Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension

Metabolomics

Volumn 10, Issue 4, 2014, Pages 737-743

  Patti, Gary J ^a   Tautenhahn, Ralf ^b   Johannsen, Darcy ^c   Kalisiak, Ewa ^b   Ravussin, Eric ^c   Brüning, Jens C ^d,f   Dillin, Andrew ^e   Siuzdak, Gary ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d UNIVERSITY OF COLOGNE   (Germany)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Aging; C. elegans; Meta analysis; Metabolism; Metabolomics; Sarcopenia

Indexed keywords

NICOTINIC ACID; PHOSPHATIDYLCHOLINE;

ADULT; AGED; AGING; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; DOWN REGULATION; FLOW RATE; HUMAN; HUMAN EXPERIMENT; LIFE EXTENSION; LIQUID CHROMATOGRAPHY; LONGEVITY; MASS SPECTROMETRY; META ANALYSIS; METABOLITE; METABOLOMICS; MUTATION; NONHUMAN; NORMAL HUMAN; SKELETAL MUSCLE; UPREGULATION; VERY ELDERLY; YOUNG ADULT;

CAENORHABDITIS ELEGANS;

EID: 84904383851     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-013-0608-8     Document Type: Article

References (38)

1. Arantes-Oliveira, N., Apfeld, J., Dillin, A., & Kenyon, C. (2002). Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science, 295, 502-505. doi: 10. 1126/science. 1065768.
2. Baker, M. (2011). Metabolomics: From small molecules to big ideas. Nature Methods, 8, 117-121.
3. Baumeister, R., Schaffitzel, E., & Hertweck, M. (2006). Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. Journal of Endocrinology, 190, 191-202. doi: 10. 1677/joe. 1. 06856.
4. Broughton, S. J., et al. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proceedings of the National Academy of Sciences of the United States of America, 102, 3105-3110. doi: 10. 1073/pnas. 0405775102.
5. Crews, B., et al. (2009). Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data. Analytical Chemistry, 81, 8538-8544. doi: 10. 1021/ac9014947.
6. Dong, M. Q., et al. (2007). Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science, 317, 660-663. doi: 10. 1126/science. 1139952.
7. Durieux, J., Wolff, S., & Dillin, A. (2011). The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell, 144, 79-91. doi: 10. 1016/j. cell. 2010. 12. 016.
8. Feng, J., Bussiere, F., & Hekimi, S. (2001). Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Developmental Cell, 1, 633-644.
9. Gerisch, B., et al. (2007). A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proceedings of the National Academy of Sciences of the United States of America, 104, 5014-5019. doi: 10. 1073/pnas. 0700847104.
10. Golden, T. R., & Melov, S. (2007). Gene expression changes associated with aging in C. elegans. WormBook, 12, 1-12. doi: 10. 1895/wormbook. 1. 127. 2.
11. Herndon, L. A., et al. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature, 419, 808-814. doi: 10. 1038/nature01135.
12. Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M., & Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature, 429, 562-566. doi: 10. 1038/nature02549.
13. Imagita, H., Yamano, S., Tobimatsu, Y., & Miyata, H. (2009). Age-related changes in contraction and relaxation of rat diaphragm. Biomedical Research, 30, 337-342.
14. Kashyap, L., Perera, S., & Fisher, A. L. (2011). Identification of Novel Genes Involved in Sarcopenia Through RNAi Screening in Caenorhabditis elegans. Journals of Gerontology. Series A,. doi: 10. 1093/gerona/glr072.
15. Kenyon, C. (2005). The plasticity of aging: Insights from long-lived mutants. Cell, 120, 449-460. doi: 10. 1016/j. cell. 2005. 02. 002.
16. Kenyon, C. J. (2010). The genetics of ageing. Nature, 464, 504-512. doi: 10. 1038/nature08980.
17. Kleemann, G. A., & Murphy, C. T. (2009). The endocrine regulation of aging in Caenorhabditis elegans. Molecular and Cellular Endocrinology, 299, 51-57. doi: 10. 1016/j. mce. 2008. 10. 048.
18. Libina, N., Berman, J. R., & Kenyon, C. (2003). Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell, 115, 489-502.
19. Motola, D. L., et al. (2006). Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell, 124, 1209-1223. doi: 10. 1016/j. cell. 2006. 01. 037.
20. Northen, T. R., et al. (2007). Clathrate nanostructures for mass spectrometry. Nature, 449, 1033-1036.
21. Panowski, S. H., & Dillin, A. (2009). Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans. Trends in Endocrinology and Metabolism, 20, 259-264. doi: 10. 1016/j. tem. 2009. 03. 006.
22. Patti, G. J., Tautenhahn, R., & Siuzdak, G. (2012). Meta-analysis of untargeted metabolomic data from multiple profiling experiments. Nature Protocols, 7, 508-516. doi: 10. 1038/nprot. 2011. 454.
23. Patti, G. J., et al. (2010). Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome. Neuroscience, 170, 858-864. doi: 10. 1016/j. neuroscience. 2010. 07. 038.
24. Psychogios, N., et al. (2011). The human serum metabolome. PLoS ONE, 6, e16957. doi: 10. 1371/journal. pone. 0016957.
25. Rottiers, V., et al. (2006). Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Developmental Cell, 10, 473-482. doi: 10. 1016/j. devcel. 2006. 02. 008.
26. Russell, S. J., & Kahn, C. R. (2007). Endocrine regulation of ageing. Nature Reviews Molecular Cell Biology, 8, 681-691. doi: 10. 1038/nrm2234.
27. Shim, Y. H., & Paik, Y. K. (2010). Caenorhabditis elegans proteomics comes of age. Proteomics, 10, 846-857. doi: 10. 1002/pmic. 200900542.
28. Sluder, A. E., & Maina, C. V. (2001). Nuclear receptors in nematodes: Themes and variations. Trends in Genetics, 17, 206-213.
29. Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., & Siuzdak, G. (2006). XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Analytical Chemistry, 78, 779-787. doi: 10. 1021/ac051437y.
30. Smith, C. A., et al. (2005). METLIN: A metabolite mass spectral database. Therapeutic Drug Monitoring, 27, 747-751.
31. Tatar, M., Bartke, A., & Antebi, A. (2003). The endocrine regulation of aging by insulin-like signals. Science, 299, 1346-1351. doi: 10. 1126/science. 1081447.
32. Tautenhahn, R., et al. (2011). metaXCMS: Second-order analysis of untargeted metabolomics data. Analytical Chemistry, 83, 696-700. doi: 10. 1021/ac102980g.
33. Wishart, D. S., et al. (2009). HMDB: A knowledgebase for the human metabolome. Nucleic Acids Research, 37, D603-D610. doi: 10. 1093/nar/gkn810.
34. Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000). Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science, 290, 147-150.
35. Woo, H. K., Northen, T. R., Yanes, O., & Siuzdak, G. (2008). Nanostructure-initiator mass spectrometry: A protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis. Nature Protocols, 3, 1341-1349. doi: 10. 1038/nprot. 2008. 110.
36. Yanes, O., Tautenhahn, R., Patti, G. J., & Siuzdak, G. (2011). Expanding coverage of the metabolome for global metabolite profiling. Analytical Chemistry, 83, 2152-2161. doi: 10. 1021/ac102981k.
37. Yanes, O., et al. (2010a). Metabolic oxidation regulates embryonic stem cell differentiation. Nature Chemical Biology, 6, 411-417. doi: 10. 1038/nchembio. 364.
38. Yanes, O., et al. (2010b). Metabolic oxidation regulates embryonic stem cell differentiation. Nature Chemical Biology, 6, 411-417. doi: 10. 1038/nchembio. 364.