Cadmium-induced testicular damage in a rat model of subchronic intoxication

Reproductive Medicine and Biology

Volumn 1, Issue 2, 2002, Pages 59-63

  Aoyagi, Teiichiro ^a   Ishikawa, Hiromichi ^a   Miyaji, Keisuke ^a   Hayakawa, Kunihiro ^a   Hata, Makoto ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

Author keywords

cadmium; spermatogenesis; testes

Indexed keywords

EID: 27944458693     PISSN: 14455781     EISSN: 14470578     Source Type: Journal    
DOI: 10.1046/j.1445-5781.2002.00010.x     Document Type: Article

References (12)

1. Friberg L, Kjellstrom T, Nordberg GF. Cadmium. In: Friberg L, Nordberg GF, Vouk VB,eds. Handbook on the Toxicology of Metals, Vol. 2. New York: Elsevier, 1986; 130–184.
2. Samarawickrama GP. In: Webb M, ed. The Chemistry, Biochemistry and Biology of Cadmium. Amsterdam: Elsevier, 1979; 341–408.
3. Waalkes MP, Rehm S, Riggs CW etal. Cadmium carcinogenesis in male Wistar rats:dose–response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res 1988; 48: 4656–4663.
4. Xu C, Johnson JE, Singh PK et al. In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 1996; 197: 1–8.
5. Tanimoto A, Hamada T, Koide O. Cell death and regeneration of renal proximal tubular cellsi n rats with subchronic cadmium intoxication. Toxicol Pathol 1993; 21: 341–352.
6. Vesterberg O, Wrangskogh K. Determination of cadmium in urine by graphite-furnace atomic absorption spectroscopy. Clin Chem 1978; 24: 681–685.pmid/639275
7. Gavrieli Y, Shrman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493–501.
8. Hamada T, Tanimoto A, Iwai S et al. Cytopathological changes induced by cadmium-exposure in canine proximal tubular cells: acytochemical and ultrastructural study. Nephron 1994; 68: 104–111.pmid/7991019
9. Nolan CV, Shaikh ZA. The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci 1986; 39: 1403–1409.
10. Suzuki JS, Kodama N, Molotkov A et al. Isolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis. Biochem J 1998; 334: 695–701.
11. Matsui H, Takahashi M. A novel quantitative morphometry of germ cells for the histopathological evaluation of rat testicular toxicity. J Toxicol Sci 1999; 24: 17–25.pmid/10073333
12. Lafuente A, Marquez N, Perez-Lorenzo M et al. Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol 2000; 38: 913–923.pmid/11039325