A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

EMBO Journal

Volumn 16, Issue 18, 1997, Pages 5697-5709

  Vivat, Valerie ^a   Zechel, Christina ^a   Wurtz, Jean Marie ^a   Bourguet, William ^a   Kagechika, Hiroyuki ^b   Umemiya, Hiroki ^b   Shudo, Koichi ^b   Moras, Dino ^a   Gronemeyer, Hinrich ^a   Chambon, Pierre ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Constitutively transcriptionally active RXR mutant; Ligand binding pocket; Retinoid receptors; RXR subordination; RXR RAR heterodimers

Indexed keywords

MUTANT PROTEIN; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR; VITAMIN D RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; DIMERIZATION; DNA-BINDING PROTEINS; HUMANS; LIGANDS; MICE; MODELS, STRUCTURAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN HYBRIDIZATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, STEROID; RECOMBINANT PROTEINS; RETINOID X RECEPTORS; RETINOIDS; TRANSCRIPTION FACTORS; TRANSFECTION; TRETINOIN;

ANIMALIA;

EID: 0030865548     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.18.5697     Document Type: Article

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