Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 3, 2002, Pages 326-331

  Blomqvist, Ola ^a   Hernandez Avila, Carlos A ^a   Van Kirk, Jeffrey ^a   Rose, Jed E ^b   Kranzler, Henry R ^a,c  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Alcohol; Mecamylamine; Pharmacodynamics; Pharmacokinetics; Reinforcement

Indexed keywords

ALCOHOL; DOPAMINE; MECAMYLAMINE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; MALE; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; REINFORCEMENT;

EID: 0036125829     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02541.x     Document Type: Article

References (44)

1. The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine
2. Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine
3. Voluntary ethanol intake in the rat: Effects of nicotinic acetylcholine receptor blockage or subchronic nicotine treatment
4. Relationship between subjective effects and drug preferences: Ethanol and diazepam
5. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats
6. Validity of alcoholic's self-reports: Duration data
7. Assessing individual differences in ethanol preference using a cumulative dosing procedure
8. Non-specific effect of naltrexone on ethanol consumption in social drinkers
9. Individual differences in behavioral and subjective responses to alcohol
10. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
11. Alcohol choice and outcome expectancies in social drinkers
12. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow is blocked by ventral tegmental mecamylamine
13. Peripheral involvement in nicotine-induced enhancement of ethanol intake
14. Individual differences in the biphasic effects of ethanol
15. Subjective and objective responses to ethanol in moderate/heavy and light social drinkers
16. Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial
17. Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence
18. Drugs of abuse: Anatomy, pharmacology and function of reward pathways
19. Involvement of nicotinic receptors in alcohol self-administration
20. The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats
21. Validation of the sensation scale, a measure of subjective physiological responses to alcohol
22. Development and validation of the biphasic alcohol effects scale
23. Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis
24. Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration
25. Age-related effects of the nicotinic antagonist mecamylamine on cognition and behavior
26. Alcohol challenge with sons of alcoholics: A critical review and analysis
27. Chronic tolerance and sensitization to alcohol in sons of alcoholics: II. Replication and reanalysis
28. A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects
29. The neural basis of drug craving: An incentive-sensitization theory of addiction
30. Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy
31. Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking
32. Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone
33. Effects of transdermal nicotine/mecamylamine on alcohol reward in excessive drinkers
34. Involvement of central nicotinic acetylcholine receptors in the mesolimbic DA-activating and reinforcing properties of ethanol
35. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol
36. Ondansetron alters human alcohol intoxication
37. Naltrexone-induced alterations in human ethanol intoxication
38. Receptor systems participating in nicotine-specific effects
39. Total body water and blood alcohol levels: Updating the fundamentals
40. A psychomotor stimulant theory of addictions
41. Mecamylamine: New therapeutic uses and toxicity/risk profile