Transgenerational effects of NMs

Advances in Experimental Medicine and Biology

Volumn 811, Issue , 2014, Pages 235-254

  Poma, Anna ^a   Colafarina, Sabrina ^a   Fontecchio, Gabriella ^a   Chichiriccò, Giuseppe ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Nanomaterials; Nanoparticles; Nanoreprotoxicity; Reproductive function; Transgenerational effects

Indexed keywords

ALUMINUM NANOPARTICLE; CARBON BLACK NANOPARTICLE; CARBON NANOTUBE; CERIUM OXIDE NANOPARTICLE; COBALT FERRITE NANOPARTICLE; FULLERENE DERIVATIVE; GOLD NANOPARTICLE; METAL NANOPARTICLE; MOLYBDENUM TRIOXIDE NANOPARTICLE; MULTI WALLED NANOTUBE; NANOMATERIAL; NANOPARTICLE; POLYMER; QUANTUM DOT; SILICA NANOPARTICLE; SILVER NANOPARTICLE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ADULT STEM CELL; ARTICLE; BIOACCUMULATION; CYTOTOXICITY; DEVELOPMENTAL TOXICITY; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; ENVIRONMENTAL EXPOSURE; EPIGENETICS; EXHAUST GAS; GAMETE; GENOTOXICITY; GERM CELL; HEALTH HAZARD; HEMOLYSIS; HUMAN; NONHUMAN; PARTICLE SIZE; PHYTOTOXICITY; PNEUMONIA; PRENATAL EXPOSURE; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; TESTIS INJURY; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEMALE; LUNG; MALE; MOUSE; PATHOPHYSIOLOGY; PLANT; PREGNANCY; REPRODUCTION; REVIEW;

ANIMALIA; DANIO RERIO; MUS; PISCES;

ANIMALS; EMBRYONIC DEVELOPMENT; FEMALE; HUMANS; LUNG; MALE; MATERNAL EXPOSURE; MICE; NANOSTRUCTURES; PLANTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTION; TITANIUM;

EID: 84904339620     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-94-017-8739-0_12     Document Type: Article

References (109)

1. Salata O (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:3
2. Oberdorster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Cartet J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H (2005) Principles for characterizing the potential human health effects from exposure: elements of screening strategy. Part Fibre Toxicol 6:2-8
3. Hoet PHM, Brüske-Hohlfeld I, Salata OV (2004) Nanoparticles: known and unknown health risks. J Nanobiotechnol 8:1-12
4. Borm PJA, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins V, Stone W, Kreyling J, Lademann R, Krutmann J, Warheit D, Oberdorster E (2006) The potential risks for nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 14:3-11
5. Wang K, Xu JJ, Chen HY (2005) A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine-glucose oxidase biocomposite. Biosens Bioelectron 20:1388-1396
6. Yang MH, Jiang JH, Yang YH, Chen XH, Shen GL, Yu RQ (2006) Carbon nanotube/cobalt hexacyanoferrate nanoparticle biopolymer system for the fabrication of biosensors. Biosens Bioelectron 21:1791-1797
7. Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K (2000) Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal Toxicol 12:1113-1126
8. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839
9. Poma A, Di Giorgio ML (2008) Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials. A review. Curr Genomics 9:571-585
10. Mishra SR, Dubenko I, Losby J, Marasinghe K, Ali M, Ali N (2005) Magnetic properties of magnetically soft nanocomposite Co-SiO 2prepared via mechanical milling. J Nanosci Nanotechnol 5: 2082-2087
11. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C (2002) Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 65(20):1531-1543
12. Champion JA, Mitragotri S (2006) Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A 103:4930-4934
13. Porter AE, Gass M, Muller K, Snepper JN, Midgley P, Wellandi M (2007) Direct imaging of singlewalled carbon nanotubes in cells. Nat Nanotechnol 2(11):713-717. doi: 10.1038/nnano.2007.347
14. Taylor U, Barchanski A, Kues W, Barcikowski S, Rath D (2012) Impact of metal nanoparticles on germ cell viability and functionality. Reprod Domest Anim 47(Suppl 4):359-368
15. Cheng J, Cheng SH (2012) Influence of carbon nanotube length on toxicity to zebrafish embryos. Int J Nanomedicine 7:3731-3739
16. Kyjovska ZO, Boisen AM, Jackson P, Wallin H, Vogel U, Hougaard KS (2013) Daily sperm production: application in studies of prenatal exposure to nanoparticles in mice. Reprod Toxicol 36: 88-89
17. Talebi AR, Khorsandi L, Moridian M (2013) The effect of zinc oxide nanoparticles on mouse spermatogenesis. J Assist Reprod Genet. doi: 10.1007/ s10815-013-0078-y
18. Di Guglielmo C, López DR, De Lapuente J, Mallafre JM, Suàrez MB (2010) Embryotoxicity of cobalt ferrite and gold nanoparticles: a first in vitro approach. Reprod Toxicol 30:271-276
19. Taylor U, Klein S, Petersen S, Kues W, Barcikowski S, Rath D (2010) Nonendosomal cellular uptake of ligand-free, positively charged gold nanoparticles. Cytometry A 77:439-446
20. Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TGG, Wright CJ, Doak SH (2009) NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30:3891-3914
21. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC (2005) In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88(2):412-419. doi: 10.1093/toxsci/kfi 256
22. Massarsky A, Dupuis L, Taylor J, Eisa-Beygi S, Strek L, Vance L. Trudeau, Thomas W (2013) Moon assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Chemosphere. http:// dx.doi.org/10.1016/j.chemosphere.2013.02.060
23. Wang Q, Ebbs SD, Chen Y, Ma X (2013) Transgenerational impact of cerium oxide nanoparticles on tomato plants. Metallomics 5:753-759
24. Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, Snyder SE, Yan B (2010) Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol 5:683-689
25. Yoshida S, Hiyoshi K, Ichinose T, Takano H, Oshio S, Sugawara I, Takeda K, Shibamoto T (2009) Effect of nanoparticles on the male reproductive system of mice. Int J Androl 32:337-342
26. Takeda K, Suzuki K-I, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, Oshio S, Nihei Y, Ihara T, Sugamata M (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55:95-102
27. Yoshida S, Hiyoshi K, Oshio S, Takano H, Takeda K, Ichinose T (2010) Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring. Fertil Steril 93:1695-1699
28. Hemmingsen JG, Hougaard KS, Talsness C, Wellejus A, Loft S, Wallin H, Møller P (2009) Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. Toxicology 264:61-68
29. Ono N, Oshio S, Niwata Y, Yoshida S, Tsukue N, Sugawara I, Takano H, Takeda K (2007) Prenatal exposure to diesel exhaust impairs mouse spermatogenesis. Inhal Toxicol 19:275-281
30. Watanabe N (2005) Decreased number of sperms and Sertoli cells in mature rats exposed to diesel exhaust as fetuses. Toxicol Lett 155:51-58
31. Ritz C, Ruminski W, Hougaard KS, Wallin H, Vogel U, Yauk CL (2011) Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation. Mutat Res 712:55-58
32. Swierstra EE (1968) A comparison of spermatozoa production and spermatozoa output of Yorkshire and Lacombe boars. J Reprod Fertil 17:459-469
33. Hougaard KS, Fadeel B, Gulumian M, Kagan VE, Savolainen K (2011) Developmental toxicity of engineered nanoparticles. In: Gupta RC (ed) Reproductive and developmental toxicology. Academic, Amsterdam, pp 269-290
34. Menezes V, Malek A, Keelan JA (2011) Nanoparticulate drug delivery in pregnancy: placental passage and fetal exposure. Curr Pharm Biotechnol 12:731-742
35. Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, Wallin H (2008) Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity, and inflammation in mice. Part Fibre Toxicol 5:3
36. Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Loschner K, Larsen EH, Birkedal RK, Vibenholt A, Boisen AM, Wallin H, Vogel U (2010) Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 7:16
37. Izawa H, Kohara M, Watanabe G, Taya K, Sagai M (2007) Effects of diesel exhaust particles on the male reproductive system in strains of mice with different aryl hydrocarbon receptor responsiveness. J Reprod Dev 53:1191-1197
38. Yoshida S, Yoshida M, Sugawara I, Takeda K (2006) Mice strain differences in effects of fetal exposure to diesel exhaust gas on male gonadal differentiation. Environ Sci 13(2):117-123
39. Sadauskas E, Jacobsen NR, Danscher G, Stoltenberg M, Vogel U, Larsen A, Kreyling W, Wallin H (2009) Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation. Chem Cent J 3:16
40. Hakonsen LB, Spano M, Bonde JP, Olsen J, Thulstrup AM, Ernst E, Ramlau-Hansen CH (2013) Exposures that may affect sperm DNA integrity: two decades of follow-up in a pregnancy cohort. Reprod Toxicol 33(3):316-321
41. Rajender S, Avery K, Agarwal A (2011) Epigenetics, spermatogenesis and male infertility. Mutat Res 727(3):62-71
42. Boisen AM, Shipley T, Jackson P, Hougaard KS, Wallin H, Yauk CL, Vogel U (2012) Nano TIO 2(UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice. Part Fibre Toxicol 9(1):19
43. Yu T, Malugin A, Ghandehari H (2011) Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano 5:5717-5728
44. Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T, Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, Tsunoda S, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y (2011) Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 6:321-328
45. Morishita Y, Yoshioka Y, Satoh H, Nojiri N, Nagano K, Abe Y, Kamada H, Tsunoda S, Nabeshi H, Yoshikawa T, Tsutsumi Y (2012) Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice. Biochem Biophys Res Commun 420:297-301
46. Kim JS, Yoon TJ, Yu KN, Kim BG, Park SJ, Kim HW, Lee KH, Park SB, Lee JK, Cho MH (2006) Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 89:338-347
47. De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29:1912-1919
48. Aitken RJ, De Iuliis GN, McLachlan RI (2009) Biologic and clinical significance of DNA damage in the male germ line. Int J Androl 32:46-56
49. Anway MD, Cupp AS, Uzumcu M, Skinner MK (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308: 1466-1469
50. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ (2010) Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143:1084-1096
51. Boekelheide K, Fleming SL, Johnson KJ, Patel SR, Schoenfeld HA (2000) Role of Sertoli cells in injuryassociated testicular germ cell apoptosis. Exp Biol Med 225(2):105-115
52. Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC (2010) Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci 116(2):577-589
53. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC (2005) In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88(2):412-419
54. Lan Z, Yang WX (2012) Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier. Nanomedicine 7(4):579-596
55. Shi L, Xun W, Yue W, Zhang C, Ren Y, Shi L, Wang Q, Yang R, Lei F (2011) Effect of sodium selenite, Se-yeast and nano-elemental selenium on growth performance, Se concentration and antioxidant status in growing male goats. Small Ruminant Res 96(1):49-52
56. Shi L, Yang R, Yue W, Xun WJ, Zhang CX, Ren YS, Shi L, Lei FL (2010) Effect of elemental nanoselenium quality, glutathione peroxidase activity, and testis ultrastructure in male Boer goats. Anim Reprod Sci 118(2,4):248-254
57. Sharma V, Singh P, Pandey AK, Dhawan A (2012) Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 745(1-2):84-91
58. Wang L, Ding W, Zhang F (2010) Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. J Nanosci Nanotechnol 10(12):8617-8624
59. Gromadzka-Ostrowskaa J, Dziendzikowskaa K, Lankoffb A, Dobrzyńska M, Instanes C, Brunborg G, Gajowik A, Radzikowska J, Wojewódzka M, Kruszewski M (2012) Silver nanoparticles effects on epididymal spermin rats. Toxicol Lett 214(3):251-258
60. Komatsu T, Tabata M, Kubo-Irie M, Shimizu T, Suzuki K, Nihei Y, Takeda K (2008) The effects of nanoparticles on mouse testis Leydig cells in vitro. Toxicol In Vitro 22(8):1825-1831
61. Yu KN, Yoon TJ, Minai-Tehrani A, Kim JE, Park SJ, Jeong MS, Ha SW, Lee JK, Kim JS, Cho MH (2013) Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro 27(4):1187-1195
62. Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, Diener PA, Zisch A, Krug HF, von Mandach U (2010) Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118:432-436
63. Myllynen PK, Loughran MJ, Howard CV, Sormunen R, Walsh AA, Vahakangas KH (2008) Kinetics of gold nanoparticles in the human placenta. Reprod Toxicol 26:130-137
64. Semmler-Behnke M, Fertsch S, Schmid G, Wenk A, Kreyling W (2007) Uptake of 1.4 nm versus 18 nm gold nanoparticles by secondary target organs is size dependent in and pregnant rats after intertracheal or intravenous application. EuroNanoForum 2007:102-104
65. Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, Danscher G (2007) Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol 4:10
66. Chu M, Wu Q, Yang H, Yuan R, Hou S, Yang Y, Zou Y, Xu S, Xu K, Ji A, Sheng L (2010) Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 6:670-678
67. Taylor U, Petersen S, Barchanski A, Mittag A, Barcikowski S, Rath D (2010) Influence of gold nanoparticles on vitality parameters of bovine spermatozoa. Reprod Domest Anim 45:60
68. Zakhidov ST, Marshak TL, Malolina EA, Kulibin AY, Zelenina IA, Pavluchenkova SM, Rudoy VM, Dement'eva OV, Skuridin SG, Evdokimov YM (2010) Gold nanoparticles disturb nuclear chromatin decondensation in mouse sperm in vitro. Biol Membr 4:349-353
69. Makhluf SBD, Qasem R, Rubinstein S, Gedanken A, Breitbart H (2006) Loading magnetic nanoparticles into sperm cells does not affect their functionality. Langmuir 22:9480-9482
70. Gopalan R, Osman I, de Matas M, Anderson D (2009) The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes. Environ Mol Mutagen 50:541-541
71. Hou J, Wan XY, Wang F, Xu GF, Liu Z (2009) Effects of titanium dioxide nanoparticles on development and maturation of rat preantral follicle in vitro. Acad J Second Mil Med Univ 29:869-873
72. Hsieh MS, Shiao NH, Chan WH (2009) Cytotoxic effects of CdSe quantum dots on maturation of mouse oocytes, fertilization, and fetal development. Int J Mol Sci 10:2122-2135
73. Bar-Ilan O, Albrecht RM, Fako VE, Furgeson DY (2009) Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. Small 5:1897-1910
74. Browning LM, Lee KJ, Huang T, Nallathamby PD, Lowman JE, Xu XHN (2009) Random walk of single gold nanoparticles in zebrafish embryos leading to stochastic toxic effects on embryonic developments. Nanoscale 1:138-152
75. Laban G, Nies LF, Turco RF, Bickham JW, Sepulveda MS (2010) The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Ecotoxicology 19:185-195
76. Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu XH (2007) In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1:133-143
77. Ringwood AH, McCarthy M, Bates TC, Carroll DL (2010) The effects of silver nanoparticles on oyster embryos. Mar Environ Res 69(Suppl):S49-S51
78. Wu Y, Zhou Q, Li H, Liu W, Wang T, Jiang G (2010) Effects of silver nanoparticles on the development and histopathology biomarkers of Japanese medaka (Oryzias latipes) using the partial-life test. Aquat Toxicol 100:160-167
79. Yeo MK, Yoon JW (2009) Comparison of the effects of nano-silver antibacterial coatings and silver ions on Zebrafish embryogenesis. Mol Cell Toxicol 5:23-31
80. Ispas C, Andreescu D, Patel A, Goia DV, Andreescu S, Wallace KN (2009) Toxicity and developmental defects of different sizes and shape nickel nanoparticles in Zebrafish. Environ Sci Technol 43:6349-6356
81. Bai W, Zhang ZY, Tian WJ, He X, Ma YH, Zhao YL, Chai ZF (2010) Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism. J Nanopart Res 5:1645-1654
82. Yeo MK, Kang M (2009) Effects of Cu (x) TiO (y) nanometer particles on biological toxicity during zebrafish embryogenesis. Korean J Chem Eng 3:711-718
83. Zhu XS, Zhu L, Duan ZH, Qi RQ, Li Y, Lang YP (2008) Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage. J Environ Sci Health A Tox Hazard Subst Environ Eng 43:278-284
84. Musee N, Oberholster PJ, Sikhwivhilu L, Botha AM (2010) The effects of engineered nanoparticles on survival, reproduction, and behaviour of freshwater snail, Physa acuta (Draparnaud, 1805). Chemosphere 81:1196-1203
85. Bai W, Tian W, Zhang Z, He X, Ma Y, Liu N, Chai Z (2010) Effects of copper nanoparticles on the development of zebrafish embryos. J Nanosci Nanotechnol 10:8670-8676
86. Zielinska AK, Sawosz E, Grodzik M, Chwalibog A, Kamaszewski M (2009) Influence of nanoparticles of gold on chicken embryos' development. Ann Warsaw Univ Life Sci SGGW Anim Sci 46:249-253
87. Grodzik M, Sawosz E (2006) The influence of silver nanoparticles on chicken embryo development and bursa of Fabricius morphology. J Anim Feed Sci 15:111-114
88. Sikorska J, Szmidt M, Sawosz E, Niemiec T, Grodzik M, Chwalibog A (2010) Can silver nanoparticles affect the mineral content, structure and mechanical properties of chicken embryo bones? J Anim Feed Sci 2:286-291
89. Studnicka A, Sawosz E, Grodzik M, Chwalibog A, Balcerak M (2009) Influence of nanoparticles of silver/ palladium alloy on chicken embryos' development. Ann Warsaw Univ Life Sci SGGW Anim Sci 46:237-242
90. Sawosz E, Grodzik M, Zielinska M, Niemiec T, Olszanka B, Chwalibog A (2009) Nanoparticles of silver do not affect growth, development and DNA oxidative damage in chicken embryos. Arch Geflugelkd 73:208-213
91. Takahashi Y, Mizuo K, Shinkai Y, Oshio S, Takeda K (2010) Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice. J Toxicol Sci 35:749-756
92. Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K (2009) Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol 6:20
93. Gao X, Yin S, Tang M, Chen J, Yang Z, Zhang W, Chen L, Yang B, Li Z, Zha Y, Ruan D, Wang M (2011) Effects of developmental exposure to TiO 2nanoparticles on synaptic plasticity in hippocampal dentate gyrus area: an in vivo study in anesthetized rats. Biol Trace Elem Res 143:1616-1628
94. Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L (2008) Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol 38:57-67
95. Li PW, Kuo TH, Chang JH, Yeh JM, Chan WH (2010) Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles. Toxicol Lett 197:82-87
96. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP (2009) Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 4:876-883
97. Genschow E, Spielmann H, Scholz G, Pohl I, Seiler A, Seiler A, Clemann N, Bremer S, Becker K (2004) Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 32:209-244
98. Cheng JP, Chan CM, Veca LM, Poon WL, Chan PK, Qu L, Sun YP, Cheng SH (2009) Acute and longterm effects after single loading of functionalized multi-walled carbon nanotubes into zebrafish (Danio rerio). Toxicol Appl Pharmacol 235:216-225
99. Kostarelos K (2008) The long and short of carbon nanotube toxicity. Nat Biotechnol 26:774-776
100. Benn TM, Westerhoff P (2008) Nanoparticle silver released into water from commercially available sock fabrics. Environ Sci Technol 42:4133-4139
101. Kashiwada S, Ariza ME, Kawaguchi T, Nakagame Y, Jayasinghe BS, Gartner K, Nakamura H, Kagami Y, Sabo-Attwood T, Ferguson PL, Chandler GT (2012) Silver nanocolloids disrupt medaka embryogenesis through vital gen expressions. Environ Sci Technol 46:6278-6287
102. Bar-Ilan O, Albrecht R, Fako V, Furgeson D (2009) Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. Small 17: 897-910
103. AshaRani PV, Lianwu Y, Gong Z, Valiyaveettil S (2011) Comparison of the toxicity of silver, gold, and platinum nanoparticles in developing zebrafish embryo. Nanotoxicology 5:43-54
104. Navarro E, Baun A, Behra R, Hartmann NB, Filser J, Miao AJ, Quigg A, Santschi PH, Sigg L (2008) Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi. Ecotoxicology 17:372-386
105. Yin L, Cheng Y, Espinasse B, Colman BP, Auffan M, Wiesner M, Rose J, Liu J, Bernhardt ES (2011) More than the ions: the effects of silver nanoparticles on Lolium multiflorum. Environ Sci Technol 45: 2360-2367
106. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE (1992) Evidence for decreasing quality of semen during past 50 years. BMJ 305:609-613
107. Yu X, Sidhu JS, Hong S, Faustman EM (2005) Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat Sertoli cell/gonocyte co-cultures: an improved in vitro model for assessment of male reproductive toxicity. Toxicol Sci 84: 378-393
108. Aoyagi T, Ishikawa H, Miyaji K, Hayakawa K, Hata M (2002) Cadmium-induced testicular damage in a rat model of subchronic intoxication. Reprod Med Biol 1:59-63
109. Rico CM, Majumdar S, Duarte-Gardea M, Peralta-Videa R, Gardea-Torresdey JL (2011) Interaction of nanoparticles with edible plants and their possible implications in the food chain. J Agric Food Chem 59(8):3485-3498