Moringa fruit inhibits LPS-induced NO/iNOS expression through suppressing the NF-κB activation in RAW264.7 cells

American Journal of Chinese Medicine

Volumn 41, Issue 5, 2013, Pages 1109-1123

  Lee, Hyo Jin ^a   Jeong, Yun Jeong ^a   Lee, Tae Sung ^a   Park, Yoon Yub ^a   Chae, Whi Gun ^a   Chung, Il Kyung ^b   Chang, Hyeun Wook ^c   Kim, Cheorl Ho ^d   Choi, Yung Hyun ^e   Kim, Wun Jae ^f   Moon, Sung Kwon ^g   Chang, Young Chae ^a  

^a The Catholic University of Korea   (South Korea)

^b Catholic University of Daegu   (South Korea)

^c Yeungnam University   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Dong Eui University   (South Korea)

^f Chungbuk National University   (South Korea)

^g Chung Ang University   (South Korea)

Author keywords

COX 2; iNOS; Moringa; NF B; NO

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MORINGA OLEIFERA EXTRACT; MORINGA OLEIFERA FRUIT EXTRACT; NITRIC OXIDE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; ENZYME DEGRADATION; ENZYME INHIBITION; FRUIT; MACROPHAGE; MORINGA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSACTIVATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MORINGA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885940250     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500754     Document Type: Article

References (43)

1. Ajizian, S.J., B.K. English and E.A. Meals. Specific inhibitors of p38 and extracellular signalregulated kinase mitogen-Activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 179: 939-944, 1999.
2. Aktan, F. iNOS-mediated nitric oxide production and its regulation. Life Sci. 75: 639-653, 2004.
3. Anwar, F., S. Latif, M. Ashraf and A.H. Gilani. Moringa oleifera: A food plant with multiple medicinal uses. Phytother. Res. 21: 17-25, 2007.
4. Au, R.Y., T.K. Al-Talib, A.Y. Au, P.V. Phan and C.G. Frondoza. Avocado soybean unsaponifiables (ASU) suppress TNF-Alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthr. Cartil. 15: 1249-1255, 2007.
5. Baeuerle, P.A. and D. Baltimore. NF-kappa B: Ten years after. Cell 87: 13-20, 1996.
6. Barnes, P.J. and M. Karin. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066-1071, 1997.
7. Baumann, H. and J. Gauldie. The acute phase response. Immunol. Today 15: 74-80, 1994.
8. Bertolini, A., A. Ottani and M. Sandrini. Dual acting anti-inflammatory drugs: A reappraisal. Pharmacol. Res. 44: 437-450, 2001.
9. Chanput, W., J. Mes, R.A. Vreeburg, H.F. Savelkoul and H.J. Wichers. Transcription profiles of LPSstimulated THP-1 monocytes and macrophages: A tool to study inflammation modulating effects of food-derived compounds. Food Funct. 1: 254-261, 2010.
10. Cheenpracha, S., E.J. Park, W.Y. Yoshida, C. Barit, M. Wall, J.M. Pezzuto and L.C. Chang. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg. Med. Chem. 18: 6598-6602, 2010.
11. Cho, H.J., M.R. Seon, Y.M. Lee, J. Kim, J.K. Kim, S.G. Kim and J.H. Park. 3,30-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. J. Nutr. 138: 17-23, 2008.
12. Chumark, P., P. Khunawat, Y. Sanvarinda, S. Phornchirasilp, N.P. Morales, L. Phivthong-Ngam, P. Ratanachamnong, S. Srisawat and K.U. Pongrapeeporn. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J. Ethnopharmacol. 116: 439-446, 2008.
13. Cui, Y., D.S. Kim, S.H. Park, J.A. Yoon, S.K. Kim, S.B. Kwon and K.C. Park. Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells. Chem. Phys. Lipids 129: 43-52, 2004.
14. Dweik, R.A., D. Laskowski, H.M. Abu-Soud, F. Kaneko, R. Hutte, D.J. Stuehr and S.C. Erzurum. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. J. Clin. Invest. 101: 660-666, 1998.
15. Fujiwara, N. and K. Kobayashi. Macrophages in inflammation. Curr. Drug Targets Inflamm. Allergy 4: 281-286, 2005.
16. Ghosh, S. and M. Karin. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl): S81-96, 2002.
17. Guevara, A.P., C. Vargas, H. Sakurai, Y. Fujiwara, K. Hashimoto, T. Maoka, M. Kozuka, Y. Ito, H. Tokuda and H. Nishino. An antitumor promoter from Moringa oleifera Lam. Mutat. Res. 440: 181-188, 1999.
18. Guzik, T.J., R. Korbut and T. Adamek-Guzik. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54: 469-487, 2003.
19. Hommes, D.W., M.P. Peppelenbosch and S.J. van Deventer. Mitogen activated protein (MAP kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52: 144-151, 2003.
20. Jacobs, A.T. and L.J. Ignarro. Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J. Biol. Chem. 276: 47950-47957, 2001.
21. Jin, F., C.F. Nathan and A. Ding. Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: Induction of matrix metalloproteinase-9. J. Immunol. 162: 3596-3600, 1999.
22. Karin, M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J. Biol. Chem. 274: 27339-27342, 1999.
23. Karin, M. Inflammation-Activated protein kinases as targets for drug development. Proc. Am. Thorac. Soc. 2: 386-390; discussion 394-385, 2005.
24. Kristof, A.S., J. Marks-Konczalik and J. Moss. Mitogen-Activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation. J. Biol. Chem. 276: 8445-8452, 2001.
25. Kroncke, K.D., K. Fehsel and V. Kolb-Bachofen. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol. Chem. Hoppe Seyler 376: 327-343, 1995.
26. Lee, Y.K., S.Y. Park, Y.M. Kim, W.S. Lee and O.J. Park. AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. Exp. Mol. Med. 41: 201-207, 2009.
27. Lenardo, M.J. and D. Baltimore. NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control. Cell 58: 227-229, 1989.
28. Li, Q. and I.M. Verma. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2: 725-734, 2002.
29. Marcus, J.S., S.L. Karackattu, M.A. Fleegal and C. Sumners. Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: Role of Erk mitogen-Activated protein kinase and NFkappaB. Glia 41: 152-160, 2003.
30. Maxwell, P.H., M.S. Wiesener, G.W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher and P.J. Ratcliffe. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
31. Moncada, S., R.M. Palmer and E.A. Higgs. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
32. Nathan, C. Points of control in inflammation. Nature 420: 846-852, 2002.
33. Ohshima, H. and H. Bartsch. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis. Mutat. Res. 305: 253-264, 1994.
34. Park, E.J., S. Cheenpracha, L.C. Chang, T.P. Kondratyuk and J.M. Pezzuto. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(20-O-Acetyl-Alpha-L-rhamnosyloxy)benzyl] isothiocyanate from Moringa oleifera. Nutr. Cancer 63: 971-982, 2011.
35. Rankin, J.A. Biological mediators of acute inflammation. AACN Clin. Issues 15: 3-17, 2004.
36. Rhee, J.W., K.W. Lee, D. Kim, Y. Lee, O.H. Jeon, H.J. Kwon and D.S. Kim. NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7. J. Biochem. Mol. Biol. 40: 88-94, 2007.
37. Ruland, J. and T.W. Mak. Transducing signals from antigen receptors to nuclear factor kappaB. Immunol. Rev. 193: 93-100, 2003.
38. Salazar-Mather, T.P., J.S. Orange and C.A. Biron. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathways. J. Exp. Med. 187: 1-14, 1998.
39. Schrader, L.I., D.A. Kinzenbaw, A.W. Johnson, F.M. Faraci and S.P. Didion. IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler. Thromb. Vasc. Biol. 27: 2576-2581, 2007.
40. Snyder, S.H. and D.S. Bredt. Biological roles of nitric oxide. Sci. Am. 266: 68-71, 74-67, 1992.
41. Staples, G. and D.R. Herbst. A Tropical Garden Flora: Plants Cultivated in the Hawaiian Islands and Other Tropical Places. Bishop Museum Press, Honolulu, Hawai'i, 2005.
42. Uto, T., M. Fujii and D.X. Hou. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 transcription by 6-(methylsulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq) Matsumura, in mouse macrophages. Biochem. Pharmacol. 70: 1772-1784, 2005.
43. Xie, B., Z. Dong and I.J. Fidler. Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages. J. Immunol. 152: 3637-3644, 1994.