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Volumn 45, Issue 3, 2014, Pages 959-968

Inflammatory cues acting on the adult intestinal stem cells and the early onset of cancer (Review)

Author keywords

Cancer stem cells; Carcinogenesis; Chronic inflammation; Colon cancer; Paneth cells

Indexed keywords

ADULT STEM CELL; CANCER INCIDENCE; CANCER PROGNOSIS; CANCER STEM CELL; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC INFLAMMATION; COLON CANCER; COLON CARCINOGENESIS; COLORECTAL CANCER; DEVELOPMENTAL BIOLOGY; DISEASE ASSOCIATION; HOMEOSTASIS; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE CANCER; INTESTINE CELL; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE STEM CELL; INTRACELLULAR SIGNALING; NONHUMAN; PANETH CELL; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; REVIEW; STEM CELL NICHE; TRANSGENICS; CELL MOTION; CELL TRANSFORMATION; COLITIS; COLORECTAL TUMOR; CYTOLOGY; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

EID: 84904387217     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2490     Document Type: Review
Times cited : (21)

References (103)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 2142810866 scopus 로고    scopus 로고
    • Inflammation and cancer: An epidemiological perspective
    • Thun MJ, Henley SJ and Gansler T: Inflammation and cancer: an epidemiological perspective. Novartis Found Symp 256: 6-21, 2004.
    • (2004) Novartis Found Symp , vol.256 , pp. 6-21
    • Thun, M.J.1    Henley, S.J.2    Gansler, T.3
  • 4
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30: 1073-1081, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 5
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell 140: 883-899, 2010.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 6
    • 84859401430 scopus 로고    scopus 로고
    • Cancer and inflammation: An old intuition with rapidly evolving new concepts
    • Trinchieri G: Cancer and inflammation: an old intuition with rapidly evolving new concepts. Annu Rev Immunol 30: 677-706, 2012.
    • (2012) Annu Rev Immunol , vol.30 , pp. 677-706
    • Trinchieri, G.1
  • 7
    • 23944462877 scopus 로고    scopus 로고
    • Infection, inflammation, and gastrointestinal cancer
    • DOI 10.1136/gut.2004.060079
    • Boland C, Luciani M, Gasche C and Goel A: Infection, inflammation, and gastrointestinal cancer. Gut 54: 1321-1331, 2005. (Pubitemid 41192496)
    • (2005) Gut , vol.54 , Issue.9 , pp. 1321-1331
    • Boland, C.R.1    Luciani, M.G.2    Gasche, C.3    Goel, A.4
  • 9
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH, et al: Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608-611, 2009.
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 10
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • DOI 10.1038/ng.165, PII NG165
    • Sangiorgi E and Capecchi MR: Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-920, 2008. (Pubitemid 351913652)
    • (2008) Nature Genetics , vol.40 , Issue.7 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 11
    • 84864859115 scopus 로고    scopus 로고
    • Colorectal cancer in inflammatory bowel disease: What is the real magnitude of the risk?
    • Dyson JK and Rutter MD: Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk? World J Gastroenterol 18: 3839-3848, 2012.
    • (2012) World J Gastroenterol , vol.18 , pp. 3839-3848
    • Dyson, J.K.1    Rutter, M.D.2
  • 12
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: A meta-analysis
    • DOI 10.1136/gut.48.4.526
    • Eaden JA, Abrams KR and Mayberry JF: The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48: 526-535, 2001. (Pubitemid 32234798)
    • (2001) Gut , vol.48 , Issue.4 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 13
    • 33646875285 scopus 로고    scopus 로고
    • Meta-analysis: Colorectal and small bowel cancer risk in patients with Crohn's disease
    • DOI 10.1111/j.1365-2036.2006.02854.x
    • Canavan C, Abrams KR and Mayberry J: Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn's disease. Aliment Pharmacol Ther 23: 1097-1104, 2006. (Pubitemid 43779348)
    • (2006) Alimentary Pharmacology and Therapeutics , vol.23 , Issue.8 , pp. 1097-1104
    • Canavan, C.1    Abrams, K.R.2    Mayberry, J.3
  • 14
    • 0035160692 scopus 로고    scopus 로고
    • Colorectal carcinoma in ulcerative colitis is decreasing in Scandinavian countries
    • Rubio CA, Befrits R, Ljung T, Jaramillo E and Slezak P: Colorectal carcinoma in ulcerative colitis is decreasing in Scandinavian countries. Anticancer Res 21: 2921-2924, 2001. (Pubitemid 33051152)
    • (2001) Anticancer Research , vol.21 , Issue.4 B , pp. 2921-2924
    • Rubio, C.A.1    Befrits, R.2    Ljung, T.3    Jaramillo, E.4    Slezak, P.5
  • 15
    • 33645998460 scopus 로고    scopus 로고
    • Risk of intestinal cancer in inflammatory bowel disease: A population-based study from Olmsted county, Minnesota
    • Jess T, Loftus EV Jr, Velayos FS, et al: Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted county, Minnesota. Gastroenterology 130: 1039-1046, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 1039-1046
    • Jess, T.1    Loftus Jr., E.V.2    Velayos, F.S.3
  • 16
    • 9944260628 scopus 로고    scopus 로고
    • Long-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County
    • DOI 10.1016/S1542-3565(04)00543-9, PII S1542356504005439
    • Winther KV, Jess T, Langholz E, Munkholm P and Binder V: Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. Clin Gastroenterol Hepatol 2: 1088-1095, 2004. (Pubitemid 40037640)
    • (2004) Clinical Gastroenterology and Hepatology , vol.2 , Issue.12 , pp. 1088-1095
    • Winther, K.V.1    Jess, T.2    Langholz, E.3    Munkholm, P.4    Binder, V.5
  • 17
    • 33748114138 scopus 로고    scopus 로고
    • Epidemiology and risk factors for colorectal dysplasia and cancer in ulcerative colitis
    • Loftus EV Jr: Epidemiology and risk factors for colorectal dysplasia and cancer in ulcerative colitis. Gastroenterol Clin North Am 35: 517-531, 2006.
    • (2006) Gastroenterol Clin North Am , vol.35 , pp. 517-531
    • Loftus Jr., E.V.1
  • 18
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman TA and Itzkowitz SH: Intestinal inflammation and cancer. Gastroenterology 140: 1807-1816, 2011.
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1    Itzkowitz, S.H.2
  • 19
    • 77953186500 scopus 로고    scopus 로고
    • Colorectal dysplasia in chronic inflammatory bowel disease: Pathology, clinical implications, and pathogenesis
    • Harpaz N and Polydorides AD: Colorectal dysplasia in chronic inflammatory bowel disease: pathology, clinical implications, and pathogenesis. Arch Pathol Lab Med 134: 876-895, 2010.
    • (2010) Arch Pathol Lab Med , vol.134 , pp. 876-895
    • Harpaz, N.1    Polydorides, A.D.2
  • 20
    • 0021017589 scopus 로고
    • Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
    • Riddell RH, Goldman H, Ransohoff DF, et al: Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 14: 931-968, 1983.
    • (1983) Hum Pathol , vol.14 , pp. 931-968
    • Riddell, R.H.1    Goldman, H.2    Ransohoff, D.F.3
  • 21
    • 4344596901 scopus 로고    scopus 로고
    • The management of dysplasia associated with ulcerative colitis: Colectomy versus continued surveillance
    • Friedlich MS, Guindi M and Stern HS: The management of dysplasia associated with ulcerative colitis: colectomy versus continued surveillance. Can J Surg 4: 212-214, 2004. (Pubitemid 39164376)
    • (2004) Canadian Journal of Surgery , vol.47 , Issue.3 , pp. 212-214
    • Friedlich, M.S.1    Guindi, M.2    Stern, H.S.3
  • 22
    • 77952959962 scopus 로고    scopus 로고
    • Ulcerative colitis and cancer
    • Kulaylat MN and Dayton MT: Ulcerative colitis and cancer. J Surg Oncol 101: 706-712, 2010.
    • (2010) J Surg Oncol , vol.101 , pp. 706-712
    • Kulaylat, M.N.1    Dayton, M.T.2
  • 23
    • 75849117800 scopus 로고    scopus 로고
    • Inflammation and oncogenesis: A vicious connection
    • Grivennikov SI and Karin M: Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev 20: 65-71, 2010.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 65-71
    • Grivennikov, S.I.1    Karin, M.2
  • 24
    • 84874105786 scopus 로고    scopus 로고
    • Inflammation and colorectal cancer: Colitis-associated neoplasia
    • Grivennikov S: Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol 35: 229-244, 2013.
    • (2013) Semin Immunopathol , vol.35 , pp. 229-244
    • Grivennikov, S.1
  • 25
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 26
    • 40049091475 scopus 로고    scopus 로고
    • Cancer in inflammatory bowel disease
    • DOI 10.3748/wjg.14.378
    • Xie J and Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol 14: 378-389, 2008. (Pubitemid 351320846)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 378-389
    • Xie, J.1    Itzkowitz, S.H.2
  • 28
    • 2442600137 scopus 로고    scopus 로고
    • Diagnosis and management of dysplasia in patients with inflammatory bowel diseases
    • DOI 10.1053/j.gastro.2004.03.025
    • Itzkowitz SH and Harpaz N: Diagnosis and management of dysplasia in patients with inflammatory bowel diseases. Gastroenterology 126: 1634-1648, 2004. (Pubitemid 38649879)
    • (2004) Gastroenterology , vol.126 , Issue.6 , pp. 1634-1648
    • Itzkowitz, S.H.1    Harpaz, N.2
  • 29
    • 0026725870 scopus 로고
    • Dysplasia in chronic ulcerative colitis: Implications for colonoscopic surveillance
    • Taylor BA, Pemberton JH, Carpenter HA, et al: Dysplasia in chronic ulcerative colitis: implications for colonoscopic surveillance. Dis Colon Rectum 35: 950-956, 1992.
    • (1992) Dis Colon Rectum , vol.35 , pp. 950-956
    • Taylor, B.A.1    Pemberton, J.H.2    Carpenter, H.A.3
  • 30
    • 0033690855 scopus 로고    scopus 로고
    • Dysplasia complicating chronic ulcerative colitis: Is immediate colectomy warranted?
    • Gorfine SR, Bauer JJ, Harris MT and Kreel I: Dysplasia complicating chronic ulcerative colitis: is immediate colectomy warranted? Dis Colon Rectum 43: 1575-1581, 2000.
    • (2000) Dis Colon Rectum , vol.43 , pp. 1575-1581
    • Gorfine, S.R.1    Bauer, J.J.2    Harris, M.T.3    Kreel, I.4
  • 31
    • 0028126001 scopus 로고
    • Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?
    • DOI 10.1016/S0140-6736(94)90813-3
    • Bernstein CN, Shanahan F and Weinstein WM: Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? Lancet 343: 71-74, 1994. (Pubitemid 24019346)
    • (1994) Lancet , vol.343 , Issue.8889 , pp. 71-74
    • Bernstein, C.N.1    Shanahan, F.2    Weinstein, W.M.3
  • 32
    • 33645994506 scopus 로고    scopus 로고
    • Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis
    • Rutter MD, Saunders BP, Wilkinson KH, et al: Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology 130: 1030-1038, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 1030-1038
    • Rutter, M.D.1    Saunders, B.P.2    Wilkinson, K.H.3
  • 35
    • 8744230698 scopus 로고    scopus 로고
    • Dysplasia in ulcerative colitis - clinical consequences?
    • Sjöqvist U: Dysplasia in ulcerative colitis - clinical consequences? Langenbecks Arch Surg 389: 354-360, 2004.
    • (2004) Langenbecks Arch Surg , vol.389 , pp. 354-360
    • Sjöqvist, U.1
  • 37
    • 5444256371 scopus 로고    scopus 로고
    • Inflammation as a tumor promoter in cancer induction
    • DOI 10.1016/j.semcancer.2004.06.006, PII S1044579X04000495
    • Philip M, Rowley DA and Schreiber H: Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol 14: 433-439, 2004. (Pubitemid 39360991)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.6 , pp. 433-439
    • Philip, M.1    Rowley, D.A.2    Schreiber, H.3
  • 39
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • Kalluri R: EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119: 1417-1419, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 40
    • 84904393925 scopus 로고    scopus 로고
    • Field cancerization in the colon: A role for aberrant DNA methylation?
    • Epub ahead of print
    • Luo Y, Yu M and Grady WM: Field cancerization in the colon: a role for aberrant DNA methylation? Gastroenterol Rep 2: 16-20, 2014 (Epub ahead of print).
    • (2014) Gastroenterol Rep , vol.2 , pp. 16-20
    • Luo, Y.1    Yu, M.2    Grady, W.M.3
  • 41
    • 73449139396 scopus 로고    scopus 로고
    • The NFkappaB/AKT-dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1beta
    • Kaler P, Godasi BN, Augenlicht L and Klampfer L: The NFkappaB/AKT- dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1beta. Cancer Microenviron 2: 69-80, 2009.
    • (2009) Cancer Microenviron , vol.2 , pp. 69-80
    • Kaler, P.1    Godasi, B.N.2    Augenlicht, L.3    Klampfer, L.4
  • 42
    • 77956138914 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis
    • Lee G, Goretsky T, Managlia E, et al: Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139: 869-881, 2010.
    • (2010) Gastroenterology , vol.139 , pp. 869-881
    • Lee, G.1    Goretsky, T.2    Managlia, E.3
  • 43
    • 47049116663 scopus 로고    scopus 로고
    • Activated macrophages promote Wnt signalling through tumor necrosis factor-alpha in gastric tumor cells
    • Oguma K, Oshima H, Aoki M, et al: Activated macrophages promote Wnt signalling through tumor necrosis factor-alpha in gastric tumor cells. EMBO J 27: 1671-1681, 2008.
    • (2008) EMBO J , vol.27 , pp. 1671-1681
    • Oguma, K.1    Oshima, H.2    Aoki, M.3
  • 44
    • 28544444039 scopus 로고    scopus 로고
    • s-axin-beta-catenin signaling axis
    • DOI 10.1126/science.1116221
    • Castellone MD, Teramoto H, Williams BO, Druey KM and Gutkind JS: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310: 1504-1510, 2005. (Pubitemid 41746348)
    • (2005) Science , vol.310 , Issue.5753 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 46
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • DOI 10.1038/nri1995, PII NRI1995
    • Yu H, Kortylewski M and Pardoll D: Crosstalk between cancer and immune cells: role of STAT3 in the tumor microenvironment. Nature Rev Immunol 7: 41-51, 2007. (Pubitemid 46020826)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 47
    • 76049120713 scopus 로고    scopus 로고
    • Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease
    • Van Immerseel F, Ducatelle R, De Vos M, et al: Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease. J Med Microbiol 59: 141-143, 2010.
    • (2010) J Med Microbiol , vol.59 , pp. 141-143
    • Van Immerseel, F.1    Ducatelle, R.2    De Vos, M.3
  • 51
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • Arthur JC, Perez-Chanona E, Mühlbauer M, et al: Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338: 120-123, 2012.
    • (2012) Science , vol.338 , pp. 120-123
    • Arthur, J.C.1    Perez-Chanona, E.2    Mühlbauer, M.3
  • 53
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suvà ML, Riggi N and Bernstein BE: Epigenetic reprogramming in cancer. Science 339: 1567-1570, 2013.
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suvà, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 54
    • 84865510127 scopus 로고    scopus 로고
    • Inflammation-associated cancer development in digestive organs: Mechanisms and roles for genetic and epigenetic modulation
    • Chiba T, Marusawa H and Ushijima T: Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 143: 550-563, 2012.
    • (2012) Gastroenterology , vol.143 , pp. 550-563
    • Chiba, T.1    Marusawa, H.2    Ushijima, T.3
  • 55
    • 77957351501 scopus 로고    scopus 로고
    • Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis
    • Niwa T and Ushijima T: Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. Adv Genet 71: 41-56, 2010.
    • (2010) Adv Genet , vol.71 , pp. 41-56
    • Niwa, T.1    Ushijima, T.2
  • 56
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson KD: DNA methylation and human disease. Nat Rev Genet 6: 597-610, 2005.
    • (2005) Nat Rev Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 57
    • 57749090255 scopus 로고    scopus 로고
    • Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    • Hahn MA, Hahn T, Lee DH, et al: Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res 68: 10280-10289, 2008.
    • (2008) Cancer Res , vol.68 , pp. 10280-10289
    • Hahn, M.A.1    Hahn, T.2    Lee, D.H.3
  • 58
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumor cells: A diabolic liaison driving cancer progression
    • Cirri P and Chiarugi P: Cancer-associated-fibroblasts and tumor cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev 31: 195-208, 2012.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 59
    • 84874760851 scopus 로고    scopus 로고
    • Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling
    • Achyut BR, Bader DA, Robles AI, et al: Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet 9: e1003251, 2013.
    • (2013) PLoS Genet , vol.9
    • Achyut, B.R.1    Bader, D.A.2    Robles, A.I.3
  • 61
    • 85044014614 scopus 로고    scopus 로고
    • The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer
    • El-Omar EM, Carrington M, Chow WH, et al: The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature 412: 99, 2001.
    • (2001) Nature , vol.412 , pp. 99
    • El-Omar, E.M.1    Carrington, M.2    Chow, W.H.3
  • 63
    • 76649145629 scopus 로고    scopus 로고
    • Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells
    • Niwa T, Tsukamoto T, Toyoda T, et al: Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res 70: 1430-1440, 2010.
    • (2010) Cancer Res , vol.70 , pp. 1430-1440
    • Niwa, T.1    Tsukamoto, T.2    Toyoda, T.3
  • 64
    • 0031049081 scopus 로고    scopus 로고
    • Interleukin-8 and inducible nitric oxide synthase mRNA levels in inflammatory bowel disease at first presentation
    • DOI 10.1002/(SICI)1096-9896(199701)181:1<87::AID-P
    • McLaughlan JM, Seth R, Vautier G, et al: Interleukin-8 and inducible nitric oxide synthase mRNA levels in inflammatory bowel disease at first presentation. J Pathol 181: 87-92, 1997. (Pubitemid 27099779)
    • (1997) Journal of Pathology , vol.181 , Issue.1 , pp. 87-92
    • McLaughlan, J.M.1    Seth, R.2    Vautier, G.3    Robins, R.A.4    Scott, B.B.5    Hawkey, C.J.6    Jenkins, D.7
  • 65
    • 78349292907 scopus 로고    scopus 로고
    • Alu and Satα hypomethylation in Helicobacter pylori-infected gastric mucosae
    • Yoshida T, Yamashita S, Takamura-Enya T, et al: Alu and Satα hypomethylation in Helicobacter pylori-infected gastric mucosae. Int J Cancer 128: 33-39, 2011.
    • (2011) Int J Cancer , vol.128 , pp. 33-39
    • Yoshida, T.1    Yamashita, S.2    Takamura-Enya, T.3
  • 66
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.1
  • 68
    • 44649179392 scopus 로고    scopus 로고
    • Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade
    • Shah YM, Ito S, Morimura K, Chen C, et al: Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology 134: 2036-2048, 2008.
    • (2008) Gastroenterology , vol.134 , pp. 2036-2048
    • Shah, Y.M.1    Ito, S.2    Morimura, K.3    Chen, C.4
  • 69
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, et al: Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 120: 2699-2714, 2010.
    • (2010) J Clin Invest , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1    Williams, E.P.2    Hickey, M.M.3    Patel, S.A.4
  • 70
  • 71
  • 72
    • 77952092406 scopus 로고    scopus 로고
    • Hypoxia: An alarm signal during intestinal inflammation
    • Colgan SP and Taylor CT: Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol 7: 281-287, 2010.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 281-287
    • Colgan, S.P.1    Taylor, C.T.2
  • 73
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey ET, McNamee EN, Westrich JA, et al: Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci USA 109: E2784-E2793, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Clambey, E.T.1    McNamee, E.N.2    Westrich, J.A.3
  • 74
    • 78650108135 scopus 로고    scopus 로고
    • Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation
    • Olaru AV, Selaru FM, Mori Y, et al: Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation. Inflamm Bowel Dis 17: 221-231, 2011.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 221-231
    • Olaru, A.V.1    Selaru, F.M.2    Mori, Y.3
  • 75
    • 34547124566 scopus 로고    scopus 로고
    • Hypoxia and adaptive landscapes in the evolution of carcinogenesis
    • DOI 10.1007/s10555-007-9065-z, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • Gillies RJ and Gatenby RA: Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 26: 311-317, 2007. (Pubitemid 47101668)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 311-317
    • Gillies, R.J.1    Gatenby, R.A.2
  • 77
    • 69249142193 scopus 로고    scopus 로고
    • Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    • Edwards RA, Witherspoon M, Wang K, et al: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res 69: 6423-6429, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6423-6429
    • Edwards, R.A.1    Witherspoon, M.2    Wang, K.3
  • 78
    • 84874780943 scopus 로고    scopus 로고
    • SnapShot: The intestinal crypt
    • Clevers H and Batlle E: SnapShot: the intestinal crypt. Cell 152: 1198-1198, 2013.
    • (2013) Cell , vol.152 , pp. 1198-1198
    • Clevers, H.1    Batlle, E.2
  • 81
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L and Clevers H: Coexistence of quiescent and active adult stem cells in mammals. Science 327: 542-545, 2010.
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 84
    • 33947433676 scopus 로고    scopus 로고
    • Cancer stem cells: At the headwaters of tumor development
    • DOI 10.1146/annurev.pathol.2.010506.091847, Annual Review of Pathology: Mechanisms of Disease
    • Ward RJ and Dirks PB: Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol 2: 175-189, 2007. (Pubitemid 46448063)
    • (2007) Annual Review of Pathology , vol.2 , pp. 175-189
    • Ward, R.J.1    Dirks, P.B.2
  • 85
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?
    • Scheel C and Weinberg RA: Phenotypic plasticity and epithelial- mesenchymal transitions in cancer and normal stem cells? Int J Cancer 129: 2310-2314, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 86
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • Roskams T: Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 25: 3818-3822, 2006.
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 89
    • 84865534083 scopus 로고    scopus 로고
    • Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
    • Shaked H, Hofseth LJ, Chumanevich A, et al: Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci USA 109: 14007-14012, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14007-14012
    • Shaked, H.1    Hofseth, L.J.2    Chumanevich, A.3
  • 91
    • 0014651489 scopus 로고
    • Naturally occurring tumors and other lesions of the digestive tract in untreated C57BL mice
    • Rowlatt C, Franks LM, Sheriff MU and Chesterman FC: Naturally occurring tumors and other lesions of the digestive tract in untreated C57BL mice. J Natl Cancer Inst 43: 1353-1364, 1969.
    • (1969) J Natl Cancer Inst , vol.43 , pp. 1353-1364
    • Rowlatt, C.1    Franks, L.M.2    Sheriff, M.U.3    Chesterman, F.C.4
  • 93
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • Sato T, van Es JH, Snippert HJ, et al: Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418, 2011.
    • (2011) Nature , vol.469 , pp. 415-418
    • Sato, T.1    Van Es, J.H.2    Snippert, H.J.3
  • 94
    • 84873672050 scopus 로고    scopus 로고
    • Paneth cells: Maestros of the small intestinal crypts
    • Clevers HC and Bevins CL: Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol 75: 289-311, 2013.
    • (2013) Annu Rev Physiol , vol.75 , pp. 289-311
    • Clevers, H.C.1    Bevins, C.L.2
  • 95
    • 54549089856 scopus 로고    scopus 로고
    • Overexpression of interleukin 1β induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    • Tu S, Bhagat G, Cui G, et al: Overexpression of interleukin 1β induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14: 408-419, 2008.
    • (2008) Cancer Cell , vol.14 , pp. 408-419
    • Tu, S.1    Bhagat, G.2    Cui, G.3
  • 98
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP and Vermeulen L: Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474: 318-326, 2011.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 99
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden DT: The stem-cell niche as an entity of action. Nature 441: 1075-1079, 2006.
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 100
    • 84881112672 scopus 로고    scopus 로고
    • The evolution of the cancer niche during multistage carcinogenesis
    • Barcellos-Hoff MH, Lyden D and Wang TC: The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer 13: 511-518, 2013.
    • (2013) Nat Rev Cancer , vol.13 , pp. 511-518
    • Barcellos-Hoff, M.H.1    Lyden, D.2    Wang, T.C.3
  • 102
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, Eckmann L and Hooper LV: Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA 105: 20858-20863, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5


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