The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 9, 2007, Pages 1271-1278

  Yokozawa, Takako ^a   Hyun, Ju Kim ^a   Yamabe, Noriko ^a   Okamoto, Takuya ^b   Eun, Ju Cho ^c  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Iskra Industry Co Ltd   (Japan)

^c Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; CHOLESTEROL; CYCLOOXYGENASE 2; FRUCTOSE; GLYCOSYLATED PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KANGEN KARYU; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN BCL 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; LIVER HOMOGENATE; MALE; METABOLIC SYNDROME X; MITOCHONDRION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BLOOD PROTEINS; CHOLESTEROL; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FRUCTOSE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; MALE; METABOLIC SYNDROME X; NF-KAPPA B; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIGLYCERIDES;

EID: 34548407858     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.9.0012     Document Type: Article

References (38)

1. Ackerman, Z., Oron-Herman, M., Grozovski, M., Rosenthal, T., Pappo, O., Link, G., Sela, B. A. (2005) Fructose-induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 45: 1012-1018
2. Aoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., Gonzalez, F. J. (1998) Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J. Biol. Chem. 273: 5678-5684
3. Basciano, H., Federico, L., Adeli, K. (2005) Fructose, insulin resistance, and metabolic dyslipidemia. Nutr. Metab. 2: 5-18
4. Buege, J. A., Aust, S. D. (1978) Microsomal lipid peroxidation. Methods Enzymol. 52: 302-310
5. Catena, C., Giacchetti, G., Novello, M., Colussi, G., Cavarape, A., Sechi, L. A. (2003) Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am. J. Hypertens. 16: 973-978
6. Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., Yu, B. P. (2002) Molecular inflammation hypothesis of aging based on the antiaging mechanism of calorie restriction. Microsc. Res. Tech. 59: 264-272
7. Dichtl, W., Nilsson, L., Goncalves, I., Ares, M. P. S., Banfi, C., Calara, F., Hamsten, A., Eriksson, P., Nilsson, J. (1999) Very low-density lipoprotein activates nuclear factor-κB in endothelial cells. Circ. Res. 84: 1085-1094
8. Eckel, R. H., Grundy, S. M., Zimmet, P. Z. (2005) The metabolic syndrome. Lancet 365: 1415-1428
9. Folch, J., Lees, M., Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509
10. Fried, S. K., Rao, S. P. (2003) Sugars, hypertriglyceridemia, and cardiovascular disease. Am. J. Clin. Nutr. 78: 873S-880S
11. Gao, M., Ikeda, K., Noguchi, T., Mori, K., Yamori, Y. (2001) Studies on preventive effect of Kangen-karyu, Chinese herbal medicine, on stroke in SHR-SP. J. Trad. Med. 18: 245-250
12. Girard, A., Madani, S., Boukortt, F., Cherkaoui-Malki, M., Belleville, J., Prost, J. (2006) Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats. Nutrition 22: 758-766
13. Hallfrisch, J. (1990) Metabolic effects of dietary fructose. FASEB J. 4: 2652-2660
14. Helenius, M., Hanninen, M., Lehtinen, S. K., Salminen, A. (1996) Changes associated with aging and replicative senescence in the regulation of transcription factor NF-κB. Biochem. J. 318: 603-608
15. Itzhaki, R. F., Gill, D. M. (1964) A micro-biuret method for estimating proteins. Anal. Biochem. 9: 401-410
16. Johnson, D., Lardy, H. (1967) Isolation of liver or kidney mitochondria. Methods Enzymol. 10: 94-96
17. Jung, K., Pergande, M. (1985) Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria. FEBS Lett. 183: 167-169
18. Kelley, G. L., Allan, G., Azhar, S. (2004) High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation. Endocrinology 145: 548-555
19. Kersten, S., Desvergne, B., Wahli, W. (2000) Roles of PPARs in health and disease. Nature 405: 421-424
20. Kim, H. J., Kim, K. W., Yu, B. P., Chung, H. Y. (2000) The effect of age on cyclooxygenase-2 gene expression: NF-κB activation and IκBα degradation. Free Radic. Biol. Med. 28: 683-692
21. Leone, T. C., Weinheimer, C. J., Kelly, D. P. (1999) A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. USA 96: 7473-7478
22. Makino, T., Wakushima, H., Okamoto, T., Okukubo, Y., Saito, K., Kano, Y. (2002) Effects of Kangen-karyu on coagulation system and platelet aggregation in mice. Biol. Pharm. Bull. 25: 523-525
23. Mayes, P. A. (1993) Intermediary metabolism of fructose. Am. J. Clin. Nutr. 58: 754S-765S
24. McFarland, K. F., Catalano, E. W., Day, J. F., Thorpe, S. R., Baynes, J. W. (1979) Nonenzymatic glucosylation of serum proteins in diabetes mellitus. Diabetes 28: 1011-1014
25. Miyazaki, M., Dobrzyn, A., Man, W. C., Chu, K., Sampath, H., Kim, H. J., Ntambi, J. M. (2004) Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and independent mechanisms. J. Biol. Chem. 279: 25164-25171
26. Naito, C., Yamanaka, T. (1978) Lipid peroxides in atherosclerotic diseases. Jpn. J. Geriat. 15: 187-191
27. Palmer, C. N., Hsu, M. H., Griffin, K. J., Raucy, J. L., Johnson, E. F. (1998) Peroxisome proliferator activated receptor α expression in human liver. Mol. Pharmacol. 53: 14-22
28. Roglans, N., Sanguino, E., Peris, C., Alegret, M., Vazquez, M., Adzet, T., Diaz, C., Hernandez, G., Laguna, J. C., Sanchez, R. M. (2002) Atorvastatin treatment induced peroxisome proliferator-activated receptor a expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats. J. Pharmacol. Exp. Ther. 302: 232-239
29. Sakurai, H., Hisada, Y., Ueno, M., Sugiura, M., Kawashima, K., Sugita, T. (1996) Activation of transcription factor NF-κB in experimental glomerulonephritis in rats. Biochim. Biophys. Acta 1316: 132-138
30. Sasaki, M., Kumazaki, T., Takano, H., Nishiyama, M., Mitsui, Y. (2001) Senescent cells are resistant to death despite low Bcl-2 level. Mech. Ageing Dev. 122: 1695-1706
31. Satoh, A., Yokozawa, T., Cho, E. J., Okamoto, T., Sei, Y. (2004a) Antioxidative effects related to the potential anti-aging properties of the Chinese prescription Kangen-karyu and Carthami Flos in senescence-accelerated mice. Arch. Gerontol. Geriatr. 39: 69-82
32. Satoh, A., Yokozawa, T., Tanaka, T., Okamoto, T., Sei, Y. (2004b) The antioxidative activity of Kangen-karyu extract delays senescence of human lung fibroblasts. J. Trad. Med. 21: 87-93
33. Satoh, A., Yokozawa, T., Kim, Y. A., Cho, E. J., Okamoto, T., Sei, Y. (2005) The mechanisms underlying the anti-aging activity of the Chinese prescription Kangen-karyu in hydrogen peroxide-induced human fibroblasts. J. Pharm. Pharmacol. 57: 1335-1343
34. Schoonjans, K., Martin, G., Staels, B., Auwerx, J. (1997) Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr. Opin. Lipidol. 8: 159-166
35. Stentz, F. B., Umpierrez, G. E., Cuervo, R., Kitabchi, A. E. (2004) Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 53: 2079-2086
36. Takahashi, H. (1991) Clinical trial of prescription of Kaketsukao. Clin. J. Chinese Med. 12: 145-151
37. Wu, L. Y., Juan, C. C., Hwang, L. S., Hsu, Y. P., Ho, P. H., Ho, L. T. (2004) Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur. J. Nutr. 43: 116-124
38. Yokozawa, T., Cho, E. J., Sasaki, S., Satoh, A., Okamoto, T., Sei, Y. (2006) The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats. Biol. Pharm. Bull. 29: 760-765