Developmental toxicity of engineered nanoparticles

Reproductive and Developmental Toxicology

Volumn , Issue , 2011, Pages 269-290

  Hougaard, Karin Sørig ^a   Fadeel, Bengt ^b   Gulumian, Mary ^c   Kagan, Valerian E ^d   Savolainen, Kai M ^e  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b KAROLINSKA INSTITUTE   (Sweden)

^c National Centre for Occupational Health   (South Africa)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 81255139774     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-382032-7.10021-9     Document Type: Chapter

References (163)

1. G. Adlakha-Hutcheon, R. Khaydarov, R. Korenstein, R. Varma, A. Vaseashta, H. Stamm and M. Abdel-Mottaleb (2009) Nanomaterials, nanotechnology: applications, consumer products, and benefits. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 195-207
2. R.J. Aitken, K.S. Creely and C.L. Tran (2004) Nanoparticles: an occupational hygiene review. Health Safety Executive (HSE) 1-113
3. M.E. Akerman, W.C. Chan, P. Laakkonen, S.N. Bhatia and E. Ruoslahti (2002) Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 99 12617-12621
4. N.S. Allen, M. Edge, G. Sandoval, J. Verran, J. Stratton and J. Maltby (2005) Photocatalytic coatings for environmental applications. Photochem Photobiol 81 279-290
5. H. Bayir, P.M. Kochanek and V.E. Kagan (2006) Oxidative stress in immature brain after traumatic brain injury. Dev Neurosci 28 420-431
6. G. Bhabra, A. Sood, B. Fisher, L. Cartwright, M. Saunders, W.H. Evans, A. Surprenant, G. Lopez-Castejon, S. Mann, S.A. Davis, L.A. Hails, E. Ingham, P. Verkade, J. Lane, K. Heesom, R. Newson and C.P. Case (2009) Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 4 876-883
7. K. Bhattacharya, M. Davoren, J. Boertz, R.P. Schins, E. Hoffmann and E. Dopp (2009) Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Part Fibre Toxicol 6 17
8. P. Bihari, M. Vippola, S. Schultes, M. Praetner, A.G. Khandoga, C.A. Reichel, C. Coester, T. Tuomi, M. Rehberg and F. Krombach (2008) Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol 5 14
9. K. Bladh, L.K.L. Falk and F. Rohmund (2000) On the iron-catalyzed growth of single-walled carbon nanotubes and encapsulated metal particles in the gas phase. Appl Phys A 70 317-322
10. S.J. Bosman, S.P. Nieto, W.C. Patton, J.D. Jacobson, J.U. Corselli and P.J. Chan (2005) Development of mammalian embryos exposed to mixed-size nanoparticles. Clin Exp Obstet Gynecol 32 222-224
11. J.A. Brant, J. Labille, J.Y. Bottero and M.R. Wiesner (2006) Characterizing the impact of preparation method on fullerene cluster structure and chemistry. Langmuir 22 3878-3885
12. S. Broos, K. Lundberg, T. Akagi, K. Kadowaki, M. Akashi, L. Greiff, C.A. Borrebaeck and M. Lindstedt (2010) Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapy. Vaccine In press
13. M. Bruchez Jr., M. Moronne, P. Gin, S. Weiss and A.P. Alivisatos (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281 2013-2016
14. O. Carp, C.L. Huisman and A. Reller (2004) Photoinduced reactivity of titanium dioxide. Progr Solid State Chem 32 33-177
15. J.C. Challier, M. Panigel and E. Meyer (1973) Uptake of colloidal 198Au by fetal liver in rat, after direct intrafetal administration. Int J Nucl Med Biol 1 103-106
16. W.C. Chan and S. Nie (1998) Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281 2016-2018
17. W.H. Chan and N.H. Shiao (2008) Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol Sin 29 259-266
18. E. Chang, N. Thekkek, W.W. Yu, V.L. Colvin and R. Drezek (2006) Evaluation of quantum dot cytotoxicity based on intracellular uptake. Small 2 1412-1417
19. X. Chen and S.S. Mao (2006) Synthesis of titanium dioxide (TiO2) nanomaterials. J Nanosci Nanotechnol 6 906-925
20. Y. Cheng and O. Zhou (2003) Electron field emission from carbon nanotubes. C R Physique 4 1021-1033
21. M.J. Cunningham (2007) Gene–cellular interactions of nanomaterials: genotoxicity to genomics. N.A. Monteiro-Riviere, C.L. Tran (Eds) Nanotoxicology – Characterization, Dosing and Health Effects New York: Informa Healthcare 173-196
22. B.O. Dabbousi, J. Rodriguez-Viejo, F.V. Mikulec, J.R. Heine, H. Mattoussi, R. Ober, K.F. Jensen and M.G. Bawendi (1997) (CdSe)ZnS Core–shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J Phys Chem B 101 9463-9475
23. J.B. Delehanty, H. Mattoussi and I.L. Medintz (2009) Delivering quantum dots into cells: strategies, progress and remaining issues. Anal Bioanal Chem 393 1091-1105
24. A. Di Sotto, M. Chiaretti, G.A. Carru, S. Bellucci and G. Mazzanti (2009) Multi-walled carbon nanotubes: lack of mutagenic activity in the bacterial reverse mutation assay. Toxicol Lett 184 192-197
25. B. Diaz, C. Sanchez-Espinel, M. Arruebo, J. Faro, M.E. de, S. Magadan, C. Yague, R. Fernandez-Pacheco, M.R. Ibarra, J. Santamaria and A. Gonzalez-Fernandez (2008) Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates. Small 4 2025-2034
26. U. Diebold (2003) The surface science of titanium dioxide. Surface Science Reports 48 53-229
27. M.A. Dobrovolskaia and S.E. McNeil (2007) Immunological properties of engineered nanomaterials. Nat Nanotechnol 2 469-478
28. A. Elder, I. Lynch, K. Grieger, S. Chan-Remillard, A. Gatti, H. Gnewuch, E. Kenaway, R. Korenstein, T. Kuhlbusch, F. Linker, S. Matias, N.A. Monteiro-Riviere, V.R.S. Pinto, R. Rudnitsky, K. Savolainen and A.A. Shvedova (2009) Human health risks of engineered nanomaterials: critical knowledge gaps in nanomaterials risk assessment. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 3-29
29. J.D.D. Evanoff and G. Chumanov (2005) Synthesis and optical properties of silver nanoparticles and arrays. Chemphyschem 6 1221-1231
30. B. Fadeel and A.E. Garcia-Bennett (2010) Better safe than sorry: understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. Adv Drug Deliv Rev 62 362-374
31. G.C. Falck, H.K. Lindberg, S. Suhonen, M. Vippola, E. Vanhala, J. Catalan, K. Savolainen and H. Norppa (2009) Genotoxic effects of nanomaterials: induction of DNA damage and micronuclei by TiO2 in human bronchial epithelial cells. Hum Exp Toxicol 28 339-352
32. A.V. Fedulov and L. Kobzik (2008) Immunotoxicologic analysis of maternal transmission of asthma risk. J Immunotoxicol 5 445-452
33. A.V. Fedulov, A. Leme, Z. Yang, M. Dahl, R. Lim, T.J. Mariani and L. Kobzik (2008) Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol 38 57-67
34. H.C. Fischer and W.C. Chan (2007) Nanotoxicity: the growing need for in vivo study. Curr Opin Biotechnol 18 565-571
35. R.D. Folkerth, R.L. Haynes, N.S. Borenstein, R.A. Belliveau, F. Trachtenberg, P.A. Rosenberg, J.J. Volpe and H.C. Kinney (2004) Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol 63 990-999
36. A. Fujimoto, N. Tsukue, M. Watanabe, I. Sugawara, R. Yanagisawa, H. Takano, S. Yoshida and K. Takeda (2005) Diesel exhaust affects immunological action in the placentas of mice. Environ Toxicol 20 431-440
37. T.L. Fynewever, E.S. Agcaoili, J.D. Jacobson, W.C. Patton and P.J. Chan (2007) In vitro tagging of embryos with nanoparticles. J Assist Reprod Genet 24 61-65
38. M. Geiser, M. Casaulta, B. Kupferschmid, H. Schulz, M. Semmler-Behnke and W. Kreyling (2008) The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am J Respir Cell Mol Biol 38 371-376
39. P. Ghosh, G. Han, M. De, C.K. Kim and V.M. Rotello (2008) Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60 1307-1315
40. L. Gonzalez, D. Lison and M. Kirsch-Volders (2008) Genotoxicity of engineered nanomaterials: a critical review. Nanotechnology 2 252-273
41. P.S. Guzelian, M.S. Victoroff, C. Halmes and R.C. James (2009) Clear path: towards an evidence-based toxicology (EBT). Hum Exp Toxicol 28 71-79
42. K. Hamada, Y. Suzaki, A. Leme, T. Ito, K. Miyamoto, L. Kobzik and H. Kimura (2007) Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A 70 688-695
43. P.M. Henson (2005) Dampening inflammation. Nat Immunol 6 1179-1181
44. M.A. Hines and P. Guyot-Sionnest (1996) Synthesis and characterization of strongly luminescing ZnS-capped CdSe nanocrystals. J Phys Chem B 100 468-471
45. L.R. Hirsch, R.J. Stafford, J.A. Bankson, S.R. Sershen, B. Rivera, R.E. Price, J.D. Hazle, N.J. Halas and J.L. West (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 100 13549-13554
46. K.S. Hougaard, P. Jackson, K.A. Jensen, J.J. Sloth, K. Löschner, E.H. Larsen, R.K. Birkedal, A. Vibenholt, A.M. Boisen, H. Wallin and U. Vogel (2010) Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 14(7), 16
47. K.S. Hougaard, K.A. Jensen, P. Nordly, C. Taxvig, U. Vogel, A.T. Saber and H. Wallin (2008) Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice. Part Fibre Toxicol 5 3
48. M.S. Hsieh, N.H. Shiao and W.H. Chan (2009) Cytotoxic effects of CdSe quantum dots on maturation of mouse oocytes, fertilization, and fetal development. Int J Mol Sci 10 2122-2135
49. J.A. Hubbell, S.N. Thomas and M.A. Swartz (2009) Materials engineering for immunomodulation. Nature 462 449-460
50. S. Iijima (1991) Helical microtubules of graphitic carbon. Nature 354 56-58
51. K. Inoue, R. Yanagisawa, E. Koike, M. Nishikawa and H. Takano (2010) Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: possible role of oxidative stress. Free Radic Biol Med 48 924-934
52. G.M. Jonakait (2007) The effects of maternal inflammation on neuronal development: possible mechanisms. Int J Dev Neurosci 25 415-425
53. V.E. Kagan, H. Bayir and A.A. Shvedova (2005) Nanomedicine and nanotoxicology: two sides of the same coin. Nanomedicine 1 313-316
54. V.E. Kagan, N.V. Konduru, W. Feng, B.L. Allen, J. Conroy, Y. Volkov, Vlasova II, N.A. Belikova, N. Yanamala, A. Kapralov, Y.Y. Tyurina, J. Shi, E.R. Kisin, A.R. Murray, J. Franks, D. Stolz, P. Gou, J. Klein-Seetharaman, B. Fadeel, A. Star and A.A. Shvedova (2010) Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol 5 354-359
55. V.E. Kagan, Y.Y. Tyurina, V.A. Tyurin, N.V. Konduru, A.I. Potapovich, A.N. Osipov, E.R. Kisin, D. Schwegler-Berry, R. Mercer, V. Castranova and A.A. Shvedova (2006) Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron. Toxicol Lett 165 88-100
56. I. Kaplan-Ashiri, S.R. Cohen, K. Gartsman, V. Ivanoskaya, T. Heine, G. Seifert, I. Wiesel, H.D. Wagner and R. Tenne (2006) On the mechanical behavior of WS2 nanotubes under axial tension and compression. Proc Natl Acad Sci USA 103 523-528
57. H.L. Karlsson, J. Gustafsson, P. Cronholm and L. Moller (2009) Size-dependent toxicity of metal oxide particles – a comparison between nano- and micrometer size. Toxicol Lett 188 112-118
58. R.D. Kennison, W.A. Bardawil and G.W. Mitchell Jr. (1971) Passage of particles across the mouse placenta. Surg Forum 22 392-394
59. E.R. Kisin, A.R. Murray, M.J. Keane, X.C. Shi, D. Schwegler-Berry, O. Gorelik, S. Arepalli, V. Castranova, W.E. Wallace, V.E. Kagan and A.A. Shvedova (2007) Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health A 70 2071-2079
60. T. Komatsu, M. Tabata, M. Kubo-Irie, T. Shimizu, K. Suzuki, Y. Nihei and K. Takeda (2008) The effects of nanoparticles on mouse testis Leydig cells in vitro. Toxicol in Vitro 22 1825-1831
61. N.V. Konduru, Y.Y. Tyurina, W. Feng, L.V. Basova, N.A. Belikova, H. Bayir, K. Clark, M. Rubin, D. Stolz, H. Vallhov, A. Scheynius, E. Witasp, B. Fadeel, P.D. Kichambare, A. Star, E.R. Kisin, A.R. Murray, A.A. Shvedova and V.E. Kagan (2009) Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS One 4 e4398
62. P. Kopf-Maier, U. Brauchle and A. Heussler (1988) Transplacental passage of titanium after treatment with titanocene dichloride. Toxicology 48 253-260
63. W.G. Kreyling, M. Semmler-Behnke, J. Seitz, W. Scymczak, A. Wenk, P. Mayer, S. Takenaka and G. Oberdörster (2009) Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol 21(Suppl. 1), 55-60
64. H.W. Kroto, J.R. Heath, S.C. O'Brien, R.F. Curl and R.E. Smalley (1985) C60: Buckminsterfullerene. Nature 318 162-163
65. T. Kuhlbusch, H. Fissan and C. Asbach (2009) Nanotechnologies and environmental risks: measurement technologies and strategies. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 233-243
66. S. Lal, S.E. Clare and N.J. Halas (2008) Nanoshell-enabled photothermal cancer therapy: impending clinical impact. Acc Chem Res 41 1842-1851
67. C.W. Lam, J.T. James, R. McCluskey, S. Arepalli and R.L. Hunter (2006) A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36 189-217
68. D.P. Lamoureux, L. Kobzik and A.V. Fedulov (2010) Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy. J Toxicol Environ Health A 73 596-606
69. R. Landsiedel, M.D. Kapp, M. Schulz, K. Wiench and F. Oesch (2009) Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations – many questions, some answers. Mutat Res 681 241-258
70. S.T. Larsen, M. Roursgaard, K.A. Jensen and G.D. Nielsen (2010) Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice. Basic Clin Pharmacol Toxicol 106 114-117
71. P. Latzin, M. Roosli, A. Huss, C.E. Kuehni and U. Frey (2009) Air pollution during pregnancy and lung function in newborns: a birth cohort study. Eur Respir J 33 594-603
72. C.C. Lawson, B. Grajewski, G.P. Daston, L.M. Frazier, D. Lynch, M. McDiarmid, E. Murono, S.D. Perreault, W.A. Robbins, M.A. Ryan, M. Shelby and E.A. Whelan (2006) Workgroup report: implementing a national occupational reproductive research agenda – decade one and beyond. Environ Health Perspect 114 435-441
73. J.G. Li, W.X. Li, J.Y. Xu, X.Q. Cai, R.L. Liu, Y.J. Li, Q.F. Zhao and Q.N. Li (2007) Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation. Environ Toxicol 22 415-421
74. Z. Liu, Y. He, F. Li and Y. Liu (2006) Photocatalytic treatment of RDX wastewater with nano-sized titanium dioxide. Environ Sci Pollut Res Int 13 328-332
75. R.O. Loutfy, T.P. Lowe, A.P. Moravesky and S. Katagiri (2002) Commercial production of fullerenes and carbon nanotubes. Perspectives of Fullerene Nanotechnology Netherlands: Springer
76. L. Ma, J. Liu, N. Li, J. Wang, Y. Duan, J. Yan, H. Liu, H. Wang and F. Hong (2010) Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials 31 99-105
77. D. Mahalu, L. Margulis, A. Wold and R. Tenne (1992) Preparation of WSe2 surfaces with high photoactivity. Phys Rev B Condens Matter 45 1943-1946
78. A.D. Maynard (2002) Experimental determination of ultrafine TiO2 de-agglomeration in surrogate pulmonary surfactant – preliminary results. Ann Occup Hyg 46 197-202
79. A.D. Maynard and R. Aitken (2007) Assessing exposure to airborne nanomaterials: current abilities and future requirements. Nanotoxicology 1 26-41
80. A.D. Maynard, R.J. Aitken, T. Butz, V. Colvin, K. Donaldson, G. Oberdörster, M.A. Philbert, J. Ryan, A. Seaton, V. Stone, S.S. Tinkle, L. Tran, N.J. Walker and D.B. Warheit (2006) Safe handling of nanotechnology. Nature 444 267-269
81. A.D. Maynard, P.A. Baron, M. Foley, A.A. Shvedova, E.R. Kisin and V. Castranova (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 67 87-107
82. I.L. Medintz and H. Mattoussi (2009) Quantum dot-based resonance energy transfer and its growing application in biology. Phys Chem Chem Phys 11 17-45
83. M. Melkonyan and S. Kozyrev (2009) The current state-of-the-art in the area of nanotechnology risk assessment in Russia. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 309-315
84. U. Meyer, J. Feldon and S.H. Fatemi (2009) In vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev 33 1061-1079
85. M.I. Montanez, A.J. Ruiz-Sanchez and E. Perez-Inestrosa (2010) A perspective of nanotechnology in hypersensitivity reactions including drug allergy. Curr Opin Allergy Clin Immunol In press
86. C. Monteiller, L. Tran, W. MacNee, S. Faux, A. Jones, B. Miller and K. Donaldson (2007) The pro-inflammatiory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med 64 609-615
87. J. Muller, I. Decordier, P.H. Hoet, N. Lombaert, L. Thomassen, F. Huaux, D. Lison and M. Kirsch-Volders (2008) Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 29 427-433
88. C.J. Murphy, A.M. Gole, J.W. Stone, P.N. Sisco, A.M. Alkilany, E.C. Goldsmith and S.C. Baxter (2008) Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res 41 1721-1730
89. P.K. Myllynen, M.J. Loughran, C.V. Howard, R. Sormunen, A.A. Walsh and K.H. Vahakangas (2008) Kinetics of gold nanoparticles in the human placenta. Reprod Toxicol 26 130-137
90. M.N. Nadagouda and R. Varma (2009) Risk reduction via greener synthesis of noble metal nanostructures. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 209-217
91. A.B.D. Nandiyanto, F. Iskandar and K. Okuyama (2008) Nano-sized polymer particle-facilitated preparation of mesoporous silica particles using a spray method. Chemistry Letters 37 1040
92. A.B.D. Nandiyanto, S.-G.F.I. Kim and K. Okuyama (2009) Synthesis of silica nanoparticles with nanometer-size controllable mesopores and outer diameters. Microporous and Mesoporous Materials 120 447-453
93. NIOSH (2009) Current Intelligence Bulletin 60: Interim Guidance for Medical Screening and Hazard Surveillance for Workers Potentially Exposed to Engineered Nanoparticles. Ref Type: Report
94. A.W. Nørgaard, K.A. Jensen, C. Janfelt, F.R. Lauritzen, P.A. Clausen and P. Wolkoff (2009) Release of VOCs and particles during use of nanofilm spray products. Environ Sci Technol 43 7824-7830
95. T.R. Nurkiewicz, D.W. Porter, A.F. Hubbs, J.L. Cumpston, B.T. Chen, D.G. Frazer and V. Castranova (2008) Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Part Fibre Toxicol 5 1
96. U.C. Nygaard, J.S. Hansen, M. Samuelsen, T. Alberg, C.D. Marioara and M. Lovik (2009) Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice. Toxicol Sci 109 113-123
97. G. Oberdörster, A. Elder and A. Rinderknecht (2009) Nanoparticles and the brain: cause for concern? J Nanosci Nanotechnol 9 4996-5007
98. G. Oberdörster, J. Ferin and B.E. Lehnert (1994) Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl. 5), 173-179
99. G. Oberdörster, E. Oberdörster and J. Oberdörster (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113 823-839
100. G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, W. Kreyling and C. Cox (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16 437-445
101. G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, A. Lunts, W. Kreyling and C. Cox (2002) Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health 45 1531-1543
102. OECD. OECD Quantitative Structure Activity Relationships [(Q)SARs] Project (2008) OECD Environment Directorate. Report
103. R. Owen, M. Crane, K. Grieger, R. Handy, I. Linkov and M. Depkedge (2009) Strategic approaches for the management of environmental risk uncertainties posed by nanomaterials. I. Linkov, J. Steevens (Eds) Nanomaterials: Risks and Benefits Dordrecht: Springer 369-384
104. E.J. Park, W.S. Cho, J. Jeong, J. Yi, K. Choi and K. Park (2009) Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology 259 113-121
105. J.H. Park, L. Gu, M.G. von, E. Ruoslahti, S.N. Bhatia and M.J. Sailor (2009) Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 8 331-336
106. M.V. Park, W. Annema, A. Salvati, A. Lesniak, A. Elsaesser, C. Barnes, G. McKerr, C.V. Howard, I. Lynch, K.A. Dawson, A.H. Piersma and W.H. de Jong (2009) In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. Toxicol Appl Pharmacol 240 108-116
107. T. Peng, D. Zhao, K. Dai, W. Shi and K. Hirao (2005) Synthesis of titanium dioxide nanoparticles with mesoporous anatase wall and high photocatalytic activity. J Phys Chem B 109 4947-4952
108. A.L. Penn, R.L. Rouse, D.W. Horohov, M.T. Kearney, D.B. Paulsen and L. Lomax (2007) In utero exposure to environmental tobacco smoke potentiates adult responses to allergen in BALB/c mice. Environ Health Perspect 115 548-555
109. T.M. Peters, S. Elzey, R. Johnson, H. Park, V.H. Grassian, T. Maher and P. O'Shaughnessy (2009) Airborne monitoring to distinguish engineered nanomaterials from incidental particles for environmental health and safety. J Occup Environ Hyg 6 73-81
110. C.A. Poland, R. Duffin, I. Kinloch, A. Maynard, W.A. Wallace, A. Seaton, V. Stone, S. Brown, W. MacNee and K. Donaldson (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3 423-428
111. S. Rothenbacher, A. Messerer and G. Kasper (2008) Fragmentation and bond strength of airborne diesel soot agglomerates. Part Fibre Toxicol 5 9
112. J.P. Ryman-Rasmussen, E.W. Tewksbury, O.R. Moss, M.F. Cesta, B.A. Wong and J.C. Bonner (2009) Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. Am J Resp Cell Mol Biol 40 349-358
113. B.A. Rzigalinski and J.S. Strobl (2009) Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots. Toxicol Appl Pharmacol 238 280-288
114. E. Sadauskas, H. Wallin, M. Stoltenberg, U. Vogel, P. Doering, A. Larsen and G. Danscher (2007) Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol 4 10
115. Y. Sakamoto, D. Nakae, N. Fukumori, K. Tayama, A. Maekawa, K. Imai, A. Hirose, T. Nishimura, N. Ohashi and A. Ogata (2009) Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 34 65-76
116. O. Salata (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2 3
117. M. Saunders (2009) Transplacental transport of nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1 671-684
118. K. Savolainen, H. Alenius, H. Norppa, L. Pylkkänen, T. Tuomi and G. Kasper (2010) Risk assessment of engineered nanomaterials and nanotechnologies – a review. Toxicology 269 92-104
119. C.M. Sayes, R. Wahi, P.A. Kurian, Y. Liu, J.L. West, K.D. Ausman, D.B. Warheit and V.L. Colvin (2006) Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92 174-185
120. SCCP (2007) Opinion on safety of nanomaterials in cosmetic products. European Commission, Health and Consumer Protection DG, Brussels. Scientific Committee on Consumer Products. Ref Type: Electronic Citation
121. SCENIHR (2007) Opinion on the appropiateness of the risk assessment methodology in accordance with the technical guidance documents for new and existing substances for assessing the risks of nanomaterials. European Commission, Health and Consumer Protection DG, Brussels. Scientific Committee on Emerging and Newly-Identified Health Risks. Ref Type: Electronic Citation
122. P.A. Schulte, M.K. Schubauer-Berigan, C. Mayweather, C.L. Geraci, R. Zumwalde and J.L. McKernan (2009) Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. J Occup Environ Med 51 323-335
123. P.A. Schulte, D. Trout, R.D. Zumwalde, E. Kuempel, C.L. Geraci, V. Castranova, D.J. Mundt, K.A. Mundt and W.E. Halperin (2008) Options for occupational health surveillance of workers potentially exposed to engineered nanoparticles: state of the science. J Occup Environ Med 50 517-526
124. M. Seipenbusch, A. Binder and G. Kasper (2008) Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg 52 707-716
125. M. Semmler-Behnke, S. Fertsch, G. Schmid, A. Wenk and W.G. Keryling (2007) Uptake of 1.4 nm versus 18 nm gold particles by secondary target organs is size dependent in control and pregnant rats after intratracheal or intravenous application. Nanotoxicology Abstract Book 14. Ref Type: Abstract
126. T. Shimada, T. Sugai, Y. Ohno, S. Kishimoto, T. Mizutani, H. Yoshida, T. Okazaki and H. Shinohara (2004) Double-wall carbon nanotube field-effect transistors: ambipolar transport characteristics. Appl Phys Lett 84 2412-2414
127. M. Shimizu, H. Tainaka, T. Oba, K. Mizuo, M. Umezawa and K. Takeda (2009) Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol 6 20
128. A.A. Shvedova, V.E. Kagan and B. Fadeel (2010) Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems. Annu Rev Pharmacol Toxicol 50 63-88
129. A.A. Shvedova, E.R. Kisin, R. Mercer, A.R. Murray, V.J. Johnson, A.I. Potapovich, Y.Y. Tyurina, O. Gorelik, S. Arepalli, D. Schwegler-Berry, A.F. Hubbs, J. Antonini, D.E. Evans, B.K. Ku, D. Ramsey, A. Maynard, V.E. Kagan, V. Castranova and P. Baron (2005) Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289 L698-L708
130. A.A. Shvedova, E.R. Kisin, A.R. Murray, O. Gorelik, S. Arepalli, V. Castranova, S.H. Young, F. Gao, Y.Y. Tyurina, T.D. Oury and V.E. Kagan (2007) Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicol Appl Pharmacol 221 339-348
131. A.A. Shvedova, E.R. Kisin, D. Porter, P. Schulte, V.E. Kagan, B. Fadeel and V. Castranova (2009) Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: two faces of Janus? Pharmacol Ther 121 192-204
132. D. Sidiropoulos, U. Herrmann Jr., A. Morell, M.G. von and S. Barandun (1986) Transplacental passage of intravenous immunoglobulin in the last trimester of pregnancy. J Pediatr 109 505-508
133. S.P. Singh, E.G. Barrett, R. Kalra, S. Razani-Boroujerdi, R.J. Langley, V. Kurup, Y. Tesfaigzi and M.L. Sopori (2003) Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. Am J Respir Crit Care Med 168 342-347
134. S.P. Singh, N.C. Mishra, J. Rir-Sima-Ah, M. Campen, V. Kurup, S. Razani-Boroujerdi and M.L. Sopori (2009) Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and atopy. J Immunol 183 2115-2121
135. S.E. Skrabalak, J. Chen, Y. Sun, X. Lu, L. Au, C.M. Cobley and Y. Xia (2008) Gold nanocages: synthesis, properties, and applications. Acc Chem Res 41 1587-1595
136. P.R. Somani, S.P. Somani, S.P. Lau, E. Flahaut, M. Tanemura and M. Umeno (2007) Field electron emission of double walled carbon nanotube film prepared by drop casting method. Solid-State Electronics 51 788-792
137. G. Speit (2002) Appropriate in vitro test conditions for genotoxicity testing of fibers. Inhal Toxicol 14 79-90
138. V.K. Srivastava, S.S. Chauhan, P.K. Srivastava, V. Kumar and U.K. Misra (1986) Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats. J Toxicol Environ Health 18 459-469
139. A. Takagi, A. Hirose, T. Nishimura, N. Fukumori, A. Ogata, N. Ohashi, S. Kitajima and J. Kanno (2008) Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33 105-116
140. S. Takahashi and O. Matsuoka (1981) Cross placental transfer of (1981) Au-colloid in near term rats. J Radiat Res (Tokyo) 22 242-249
141. K. Takeda, K. Suzuki, A. Ishihara, M. Kubo-Irie, R. Fujimoto, M. Tabata, S. Oshio, Y. Nihei, T. Ihara and M. Sugamata (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55 95-102
142. R. Tenne, M. Remskar, A. Enyashin and G. Seifert (2008) Inorganic nanotubes and fullerene-like structures. A. Jorio, G. Dresselhaus, M.S. Dresselhaus (Eds) Carbon Nanotubes Berlin Heidelberg: Springer-Verlag 631-671
143. J. Thompson and J. Bannigan (2008) Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 25 304-315
144. F. Tian, D. Razansky, G.G. Estrada, M. Semmler-Behnke, A. Beyerle, W. Kreyling, V. Ntziachristos and T. Stoeger (2009) Surface modification and size dependence in particle translocation during early embryonic development. Inhal Toxicol 21 92-96
145. Y. Tozuka, N. Watanabe, M. Osawa, A. Toriba, R. Kizu and K. Hayakawa (2004) Transfer of polycyclic aromatic hydrocarbons to fetuses and breast milk of rats exposed to diesel exhaust. J Health Sci 50 497-502
146. T. Tsuchiya, I. Oguri, Y.N. Yamakoshi and N. Miyata (1996) Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Lett 393 139-145
147. United States Environmental Protection Agency (1991) Guidelines for developmental toxicity risk assessment. Fed Regist 56 63798-63826
148. US Environmental Protection Agency. Nanomaterials Research Strategy. EPA 620/K-09/011 (2009) Washington DC. Office of Research and Development, US Environmental Protection Agency. Ref Type: Report
149. C.Y. Usenko, S.L. Harper and R.L. Tanguay (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon NY 45 1891-1898
150. H. Wang, D.W. Brandl, F. Le, P. Nordlander and N.J. Halas (2006) Nanorice: a hybrid plasmonic nanostructure. Nano Lett 6 827-832
151. D.B. Warheit, R.A. Hoke, C. Finlay, E.M. Donner, K.L. Reed and C.M. Sayes (2007) Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 171 99-110
152. N. Watanabe and M. Ohsawa (2002) Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods. BMC Pregnancy Childbirth 2 2-11
153. P. Wick, A. Malek, P. Manser, D. Meili, X. Maeder-Althaus, L. Diener, P.A. Diener, A. Zisch, H.F. Krug and M.U. von (2010) Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118 432-436
154. U. Wirnitzer, B. Herbold, M. Voetz and J. Ragot (2009) Studies on the in vitro genotoxicity of baytubes, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT). Toxicol Lett 186 160-165
155. Woodrow Wilson. Woodrow Wilson International Centre for Scholars (2010) Ref Type: Electronic Citation
156. T. Xia, M. Kovochich, J. Brant, M. Hotze, J. Sempf, T. Oberley, C. Sioutas, J.I. Yeh, M.R. Wiesner and A.E. Nel (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6 1794-1807
157. T. Xia, M. Kovochich, M. Liong, L. Madler, B. Gilbert, H. Shi, J.I. Yeh, J.I. Zink and A.E. Nel (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2 2121-2134
158. H. Yang, C. Liu, D. Yang, H. Zhang and Z. Xi (2009) Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 29 69-78
159. H.L. Yang, J.C. Lin and C. Huang (2009) Application of nanosilver surface modification to RO membrane and spacer for mitigating biofouling in seawater desalination. Water Res. 43 3777-3786
160. S.T. Yang, X. Wang, G. Jia, Y. Gu, T. Wang, H. Nie, C. Ge, H. Wang and Y. Liu (2008) Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol Lett 181 182-189
161. S. Yoshida, K. Hiyoshi, S. Oshio, H. Takano, K. Takeda and T. Ichinose (2009) Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring. Fertil Steril 93 1695-1699
162. X. Zhu, J. Wang, X. Zhang, Y. Chang and Y. Chen (2009) The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio). Nanotechnology 20 195103
163. X. Zhu, L. Zhu, Y. Li, Z. Duan, W. Chen and P.J. Alvarez (2007) Developmental toxicity in zebrafish (Danio rerio) embryos after exposure to manufactured nanomaterials: buckminsterfullerene aggregates (nC60) and fullerol. Environ Toxicol Chem 26 976-979