-
1
-
-
20344366079
-
Mitochondrial DNA and disease
-
Dimauro S, Davidzon G. Mitochondrial DNA and disease. Ann Med 2005;37:222-32
-
(2005)
Ann Med
, vol.37
, pp. 222-232
-
-
Dimauro, S.1
Davidzon, G.2
-
2
-
-
0036739108
-
Effects of troglitazone on HepG2 viability and mitochondrial function
-
Tirmenstein MA, Hu CX, Gales TL, et al. Effects of troglitazone on HepG2 viability and mitochondrial function. Toxicol Sci 2002;69:131-8
-
(2002)
Toxicol Sci
, vol.69
, pp. 131-138
-
-
Tirmenstein, M.A.1
Hu, C.X.2
Gales, T.L.3
-
3
-
-
15044359843
-
Statin-induced muscle necrosis in the rat: Distribution, development, and fibre selectivity
-
Westwood FR, Bigley A, Randall K, et al. Statin-induced muscle necrosis in the rat: distribution, development, and fibre selectivity. Toxicol Pathol 2005;33:246-57
-
(2005)
Toxicol Pathol
, vol.33
, pp. 246-257
-
-
Westwood, F.R.1
Bigley, A.2
Randall, K.3
-
4
-
-
34047154993
-
Strategies to reduce late-stage drug attrition due to mitochondrial toxicity
-
Dykens JA, Marroquin LD, Will Y. Strategies to reduce late-stage drug attrition due to mitochondrial toxicity. Expert Rev Mol Diagn 2007;7:161-75
-
(2007)
Expert Rev Mol Diagn
, vol.7
, pp. 161-175
-
-
Dykens, J.A.1
Marroquin, L.D.2
Will, Y.3
-
5
-
-
84904286582
-
-
Website describing oxygraphs. Available from www.hansatech.com [Last accessed 20 June 2014]
-
-
-
-
6
-
-
84904306434
-
-
Website describing high resolution respirometry. Available from www.orosboros.com [Last accessed 20 June 2014]
-
-
-
-
7
-
-
84904353098
-
-
Website desribign soluble oxygen sensors. Available from www.luxcel.com [Last accessed 20 June 2014]
-
-
-
-
8
-
-
33745584060
-
Investigation of drug-induced mitochondrial toxicity using fluorescencebased oxygen-sensitive probes
-
Hynes J, Marroquin LD, Ogurtsov VI, et al. Investigation of drug-induced mitochondrial toxicity using fluorescencebased oxygen-sensitive probes. Toxicol Sci 2006;92:186-200
-
(2006)
Toxicol Sci
, vol.92
, pp. 186-200
-
-
Hynes, J.1
Marroquin, L.D.2
Ogurtsov, V.I.3
-
9
-
-
65549156637
-
Fluorescent pH and oxygen probes of the assessment of mitochondrial toxicity in isolated mitochondria and whole cells. Curr Protoc Toxicol
-
Hynes J, Natoli E Jr, Will Y. Fluorescent pH and oxygen probes of the assessment of mitochondrial toxicity in isolated mitochondria and whole cells. Curr Protoc Toxicol 2009;Chapter 2:Unit 2.16
-
(2009)
Chapter 2:Unit 2.16
-
-
Hynes, J.1
Natoli, Jr.E.2
Will, Y.3
-
10
-
-
82355183884
-
High-throughput analysis of mitochondrial oxygen consumption
-
Hynes J, Swiss RL, Will Y. High-throughput analysis of mitochondrial oxygen consumption. Methods Mol Biol 2012;810:59-72
-
(2012)
Methods Mol Biol
, vol.810
, pp. 59-72
-
-
Hynes, J.1
Swiss, R.L.2
Will, Y.3
-
11
-
-
34247096170
-
Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays
-
Nadanaciva S, Bernal A, Aggeler R, et al. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicol In Vitro 2007;21:902-11
-
(2007)
Toxicol in Vitro
, vol.21
, pp. 902-911
-
-
Nadanaciva, S.1
Bernal, A.2
Aggeler, R.3
-
12
-
-
34548410988
-
Mitochondrial toxicity of PPAR agonists and statins is exacerbated by combined exposure
-
Nadanaciva S, Dykens JA, Bernal A, et al. Mitochondrial toxicity of PPAR agonists and statins is exacerbated by combined exposure. Toxicol Appl Pharmacol 2007;223:277-87
-
(2007)
Toxicol Appl Pharmacol
, vol.223
, pp. 277-287
-
-
Nadanaciva, S.1
Dykens, J.A.2
Bernal, A.3
-
13
-
-
0033569442
-
The protonlinked monocarboxylate transporter (MCT) family: Structure, function and regulation
-
Halestrap AP, Price NT. The protonlinked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999;343:281-99
-
(1999)
Biochem J
, vol.343
, pp. 281-299
-
-
Halestrap, A.P.1
Price, N.T.2
-
14
-
-
0037381942
-
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin
-
Wang DS, Kusuhara H, Kato Y, et al. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Mol Pharmacol 2003;63:844-8
-
(2003)
Mol Pharmacol
, vol.63
, pp. 844-848
-
-
Wang, D.S.1
Kusuhara, H.2
Kato, Y.3
-
15
-
-
56049086590
-
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
-
Dykens JA, Jamieson J, Marroquin L, et al. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol 2008;233:203-10
-
(2008)
Toxicol Appl Pharmacol
, vol.233
, pp. 203-210
-
-
Dykens, J.A.1
Jamieson, J.2
Marroquin, L.3
-
16
-
-
43349090542
-
-
Dykens JA, Jamieson JD, Marroquin LD, et al. In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone. Toxicol Sci 2008;103:335-45
-
(2008)
In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone. Toxicol Sci
, vol.103
, pp. 335-345
-
-
Dykens, J.A.1
Jamieson, J.D.2
Marroquin, L.D.3
-
17
-
-
34447577912
-
Circumventing the Crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants
-
Marroquin LD, Hynes J, Dykens JA, et al. Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol Sci 2007;97:539-47
-
(2007)
Toxicol Sci
, vol.97
, pp. 539-547
-
-
Marroquin, L.D.1
Hynes, J.2
Dykens, J.A.3
-
18
-
-
84858279070
-
Assessment of mitochondrial toxicity in HepG2 cells cultured in high-glucose- or galactosecontaining media
-
Swiss R, Will Y. Assessment of mitochondrial toxicity in HepG2 cells cultured in high-glucose- or galactosecontaining media. Curr Protoc Toxicol 2011;Chapter 2:Unit2.20
-
Curr Protoc Toxicol 2011;Chapter 2:Unit2.20
-
-
Swiss, R.1
Will, Y.2
-
19
-
-
0018386209
-
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
-
Reitzer LJ, Wice BM, Kennell D. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 1979;254:2669-76
-
(1979)
J Biol Chem
, vol.254
, pp. 2669-2676
-
-
Reitzer, L.J.1
Wice, B.M.2
Kennell, D.3
-
20
-
-
84875277824
-
A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays
-
Hynes J, Nadanaciva S, Swiss R, et al. A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays. Toxicol In Vitro 2013;27:560-9
-
(2013)
Toxicol in Vitro
, vol.27
, pp. 560-569
-
-
Hynes, J.1
Nadanaciva, S.2
Swiss, R.3
-
21
-
-
84879353352
-
Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death
-
Swiss R, Niles A, Cali JJ, et al. Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death. Toxicol In Vitro 2013;27:1789-97
-
(2013)
Toxicol in Vitro
, vol.27
, pp. 1789-1797
-
-
Swiss, R.1
Niles, A.2
Cali, J.J.3
-
22
-
-
84904367515
-
-
Website describing the mitochondrial toxicity test. Available from www.promega.com [Last accessed 20 June 2014]
-
-
-
-
23
-
-
84904341824
-
-
Website describing the metablic flux analyzer. Available from www.seahorsebiosciences.com [Last accessed 20 June 2014]
-
-
-
-
24
-
-
84866736730
-
Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform
-
Nadanaciva S, Rana P, Beeson GC, et al. Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform. J Bioenerg Biomembr 2012;44:421-37
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 421-437
-
-
Nadanaciva, S.1
Rana, P.2
Beeson, G.C.3
-
25
-
-
84866596506
-
Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria
-
Porceddu M, Buron N, Roussel C, et al. Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria. Toxicol Sci 2012;129:332-45
-
(2012)
Toxicol Sci
, vol.129
, pp. 332-345
-
-
Porceddu, M.1
Buron, N.2
Roussel, C.3
-
26
-
-
84906937883
-
Human drug-induced liver injury severity is highly associated to dual inhibition of liver mitochondrial function and bile salt export pump
-
Epub ahead of print
-
Aleo MD, Luo Y, Swiss R, et al. Human drug-induced liver injury severity is highly associated to dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology 2014; Epub ahead of print
-
(2014)
Hepatology
-
-
Aleo, M.D.1
Luo, Y.2
Swiss, R.3
-
27
-
-
34347250517
-
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
-
Ong MM, Latchoumycandane C, Boelsterli UA. Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. Toxicol Sci 2007;97:205-13
-
(2007)
Toxicol Sci
, vol.97
, pp. 205-213
-
-
Ong, M.M.1
Latchoumycandane, C.2
Boelsterli, U.A.3
-
28
-
-
77956180672
-
Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction
-
Hsiao CJ, Younis H, Boelsterli UA. Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction. Chem Biol Interact 2010;188:204-13
-
(2010)
Chem Biol Interact
, vol.188
, pp. 204-213
-
-
Hsiao, C.J.1
Younis, H.2
Boelsterli, U.A.3
-
29
-
-
84866878955
-
Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms
-
Pereira CV, Oliveira PJ, Will Y, Nadanaciva S. Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms. Toxicol Appl Pharmacol 2012;264:167-81
-
(2012)
Toxicol Appl Pharmacol
, Issue.264
, pp. 167-181
-
-
Pereira, C.V.1
Oliveira, P.J.2
Will, Y.3
Nadanaciva, S.4
-
30
-
-
56249114493
-
Mitochondrial function in vivo: Spectroscopy provides window on cellular energetics
-
Amara CE, Marcinek DJ, Shankland EG, et al. Mitochondrial function in vivo: spectroscopy provides window on cellular energetics. Methods 2008;46:312-18
-
(2008)
Methods
, vol.46
, pp. 312-318
-
-
Amara, C.E.1
Marcinek, D.J.2
Shankland, E.G.3
-
31
-
-
84904320924
-
-
Website describing antibodies commonly used for mitochondrial research. Available from www.mitosciences.com [Last accessed 20 June 2014]
-
-
-
-
32
-
-
84872418997
-
The development of structureactivity relationships for mitochondrial dysfunction: Uncoupling of oxidative phosphorylation
-
Naven RT, Swiss R, Klug-McLeod J, et al. The development of structureactivity relationships for mitochondrial dysfunction: uncoupling of oxidative phosphorylation. Toxicol Sci 2013;131:271-8
-
(2013)
Toxicol Sci
, vol.131
, pp. 271-278
-
-
Naven, R.T.1
Swiss, R.2
Klug-Mcleod, J.3
-
33
-
-
78449283897
-
High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells
-
Nadanaciva S, Dillman K, Gebhard DF, et al. High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells. J Biomol Screen 2010;15:937-48
-
(2010)
J Biomol Screen
, vol.15
, pp. 937-948
-
-
Nadanaciva, S.1
Dillman, K.2
Gebhard, D.F.3
-
34
-
-
84891306505
-
Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury
-
Laifenfeld D, Qiu L, Swiss R, et al. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci 2014;137:234-48
-
(2014)
Toxicol Sci
, vol.137
, pp. 234-248
-
-
Laifenfeld, D.1
Qiu, L.2
Swiss, R.3
-
35
-
-
84887121206
-
Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers
-
McGill MR, Jaeschke H. Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers. Crit Care Med 2013;41:2653-4
-
(2013)
Crit Care Med
, vol.41
, pp. 2653-2654
-
-
McGill, M.R.1
Jaeschke, H.2
-
36
-
-
84899766207
-
Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans
-
McGill MR, Cao M, Svetlov A, et al. Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers 2014;19:222-30
-
(2014)
Biomarkers
, vol.19
, pp. 222-230
-
-
McGill, M.R.1
Cao, M.2
Svetlov, A.3
-
37
-
-
84904293212
-
ATP synthase beta is a novel urinary biomarker of renal mitochondrial dysfunction
-
Korrapati M, Whitaker RM, Stallons LJ, et al. ATP synthase beta is a novel urinary biomarker of renal mitochondrial dysfunction. Toxicologist 2014;138:25
-
(2014)
Toxicologist
, vol.138
, pp. 25
-
-
Korrapati, M.1
Whitaker, R.M.2
Stallons, L.J.3
-
38
-
-
84904341149
-
Urinary mitochondrial DNA as a novel biomarker of mitochondrial dysfunction in human acute kidney injury
-
Stallons LJ, Arthur J, Beeson C, Schnellmann RG. Urinary mitochondrial DNA as a novel biomarker of mitochondrial dysfunction in human acute kidney injury. Toxicologist 2014;138:24
-
(2014)
Toxicologist
, vol.138
, pp. 24
-
-
Stallons, L.J.1
Arthur, J.2
Beeson, C.3
Schnellmann, R.G.4
-
39
-
-
84904290435
-
-
Website of global provider of genetically modified mouse and rat models and services. Available from: www.taconic.com [Last accessed 25 June 2014]
-
-
-
|