The predicted impact of reducing the nicotine content in cigarettes on alcohol use

Nicotine and Tobacco Research

Volumn 16, Issue 8, 2014, Pages 1033-1044

  Dermody, Sarah S ^a   Donny, Eric C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE;

ADVERSE OUTCOME; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; COPING BEHAVIOR; DRINKING BEHAVIOR; DRUG CONCENTRATION; DRUG EXPOSURE; HEALTH BEHAVIOR; HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; SMOKELESS TOBACCO; SMOKING; SMOKING CESSATION; STOMACH EMPTYING; TOBACCO; TOBACCO DEPENDENCE; TOBACCO USE; VERY LOW NICOTINE CONTENT; WITHDRAWAL SYNDROME; ANALYSIS; ASSOCIATION; PATHOPHYSIOLOGY; PSYCHOLOGY;

ALCOHOL DRINKING; CUES; HUMANS; NICOTINE; SMOKING; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO PRODUCTS;

EID: 84904351462     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntu037     Document Type: Review

References (129)

1. Acheson, A., Mahler, S. V., Chi, H., & de Wit, H. (2006). Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology, 186, 54-63. doi:10.1007/s00213-006-0338-y.
2. Adhikari, B., Kahende, J., Malarcher, A., Pechacek, T., & Tong, V. (2009). Smoking-attributable mortality, years of potential life lost, and productivity losses-United States, 2000-2004. Journal of the American Medical Association, 301, 593-594. doi:10.1001/jama.301.6.593.
3. Agaku, I. T., Ayo-Yusuf, O. A., Vardavas, C. I., Alpert, H. R., & Connolly, G. N. (2013). Use of conventional and novel smokeless tobacco products among US adolescents. Pediatrics, 132, e578-e586. doi:10.1542/peds.2013-0843.
4. Agarwal, D. P., & Goedde, H. W. (1992). Medicobiological and genetic studies on alcoholism. Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcoholrelated mortality. The Clinical Investigator, 70, 465-477. doi:10.1007/BF00210227.
5. Baker, T. B., Brandon, T. H., & Chassin, L. (2004). Motivational influences on cigarette smoking. Annual Review of Psychology, 55, 463-491. doi:10.1146/annurev. psych.55.090902.142054.
6. Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173-1182.
7. Barr, R. S., Pizzagalli, D. A., Culhane, M. A., Goff, D. C., & Evins, A. E. (2008). A single dose of nicotine enhances reward responsiveness in nonsmokers: Implications for development of dependence. Biological Psychiatry, 63, 1061-1065. doi:10.1016/j.biopsych.2007.09.015.
8. Barrett, S. P., Tichauer, M., Leyton, M., & Pihl, R. O. (2006). Nicotine increases alcohol self-administration in nondependent male smokers. Drug and Alcohol Dependence, 81, 197-204. doi:10.1016/j.drugalcdep.2005.06.009.
9. Benowitz, N. L. (2001). Compensatory smoking of low-yield cigarettes. National Cancer Institute. Risks associated with smoking cigarettes with low machine yields of tar and nicotine. Smoking and Tobacco Control Monograph No. 13, 39-63.
10. Benowitz, N. L., Dains, K. M., Hall, S. M., Stewart, S., Wilson, M., Dempsey, D., & Jacob, P. (2012). Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes. Cancer Epidemiology, Biomarkers and Prevention, 21, 761-769. doi:10.1158/1055-9965.epi-11-0644.
11. Benowitz, N. L., Hall, S. M., Stewart, S., Wilson, M., Dempsey, D., & Jacob, P. 3rd. (2007). Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Cancer Epidemiology, Biomarkers and Prevention, 16, 2479-2485. doi:10.1158/1055-9965.epi-07-0393.
12. Benowitz, N. L., & Henningfield, J. E. (1994). Establishing a nicotine threshold for addiction. The implications for tobacco regulation. New England Journal of Medicine, 331, 123-125.
13. Benowitz, N. L., Jacob, P. 3rd, & Herrera, B. (2006). Nicotine intake and dose response when smoking reduced-nicotine content cigarettes. Clinical Pharmacology and Therapeutics, 80, 703-714. doi:10.1016/j.clpt.2006.09.007.
14. Benwell, M. E., Balfour, D. J., & Anderson, J. M. (1988). Evidence that tobacco smoking increases the density of (-)-[3H]nicotine binding sites in human brain. Journal of Neurochemistry, 50, 1243-1247.
15. Bernert, J. T., Jain, R. B., Pirkle, J. L., Wang, L., Miller, B. B., & Sampson, E. J. (2005). Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes. Nicotine and Tobacco Research, 7, 729-738. doi:10.1080/1462220050025976.
16. Blomqvist, O., Hernandez-Avila, C. A., Van Kirk, J., Rose, J. E., & Kranzler, H. R. (2002). Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. Alcoholism, Clinical and Experimental Research, 26, 326-331. doi:10.1111/j.1530-0277.2002.tb02541.x.
17. Buchhalter, A. R., Acosta, M. C., Evans, S. E., Breland, A. B., & Eissenberg, T. (2005). Tobacco abstinence symptom suppression: The role played by the smokingrelated stimuli that are delivered by denicotinized cigarettes. Addiction (Abingdon, England), 100, 550-559. doi:10.1111/j.1360-0443.2005.01030.x.
18. Buchhalter, A. R., Schrinel, L., & Eissenberg, T. (2001). Withdrawal-suppressing effects of a novel smoking system: Comparison with own brand, not own brand, and denicotinized cigarettes. Nicotine and Tobacco Research, 3, 111-118. doi:10.1080/14622200110042636.
19. Buisson, B., & Bertrand, D. (2002). Nicotine addiction: The possible role of functional upregulation. Trends in Pharmacological Sciences, 23, 130-136. doi:10.1016/S0165-6147(00)01979-9.
20. Caggiula, A. R., Donny, E. C., Palmatier, M. I., Liu, X., Chaudhri, N., & Sved, A. F. (2009). The role of nicotine in smoking: A dual-reinforcement model. In Rick A. Bevins & Anthony R. Caggiula (Eds.), The motivational impact of nicotine and its role in tobacco use (Vol. 5, pp. 91-109). University of Nebraska: Lincoln, NE.
21. Carpenter, K. M., & Hasin, D. S. (1999). Drinking to cope with negative affect and DSM-IV alcohol use disorders: A test of three alternative explanations. Journal of Studies on Alcohol, 60, 694-704.
22. Carter, B. L., & Tiffany, S. T. (1999). Meta-analysis of cue-reactivity in addiction research. Addiction (Abingdon, England), 94, 327-340. doi:10.1046/j.1360-0443.1999.9433273.x.
23. Centers for Disease Control and Prevention. (2011). Vital signs: Current cigarette smoking among adults aged ≥18-United States 2005-2010. MMWR: Morbidity and Mortality Weekly Report, 60, 1207-1212.
24. Chandra, S., Shiffman, S., Scharf, D. M., Dang, Q., & Shadel, W. G. (2007). Daily smoking patterns, their determinants, and implications for quitting. Experimental and Clinical Psychopharmacology, 15, 67-80. doi:10.1037/1064-1297.15.1.67.
25. Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M., Craven, L., Sved, A. F. (2006). Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine. Psychopharmacology, 189, 27-36. doi:10.1007/s00213-006-0522-0.
26. Chen, W. J., Parnell, S. E., & West, J. R. (2001). Nicotine decreases blood alcohol concentration in neonatal rats. Alcoholism, Clinical and Experimental Research, 25, 1072-1077. doi:10.1111/j.1530-0277.2001.tb02319.x.
27. Chi, H., & de Wit, H. (2003). Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcoholism, Clinical and Experimental Research, 27, 780-786. doi:10.1097/01.ALC.0000065435.12068.24.
28. Clark, A., Lindgren, S., Brooks, S. P., Watson, W. P., & Little, H. J. (2001). Chronic infusion of nicotine can increase operant self-administration of alcohol. Neuropharmacology, 41, 108-117. doi:10.1016/s0028-3908(01)00037-5.
29. Collins, A. C., Burch, J. B., de Fiebre, C. M., & Marks, M. J. (1988). Tolerance to and cross tolerance between ethanol and nicotine. Pharmacology, Biochemistry, and Behavior, 29, 365-373. doi:10.1016/0091-3057(88)90170-0.
30. Collins, C. C., Epstein, D. H., Parzynski, C. S., Zimmerman, D., Moolchan, E. T., & Heishman, S. J. (2010). Puffing behavior during the smoking of a single cigarette in tobaccodependent adolescents. Nicotine and Tobacco Research, 12, 164-167. doi:10.1093/ntr/ntp176.
31. Congress. (2009). Family Smoking Prevention and Tobacco Control Act. H.R. 1256. U.S. Congress. Washington, DC: U.S. Government Printing Office.
32. Cooney, J. L., Cooney, N. L., Pilkey, D. T., Kranzler, H. R., & Oncken, C. A. (2003). Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers. Addiction (Abingdon, England), 98, 913-921. doi:10.1046/j.1360-0443.2003.00337.x.
33. Cooper, M. L., Frone, M. R., Russell, M., & Mudar, P. (1995). Drinking to regulate positive and negative emotions: A motivational model of alcohol use. Journal of Personality and Social Psychology, 69, 990-1005. doi:10.1037/0022-3514.69.5.990.
34. Corrigall, W. A. (1999). Nicotine self-administration in animals as a dependence model. Nicotine and Tobacco Research, 1, 11-20. doi:10.1080/14622299050011121.
35. Crabb, D. W. (1995). Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease. Progress in Liver Diseases, 13, 151-172.
36. Davis, T. J., & de Fiebre, C. M. (2006). Alcohol's actions on neuronal nicotinic acetylcholine receptors. Alcohol Research and Health, 29, 179-185.
37. Dermody, S. S., Cheong, J., & Manuck, S. (2013). An evaluation of the stress-negative affect model in explaining alcohol use: The role of components of negative affect and coping style. Substance Use and Misuse, 48, 297-308. doi:10.3109/10826084.2012.761713.
38. Dohrman, D. P., & Reiter, C. K. (2003). Ethanol modulates nicotine-induced upregulation of nAChRs. Brain Research, 975, 90-98. doi:10.1016/s0006-8993(03)02593-9.
39. Donny, E. C., Chaudhri, N., Caggiula, A. R., Evans-Martin, F. F., Booth, S., Gharib, M. A., Sved, A. F. (2003). Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: Implications for nicotine self-administration and reinforcement. Psychopharmacology, 169, 68-76. doi:10.1007/s00213-003-1473-3.
40. Donny, E. C., Houtsmuller, E., & Stitzer, M. L. (2007). Smoking in the absence of nicotine: Behavioral, subjective and physiological effects over 11 days. Addiction (Abingdon, England), 102, 324-334. doi:10.1111/j.1360-0443.2006.01670.x.
41. Donny, E. C., & Jones, M. (2009). Prolonged exposure to denicotinzied cigarettes with or without transdermal nicotine. Drug and Alcohol Dependence, 104, 23-33. doi:10.1016/j. drugalcdep.2009.01.021.
42. Donny, E. C., Taylor, T. G., LeSage, M. G., Levin, M., Buffalari, D. M., Joel, D., & Sved, A. F. (2012). Impact of tobacco regulation on animal research: New perspectives and opportunities. Nicotine and Tobacco Research, 14, 1319-1338. doi:10.1093/ntr/nts162.
43. Doyon, W. M., Dong, Y., Ostroumov, A., Thomas, A. M., Zhang, T. A., & Dani, J. A. (2013). Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones. Neuron, 79, 530-540. doi:http://dx.doi.org/10.1016/j.neuron.2013.06.006.
44. Drobes, D. J. (2002). Cue reactivity in alcohol and tobacco dependence. Alcoholism, Clinical and Experimental Research, 26, 1928-1929. doi:10.1097/01. ALC.0000040983.23182.3A.
45. Evans, S. E., Blank, M., Sams, C., Weaver, M. F., & Eissenberg, T. (2006). Transdermal nicotine-induced tobacco abstinence symptom suppression: Nicotine dose and smokers' gender. Experimental and Clinical Psychopharmacology, 14, 121-135. doi:10.1037/1064-1297.14.2.121.
46. Falk, D. E., Yi, H. Y., & Hiller-Sturmhöfel, S. (2006). An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Research and Health, 29, 162-171.
47. Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990). High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. The New England Journal of Medicine, 322, 95-99. doi:10.1056/NEJM199001113220205.
48. George, M. S., Anton, R. F., Bloomer, C., Teneback, C., Drobes, D. J., Lorberbaum, J. P., Vincent, D. J. (2001). Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues. Archives of General Psychiatry, 58, 345-352. doi:10.1001/archpsyc.58.4.345.
49. Gritz, E. R., Ippoliti, A., Jarvik, M. E., Rose, J. E., Shiffman, S., Harrison, A., & Vunakis, H. V. (1988). The effect of nicotine on the delay of gastric emptying. Alimentary Pharmacology and Therapeutics, 2, 173-178. doi:10.1111/j.1365-2036.1988.tb00685.x.
50. Grucza, R. A., & Bierut, L. J. (2006). Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers. Alcoholism, Clinical and Experimental Research, 30, 2046-2054. doi:10.1111/j.1530-0277.2006.00255.x.
51. Harrison, E. L., Desai, R. A., & McKee, S. A. (2008). Nondaily smoking and alcohol use, hazardous drinking, and alcohol diagnoses among young adults: Findings from the NESARC. Alcoholism, Clinical and Experimental Research, 32, 2081-2087. doi:10.1111/j.1530-0277.2008.00796.x.
52. Harrison, E. L., & McKee, S. A. (2008). Young adult non-daily smokers: Patterns of alcohol and cigarette use. Addictive Behaviors, 33, 668-674. doi:10.1016/j. addbeh.2007.11.012.
53. Harvey, D. M., Yasar, S., Heishman, S. J., Panlilio, L. V., Henningfield, J. E., & Goldberg, S. R. (2004). Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers. Psychopharmacology, 175, 134-142. doi:10.1007/s00213-004-1818-6.
54. Hatsukami, D. K., Heishman, S. J., Vogel, R. I., Denlinger, R. L., Roper-Batker, A. N., Mackowick, K. M., Donny, E. (2013). Dose-response effects of spectrum research cigarettes. Nicotine and Tobacco Research, 15, 1113-1121. doi:10.1093/ntr/nts247.
55. Hatsukami, D. K., Hertsgaard, L. A., Vogel, R. I., Jensen, J. A., Murphy, S. E., Hecht, S. S., Allen, S. S. (2013). Reduced nicotine content cigarettes and nicotine patch. Cancer Epidemiology, Biomarkers and Prevention, 22, 1015-1024. doi:10.1158/1055-9965.epi-12-1439.
56. Hatsukami, D. K., Kotlyar, M., Hertsgaard, L. A., Zhang, Y., Carmella, S. G., Jensen, J. A., Stepanov, I. (2010). Reduced nicotine content cigarettes: Effects on toxicant exposure, dependence and cessation. Addiction (Abingdon, England), 105, 343-355. doi:10.1111/j.1360-0443.2009.02780.x.
57. Hatsukami, D. K., Perkins, K. A., LeSage, M. G., Ashley, D. L., Henningfield, J. E., Benowitz, N. L., Zeller, M. (2010). Nicotine reduction revisited: Science and future directions. Tobacco Control, 19, e1. doi:10.1136/tc.2009.035584.
58. Hecht, S. S., Murphy, S. E., Carmella, S. G., Li, S., Jensen, J., Le, C., Hatsukami, D. K. (2005). Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. Cancer Epidemiology, Biomarkers and Prevention, 14, 693-698. doi:10.1158/1055-9965.EPI-04-0542.
59. Henningfield, J. E., Benowitz, N. L., Slade, J., Houston, T. P., Davis, R. M., & Deitchman, S. D. (1998). Reducing the addictiveness of cigarettes. Council on Scientific Affairs, American Medical Association. Tobacco Control, 7, 281-293.
60. Hesselbrock, V. M., & Hesselbrock, M. N. (2006). Are there empirically supported and clinically useful subtypes of alcohol dependence? Addiction (Abingdon, England), 101(suppl. 1), 97-103. doi:10.1111/j.1360-0443.2006.01596.x.
61. Holt, S., Stewart, M. J., Adam, R. D., & Heading, R. C. (1980). Alcohol absorption, gastric emptying and a breathalyser. British Journal of Clinical Pharmacology, 9, 205-208. doi:10.1111/j.1365-2125.1980.tb05834.x.
62. Hughes, J. R. (2007). Effects of abstinence from tobacco: Etiology, animal models, epidemiology, and significance: A subjective review. Nicotine & Tobacco Research, 9, 329-339. doi:10.1080/14622200701188927.
63. Hughes, J. R., Higgins, S. T., & Hatsukami, D. (1990). Effects of abstinence from tobacco: A critical review. In L. T. Kozlowski, H. M. Annis, H. D. Cappell, F. B. Glaser, M. S. Goodstadt, Y. Israel, H. Kalant, E. M. Sellers, & E. R. Vingilis (Eds.), Research advances in alcohol and drug problems (Vol. 10, pp. 317-398).
64. Hussong, A. M., & Chassin, L. (1994). The stress-negative affect model of adolescent alcohol use: Disaggregating negative affect. Journal of Studies on Alcohol, 55, 707-718.
65. Hussong, A. M., Hicks, R. E., Levy, S. A., & Curran, P. J. (2001). Specifying the relations between affect and heavy alcohol use among young adults. Journal of Abnormal Psychology, 110, 449-461. doi:10.1037//0021-843x.110.3.449.
66. Jackson, K. M., Colby, S. M., & Sher, K. J. (2010). Daily patterns of conjoint smoking and drinking in college student smokers. Psychology of Addictive Behaviors, 24, 424-435. doi:10.1037/a0019793.
67. Johnson, R. D., Horowitz, M., Maddox, A. F., Wishart, J. M., & Shearman, D. J. (1991). Cigarette smoking and rate of gastric emptying: Effect on alcohol absorption. BMJ: British Medical Journal, 302, 20-23.
68. Kassel, J. D., Greenstein, J. E., Evatt, D. P., Wardle, M. C., Yates, M. C., Veilleux, J. C., & Eissenberg, T. (2007). Smoking topography in response to denicotinized and high-yield nicotine cigarettes in adolescent smokers. Journal of Adolescent Health, 40, 54-60. doi:http://dx.doi.org/10.1016/j.jadohealth.2006.08.006.
69. Kassel, J. D., Stroud, L. R., & Paronis, C. A. (2003). Smoking, stress, and negative affect: Correlation, causation, and context across stages of smoking. Psychological Bulletin, 129, 270-304. doi:10.1037/0033-2909.129.2.270.
70. Kemppainen, H., Hyytiä, P., & Kiianmaa, K. (2009). Behavioral consequences of repeated nicotine during adolescence in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcoholism, Clinical and Experimental Research, 33, 340-349. doi:10.1111/j.1530-0277.2008.00838.x.
71. King, A. C., de Wit, H., McNamara, P. J., & Cao, D. (2011). Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Archives of General Psychiatry, 68, 389-399. doi:10.1001/archgenpsychiatry.2011.26.
72. Kouri, E. M., McCarthy, E. M., Faust, A. H., & Lukas, S. E. (2004). Pretreatment with transdermal nicotine enhances some of ethanol's acute effects in men. Drug and Alcohol Dependence, 75, 55-65. doi:10.1016/j. drugalcdep.2004.01.011.
73. Kozlowski, L. T., Mehta, N. Y., Sweeney, C. T., Schwartz, S. S., Vogler, G. P., Jarvis, M. J., & West, R. J. (1998). Filter ventilation and nicotine content of tobacco in cigarettes from Canada, the United Kingdom, and the United States. Tobacco Control, 7, 369-375. doi:10.1136/tc.7.4.369.
74. Kuntsche, E., Knibbe, R., Gmel, G., & Engels, R. (2006). Who drinks and why? A review of socio-demographic, personality, and contextual issues behind the drinking motives in young people. Addictive Behaviors, 31, 1844-1857. doi:10.1016/j. addbeh.2005.12.028.
75. Lanza, S. T., Vasilenko, S. A., Liu, X., Li, R., & Piper, M. E. (2013). Advancing the understanding of craving during smoking cessation attempts: A demonstration of the time-varying effect model. Nicotine & Tobacco Research. Advance online publication. doi:10.1093/ntr/ntt128.
76. Lê, A. D., Corrigall, W. A., Harding, J. W., Juzytsch, W., Li, T. K. (2000). Involvement of nicotinic receptors in alcohol self-administration. Alcoholism, Clinical and Experimental Research, 24, 155-163. doi:10.1111/j.1530-0277.2000. tb04585.x.
77. Leventhal, A. M., Waters, A. J., Boyd, S., Moolchan, E. T., Lerman, C., & Pickworth, W. B. (2007). Gender differences in acute tobacco withdrawal: Effects on subjective, cognitive, and physiological measures. Experimental and Clinical Psychopharmacology, 15, 21-36. doi:10.1037/1064-1297.15.1.21.
78. Lieber, C. S. (1994). Mechanisms of ethanol-drug-nutrition interactions. Clinical Toxicology, 32, 631-681. doi:10.3109/15563659409017974.
79. Lim, R. T. Jr, Gentry, R. T., Ito, D., Yokoyama, H., Baraona, E., & Lieber, C. S. (1993). First-pass metabolism of ethanol is predominantly gastric. Alcoholism, Clinical and Experimental Research, 17, 1337-1344. doi:10.1111/j.1530-0277.1993. tb05250.x.
80. Lucas, D., Ferrara, R., Gonzalez, E., Bodenez, P., Albores, A., Manno, M., & Berthou, F. (1999). Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans. Pharmacogenetics, 9, 377-388.
81. Lucas, D., Ménez, C., Girre, C., Berthou, F., Bodénez, P., Joannet, I., Menez, J. F. (1995). Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics, 5, 298.
82. Lucas, D., Ménez, C., Girre, C., Bodénez, P., Hispard, E., & Ménez, J.-F. (1995). Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase. Alcoholism: Clinical and Experimental Research, 19, 362-366. doi:10.1111/j.1530-0277.1995.tb01516.x.
83. Macqueen, D. A., Heckman, B. W., Blank, M. D., Janse Van Rensburg, K., Evans, D. E., & Drobes, D. J. (2012). Transient compensatory smoking in response to placebo cigarettes. Psychopharmacology, 223, 47-54. doi:10.1007/s00213-012-2685-1.
84. Malson, J. L., Sims, K., Murty, R., & Pickworth, W. B. (2001). Comparison of the nicotine content of tobacco used in bidis and conventional cigarettes. Tobacco Control, 10, 181-183. doi:10.1136/tc.10.2.181.
85. Martin, C. S., Earleywine, M., Musty, R. E., Perrine, M. W., & Swift, R. M. (1993). Development and validation of the Biphasic Alcohol Effects Scale. Alcoholism, Clinical and Experimental Research, 17, 140-146. doi:10.1111/j.1530-0277.1993.tb00739.x.
86. Matsumoto, M., Takahashi, H., Maruyama, K., Higuchi, S., Matsushita, S., Muramatsu, T., Ishii, H. (1996). Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. Alcoholism, Clinical and Experimental Research, 20(suppl. 9), 289A-292A.
87. McClave-Regan, A. K., & Berkowitz, J. (2011). Smokers who are also using smokeless tobacco products in the US: A national assessment of characteristics, behaviours and beliefs of 'dual users'. Tobacco Control, 20, 239-242. doi:10.1136/tc.2010.039115.
88. McClernon, F. J., Van Voorhees, E. E., English, J., Hallyburton, M., Holdaway, A., & Kollins, S. H. (2011). Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: Results from a 12-day contingency-managed abstinence trial. Nicotine and Tobacco Research, 13, 784-792. doi:10.1093/ntr/ntr073.
89. McKee, S. A., Harrison, E. L. R., O'Malley, S. S., Krishnan-Sarin, S., Shi, J., Tetrault, J. M., Balchunas, E. (2009). Varenicline reduces alcohol self-administration in heavydrinking smokers. Biological Psychiatry, 66, 185-190. doi:http://dx.doi.org/10.1016/j.biopsych.2009.01.029
90. McKee, S. A., O'Malley, S. S., Shi, J., Mase, T., & Krishnan-Sarin, S. (2008). Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology, 196, 189-200. doi:10.1007/s00213-007-0952-3.
91. McKee, S. A., & Weinberger, A. H. (2013). How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use? Annual Review of Clinical Psychology, 9, 649-674. doi:10.1146/annurev-clinpsy-050212-185549.
92. Mokdad, A. H., Marks, J. S., Stroup, D. F., & Gerberding, J. L. (2004). Actual causes of death in the United States, 2000. JAMA: The Journal of the American Medical Association, 291, 1238-1245. doi:10.1001/jama.291.10.1238.
93. Nadal, R., Chappell, A. M., & Samson, H. H. (1998). Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration. Alcoholism, Clinical and Experimental Research, 22, 1190-1198. doi:10.1111/j.1530-0277.1998.tb03898.x.
94. Neale, M. C., & Kendler, K. S. (1995). Models of comorbidity for multifactorial disorders. American Journal of Human Genetics, 57, 935-953.
95. Nolen-Hoeksema, S. (2004). Gender differences in risk factors and consequences for alcohol use and problems. Clinical Psychology Review, 24, 981-1010. doi:10.1016/j.cpr.2004.08.003.
96. Novak, A., Burgess, E. S., Clark, M., Zvolensky, M. J., & Brown, R. A. (2003). Anxiety sensitivity, self-reported motives for alcohol and nicotine use, and level of consumption. Journal of Anxiety Disorders, 17, 165-180. doi:10.1016/S0887-6185(02)00175-5.
97. Palfai, T. P., Monti, P. M., Ostafin, B., & Hutchison, K. (2000). Effects of nicotine deprivation on alcohol-related information processing and drinking behavior. Journal of Abnormal Psychology, 109, 96-105. doi:10.1037/0021-843X.109.1.96.
98. Parnell, S. E., West, J. R., & Chen, W. J. (2006). Nicotine decreases blood alcohol concentrations in adult rats: A phenomenon potentially related to gastric function. Alcoholism, Clinical and Experimental Research, 30, 1408-1413. doi:10.1111/j.1530-0277.2006.00168.x.
99. Parra, G. R., O'Neill, S. E., & Sher, K. J. (2003). Reliability of self-reported age of substance involvement onset. Psychology of Addictive Behaviors, 17, 211-218. doi:http://dx.doi.org/10.1037/0893-164X.17.3.211.
100. Perkins, K. A. (1997). Combined effects of nicotine and alcohol on subjective, behavioral and physiological responses in humans. Addiction Biology, 2, 255-267.
101. Perkins, K. A., Fonte, C., & Grobe, J. E. (2000). Sex differences in the acute effects of cigarette smoking on the reinforcing value of alcohol. Behavioural Pharmacology, 11, 63-70.
102. Perkins, K. A., Jacobs, L., Sanders, M., & Caggiula, A. R. (2002). Sex differences in the subjective and reinforcing effects of cigarette nicotine dose. Psychopharmacology, 163, 194-201. doi:10.1007/s00213-002-1168-1.
103. Perkins, K. A., & Karelitz, J. L. (2013). Reinforcement enhancing effects of nicotine via smoking. Psychopharmacology, 228, 479-486. doi:10.1007/s00213-013-3054-4.
104. Perkins, K. A., Sexton, J. E., DiMarco, A., Grobe, J. E., Scierka, A., & Stiller, R. L. (1995). Subjective and cardiovascular responses to nicotine combined with alcohol in male and female smokers. Psychopharmacology, 119, 205-212.
105. Picciotto, M. R., Addy, N. A., Mineur, Y. S., & Brunzell, D. H. (2008). It is not "either/or": Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress in Neurobiology, 84, 329-342. doi:10.1016/j. pneurobio.2007.12.005.
106. Pickworth, W. B., Fant, R. V., Nelson, R. A., Rohrer, M. S., & Henningfield, J. E. (1999). Pharmacodynamic effects of new de-nicotinized cigarettes. Nicotine and Tobacco Research, 1, 357-364. doi:10.1080/14622299050011491.
107. Pomerleau, C. S., Marks, J. L., & Pomerleau, O. F. (2000). Who gets what symptom? Effects of psychiatric cofactors and nicotine dependence on patterns of smoking withdrawal symptomatology. Nicotine and Tobacco Research, 2, 275-280. doi:10.1080/14622200050147547.
108. Pomerleau, O. F., Pomerleau, C. S., Mehringer, A. M., Snedecor, S. M., Ninowski, R., & Sen, A. (2005). Nicotine dependence, depression, and gender: Characterizing phenotypes based on withdrawal discomfort, response to smoking, and ability to abstain. Nicotine and Tobacco Research, 7, 91-102. doi:10.1080/14622200412331328466.
109. Quinn, P. D., & Fromme, K. (2011). Subjective response to alcohol challenge: A quantitative review. Alcoholism, Clinical and Experimental Research, 35, 1759-1770. doi:10.1111/j.1530-0277.2011.01521.x.
110. Ralevski, E., Perry, E. B. Jr, D'Souza, D. C., Bufis, V., Elander, J., Limoncelli, D., McKee, S. (2012). Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: A laboratory study. Nicotine and Tobacco Research, 14, 596-606. doi:10.1093/ntr/ntr258.
111. Rath, J. M., Villanti, A. C., Abrams, D. B., & Vallone, D. M. (2012). Patterns of tobacco use and dual use in US young adults: The missing link between youth prevention and adult cessation. Journal of Environmental and Public Health, 2012. doi:http://dx.doi.org/10.1155/2012/679134.
112. Rose, J. E., & Behm, F. M. (2004). Effects of low nicotine content cigarettes on smoke intake. Nicotine and Tobacco Research, 6, 309-319. doi:10.1080/14622200410001676378.
113. Shiffman, S. (2009). Ecological momentary assessment (EMA) in studies of substance use. Psychological Assessment, 21, 486-497. doi:10.1037/A0017074.
114. Shiffman, S., Balabanis, M., Fertig, J., & Allen, J. (1995). Associations between alcohol and tobacco. Alcohol and tobacco: From basic science to clinical practice. NIAAA Research Monograph, 30, 17-36.
115. Shiffman, S., Paty, J. A., Gnys, M., Kassel, J. D., & Elash, C. (1995). Nicotine withdrawal in chippers and regular smokers: Subjective and cognitive effects. Health Psychology, 14, 301-309. doi:10.1037/0278-6133.14.4.301.
116. Smith, B. R., Horan, J. T., Gaskin, S., & Amit, Z. (1999). Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm. Psychopharmacology, 142, 408-412.
117. Stratton, K., Shetty, P., Wallace, R., & Bondurant, S. (2001). Clearing the smoke: The science base for tobacco harm reduction-executive summary. Tobacco Control, 10, 189-195.
118. Thomas, S. E., Drobes, D. J., & Deas, D. (2005). Alcohol cue reactivity in alcohol-dependent adolescents. Journal of Studies on Alcohol, 66, 354-360.
119. Tidey, J. W., Rohsenow, D. J., Kaplan, G. B., Swift, R. M., & Ahnallen, C. G. (2013). Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine and Tobacco Research, 15, 121-129. doi:10.1093/ntr/nts098.
120. USDHSS. (1988). Nicotine addiction: A report of the surgeon general. Rockville, MD: US Department of Health and Human Services Office of the Assistant Secretary for Health Office on Smoking and Health.
121. Veilleux, J. C., Kassel, J. D., Heinz, A. J., Braun, A., Wardle, M. C., Greenstein, J., Conrad, M. (2011). Predictors and sequelae of smoking topography over the course of a single cigarette in adolescent light smokers. The Journal of Adolescent Health, 48, 176-181. doi:10.1016/j.jadohealth.2010.06.015.
122. Walker, N., Howe, C., Bullen, C., Grigg, M., Glover, M., McRobbie, H., Whittaker, R. (2012). The combined effect of very low nicotine content cigarettes, used as an adjunct to usual Quitline care (nicotine replacement therapy and behavioural support), on smoking cessation: A randomized controlled trial. Addiction (Abingdon, England), 107, 1857-1867. doi:10.1111/j.1360-0443.2012.03906.x.
123. Weinberger, A. H., Desai, R. A., & McKee, S. A. (2010). Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders. Drug and Alcohol Dependence, 108, 7-12. doi:10.1016/j.drugalcdep.2009.11.004.
124. Weitzman, E. R., & Chen, Y. Y. (2005). The co-occurrence of smoking and drinking among young adults in college: National survey results from the United States. Drug and Alcohol Dependence, 80, 377-386. doi:10.1016/j. drugalcdep.2005.05.008.
125. World Health Organization. (2003). WHO framework convention on tobacco control. A56/8. Geneva: WHO. Retrieved March 3, 2014 from http://whqlibdoc.who.int/publications/2003/9241591013.pdf?ua=1.
126. Wills, T. A., & Shiffman, S. (1985). Coping and substance use: A conceptual framework. In S. Shiffman & T. A. Wills (Eds.), Coping and substance use (pp. 3-24). Orlando, FL: Academic Press.
127. Young, E. M., Mahler, S., Chi, H., & de Wit, H. (2005). Mecamylamine and ethanol preference in healthy volunteers. Alcoholism, Clinical and Experimental Research, 29, 58-65. doi:10.1097/01.ALC.0000150007.34702.16.
128. Zacny, J. P. (1990). Behavioral aspects of alcohol-tobacco interactions. In M. Galanter (Ed.), Recent developments in alcoholism: An official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism (Vol. 8, pp. 205-219). New York: Plenum.
129. Zeller, M., & Hatsukami, D.; Strategic Dialogue on Tobacco Harm Reduction Group. (2009). The Strategic Dialogue on Tobacco Harm Reduction: A vision and blueprint for action in the US. Tobacco Control, 18, 324-332. doi:10.1136/tc.2008.027318.