A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen

Lupus

Volumn 13, Issue 3, 2004, Pages 192-200

  Wu, Henry Yim ^a,b   Staines, N A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD4+CD25+ T cells; Histone peptide; Nasal tolerance; Spontaneous lupus

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; HISTONE PEPTIDE H417; INTERLEUKIN 2 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFECT; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; LUPUS ERYTHEMATOSUS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 1842681797     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203303lu1002oa     Document Type: Article

References (28)

1. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349-56.
2. Miller JF, Heath WR. Self-ignorance in the peripheral T-cell pool. Immunol Rev 1993; 133: 131-50.
3. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995; 80: 695-705.
4. Sakaguchi SK, Kuribayashi K, Massuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. 1. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985; 161: 72-87.
5. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10: 1969-80.
6. Papiemik M, deMoraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T-cells: expression of IL-2Rα-chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 1998; 10: 371-78.
7. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 5317-26.
8. Suri-Payer E, Amar AZ, McHugh R, Natarajan K, Margulies DH, Shevach EM. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur J Immunol 1999; 29: 669-77.
9. + T cells as a functionally and phenotypically distinct immunoregulatory T cell as subpopulation. Int Immunol 2000; 12: 1145-55.
10. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 303-10.
11. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996; 184: 387-96.
12. + T-cells inhibit both the induction and effector function of autoreactive T-cells and represent a unique linage of immunoregulatory cells. J Immunol 1998; 160: 1212-18.
13. Bach JF, Francois Bach J. Regulatory T cells under scrutiny. Nat Rev Immunol 2003; 3: 89-198.
14. Wu HY, Ward FJ, Staines NA. Histone peptide-induced nasal tolerance: suppression of murine lupus. J Immunol 2002; 169: 1126-34.
15. Takabayashi K, Libet L, Chisholm D, Zubeldia J, Homer AA. Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice. J Immunol 2003; 170: 3898-905.
16. Kaliyaperumal A, Mohan C, Wu W, Data SK. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med 1996; 183: 2459-69.
17. Stoll ML, Gavalchin J. Systemic lupus erythematosus - messages from experimental models. Rheumatology (Oxford) 2000; 39(1): 18-27.
18. Saloga J, Enk AH, Becker D, Bellinghausen I, Kuhn S, Knop J. Active suppression induced by cutaneous exposure to bacterial superantigen is prevented by interleukin-12 treatment in vivo. Immunology 1998; 93: 485-92.
19. Thompson HSG, Staines NA. Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats. Clin Exp Immunol 1986; 64: 581-86.
20. Shevach EM. Regulatory T cells in autoimmunity. Ann Rev Immunol 2000; 18: 423-49.
21. + cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003; 48: 1452-60.
22. + regulatory T cells is necessary, but not sufficient, for the induction of organ-specific autoimmune disease. J Immunol 2002; 168: 5979-83.
23. +T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 1998; 188: 1883-94.
24. + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 1998; 188: 1875-82.
25. Akbari O, DeKruyff RH, and Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2: 725-31.
26. + T regulatory cells suppress naïve and memory T-cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295-302.
27. Roncarolo MG, Bacchetta R, Bordignon C, Narula S, Levings MK. Type I T regulatory cells. Immunol Rev 2001; 182: 68-79.
28. + regulatory T cells by oral antigen administration. J Immunol 2001; 167: 4245-53.