Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression

Journal of the American Society of Nephrology

Volumn 22, Issue 7, 2011, Pages 1240-1251

  Cheng, Huifang ^a   Fan, Xiaofeng ^a   Moeckel, Gilbert W ^c   Harris, Raymond C ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLUCOSE; PRORENIN RECEPTOR;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CELL DAMAGE; CELL EXPANSION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; HYPERGLYCEMIA; IN VIVO STUDY; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC MOUSE;

EID: 79960134417     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010111149     Document Type: Article

References (49)

1. Tan AL, Forbes JM, Cooper ME: AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol 27: 130-143, 2007 (Pubitemid 46550311)
2. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR: Diabetic nephropathy: Mechanisms of renal disease progression. Exp Biol Med (Maywood) 233: 4-11, 2008
3. Marshall SM: The podocyte: A major player in the development of diabetic nephropathy? Horm Metab Res 37 [Suppl 1]: 9-16, 2005
4. Marshall SM: The podocyte: A potential therapeutic target in diabetic nephropathy? Curr Pharm Des 13: 2713-2720, 2007
5. Reddy GR, Kotlyarevska K, Ransom RF, Menon RK: The podocyte and diabetes mellitus: Is the podocyte the key to the origins of diabetic nephropathy? Curr Opin Nephrol Hypertens 17: 32-36, 2008
6. Coimbra TM, Janssen U, Grone HJ, Ostendorf T, Kunter U, Schmidt H, Brabant G, Floege J: Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int 57: 167-182, 2000 (Pubitemid 30227764)
7. Siu B, Saha J, Smoyer WE, Sullivan KA, Brosius FC 3rd: Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: Prevention by lipoic acid treatment. BMC Nephrol 7: 6, 2006
8. Susztak K, Raff AC, Schiffer M, Bottinger EP: Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55: 225-233, 2006 (Pubitemid 43343319)
9. Dalla Vestra M, Masiero A, Roiter AM, Saller A, Crepaldi G, Fioretto P: Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 52: 1031-1035, 2003 (Pubitemid 36384274)
10. Doublier S, Salvidio G, Lupia E, Ruotsalainen V, Verzola D, Deferrari G, Camussi G: Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 52: 1023-1030, 2003 (Pubitemid 36384273)
11. Komhoff M, Grone HJ, Klein T, Seyberth HW, Nusing RM: Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: Implication for renal function. Am J Physiol 272: F460-F468, 1997
12. Adegboyega PA, Ololade O: Immunohistochemical expression of cyclooxygenase- 2 in normal kidneys. Appl Immunohistochem Mol Morphol 12: 71-74, 2004 (Pubitemid 38332323)
13. Rangel EB, Moura LA, Franco MF, Pacheco-Silva A: Up-regulation of cyclooxygenase-2 during acute human renal allograft rejection. Clin Transplant 19: 543-550, 2005 (Pubitemid 40990668)
14. Rangel EB, Moura LA, Franco M, Pacheco-Silva A: Expression of cyclooxygenases during renal allograft rejection. Transplant Proc 36: 838-839, 2004 (Pubitemid 38766194)
15. Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA, Harris RC: Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int 62: 929-939, 2002 (Pubitemid 35316722)
16. Komers R, Lindsley JN, Oyama TT, Schutzer WE, Reed JF, Mader SL, Anderson S: Immunohistochemical and functional correlations of renal cyclooxygenase- 2 in experimental diabetes. J Clin Invest 107: 889-898, 2001 (Pubitemid 32274042)
17. Yabuki A, Taniguchi K, Yamato O: Immunohistochemical examination of cyclooxygenase-2 and renin in a KK-A(y) mouse model of diabetic nephropathy. Exp Anim 59: 479-486, 2010
18. Gurley SB, Clare SE, Snow KP, Hu A, Meyer TW, Coffman TM: Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol 290: F214-F222, 2006
19. Zhao HJ, Wang S, Cheng H, Zhang MZ, Takahashi T, Fogo AB, Breyer MD, Harris RC: Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol 17: 2664-2669, 2006 (Pubitemid 44484656)
20. Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T: Mouse models of diabetic nephropathy. J AmSoc Nephrol 20: 2503-2512, 2009
21. Harris RC, Zhang MZ, Cheng HF: Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand 181: 543-547, 2004 (Pubitemid 39078853)
22. Durvasula RV, Petermann AT, Hiromura K, Blonski M, Pippin J, Mundel P, Pichler R, Griffin S, Couser WG, Shankland SJ: Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65: 30-39, 2004 (Pubitemid 38037489)
23. Velez JC, Bland AM, Arthur JM, Raymond JR, Janech MG: Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes. Am J Physiol Renal Physiol 293: F398-F407, 2007 (Pubitemid 47345041)
24. Durvasula RV, Shankland SJ: Activation of a local renin angiotensin system in podocytes by glucose. Am J Physiol Renal Physiol 294: F830-F839, 2008
25. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109: 1417-1427, 2002 (Pubitemid 34596167)
26. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Itoh H: The (pro)renin receptor and the kidney. Semin Nephrol 27: 524-528, 2007 (Pubitemid 47374903)
27. Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC: Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol 18: 551-559, 2007 (Pubitemid 46193320)
28. Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC: Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase- 2 in podocytes. Nephron Exp Nephrol 107: e87-e94, 2007 (Pubitemid 350073618)
29. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-converting- enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 329: 1456-1462, 1993 (Pubitemid 23335891)
30. Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK: Aliskiren combined with losartan in type 2-diabetes and nephropathy. N Engl J Med 358: 2433-2446, 2008 (Pubitemid 351793017)
31. Durvasula RV, Shankland SJ: The renin-angiotensin system in glomerular podocytes: Mediator of glomerulosclerosis and link to hypertensive nephropathy. Curr Hypertens Rep 8: 132-138, 2006 (Pubitemid 43796690)
32. Derkx FH, Schalekamp MA: Human prorenin: Pathophysiology and clinical implications. Clin Exp Hypertens A 10: 1213-1225, 1988 (Pubitemid 19051360)
33. Deinum J, Ronn B, Mathiesen E, Derkx FH, Hop WC, Schalekamp MA: Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia 42: 1006-1010, 1999 (Pubitemid 29369610)
34. Wilson DM, Luetscher JA: Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med 323: 1101-1106, 1990 (Pubitemid 20370731)
35. Wilkinson-Berka JL: Prorenin and the (pro)renin receptor in ocular pathology. Am J Pathol 173: 1591-1594, 2008
36. Nabi AH, Kageshima A, Uddin MN, Nakagawa T, Park EY, Suzuki F: Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18: 483-488, 2006
37. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W: Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69: 105-113, 2006 (Pubitemid 43117745)
38. Burckle CA, Jan Danser AH, Muller DN, Garrelds IM, Gasc JM, Popova E, Plehm R, Peters J, Bader M, Nguyen G: Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 47: 552-556, 2006 (Pubitemid 43843874)
39. Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AH, Ishida Y, Inagami T, Saruta T: Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest 114: 1128-1135, 2004
40. Takahashi H, Ichihara A, Kaneshiro Y, Inomata K, Sakoda M, Takemitsu T, Nishiyama A, Itoh H: Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J Am Soc Nephrol 18: 2054-2061, 2007 (Pubitemid 47041071)
41. Muller DN, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder RE, Luft FC, Hilgers KF: (Pro)renin receptor peptide inhibitor "handleregion" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 51: 676-681, 2008
42. Huang J, Siragy HM: Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression. Endocrinology 150: 5557-5565, 2009
43. Kaneshiro Y, Ichihara A, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Hayashi M, Inagami T: Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. Kidney Int 70: 641-646, 2006 (Pubitemid 44215337)
44. Takemoto M, Asker N, Gerhardt H, Lundkvist A, Johansson BR, Saito Y, Betsholtz C: A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 161: 799-805, 2002 (Pubitemid 34988366)
45. Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC: Distinct roles for basal and induced COX-2 in podocyte injury. J Am Soc Nephrol 20: 1953-1962, 2009
46. Cheng HF, Harris RC: Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. J Biol Chem 277: 45638-45643, 2002
47. Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N, Boim MA: High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol 286: F1039-F1045, 2004 (Pubitemid 38656357)
48. Singh R, Singh AK, Alavi N, Leehey DJ: Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J Am Soc Nephrol 14: 873-880, 2003 (Pubitemid 36359269)
49. Cheng HF, Wang JL, Zhang MZ, Wang SW, McKanna JA, Harris RC: Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Am J Physiol Renal Physiol 280: F449-F456, 2001