The development of structure-activity relationships for mitochondrial dysfunction: Uncoupling of oxidative phosphorylation

Toxicological Sciences

Volumn 131, Issue 1, 2013, Pages 271-278

  Naven, Russell T ^a   Swiss, Rachel ^a   Klug Mcleod, Jacquelyn ^a   Will, Yvonne ^a   Greene, Nigel ^a  

^a PFIZER INC   (United States)

Author keywords

Mitochondrial dysfunction; SAR; Structural alerts; Structure activity relationships; Uncoupling

Indexed keywords

ACYLINDOLONE DERIVATIVE; ANILIDE; ANTHRANILIC ACID DERIVATIVE; FLUOROMETHYLSULFONANILIDE DERIVATIVE; HYDRONAPHTHOQUINONE; INDOLE DERIVATIVE; NAPHTHOQUINONE; NITROPHENOL; NITROSULFONANILIDE DERIVATIVE; PHENYLHYDRAZONE DERIVATIVE; SALICYLIC ACID DERIVATIVE; THIADIAZINE DERIVATIVE; THIADIAZINEDIONE DERIVATIVE; THIAZOLE DERIVATIVE; THIAZOLINEDIONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DEPROTONATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DATABASE; LIPOPHILICITY; LIVER MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PHYSICAL CHEMISTRY; PKA; PREDICTIVE VALUE; PROTON TRANSPORT; RAT; RESPIRATORY SCREENING TECHNOLOGY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHARMACEUTICAL PREPARATIONS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UNCOUPLING AGENTS;

EID: 84872418997     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs279     Document Type: Article

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