-88
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 32
    • 0031229830 scopus 로고    scopus 로고
    • Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
    • Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997 40 : 1725.
    • (1997) Arthritis Rheum , vol.40 , pp. 1725
    • Hochberg, M.C.1
  • 34
    • 28444455974 scopus 로고    scopus 로고
    • Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse
    • Carlin LM, Yanagi K, Verhoef A et al. Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse. Blood 2005 106 : 3874 9.
    • (2005) Blood , vol.106 , pp. 3874-9
    • Carlin, L.M.1    Yanagi, K.2    Verhoef, A.3
  • 35
    • 0036499025 scopus 로고    scopus 로고
    • Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus
    • Kaliyaperumal A, Michaels MA, Datta SK. Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus. J Immunol 2002 168 : 2530 7.
    • (2002) J Immunol , vol.168 , pp. 2530-7
    • Kaliyaperumal, A.1    Michaels, M.A.2    Datta, S.K.3
  • 36
    • 0032728568 scopus 로고    scopus 로고
    • Major peptide autoepitopes for nucleosome-specific T cells of human lupus
    • Lu L, Kaliyaperumal A, Boumpas DT, Datta SK. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J Clin Invest 1999 104 : 345 55.
    • (1999) J Clin Invest , vol.104 , pp. 345-55
    • Lu, L.1    Kaliyaperumal, A.2    Boumpas, D.T.3    Datta, S.K.4
  • 37
    • 0034989222 scopus 로고    scopus 로고
    • Counter-proliferative effects of nucleosomal antigens in cultures from lupus patients
    • Salaman MR, Mawer DP, Hogarth MB, Seifert MH, Isenberg DA. Counter-proliferative effects of nucleosomal antigens in cultures from lupus patients. Lupus 2001 10 : 332 9.
    • (2001) Lupus , vol.10 , pp. 332-9
    • Salaman, M.R.1    Mawer, D.P.2    Hogarth, M.B.3    Seifert, M.H.4    Isenberg, D.A.5
  • 38
    • 33746356813 scopus 로고    scopus 로고
    • Human regulatory T cells and their role in autoimmune disease
    • Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunol Rev 2006 212 : 203 16.
    • (2006) Immunol Rev , vol.212 , pp. 203-16
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 39
    • 0142218428 scopus 로고    scopus 로고
    • Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease
    • Salama AD, Chaudhry AN, Holthaus KA et al. Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 2003 64 : 1685 94.
    • (2003) Kidney Int , vol.64 , pp. 1685-94
    • Salama, A.D.1    Chaudhry, A.N.2    Holthaus, K.A.3
  • 40
    • 20844432359 scopus 로고    scopus 로고
    • Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    • Karagiannidis C, Akdis M, Holopainen P et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004 114 : 1425 33.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1425-33
    • Karagiannidis, C.1    Akdis, M.2    Holopainen, P.3
  • 41
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T cell receptor stimulation is TGF{beta}-dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T cell receptor stimulation is TGF{beta}-dependent but does not confer a regulatory phenotype. Blood 2007 110 : 2983 90.
    • (2007) Blood , vol.110 , pp. 2983-90
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 42
    • 33846283803 scopus 로고    scopus 로고
    • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    • Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007 319 : 41 52.
    • (2007) J Immunol Methods , vol.319 , pp. 41-52
    • Hartigan-O'Connor, D.J.1    Poon, C.2    Sinclair, E.3    McCune, J.M.4
  • 43
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006 203 : 1701 11.
    • (2006) J Exp Med , vol.203 , pp. 1701-11
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 44
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006 203 : 1693 700.
    • (2006) J Exp Med , vol.203 , pp. 1693-700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 45
    • 33745832286 scopus 로고    scopus 로고
    • Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells
    • Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells. J Immunol 2006 177 : 840 51.
    • (2006) J Immunol , vol.177 , pp. 840-51
    • Lim, H.W.1    Broxmeyer, H.E.2    Kim, C.H.3
  • 46
    • 18644376988 scopus 로고    scopus 로고
    • Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms
    • Min B, Yamane H, Hu-Li J, Paul WE. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J Immunol 2005 174 : 6039 44.
    • (2005) J Immunol , vol.174 , pp. 6039-44
    • Min, B.1    Yamane, H.2    Hu-Li, J.3    Paul, W.E.4
  • 47
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007 445 : 766 70.
    • (2007) Nature , vol.445 , pp. 766-70
    • Wan, Y.Y.1    Flavell, R.A.2
  • 48
    • 33947118656 scopus 로고    scopus 로고
    • Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
    • Sfikakis PP, Souliotis VL, Fragiadaki KG, Moutsopoulos HM, Boletis JN, Theofilopoulos AN. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin Immunol 2007 123 : 66 73.
    • (2007) Clin Immunol , vol.123 , pp. 66-73
    • Sfikakis, P.P.1    Souliotis, V.L.2    Fragiadaki, K.G.3    Moutsopoulos, H.M.4    Boletis, J.N.5    Theofilopoulos, A.N.6
  • 49
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J, Rainbow D, Serra P et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007 39 : 329 37.
    • (2007) Nat Genet , vol.39 , pp. 329-37
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3
  • 50
    • 0019490514 scopus 로고
    • Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2
    • Altman A, Theofilopoulos AN, Weiner R, Katz DH, Dixon FJ. Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med 1981 154 : 791 808.
    • (1981) J Exp Med , vol.154 , pp. 791-808
    • Altman, A.1    Theofilopoulos, A.N.2    Weiner, R.3    Katz, D.H.4    Dixon, F.J.5
  • 51
    • 14844346513 scopus 로고    scopus 로고
    • Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets
    • Kang HK, Michaels MA, Berner BR, Datta SK. Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol 2005 174 : 3247 55.
    • (2005) J Immunol , vol.174 , pp. 3247-55
    • Kang, H.K.1    Michaels, M.A.2    Berner, B.R.3    Datta, S.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.