RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 2, 2014, Pages

  Manickam, Nagaraj ^b   Patel, Mandakini ^b   Griendling, Kathy K ^c   Gorin, Yves ^b   Barnes, Jeffrey L ^a,b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fibrosis; GTPase; Myofibroblast differentiation; NADPH oxidase; Oxidative stress; Polymerase (DNA directed) interacting protein 2; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA SMOOTH MUSCLE ACTIN; ALTERNATIVELY SPLICED FIBRONECTIN VARIANT; DIPHENYLIODONIUM SALT; DNA DIRECTED DNA POLYMERASE; FIBRONECTIN; POLYMERASE DELTA INTERACTING PROTEIN 2; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; KIDNEY CELL; KIDNEY MYOFIBROBLAST; MYOFIBROBLAST; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

FIBROSIS; GTPASE; MYOFIBROBLAST DIFFERENTIATION; NADPH OXIDASE; OXIDATIVE STRESS; POLYMERASE (DNA-DIRECTED) Δ-INTERACTING PROTEIN 2; RHO KINASE; TRANSFORMING GROWTH FACTOR-Β1;

ACTINS; ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; ENZYME ACTIVATION; FIBRONECTINS; FIBROSIS; KIDNEY; MYOFIBROBLASTS; NADPH OXIDASE; OXIDATION-REDUCTION; PHENOTYPE; PROTEIN KINASE INHIBITORS; RAC1 GTP-BINDING PROTEIN; RATS; REACTIVE OXYGEN SPECIES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84904357131     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00546.2013     Document Type: Article

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